• Biomedical Science Letters
• /
• v.19 no.2
• /
• pp.158-163
• /
• 2013

Cholestatic liver is associated with hepatic inflammation and elevated proinflammatory cytokines. Recent studies indicate that certain cytokines can modulate bile secretion. In the present study, we have examined the role of interleukin (IL-2) on the bile secretion by a combination of study models. To examine the relevance of IL-2 on bile secretion, the expression of IL-2 and IL-2 receptor (IL-2R) of isolated normal and bile duct ligated (BDL) rats cholangiocytes was first measured by RT-PCR. In BDL rats, the expression of IL-2 and IL-2R was significantly increased compared with normal rats. To study the effect of IL-2 on bile secretion, bile flow was measured in normal and BDL rats. At the level of cholangiocytes, secretory responses of isolated bile duct unit (IBDU)s were quantified by videomicroscopy. The administrations of IL-2 had no significant effect on basal bile secretion in normal and BDL rats. There was no significant effect of IL-2 on basal bile ductular secretion as evidenced by no significant difference in luminal area of the IBDUs perfusedwith 100 pM of IL-2 from those of albumin carrier control. However, the secretin-stimulated bile ductular secretion was significantly (P < 0.01) inhibited by $34{\pm}4%$ (normal, n = 12), $21{\pm}5.3%$ (BDL 2 wk, n = 12) and $15{\pm}5.2%$ (BDL 4 wk, n = 12) with the co-administration of IL-2. As with other cytokines, physiologically relevant concentration of IL-2 can significantly inhibit secretin-stimulated bile ductular secretion. These findings support the important roles of cytokines in modulating bile secretion and may contribute to the cholestasis seen in cholestatic liver diseases.

• Journal of Korean Society for Atmospheric Environment
• /
• v.15 no.E
• /
• pp.17-28
• /
• 1999

Gas-liquid contact tests above a perforated-plate were conducted with air and water at flooding gas-flow conditions in order to study two-phase flow characteristics in a limestone-gypsum SO2 absorber. Gas layers were in the form of air pockets and confined to the limited areas around each duct pipe, while the remaining tary area were in the wet condition. The liquid above the tray was always in the flooded and even fluidized conditions at gas flows over the range studied, although vigorous bubbly or churn-turbulent two-phase regime was only observed in the immediate vicinity of the gas hole exit at low gas loads. The froth zone was extremely active to provide intimate contact between gas and liquid so that the necessary mass transfer operation can take place, which is the primary purpose of high-performance SO2 absorbers. Howefer, the absorber $\Delta$P was 250mmH2O for the initial water level at 150mm, which is an important issue to be resolved for economical operation of the SO2 absorber. It was seen in the liquid level-and gas flow-transient tests that changes in the absorber liquid inventory were much more pronounced for intimate gas-liquid contact than changes in the gas flow. Based on the 4- and 8-duct pipe test results, grouping the duct pipes near the center of the test tray seemed to promote better recirulation of liquid from gas-liquid contact zone back to the reaction tank so that the absorbed SO2 can be neutralized.

• Tunnel and Underground Space
• /
• v.26 no.5
• /
• pp.375-383
• /
• 2016

High-speed trains have been developed widely in many countries in order to transport a large quantity of people and commodities rapidly. When a high speed train enters a tunnel, aerodynamic resistance is generated suddenly. This resistance causes micro pressure wave and discomfort to passengers. Therefore, it is essential to incorporate a pressure relief system in a tunnel and streamlined shape of a train in order to reduce aerodynamic resistance caused by a high-speed train. Additionally, the cross-sectional area of a tunnel should be carefully determined to reduce discomfort of passengers. A pressure relief duct and a vertical shaft are representative measures in a tunnel. This study represents the effect of pressure relief ducts in order to alleviate pressure changes within a time period in a tunnel. One-dimensional network numerical simulations were carried out in order to estimate the effect of pressure relief systems.

• Journal of KSNVE
• /
• v.9 no.3
• /
• pp.600-606
• /
• 1999

A reactive type acoustic filter is developed based on the phase cancellation effect which is occurring in the plane wave propagation through the two paths where the cross sectional areas are reversely changing. The theory is experimentally validated by the use of a cylindrical duct and an inserted hollowed cone of which vertex part is eliminated. Noise attenuation and the filtered frequency are dependent on the area variation and the effective length of the filter. Experimental comparison shows that the filtered frequencies of 1st and 2nd mode are lower than the analytical prediction due to the mass loading effects, and the 3rd mode is in good agreement. The proposed filter can be applied as an in-duct noise filter for improving the sound quality in a narrow space for various industrial applications.

• Parasites, Hosts and Diseases
• /
• v.31 no.1
• /
• pp.21-30
• /
• 1993

The study was carried out to observe the effects of Clonorchis sinensis Infection on induction of cholangiocarcinoma in Syrian golden hamsters to which 15 ppm dimethylnitrosamine (DMN) solution was administered for 8 weeks. The histopathological changes of the bile duct and liver cells were observed at the 11th week. In six of 8 hamsters (75%) which were treated with DMN and then infected with C. sinenis, the livers developed cholangiocarcinoma at 10 weeks after the infestation of C. sinenis. The features of cholangiocarcinoma lesions were adenomatous or papillary hyperplasia of the bile duct epithelia showing distinct anaplastic changes with mucinous cell metaplasia and necrotic area. In the hamsters which received either DMN or C. sinenis alone, the livers showed only hyperplastic changes of the bile duct epithelial cells. It was suggested that C. sinensis infection and DMN administration could be a synergism on the development of cholangiocarcinoma in Syrian golden hamsters.

• Proceedings of the SAREK Conference
• /
• 2004.11a
• /
• pp.14-14
• /
• 2004

• Archives of Craniofacial Surgery
• /
• v.21 no.3
• /
• pp.143-155
• /
• 2020

Surgical anatomy for Asian rhinoplasty Part I reviewed layered anatomy with neurovascular system of the nose. Part II discusses upper two-thirds of nose which consists of nasal bony and cartilaginous structures. Nasal physiology is mentioned briefly since there are several key structures that are important in nasal function. Following Part III will cover lower one-third of nose including in-depth anatomic structures which are important for advanced Asian rhinoplasty.

• Nuclear Engineering and Technology
• /
• v.37 no.6
• /
• pp.525-536
• /
• 2005

The interfacial area transport equation dynamically models the changes in interfacial structures along the flow field by mechanistically modeling the creation and destruction of dispersed phase. Hence, when employed in the numerical thermal-hydraulic system analysis codes, it eliminates artificial bifurcations stemming from the use of the static flow regime transition criteria. Accounting for the substantial differences in the transport mechanism for various sizes of bubbles, the transport equation is formulated for two characteristic groups of bubbles. The group 1 equation describes the transport of small-dispersed bubbles, whereas the group 2 equation describes the transport of large cap, slug or chum-turbulent bubbles. To evaluate the feasibility and reliability of interfacial area transport equation available at present, it is benchmarked by an extensive database established in various two-phase flow configurations spanning from bubbly to chum-turbulent flow regimes. The geometrical effect in interfacial area transport is examined by the data acquired in vertical fir-water two-phase flow through round pipes of various sizes and a confined flow duct, and by those acquired In vertical co-current downward air-water two-phase flow through round pipes of two different sizes.

• Journal of computational fluids engineering
• /
• v.16 no.2
• /
• pp.66-74
• /
• 2011

The SCR catalyst in coal-fired power plant is eroded by the collision of fly ash on the catalyst surface. However the erosion of SCR catalyst by the collision of fly ash has not been fully studied, especially in terms of fluid dynamics. Hence, in the present study, we focus on the gas and solid flows inside the SCR catalyst duct and their consequent effect on the erosion characteristics. For this purpose, computational fluid dynamics is applied to investigate the two-phase flows and to evaluate the erosion rate for different flow and particle injection conditions. Also, the erosion rate and pressure drop of commonly used square shape are compared with equilateral triangle and hexagon shapes. The pressure drop of SCR catalyst is increased when SCR catalyst surface area per unit volume increases. The erosion rate of SCR catalyst is enhanced when the particle velocity, mass flow rate of particle, particle diameter and cell density of SCR catalyst are increased. From the results, the pressure drop and erosion rate at the catalyst surface can be minimized by reducing cell density of SCR catalyst to decrease particle velocity and number of particle impacts.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
• /
• v.30 no.2
• /
• pp.57-64
• /
• 2016

Power demand has continuously increased with technological and economical development. The load density is also growing in the center of downtown area. In particular, underground facilities have been increased on the purpose of the prevention of urban disasters and pedestrian environment improvement. Based on this situation, the underground space in urban surroundings has gradually decreased because of the limited space. The ampacity of buried cables is affected by various factors such as cable size, soil thermal resistance, burial depth and filling material. The thermal capacity of the facilities is determined by the absorb heat surrounding the cable and the soil. The maximum operating temperature of cable is the highest temperature when the insulator of cable is not damaged in the case of high enough temperature. In this paper, the most effective cabling configuration is suggested using the duct array adjustment. It was also considered to increase the number of cable line. This underground distribution system was simulated by using ETAP(Electrical Transient Analysis Program).