• Journal of Pharmaceutical Investigation
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• v.22 no.2
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• pp.115-124
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• 1992

The characteristics and stabilities of phosphatidylcholine liposomes covalently coupled with immunoglobulin fragments prepared by the REV method were investigated by the dynamic light scattering, absorbance and calcein release. Using a sulfhydryl-reactive phospholipid derivative of N-[4$({\rho}-maleimido-phenyl)$ butyl] phosphatidylethanolamine (MPB-PE), Fab' antibody fragments were covalently combined with preformed large unilamellar vesicles (LUV), Coupling ratio was $250\;{\mu}g$ of $Fab'/{\mu}mol$ of phospholipid in vesicles, From dynamic light scattering, it was found that the size of the vesicles increases as the ratio of cholesterol to lipid increases, but that apparently, the size of liposomes was not sensitive to the existence of Fab' fragments. Regardless of inserting Fab' fragments, the absorbance of liposomes decreased as the amounts of bile salt (BS) added. At very low BS concentrations, BS/lipid aggregates would be formed in the outer vesicles monolayer, while, at the high BS concentrations, mixed micelles would be preferred. The vesicles incorporated with Fab' fragments, however, are more resistant to the bile salts than the MPB-PE vesicle are. The absorbance of vacant liposomes and calcein release resulted in that the Fab' vesicles and MPB-PE vesicles by the REV method are very stable, but that those by the sonication method sufferred the significant change of turbidities.

• Journal of Institute of Control, Robotics and Systems
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• v.22 no.5
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• pp.346-352
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• 2016

This paper proposes an adaptive robust control method for an acrobot system in the presence of input disturbance. The acrobot system is a typical example of the underactuated system with complex nonlinearity and strong dynamic coupling. Also, disturbance can cause limit cycle phenomenon which appears in the acrobot system around the desired unstable equilibrium point. To minimize the effect of the disturbance, we apply a fuzzy disturbance estimation method for the swing-up and balancing control of the acrobot system. In this paper, both disturbance observer and controller for the acrobot system are designed and verified through mathematical proof and simulations.

• Journal of KSNVE
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• v.6 no.1
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• pp.71-82
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• 1996

The finite element analysis for rotor bearing systems has been an essential tool for design, identification, and diagnosis of rotating machinery. Among others, the unbalance response analysis is fundamental in the vibration analysis of rotor bearing systems because rotating unbalance is recognized as a common sourve of vibration in rotating machinery. However there still remains a problem in the aspect of computational efficiency for unbalance response analysis of large rotor bearing systems. Gyroscopic terms and local bearing parameters in rotor bearing systems often make matters worse in unbalance response computation due to the complicated dynamic properties such as rotational speed dependency and/or anisotropy. The present paper proposes an efficient method for unbalance responses of multi-span rotor bearing systems. An improved substructure synthesis scheme is introduced which makes it possible to compute unbalance responses of the system by coupling unbalance responses of substructures that are of self adjoint problem with small order matrices. The present paper also suggests a scheme to easily deal with gyroscopic tems and local, coupling or bearing parameters. The proposed method causes no errors even though the computational effort is reduced drastically. The present method is demonstrated through three test examples.

• Journal of the Society of Naval Architects of Korea
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• v.40 no.6
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• pp.80-87
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• 2003

Tank structures in ships are in contact with various fluid. The vibration characteristics of those structures are strongly affected by the added mass due to containing fluid. It is important to predict vibration characteristics of tank structures, but it is difficult to do. That's because the interaction problem concerned with the free surface, the variation of water depth and stiffener is to be considered between the fluid and the structure. Many authors have studied vibration of rectangular tank structures containing water. Kito studied added mass effect of water in contact with thin elastic flat plates. Kim et al. studied flexural vibration of stiffened plates in contact with water. However, few researches on dynamic interaction tank walls with water are reported in the vibration of rectangular tanks recently. in the present report, the coupling effect of added mass of fluid and structural constraint between panels on each vibration mode changing breadth of elastic plate, and dynamic pressure distribution have investigated numerically and discussed.

• Proceedings of the Korean Nuclear Society Conference
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• 1998.05a
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• pp.641-646
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• 1998

In order to enhance the dynamic and interactive simulation capability of a system thermal hydraulic code for nuclear power plant, applicability of flow network models in SINDA/FLUIN $T^{™}$ has been tested by modeling feedwater system and coupling to DSNP which is one of a system thermal hydraulic simulation code for a pressurized heavy water reactor. The feedwater system is selected since it is one of the most important balance of plant systems with a potential to greatly affect the behavior of nuclear steam supply system. The flow network model of this feedwater system consists of condenser, condensate pumps, low and high pressure heaters, deaerator, feedwater pumps, and control valves. This complicated flow network is modeled and coupled to DSNP and it is tested for several normal and abnormal transient conditions such turbine load maneuvering, turbine trip, and loss of class IV power. The results show reasonable behavior of the coupled code and also gives a good dynamic and interactive simulation capabilities for the several mild transient conditions. It has been found that coupling system thermal hydraulic code with a flow network code is a proper way of upgrading simulation capability of DSNP to mature nuclear plant analyzer (NPA).

• Steel and Composite Structures
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• v.20 no.1
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• pp.107-125
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• 2016

Steel shear wall system has been used in recent years in tall buildings due to its appropriate behavior advantages such as stiffness, high strength, economic feasibility and high energy absorption capability. Coupled steel plate shear walls consist of two steel shear walls that are connected to each other by steel link beam at each floor level. In this article the frames of 3, 10, and 15 of (C-SPSW) floor with rigid connection were considered in three different lengths of 1.25, 2.5 and 3.75 meters and link beams with plastic section modulus of 100% to the panel beam at each floor level and analyzed using three pairs of accelerograms based on nonlinear dynamic analysis through ABAQUS software and then the performance of walls and link beams at base shear, drift, the period of structure, degree of coupling (DC) and dissipated energy evaluated. The results show that the (C-SPSW) system base shear increases with a decrease in the link beam length, and the drift, main period and dissipated energy of structure decreases. Also the link beam length has different effects on parameters of coupling degrees.

• Proceedings of the KSME Conference
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• 2001.06b
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• pp.601-606
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• 2001

Free vibration analysis was performed for a spinning disk/spindle system mounted on a flexible baseplate. A simplified model was presented considering the effects of the baseplate flexibility on a disk/spindle system, and the equations of motion were derived by the assumed mode method and Lagrange's equation. From the results of the tree vibration analysis, the variations of the natural frequencies were investigated by changing rotating speed, baseplate thickness. They were attributed to the coupling between the flexible modes of the spinning disk/spindle system and the baseplate. This simplified model was used to predict the dynamic characteristics of a small size disk drive. The validity of the simplified model was verified by experiments and FE analysis.

• Earthquakes and Structures
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• v.13 no.1
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• pp.67-77
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• 2017

Oil storage tanks are vital life-line structures, suffered significant damages during past earthquakes. In this study, a numerical model for an unanchored vertical vaulted-type tank was established by ANSYS software, including the tank-liquid coupling, nonlinear uplift and slip effect between the tank bottom and foundation. Four actual earthquakes recorded at different soil sites were selected as input to study the dynamic characteristics of the tank by nonlinear time-history dynamic analysis, including the elephant-foot buckling, the liquid sloshing, the uplift and slip at the bottom. The results demonstrate that, obvious elephant-foot deformation and buckling failure occurred near the bottom of the tank wall under the seismic input of Class-I and Class-IV sites. The local buckling failure appeared at the location close to the elephant-foot because the axial compressive stress exceeded the allowable critical stress. Under the seismic input of Class-IV site, significant nonlinear uplift and slip occurred at the tank bottom. Large amplitude vertical sloshing with a long period occurred on the free surface of the liquid under the seismic wave record at Class-III site. The seismic properties of the storage tank were affected by site class and should be considered in the seismic design of large tanks. Effective measures should be taken to reduce the seismic response of storage tanks, and ensure the safety of tanks.

• Proceedings of the KIEE Conference
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• 2003.11c
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• pp.735-739
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• 2003

This paper presents a direct seek control algorithm for swing-arm type dual stage servo system that consists of a coarse actuator and a fine actuator. The proposed scheme is to design a control system that attenuates the effect of dynamic coupling between the two actuators so that the seek operation can be performed in a single-shot with stability. In an optical drive system with dual stage servo mechanism, the effect of dynamic coupling between the two actuators needs to be handled during the coarse seek operation due to its inherent structure. In an extreme case, the two actuators can collide each other, which leads to critical degradation of the seek performance. To handle this problem, our proposed control scheme is to generate the drive signals such that the two actuators behave as if they are a single fixed body. To this end, a feedforward controller and two feedback controllers are designed that enable the current drive system perform wide range of track seek. Simulation results are provided to show the validity and feasibility of our proposed algorithm.

• Ocean Systems Engineering
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• v.9 no.1
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• pp.21-42
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• 2019

In this paper, the Finite-Analytic Navier-Stokes (FANS) code is coupled with an in-house finite-element code to study the dynamic interaction between a floating buoy and its mooring system. Hydrodynamic loads on the buoy are predicted with the FANS module, in which Large Eddy Simulation (LES) is used as the turbulence model. The mooring lines are modeled based on a slender body theory. Their dynamic responses are simulated with a nonlinear finite element module, MOORING3D. The two modules are coupled by transferring the forces and displacements of the buoy and its mooring system at their connections through an interface module. A free-decay model test was used to calibrate the coupled method. In addition, to investigate the capability of the present coupled method, numerical simulations of two degree-of-freedom vortex-induced motion of a CALM buoy in uniform currents were performed. With the study it can be verified that accurate predictions of the motion responses and tension responses of the CALM buoy system can be made with the coupling CFD-FEM method.