• Molecules and Cells
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• v.46 no.6
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• pp.374-386
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• 2023

Thermal stress induces dynamic changes in nuclear proteins and relevant physiology as a part of the heat shock response (HSR). However, how the nuclear HSR is fine-tuned for cellular homeostasis remains elusive. Here, we show that mitochondrial activity plays an important role in nuclear proteostasis and genome stability through two distinct HSR pathways. Mitochondrial ribosomal protein (MRP) depletion enhanced the nucleolar granule formation of HSP70 and ubiquitin during HSR while facilitating the recovery of damaged nuclear proteins and impaired nucleocytoplasmic transport. Treatment of the mitochondrial proton gradient uncoupler masked MRP-depletion effects, implicating oxidative phosphorylation in these nuclear HSRs. On the other hand, MRP depletion and a reactive oxygen species (ROS) scavenger non-additively decreased mitochondrial ROS generation during HSR, thereby protecting the nuclear genome from DNA damage. These results suggest that suboptimal mitochondrial activity sustains nuclear homeostasis under cellular stress, providing plausible evidence for optimal endosymbiotic evolution via mitochondria-to-nuclear communication.

• International conference on construction engineering and project management
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• 2017.10a
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• pp.321-327
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• 2017

China is experiencing the urbanization at an unprecedented speed and scale in human history. The continuing growth of China's big cities, both in city land and population, has already led to great challenges in China's urban planning and construction activities, such as the continuous increase of construction and demolition (C&D) waste. Therefore, how to characterize cities' construction activities, particularly dynamically quantify the flows of building materials and construction debris, has become a pressing problem to alleviate the current shortage of resources and realize urban sustainable development. Accordingly, this study is designed to employ 4D-GIS (four dimensions-Geographic Information System) and Internet Plus to offer new approach for accurate but dynamic C&D waste management. The present study established a spatio-temporal pattern and material metabolism evolution model to characterize the geo-distribution of C&D waste by combing material flow analysis (MFA) and 4D-GIS. In addition, this study developed a mobile application (APP) for C&D waste trading and information management, which could be more effective for stakeholders to obtain useful information. Moreover, a cloud database was built in the APP to disclose the flows of C&D waste by the monitoring information from vehicles at regional level. To summarize, these findings could provide basic data and management methods for the supply and reverse supply of building materials. Meanwhile, the methodologies are practical to C&D waste management and beyond.

• Journal of English Language & Literature
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• v.55 no.4
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• pp.661-692
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• 2009

From the Darwinian perspective, all the human behaviors and thoughts are operated by "the selfish gene," the term coined by Richard Dawkins, which has long been evolving to survive by utilizing the limited quality and quantity of resources. And an organism which fails to regenerate by creating its "replicator" is doomed to extinction, for gene combinations which help an organism to survive and reproduce tend to also improve the gene's own chances of being passed on through generations. Dawkins also coins the term "meme" for a unit of human cultural evolution analogous to the gene, suggesting that such selfish replication may also be the principle for human culture. Ian McEwan is not only a controversial but more importantly influential writer in the 21st century academic world. His 1997 book Enduring Love is not exceptional in that it draws both literary and scientific attention. Intentionally set up with the dynamic conflict between the two cultures, namely art and science, the book explores the way in which the state of the modern minds is misinterpreted and estranged by each other. In this novel, the three main protagonists, Joe, Clarissa, and Jed, each representing the very important three elements of human civilization-cognition/science, emotion/art, and faith/religion-meet an unexpected peril of life. The author of the novel employs the narrative of evolutionary science-in particular the narratives of gene and meme-to provoke the question of the two cultures famously addressed by Snow in the mid 20th century and the further discussions followed by the later Darwinian scholars such as Richard Dawkins. In this paper I aim to illustrate the way in which the author develops the idea of gene science and literature and how he proceeds to provide a sophisticated bridge between the two cultures and induce a kind of consilience by the recurrent name of love in the story of Enduring Love.

• Steel and Composite Structures
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• v.48 no.1
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• pp.103-111
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• 2023

The caving property of top coal is a key factor to the success of top coal caving mining. The influence law of cyclic loading and unloading of hydraulic support on top coal caving is of great significance to improve the recovery rate of top coal. The similar simulation methods were used to study the dynamic evolution of the top coal cracks under the multi-cycle action of the support, and the parameters of top coal cracks were analyzed quantitatively in this paper. The results show that the top coal cracks can be divided into horizontal cracks and vertical cracks under the cyclic loading and unloading of the support. With the increase of the times of the support cycles loading and unloading, the load on the support decreases, the fractal dimension of the cracks increases, the number and total length of the top coal cracks increases, and the top coal caving is getting better. With the increase of the times of multi-cycle loading and unloading, the fractal dimension, total crack length and crack rate of top coal show a trend of rapid increase first and then increase slowly. Both the total length of the top coal cracks and the crack rate basically show linear growth with the change of the fractal dimension. The top coal caving can be well improved and the coal resource recovery rate increased through the multi-cycle loading and unloading.

• Journal of Korea Water Resources Association
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• v.56 no.10
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• pp.603-617
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• 2023

This study aims to provide a better understanding of the turbulent flow characteristics in swash zone. A double dam-break method is employed to generate the swash zone flow. Comparing with the conventional single dam-break method, a delay between two gate opening can be controlled to reproduce various interactions between uprush and backwash. For numerical simulations, overInterDyMFoam based on OpenFOAM is adopted. Using overInterDyMFoam, interface between two immiscible fluids having different densities (i.e., air and water phases) can be tracked in a moving mesh with multiple layers. Two-dimensional Reynolds-Averaged Navier-Stokes equations are solved with a standard 𝜅-𝜖 turbulence model for momentum and continuity. Numerical model results are validated with laboratory experiment data for the time series of water depth and streamwise velocity. Turbulent kinetic energy distribution is further investigated to identify the turbulence evolution for each flow regime (i.e., uprush, backwash, and swash-swash interaction).

• Journal of Intelligence and Information Systems
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• v.13 no.1
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• pp.59-79
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• 2007

P2P (Peer to Peer) techniques have been well applied to file sharing due to its cost-effectiveness and convenience. Dynamic network evolution is another good thing for P2P according to addition and deletion of nodes and change of files a node has. Our research proposes a P2P-based KMS (Knowledge Management System). Knowledge of enterprises spreads all over sub-organizations like oversea factories and sales departments and is changed in dynamic manner. P2P techniques are, therefore well matched with knowledge management domain. In order to increase search efficiency, we introduce social network theory into P2P-based KMS. Social network technique makes the most similar nodes (in KMS domain, nodes which has the most similar knowledge) its own neighbors, which makes eventually search efficiency increase. We developed our prototype system P2P-SN-KMS and evaluated by simulation.

• The Journal of the Korea Contents Association
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• v.18 no.12
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• pp.468-488
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• 2018

The maker movement is a phenomenon of society and culture where people who make necessary things come together and share knowledge and experience through creativity. However, as the maker movement has grown rapidly over the past decade, there is still a lack of consensus for how far they will be viewed as a maker movement. We need to look at how the maker movement has changed so far in order to find the direction of development of the maker movement. This study analyzes the media articles using text-based big data analysis methodology to understand how the issue of the maker movement has changed in general media. In particular, we apply Keyword Network Analysis and DTM(Dynamic Topic Model) to analyze changes of interest according to time. The Keyword Network Analysis derives major keywords at the word level in order to analyze the evolution of the maker movement, and DTM helps to identify changes in interest in different areas of the maker movement at three levels: word, topic, and document. As a result, we identified major topics such as start-ups, makerspaces, and maker education, and the major keywords have changed from 3D printer and enterprise to education.

• Journal of the Society of Disaster Information
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• v.17 no.3
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• pp.655-666
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• 2021

Purpose: This study is to develop a method for measuring dynamic speeding risks using vehicle trajectory big data and to demonstrate the feasibility of the devised speeding index. Method: The speed behaviors of vehicles were analysed in microscopic space and time using individual vehicle trajectories, and then the boundary condition of speeding (i.e., boundary speed) was determined from the standpoint of crash risk. A novel index for measuring the risk exposure of speeding was developed in microscopic space and time with the boundary speed. Result: A validation study was conducted with vehicle-GPS trajectory big data and ground-truth vehicle crash data. As a result of the analysis, it turned out that the index of speeding-risk exposure has a strong explanatory power (R²=0.7) for motorway traffic accidents. This directly indicates that speeding behaviors should be analysed at a microscopic spatiotemporal dimension. Conclusion: The spatial and temporal evolution of vehicle velocity is very variable. It is, hence, expected that the method presented in this study could be efficaciously employed to analyse the causal factors of traffic accidents and the crash risk exposure in microscopic space using mobility trajectory data.

• Journal of the Korean Institute of Landscape Architecture
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• v.52 no.4
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• pp.18-31
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• 2024

This study examines the inscription trends and characteristics of 121 cultural landscapes inscribed on the UNESCO World Heritage List to gain a comprehensive understanding of their inherent values and attributes. By employing a dual methodology involving descriptive statistical analysis and in-depth case studies, this research investigates the geographical distribution, temporal inscription patterns, selection criteria, and typologies of these landscapes. The data for this study were collected from official documents and databases available on the UNESCO World Heritage Center website, ensuring the reliability and authenticity of the information. The analysis reveals that cultural landscapes are predominantly concentrated in Europe and Asia, with a steady increase in inscriptions since 1992. These landscapes are primarily recognized for their uniqueness in reflecting human-nature interactions, as well as the importance of traditional culture and land-use practices, resulting in their inscription mainly under criteria (iv), (iii), (v), and (ii). Furthermore, cultural landscapes can be broadly categorized into three types: designed landscapes, organically evolved landscapes, and associative landscapes. Among these, organically evolved landscapes, formed through long-term interactions between human activities such as agriculture and industry and the natural environment, constitute a significant proportion. These findings suggest that UNESCO World Heritage cultural landscapes possess a complex value system encompassing nature and culture, tangible and intangible elements, and material and non-material aspects. This necessitates a fundamental shift in the perception and preservation approaches to cultural heritage, requiring an integrated approach that emphasizes the overall context rather than individual elements and focuses on the dynamic process of landscape evolution itself. Moreover, cultural landscapes have the potential to contribute to sustainable development models by fostering regional identity, strengthening community resilience, and promoting sustainable economic growth. Therefore, the preservation and management of cultural landscapes require a perspective that holistically views the dynamic evolution process of the landscape and a governance system based on the active participation of local communities and stakeholders. This study contributes to enhancing the in-depth understanding of the characteristics and values of cultural landscapes and provides a foundation for the selection and management of future cultural landscape heritage sites.

• Korean Journal of Agricultural and Forest Meteorology
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• v.12 no.2
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• pp.95-106
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• 2010

The performance of Community Land Model version 3.5 - Dynamic Global Vegetation Model (CLM-DGVM) was evaluated through a comparison with the observation over temperate deciduous forest in Gwangneung, Korea. Influence of plant phenology, composition of plant functional type, and climate variability on carbon exchanges was also examined through sensitivity test. To get equilibrium carbon storage, the model was run for 400 years driven by the observed atmospheric data at the deciduous forest of the year 2006. We run the model for 2006 with the equilibrium carbon storage at Gwangneung forest and compared the model output with the observation. A comparison of leaf area index (LAI) between the model and observation indicated that the simulated phenology poorly represented the timing of budburst, leaf-fall, and evolution of LAI. Senescence of the phenology was delayed about four weeks and the simulated maximum LAI (of 5.8 $m^2$ $m^{-2}$) was greater than the observed value (of 4.5 $m^2$ $m^{-2}$). The overestimated LAI contributed to overestimation of both gross primary productivity (GPP) and ecosystem respiration $(R_e)$ through increased photosynthesis and foliar autotropic respiration $(R_a)$, respectively. Despite the discrepancy between the simulated and observed LAI, the simulated tree carbon storage amounts were comparable with the reported values at the site. Change in plant phenology from the simulated to the observed reduced more than six weeks of the plant growth period, resulting in the decreased amount of GPP and $R_e$. These values, however, were still higher (~10% of GPP and 40% of $R_e$) than the observed values. The effect of change in plant functional type composition (from dominant temperate deciduous forest to the coexistence of temperate deciduous and needle leaf forests) on the estimated amount of GPP and $R_e$ was marginal. The influence of climate variability on carbon storage amounts was not significant. The simulated inter-annual variation of GPP and $R_e$ from 1994 to 2003 depended on annual mean air temperature and total radiation but not on precipitation. Other deficiencies of CLM3.5-DGVM have been discussed.