• 한국자기공명학회논문지
• /
• 제9권2호
• /
• pp.93-102
• /
• 2005

Purpose: To develop an advanced non-linear curve fitting (NLCF) algorithm for dynamic susceptibility contrast study of brain. Materials and Methods: The first pass effects give rise to spuriously high estimates of $K^{trans}$ in voxels with large vascular components. An explicit threshold value has been used to reject voxels. Results: By using this non-linear curve fitting algorithm, the blood perfusion and the volume estimation were accurately evaluated in T2*-weighted dynamic contrast enhanced (DCE)-MR images. From the recalculated each parameters, perfusion weighted image were outlined by using modified non-linear curve fitting algorithm. This results were improved estimation of T2*-weighted dynamic series. Conclusion: The present study demonstrated an improvement of an estimation of kinetic parameters from dynamic contrast-enhanced (DCE) T2*-weighted magnetic resonance imaging data, using contrast agents. The advanced kinetic models include the relation of volume transfer constant $K^{trans}\;(min^{-1})$ and the volume of extravascular extracellular space (EES) per unit volume of tissue $\nu_e$.

• Korean Journal of Radiology
• /
• 제1권4호
• /
• pp.185-190
• /
• 2000

Objective: To document the imaging findings of hepatic cavernous hemangioma detected in cirrhotic liver. Materials and Methods: The imaging findings of 14 hepatic cavernous hemangiomas in ten patients with liver cirrhosis were retrospectively analyzed. A diagnosis of hepatic cavernous hemangioma was based on the findings of two or more of the following imaging studies: MR, including contrast-enhanced dynamic imaging (n = 10), dynamic CT (n = 4), hepatic arteriography (n = 9), and US (n = 10). Results: The mean size of the 14 hepatic hemangiomas was 0.9 (range, 0.5-1.5) cm in the longest dimension. In 11 of these (79%), contrast-enhanced dynamic CT and MR imaging showed rapid contrast enhancement of the entire lesion during the early phase, and hepatic arteriography revealed globular enhancement and rapid filling-in. On contrast-enhanced MR images, three lesions (21%) showed partial enhancement until the 5-min delayed phases. US indicated that while three slowly enhancing lesions were homogeneously hyperechoic, 9 (82%) of 11 showing rapid enhancement were not delineated. Conclusion: The majority of hepatic cavernous hemangiomas detected in cirrhotic liver are small in size, and in many, hepatic arteriography and/or contrast-enhanced dynamic CT and MR imaging demonstrates rapid enhancement. US, however, fails to distinguish a lesion of this kind from its cirrhotic background.

• Investigative Magnetic Resonance Imaging
• /
• 제23권1호
• /
• pp.1-16
• /
• 2019

Dynamic contrast enhanced (DCE) magnetic resonance (MR) imaging plays an important role in non-invasive detection and characterization of primary and metastatic lesions in the liver. Recently, efforts have been made to improve spatial and temporal resolution of DCE liver MRI for arterial phase imaging. Review of recent publications related to arterial phase imaging of the liver indicates that there exist primarily two approaches: breath-hold and free-breathing. For breath-hold imaging, acquiring multiple arterial phase images in a breath-hold is the preferred approach over conventional single-phase imaging. For free-breathing imaging, a combination of three-dimensional (3D) stack-of-stars golden-angle sampling and compressed sensing parallel imaging reconstruction is one of emerging techniques. Self-gating can be used to decrease respiratory motion artifact. This article introduces recent MRI technologies relevant to hepatic arterial phase imaging, including differential subsampling with Cartesian ordering (DISCO), golden-angle radial sparse parallel (GRASP), and X-D GRASP. This article also describes techniques related to dynamic 3D image reconstruction of the liver from golden-angle stack-of-stars data.

• 대한디지털의료영상학회논문지
• /
• 제15권1호
• /
• pp.27-31
• /
• 2013

Perfusion MR imaging is how to use exogenous and endogenous contrast agent. Exogenous perfusion MRI methods which are dynamic susceptibility contrast using $T2^*$ effect and dynamic contrast-enhanced using T1 weighted image after injection contrast media. An endogenous perfusion MRI method which is arterial spin labeling using arterial blood flow in body. In order to exam perfusion MRI in human, technical access are very important according to disease conditions. For instance, dynamic susceptibility contrast is used in patients with acute stroke because of short exam time, while dynamic susceptibility contrast or dynamic contrast enhancement provides the various perfusion information for patients with tumor, vascular stenosis. Arterial spin labeling is useful for children, women who are expected to be pregnant. In this regard, perfusion MR imaging is required to understanding, and the author would like to share information with clinical users

• 대한자기공명의과학회:학술대회논문집
• /
• 대한자기공명의과학회 2002년도 제7차 학술대회 초록집
• /
• pp.135-135
• /
• 2002

Purpose： To assess diagnostic accuracy of dynamic contrast enhanced MR mammography in differentiating between benign and malignant lesions. Materials and methods： Ninety-three patients with suspicious mammographic, sonographic or palpable findings underwent pre- or postoperative contrast-enhanced MR imaging of breast using three dimensional fast low-angle shot (3D FLASH) sequence (16/4 msec［repetition time / echo time］, 20 flip angle, 3mm slice thickness with no slice gap, 256 by 256 in-plane matrix) covering whole breasts. T1 weighted images were obtained before and after bolus administration of gadopentetate dimeglumine (0.15 mmol/kg). Subtraction images and time-signal intensity curves of region of interest were obtained sequentially and correlated with pathologic diagnoses of lesions.

• 정보처리학회논문지:소프트웨어 및 데이터공학
• /
• 제9권2호
• /
• pp.69-76
• /
• 2020

본 연구에서는 조영증강 초음파 영상에서 조영효과 확산 패턴과 동적 혈류 패턴을 가시화 하는 방법론을 제시한다. 세부적으로 조영증강 초음파 데이터에서 조영제의 전이시간, 최대 명도변화, 조영효과의 감쇄 시간 등과 같은 진단 파라미터를 영상으로 생성하는 기법을 제안한다. 간병변 진단과 같은 의료 진단에서 조영제의 전이와 확산 속도는 매우 중요한 요소가 된다. 이에 본 연구에서는 조영효과의 확산 패턴을 하나의 영상으로 표현하는 방법을 제시하였다. 이 과정에서 호흡에 의한 흔들림으로 인하여 영상의 정확도가 저하시키는 현상을 개선하기 위하여 호흡주기에 따른 동적 가중치와 모멘텀 요소를 사용하는 영상추적 기법을 제안하였다. 총 72개의 조영증강 데이터를 사용한 실험을 통하여, 제안된 기법이 초음파진단에서 육안 판별의 한계를 극복할 수 있게 하고, 호흡에 의한 흔들림을 보정함으로써 진단 파라미터의 신뢰도를 향상시킬 수 있음을 보인다.

• Investigative Magnetic Resonance Imaging
• /
• 제23권3호
• /
• pp.220-227
• /
• 2019

Purpose: To evaluate the usefulness of wash-in color map in detecting early enhancement of prostate focal lesion compared to whole dynamic contrast-enhanced MRI (DEC MRI) images. Materials and Methods: This study engaged 50 prostate cancer patients who underwent multiparametric MRI and radical prostatectomy as subjects. An expert [R1] and a trainee [R2] independently evaluated early enhancement and recorded the time needed to review 1) a wash-in color map and 2) whole DCE MRI images. Results: The review of whole DCE images by R1 showed fair agreement with color map by R1, whole images by R2, and color map by R2 (weighted kappa values = 0.59, 0.44, and 0.58, respectively). Both readers took a significantly shorter time to review the color maps as compared to whole images (P < 0.001). Conclusion: A trainee could achieve better agreement with an expert when using wash-in color maps than when using whole DCE MRI images. Also, color maps took a significantly shorter evaluation time than whole images.

• Korean Journal of Radiology
• /
• 제22권8호
• /
• pp.1369-1378
• /
• 2021

Objective: Few attempts have been made to investigate the prognostic value of dynamic contrast-enhanced (DCE) MRI or dynamic susceptibility contrast (DSC) MRI of non-enhancing, T2-high-signal-intensity (T2-HSI) lesions of glioblastoma multiforme (GBM) in newly diagnosed patients. This study aimed to investigate the prognostic values of DCE MRI and DSC MRI parameters from non-enhancing, T2-HSI lesions of GBM. Materials and Methods: A total of 76 patients with GBM who underwent preoperative DCE MRI and DSC MRI and standard treatment were retrospectively included. Six months after surgery, the patients were categorized into early progression (n = 15) and non-early progression (n = 61) groups. We extracted and analyzed the permeability and perfusion parameters of both modalities for the non-enhancing, T2-HSI lesions of the tumors. The optimal percentiles of the respective parameters obtained from cumulative histograms were determined using receiver operating characteristic (ROC) curve and univariable Cox regression analyses. The results were compared using multivariable Cox proportional hazards regression analysis of progression-free survival. Results: The 95th percentile value (PV) of Ktrans, mean Ktrans, and median Ve were significant predictors of early progression as identified by the ROC curve analysis (area under the ROC curve [AUC] = 0.704, p = 0.005; AUC = 0.684, p = 0.021; and AUC = 0.670, p = 0.0325, respectively). Univariable Cox regression analysis of the above three parametric values showed that the 95th PV of Ktrans and the mean Ktrans were significant predictors of early progression (hazard ratio [HR] = 1.06, p = 0.009; HR = 1.25, p = 0.017, respectively). Multivariable Cox regression analysis, which also incorporated clinical parameters, revealed that the 95th PV of Ktrans was the sole significant independent predictor of early progression (HR = 1.062, p < 0.009). Conclusion: The 95th PV of Ktrans from the non-enhancing, T2-HSI lesions of GBM is a potential prognostic marker for disease progression.

• 한국콘텐츠학회논문지
• /
• 제12권9호
• /
• pp.270-279
• /
• 2012

토끼 뇌에 대장균을 주입하여 CT 소견을 알아보고, 시간에 따른 동맥혈의 하운스필드 값의 변화를 알아보고자 하였다. 토끼 두개관에 천두공(burr hole)을 뚫고 2~3 mm 깊이에 대장균 $1{\times}10^7$ CFU/ml, 0.1 ml을 주입하여 뇌염증 모델을 제작하고, 조영 증강 CT와 동적 CT, 그리고 동맥혈의 CT영상을 얻었다.조영 증강 CT에서 뇌농양, 뇌실염 그리고 뇌막염등 다양한 뇌염증 소견이 보였다. 뇌농양은 중앙부가 거의 조영되지 않고 주변부가 강하게 조영되는 전형적인 양상을 보였고, 뇌실염은 측뇌실 벽을 따라 강하게 조영되는 소견을 보였으며, 뇌막염은 종뇌와 간뇌의 접히는 부위 뇌막이 강하게 조영되었다. 동적 CT영상에서 염증 중앙부의 조영제 주입 전 HU 값은 $31.01{\pm}3.55$였고, 주입 후 10분까지 $40.36{\pm}3.76$으로 서서히 증가하였다. 그리고 염증 가장자리구역에서 HU 값은 조영제 주입 전에 $47.23{\pm}3.12$였고, 조영제 주입 후 약 45초에 $63.59{\pm}3.31$로 가장 많이 증가 하였으나 이후 20분까지 약간 떨어졌다. 또한 균 주입 반대쪽 정상 뇌조직에서 측정한 HU 값은 조영제 주입 전에 $39.01{\pm}3.24$이었고, 조영제 주입 후 약 30초에 $49.01{\pm}4.29$로 가장 많이 조영되었고, 이후 서서히 낮아졌다. 동맥 혈액 CT에서 조영제 주입 전 HU 값은 $87.78{\pm}6.88$이었고, 조영제 주입 후 10초부터 30초까지 급격히 증가하여 $749.13{\pm}98.48$로 최대값을 보이고, 30초부터 45초까지 $467.85{\pm}62.98$로 급격히 감소하며, 45초에서 60초까지는 정체기(plateau)를 보였으며, 이후 20분까지 $188.28{\pm}25.03$으로 감소되었다. 결과적으로 대장균으로 뇌염증 모델을 만들 수 있고, 조영 증강 CT를 통하여 뇌염증의 특징적인 소견을 잘 알 수 있었으며, 동적 CT를 통해 염증 중앙부와 가장자리구역의 조영 양상을 알 수 있고, 동맥혈은 조영제 주입 후 10초부터 30초 까지 급격히 증가하다 정체기를 거쳐 서서히 감소하는 것으로 나타났다.

• 대한자기공명의과학회:학술대회논문집
• /
• 대한자기공명의과학회 2001년도 제6차 학술대회 초록집
• /
• pp.140-140
• /
• 2001

We present two cases of surgically proven focal nodular hyperplasia whou underwent tri contrast-enhance MR imaging using gadolinium chelates, mangafodipir trisodium, and ferumoxides After the unehanced MR images were obtained, dynamic gadolinium-enhanced T1-weighted imagi were performed, then mangafodipir enhanced and ferumoxides-enhanced images were obtained. In one case, the mass was isointense on both T1- and T2-weighted images on the unehanced M images, iso and slightly hyperintense on ferumoxides-enhanced FSE and GRE images, strong hyperintense on the mangafodipir enhanced and gadolinium enhanced arterial phase images. In th other case, the mass was isointense on T2-weighted and hypointense on T1-weighted image isointense on ferumoxides-enhanced images, and hyperintense on mangafodipir enhanced an gadolinium enhanced arterial phase images. Triple contrast enhanced MR images were useful correctly diagnose these two cases preoperatively.