• Advances in nano research
• /
• v.13 no.3
• /
• pp.217-231
• /
• 2022

This study investigates the geometrical impact on the nanomedicine drug delivery via nanodevices. A nanomotor made of the nanotube carrying the drug as the motor blade is considered in the blood flow. Physical activities change the blood flow, and sports training enhances the blood flow and plays a significant role in the stability of drug delivery devices. This paper studies the impact of geometrical parameters on the nanomotors carrying the nanomedicine. The effect of physical exercise on the dynamic response regarding the stability of drug delivery devices is discussed in detail.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.10 no.2
• /
• pp.103-112
• /
• 1990

This study examines the characteristics of soil behavior which includes many uncertainties in seismic design, evaluates the dynamic soil properties and studies the soil-structure interaction to generalize the applicability and economy of the available sites. An example analysis is performed for soil-structure system response assuming a containment structure built on site which includes soil layers using both elastic halfspace analysis and FEM analysis against the seismic loads from the actual design. This exercise is performed as a part of the safety analysis and economic assessment of the nuclear power plant built on soils. It includes the preparation of computer program capable of incorporating large nonlinearity in the analysis, resonable evaluation procedures to determine input soil data. Nonlinear FEM analysis of Seed and Idriss model is found suitable for the accurate analysis of dynamic response of soils. Linear FEM analysis using dynamic soil properties at strain level obtained by one-dimensional seismic response, and elastic half-space analysis using dynamic soil properties at strain level under static loads are recommended to evaluate the dynamic soil properties.

• PNF and Movement
• /
• v.22 no.2
• /
• pp.191-199
• /
• 2024

Purpose: This study aimed to investigate the effects of ankle stretching with intrinsic muscles on ankle range of motion, static and dynamic balance, and gait speed in chronic stroke patients. Methods: The participants were 20 chronic stroke patients, divided into two groups, 10 in the ankle stretching with intrinsic muscles group and 10 in the slant board exercise group. Both groups performed their respective interventions once daily, with three sets per session, five times a week for four weeks. Ankle range of motion, dynamic and static balance, and gait speed were measured before and after the intervention. An independent t-test was used to compare the results between the two groups before and after the intervention. Results: Both groups showed significant improvements in ankle range of motion, dynamic and static balance, and gait speed after the intervention (p < .05). The ankle stretching with intrinsic muscles group showed more significant improvements in ankle range of motion, dynamic and static balance, and gait speed after the intervention compared to the slant board group (p < .05). These results suggest that ankle stretching with intrinsic muscles may be more effective than the slant board for certain outcomes. Conclusion: Ankle stretching with intrinsic muscles is effective in improving ankle range of motion, dynamic and static balance, and walking speed.

• The Korean Journal of Nuclear Medicine
• /
• v.26 no.1
• /
• pp.72-81
• /
• 1992

Pharmacologic coronary vasodilation in conjunction with myocardial scintigraphy has become an accepted alternative to dynamic exercise testing for the diagnosis of coronary artery disease. Although dipyridamole has traditionally been used for this purpose, it causes frequent side effect, which at times can be life-threatening. Moreover, dipyridamole dose not elicit maximal coronary vasodilation in a substantial number of patients receiving the usual i.v. dose. Adenosine is an endogenously produced compound that has significant effects as a coronary vasodilator and rapid onset action and extremely short half-life (< 10 seconds). The diagnostic accuracy and safety profile of adenosine $^{99m}Tc-MIBI$ myocardial scintigraphy were evaluated and comparison with exercise $^{99m}Tc-MIBI$ was performed. Twenty-eight subjects underwent $^{99m}Tc-MIBI$ imaging after adenosine infusion and exercise $^{99m}Tc-MIBI$ imaging. Adenosine was infused intravenously at a dose of 0.14mg/kg/body weight per minute for 6 min and MIBI was injected at 3 minute. Adenosine caused an incerease in heart rate ($64{\pm}12$ at baseline versus $74{\pm}16$ beats/min at peak effect, p<0.001), a mild decrease in systolic and diastolic blood pressure and a slightly increase in PR interval(p; NS). Side effects were reported in 92% of patients and were mostly mild in nature and promptly resolved within 1 or 2 minutes of termination of adenosine infusion. Facial flushing (53%), chest pain (36%), mild dyspnea (39%), headache (21%), throat discomfort (21%) were frequent symptoms. ST segment depression (> 1 mm) and second degree AV block in electrocardiography occured in 11% of the patients, respectively. The overall sensitivity and specificity for individual coronary stenoses in 16 patients underwent coronary angiography were 88% and 95%, respectively. The agreement ratio of segmental perfusion between adenosine and exercise images was 92% (Kappa index=0.82). In conclusion, $^{99m}Tc-MIBI$ myocardial perfusion scintigraphy with intravenous adenosine is a feasible, safe and highly accurate noninvasive technique for the detection of coronary artery disease and results are at least comparable with those of exercise $^{99m}Tc-MIBI$ scintigraphy.

• Journal of Obesity & Metabolic Syndrome
• /
• v.27 no.4
• /
• pp.203-212
• /
• 2018

Dynamic energy balance can give clinicians important answers for why obesity is so resistant to control. When food intake is reduced for weight control, all components of energy expenditure change, including metabolic rate at rest (resting energy expenditure [REE]), metabolic rate of exercise, and adaptive thermogenesis. This means that a change in energy intake influences energy expenditure in a dynamic way. Mechanisms associated with reduction of total energy expenditure following weight loss are likely to be related to decreased body mass and enhanced metabolic efficiency. Reducing calorie intake results in a decrease in body weight, initially with a marked reduction in fat free mass and a decrease in REE, and this change is maintained for several years in a reduced state. Metabolic adaptation, which is not explained by changes in body composition, lasts for more than several years. These are powerful physiological adaptations that induce weight regain. To avoid a typically observed weight-loss and regain trajectory, realistic weight loss goals should be established and maintained for more than 1 year. Using a mathematical model can help clinicians formulate advice about diet control. It is important to emphasize steady efforts for several years to maintain reduced weight over efforts to lose weight. Because obesity is difficult to reverse, clinicians must prioritize obesity prevention. Obesity prevention strategies should have high feasibility, broad population reach, and relatively low cost, especially for young children who have the smallest energy gaps to change.

• Physical Therapy Korea
• /
• v.23 no.1
• /
• pp.1-10
• /
• 2016

Background: Patients with chronic low back pain (CLBP) functionally adapt to decreased postural control due to impaired processing of sensory information. Standing postural control has been the focus of recent research in CLBP. Change in postural control may be a risk factor for CLBP, although available studies are not conclusive. Objects: This study aimed to identify the role of partial weight supported treadmill training (PWSTT) in improving balance, dysfunction, and pain in patients with chronic low back pain. Methods: The study included 22 patients with CLBP. Patients in the control group ($n_1=8$) performed three 20 min stabilization exercise sessions per week, for 4 weeks. Patients in the full weight treadmill training group ($n_2=7$) performed treadmill training for 30 min after stabilization exercise. Patients in the PWSTT group ($n_3=7$) performed PWSTT with 20% of their body weight unloaded after stabilization exercises. By using the Biodex balance system, the dynamic balance abilities of the patients in the three groups were assessed in the quiet standing position under combined conditions of visual feedback (eyes open and closed) and platform stability (level 8). The Korean version of the Oswestry Disability Index and visual analogue scale score were used as the main measure. Results: The results of this study showed that dysfunction and pain were significantly improved in all groups. Although dynamic postural stability with eyes closed was significantly improved only in the PWSTT group (p<.05), no significant difference was found in the other groups. Conclusion: The results of this study indicate that PWSTT improved balance, dysfunction and pain in the patients with CLBP. Thus, this intervention is necessary for patients with CLBP with decreased postural control.

• The Journal of Korean Physical Therapy
• /
• v.31 no.4
• /
• pp.176-183
• /
• 2019

Purpose: The purpose of this study was to investigate the short term effects of ASEJ (ankle strengthening with emphasis on jumping) for 3weeks on strength, mechanical properties, and balance and to compare the balance with and without HH(high-heel) condition. Methods: ASEJ (a combined exercise of squat, heel raise up, and jumping) were performed for the subjects in 11 female ankle instability young females ($21.7{\pm}2.0yrs$ Cumberland ankle instability score $19{\pm}6.5$). To investigate the effect of ASEJ, investigator used dynamometer for measuring strength, MyotonPRO for measuring mechanical properties(tone, stiffness, and elasticity of the muscles), I-Balance test for static balance, and Y-balance test for dynamic balance between the condition with and without HH condition. All data were normally distributed and analyzed using the SPSS 22.0 statistical program. Comparing pre- and post-intervention and the condition with and without HH conditions data were examined using the paired t-test. The level of significance was chosen as 0.05 for all the analyses. Results: 3wks of ASEJ would strengthen leg muscles and increasing muscle tone and stiffness in most muscles however there was decreasing muscle elasticity of gastrocnemious. In addition, the ASEJ improves the static balance for ankle instability young females and increases the dynamic balance when wearing the heels especially. Conclusions: the ASEJ could recommend to improve the strength and balance for ankle instability young females. Also, measuring the balance with HH conditions well represents the risk of ankle damage in female.

• Fashion & Textile Research Journal
• /
• v.22 no.6
• /
• pp.853-861
• /
• 2020

Various types of clothing are being developed to boost thermal comfort during cold winters along with research on change of body temperature when heating is applied. There is a noticeable behavioral difference by gender when using heating panels in a cold environment; however, research on women has been insufficient. This study find a temperature range that provides sustainable thermal comfort in a low temperature environment by observing temperature and change of temperature when subjects are classified according to physical activities or cold sensitivities. For the study results, 8 women in their 20s were subjected to experiment in a low temperature environment for 75 minutes (sitting position: 30 min., running: 15 min., and sitting position: 30 min.). Subjects were asked to turn on/off the heating panel freely to analyze the range of comfortable temperature and clothing microclimate; in addition, skin temperature and heating panel temperature were measured and analyzed at 9 points. As a result, temperature at which subjects turn on and off the heating panel indicated a statistically meaningful difference between the cold sensitivity group depending on exercise or non-exercise. The range of comfortable abdomen temperature was wider than the lower back and was significantly reduced when the subject was running. The range of comfortable temperature was also largest for the heating panel temperature, microclimate, and skin temperature in suggesting that adequate adjustment will be required depending on the surrounding environment or movement of the wearer.

• The Journal of Korean Physical Therapy
• /
• v.34 no.5
• /
• pp.212-217
• /
• 2022

Purpose: This study sought to investigate the effects of visual cue deprivation balance training by applying head control feedback to the balance function and the fall index in older people. Methods: The study was conducted on 26 older people at the S Hospital in Gyeongsansi. The patients were randomly divided into the experimental groupI (EGI, n=9), the experimental groupII (EGII, n=9), and the control group (CG, n=8). The three groups were trained for 30 minutes three times a week for four weeks. To assess the patients' static balance function, their limits of stability (LOS) was measured using the BioRescue system, (RM Ingenierie, France), composed of a pressure platform that can measure force in diverse ways, a computer, and a monitor. The dynamic balance function was measured using the Berg Balance Scale (BBS). Also, the fall index was measured to evaluate the risk of falling. A paired t-test was performed to compare pre- and post-training performance within the groups. One-way ANOVA was performed for comparing the three groups. A post hoc least significant difference (LSD) test was also performed. Results: The results of the LOS showed a significant difference after training in the EGI and EGII groups (p<0.05). As a result of the difference between the three groups, there was a significant difference after training (p<0.05). The results of the BBS showed a significant difference after training in the EGI group (p<0.05). As a result of the difference between the three groups, there was a significant difference after training (p<0.05). Conclusion: Visual cue deprivation balance training applying head control feedback is effective in improving the dynamic balance function in older people. It is also necessary to constantly maintain the head orientation by feedback and to properly control the head movement.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.18 no.12
• /
• pp.597-604
• /
• 2017

This study examined the effects of vestibular stimulation training on the static and dynamic balance of patients with chronic stroke. This study was conducted from July 15th to September 6th, 2014 and 20 subjects diagnosed with stroke participated in this study. The subjects were divided randomly into Group I (general therapeutic exercise, n=10) and Group II (vestibular stimulation training, n=10). Both groups were trained for 40 minutes, 3 times a week, for 6 weeks. The balance ability, static balance and dynamic balance, were evaluated using a Good Balance System and compared before-and-after intervention. In the vestibular training group, there were statistically significant differences in the left-right and anterior-posterior balance with the eyes closed and standing posture, in the left-right and anterior-posterior balance with the eyes open and standing posture, and moving time and distance. In the general therapeutic exercise group, there was no significant difference except in the left-right balance with the eyes open and standing posture. In conclusion, vestibular stimulation training had positive effects on the static and dynamic balance of chronic stroke patients, and this training can be effective in a treatment program to improve the balance ability of stroke patients.