• 제목/요약/키워드: Dust damage

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Urban Particulate Matter-Induced Oxidative Damage Upon DNA, Protein, and Human Lung Epithelial Cell (A549): PM2.5 is More Damaging to the Biomolecules than PM10 Because of More Mobilized Transition Metals

  • Song, H-S;Chang, W-C;Bang, W-G;Kim, Y-S;Chung, N
    • 한국환경독성학회:학술대회논문집
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    • 한국환경독성학회 2002년도 추계국제학술대회
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    • pp.169-169
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    • 2002
  • The mobilizable amount of transition metals is a fraction of the total amount of the metal from urban particulate matter. Although the fraction is small, some metals (Fe, Cu) are the major participants in a reaction that generates reactive oxygen species (ROS), which can damage various biomolecules. Damaging effects of the metals can be measured by the single strand breakage (SSB) of X174 RFI DNA or the carbonyl formation of protein. In another study, we have shown that more metals are mobilized by PM2.5 than by PM10 in general. DNA SSB of >20% for PM2.5 and >15% for PM10 was observed in the presence of chelator (EDTA or citrate)/reductant (ascorbate), compared to the control (<3%) only with the chelator. The carbonyl formation by both PMs was very similar in the presence of the chelator, regardless of the kind of proteins. Compared to the control in the absence of chelator/reductant, 3.3 times and 4.9 times more carbonyl formation for PM2.5 and PM10, respectively, was obtained with BSA in the presence of chelator/reductant, showing that PM10 induced 33% more damage than PM2.5. However, 4.8 times and 1.9 times more carbonyl formation for PM2.5 and PM10, respectively, was observed with lysozyme in the presence of chelator/reductant, showing that PM2.5 induced 250% more damage than PM10. Although different proteins showed different sensitivities toward ROS, all these results indicate that the degrees of the oxidation of or damage to the biomolecules by the mobilized metals were higher with PM2.5 than with PM10. Therefore, it is expected that more metals mobilized from PM2.5 than from PM10, more damage to the biomolecules by PM2.5 than by PM10. We suggest that when the toxicity of the dust particle is considered, the particle size as well as the mobilizable fraction of the metal should be considered in place of the total amounts.

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The Effect of Chelators and Reductants on the Mobilization of Metals from Ambient Particulate Matter: More Transition Metals are Mobilized with PM2.5 than with PM10

  • Song, H-S;Chang, W-C;Bang, W-G;Kim, Y-S;Chung, N
    • 한국환경독성학회:학술대회논문집
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    • 한국환경독성학회 2002년도 추계국제학술대회
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    • pp.155-155
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    • 2002
  • Ambient urban particulate matters contain various transition metals. When the particulate matters are inhaled into the lung, not all but some part of metals from the particles might be mobilized to participate in a reaction that can damage various biomolecules, such as DNA and proteins. The dust particle size as well as organic acids may influence the metal mobilization. Thus, the mobilization of the metal from SRM1648 (NIST, USA) and urban particulate matters (PM2.5 and PM10) was measured in the presence of artificial or biological chelator with or without reductant. The degree of the mobilization was higher with the artificial or biological chelator than the control with saline. In some cases, a reductant increased the mobilization as much as about 5 times the control without the reductant. Especially, the mobilization of Fe was greatly influenced by the presence of reductants. In general, the degree of the mobilization of the transition metal was higher with PM2.5 than with PM10. Therefore, it is expected that, considering the previously known toxicities of the transition metals, the PM2.5 is more damaging to various biomolecules than PM10. The results also suggest that not the total amount but the mobilizable fraction of the metal in the dust particles should be considered with regard to the toxicity of the urban particulate matters.

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고유동 충전재의 개발과 노후 터널의 배면공동 뒤채움에 관한 연구 (A Study on Development of the Controlled Low-Strength and High-Flowable Filling Material and Application of the Backfilling in Cavities behind the Old Tunnel Lining)

  • 마상준;서경원;배규진;안상철;임경하
    • 한국구조물진단유지관리공학회 논문집
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    • 제6권3호
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    • pp.177-184
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    • 2002
  • The most tunnel damage such as cracks or leakage which exist in tunnel lining commonly, is caused by the cavities where exist behind the tunnel lining, through the tunnel safety inspections. These cavities were analysed to affect a stability of a running-tunnel seriously. This study is on the development of the controlled low-strength and flowable filling material which is able to apply to the cavity behind the tunnel lining. The major materials of backfilling developed are a crushed sand and a stone-dust which exists as a cake-state and is a by-product obtained in the producting process of aggregate. It is conformed with the design standard to the physical characteristics of backfilling. The backfilling material developed is designed to reduce the fair amount of cement. According to the designed compound ratio, it is carried out the laboratory tests such as a compressive strength and a chemical analyses and is applied to dilapidated old tunnel for an application assessment.

폐톱밥 혼입 콘크리트의 온도 이력에 관한 실험적 연구 (Temperature Strength of Sawdust-Mixing Concrete)

  • 손기상;홍승렬
    • 한국안전학회지
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    • 제20권4호
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    • pp.46-53
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    • 2005
  • Existing study far fire-resistant concrete has been done already. but it is not found out how the waste tyre mixing concrete will be acted against fire. This waste tyre concrete molds under the condition of $0^{\circ}C,\;200^{\circ}C,\;400^{\circ}C,\;600^{\circ}C$ were heated in gas oven. It was worried about that they might be fractured down at about $800^{\circ}C$ so that they can not be tested. compressive strength for the test molds are made with commercially used $180kg/cm^2,\;210kg/cm^2,\;240kg/cm^2,\;270kg/cm^2$ mixing saw dust with proportion such as 0.05%, 0.1%, 0.2%, 0.4%, 0.6%, 0.8%, 1.0%, 1.2%, 1.4%, 1.6%, 1.8%, 2.0% compressive strength at $200^{\circ}C$ was approximately 20% from the original, while approximately 30% deoreased at $400^{\circ}C$. their results are not quite different from the normal concrete condition even though they contains saw dust in it. The higher strength the concrete has, the less strength was decreased. There are almost no difference in strength under the condition of less than $400^{\circ}C$, but damage of concrete structure could be considerable large with more than $400^{\circ}C$.

지진·화재·미세먼지에 대한 재난환경 정보 데이터의 표준 코드 체계화 연구 (A Study on the Standard Code Systematization of Disaster Environmental Information Data for Earthguakes, Fires and Fine Dusts)

  • 이용수;류상훈;고현아;정인수
    • 한국지반환경공학회 논문집
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    • 제20권12호
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    • pp.27-32
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    • 2019
  • 재난안전 관리정보 표준화는 재난관리의 과정(예방, 대비, 대응, 복구)을 통일화 및 단순화함으로써 재난관리의 효율성을 높이고, 국민의 생명과 재산 피해를 최소화하기 위해 필요하다. 재난안전 표준화는 과거의 재난안전 정보를 표준화하여 불확실한 미래에 대응하고 이에 따른 재난안전 관리를 체계적으로 하는 데 있다. 본 연구는 다양하고 복잡한 환경 재난 중 최근 사회적으로 관심이 많은 지진, 화재, 미세먼지 등의 재난안전 정보를 목적에 적합하게 데이터로 활용할 수 있도록 표준 코드 체계를 개발하였다. 이는 재난이 발생하면 실무자가 효율적인 재난 업무를 수행 할 수 있도록 지원하고자 한다.

A Development of the Safety Accident Prevention Fence System Based on Internet of Things

  • PARK, Mi-Seon;KIM, Ji-Yeong;KANG, Min-Soo
    • 한국인공지능학회지
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    • 제8권2호
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    • pp.1-5
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    • 2020
  • Children's home accidents are less common than in the past. However, safety accidents continue to occur due to carelessness of the parents. To solve the problem, there are fall prevention screens that can withstand the weight of children, and safety railings that can be adjusted directly to solve the problem. However, these have disadvantages such as stability, convenience, and damage to the landscape. In this paper, we developed an automatic safety accident prevention fence system that can be installed on a window using Arduino, eliminating the disadvantages of previous safety accident prevention products. This system measures the height of a person standing in front of the fence and the distance between the person and the fence with two infrared sensors and moves automatically using a motor. In addition, in accordance with the U-Healthcare society, users can check the temperature, humidity, and fine dust concentration of the external environment through mobile. Each information can be obtained through DHT 11 sensor, fine dust concentration sensor, and Bluetooth connected toArduino. These can help the user's health care.

MODIS 영상을 이용한 중국 산시성 위린시의 조림 효과 분석 (Afforestation Effect Analysis Using MODIS Imagery: Yulin, Shaanxi, China As a Case Study)

  • 장효선;김상필;김미경;손홍규
    • 대한토목학회논문집
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    • 제35권4호
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    • pp.1007-1013
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    • 2015
  • 황사의 발원지인 중국의 사막화는 과도한 경지개간과 산업화 등으로 인해 계속해서 심각해지고 있으며, 이로 인해 국내의 황사 피해 역시 증가하고 있다. 중국에서 발생하는 황사는 중국 자국 뿐만 아니라 인접 국가에도 영향을 미치기 때문에 국제적인 문제가 되고 있으며 중국은 국제사회의 지원을 받으며 황사의 원인인 사막화를 막기 위한 조림사업을 시행하고 있다. 그러나 이러한 조림사업에 대한 확인은 중국 통계청에서 작성한 조림 성과 보고서를 통해서만 가능하여 공여국에서 조림 사업의 성과를 실질적으로 파악하는 데에 한계가 있다. 이에 본 연구에서는 중국의 조림사업이 꾸준히 진행되어 온 중국 산시성 위린 지역을 대상으로 원격탐측 방법을 이용하여 중국 조림 현황에 대한 모니터링을 수행하고자 하였다. 원격탐측 자료로는 MODIS 영상이 사용되었으며, 식생지수를 통해 2000년부터 2014년까지 식생이 증가함을 확인할 수 있었고, 추정된 조림면적이 실측 자료와 일치하는 경향을 보이는 것으로 확인되었다.

Anti-apoptotic Effects of House Dust Mite, S100A8 and S100A9 on Spontaneous Apoptosis of Neutrophils in Coculture with Immune Cells and in the Presence of T Helper Cytokines

  • Kim, In Sik;Lee, Ji-Sook
    • 대한의생명과학회지
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    • 제21권2호
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    • pp.122-125
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    • 2015
  • House dust mite (HDM) as a major allergen and damage-associated molecular pattern (DAMP) such as S100A8 and S100A9 trigger the pathogenesis and severity of allergic disease such as asthma. Regulation of neutrophil apoptosis is an important immune response and its dysregulation is involved in pathogenesis of allergic diseases. In this study, we examined the effects of HDM, S100A8 and S100A9 on spontaneous apoptosis of normal neutrophils. We considered the importance of the difference between in vitro and in vivo results and developed a new in vitro system consisting of a combination of immune cells and T helper (Th) cytokines. Extract of Dermatophagoides pteronyssinus (DP), S100A8, and S100A9 inhibited neutrophil apoptosis in culture of neutrophils alone without other leukocytes. DP and S100A8 more strongly suppressed neutrophil apoptosis in combinations of neutrophils, eosinophils, lymphocytes or monocytes than in a culture of neutrophils alone. Anti-apoptotic effect of S100A9 in the mixture of immune cells was similar to that in neutrophils. DP, S100A8, and S100A9 blocked neutrophil apoptosis, regardless of pretreatment with a T helper (Th) 1 cytokine (IFN-$\gamma$), Th2 cytokines (IL-4 and IL-10), a Th9 cytokine (IL-9), a Th17 cytokine (IL-17), a Treg-producing cytokine (TGF-$\beta$). These findings may enable elucidation of allergy pathogenesis due to HDM and DAMP.

A study on nanoparticle filtration characteristics of multilayer meltblown depth filters

  • Lee, Kang-San;Hasolli, Naim;Jeon, Seong-Min;Lee, Jae-Rang;Kim, Kwang-Deuk;Park, Young-Ok;Hwang, Jungho
    • 한국입자에어로졸학회지
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    • 제12권3호
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    • pp.51-56
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    • 2016
  • Due to recent development in nanotechnology and increasing usage and production of nanomaterials, numerous studies related to environment, sanitation and safety handling of nanoparticle are being conducted. Since nanoparticles can be easily absorbed into human bodies through breathing process, based on their toxic substances and their large specific surface, these particles can cause serious health damage. Therefore, to reduce nanoparticle emissions, nanofiltration technology is becoming a serious issue. Filtration is a separation process during which a fluid passes through a barrier by removing the particles from the stream. Barrier filters can be made of various materials and shapes. One of the most common type of barrier filter is the fibrous filter. Fibrous filters are divided in two types: nonwoven and woven fabrics. Polypropylene is a thermoplastic material, used as a base material for melt blown nonwoven fabric. In this study, we examined filtration property of KCl nanoparticles with a mean particle diameter of 75 nm using multilayer meltblown filter samples. These experiments verify that the penetration of nanoparticle in the filter correlate with pressure drop; the meltblown layer MB1 has the greatest effect on dust collection efficiency of the filter. Among all tested samples, dust collection efficiency of 2-layer filter was best. However, when considering the overall pressure drop and dust collection efficiency, the 4-layer filter has the highest quality factor for particles smaller than 70 nm.

석분토를 이용한 지하공동의 친환경적 충전재 개발과 충전 및 재료특성 평가 (Development of the Environmentally Friendly Filling Material for the Underground Cavities using the Rock-dust and an Assessment on Filling and Material Characteristics)

  • 마상준;김동민
    • 한국지반공학회논문집
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    • 제21권9호
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    • pp.35-44
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    • 2005
  • 최근 지하에 존재하는 석회공동이나 폐광산 채굴적과 같은 지하공동에 의한 사회간접시설물의 피해 사례가 많이 보고되고 있다. 특히 국내 건설 현장에서는 지하공동으로 인해 기존 설계 변경 및 새로운 대책공법 마련으로 과다한 공사비가 지출되는 등 많은 어려움을 겪고 있는 상황이다. 본 연구에서는 산업패기물로 처리되어 국내 환경을 오염시키고 있는 석분토를 이용하여 새로운 지하공동 충전재를 개발하였다. 재발된 충전재의 재료시험결과 압축강도는 $34{\~}60 kgf/cm^2$, 길이변화율은 $0.268{\~}0.776\%$, 흡수율은 $34.3{\~}46.9\%$로 나타났다. 또한, 현탁물 질량시험과 PH 시험을 통하여 개발된 충전재가 수중에서 분리되지 않는 성질이 있으며 환경친화적인 재료임을 확인할 수 있었다.