• Journal of Pharmaceutical Investigation
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• v.25 no.3
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• pp.249-264
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• 1995

Although liposome has many advantages as a pharmaceutical dosage form, its application in the industrial field has been limited because of some problems such as preparation method, reproducibility, scale-up, stability and sterilization etc. Liposomes prepared by microemulsification method had defined size, narrow size distribution, reproducibility and high entrapment efficiency. For enhancing the stability, the dry form of liposome was recommended. These types of liposome are proliposome and freeze-dried liposome. The liposome must have some properties for preparing of freeze-dried liposome; small size $(50{\sim}200\;nm)$, narrow size distribution and cryoprotectant. In this experiment, the liposomes containing 5-Fluorouracil(5-FU) and its prodrug(pentyl-5-FU-1-acetate; PFA, hexyl-5-FU-1-acetate; HFA) were made with soybean phosphatidylcholine, cholesterol, stearylamine(SA) and dicetyl phosphate(DCP) employing hydration method or microemulsification method using $Microfluidizer^{TM}$. Both or liposome types were MLV and MEL. After preparation, freeze drying and rehydration were performed. In the process of freezing, trehalose(Tr) was added as a cryoprotectant. Their evaluation methods were as follows; entrapment efficiency, mean particle size and size distribution, dissolution test, retain of entrapment efficiency and turbidity after freeze-drying. The results are summarized as belows. The entrapment efficiency of 5-FU was dependent on total lipid concentration and cholesterol content but that of PFA and HFA was decreased when cholesterol was added. When DCP and SA were added, entrapment efficiency was decreased. As the partition coefficient of drug was increased, entrapment efficiency was increased. Under the same condition, entrapment efficiency of MEL is similar to that of MLV. The mean particle size and size distribution of MEL were smaller than those of MLV. Dissolution rates of drug from both liposome types were comparatively similar. Dissolution rates of drugs with serum and liver homogenate were faster than without these material. After preparation of liposome, free drug was removed efficiency by Dowex 50W-X4. When liposome was freeze-dried and then rehydrated in the presence of Tr, characteristics of liposome were maintained well in MEL than MLV. Tr Was used successfully as a cryoprotectant in the process of freeze drying and the optimal ratio of Tr:Lipid was 4:1(g/g).

• Journal of agriculture & life science
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• v.53 no.5
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• pp.137-143
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• 2019

To manufacturing of solid fuel by reuse of the wastes, the drying unit which have 500 kg/hr of drying capacity was developed and experimentally evaluate the performance. The spinach grown in Nam-hae island were used for the experiments and investigated of the heated-air drying characteristics as the inlet amount of raw materials, raw material stirring status, conveying type and drying time. The drying air heated by the energy derived from the steam which is supplied from the incineration plant. The moisture contents of raw materials were measured 85.65%. The inlet flow rate of drying air made a difference as the depth of the raw materials loaded on the drying unit and temperature has showed 108~144℃. The drying speed of the mixed drying more than doubled as that of non mixed drying under the same drying type, inlet amount, drying time and drying air temperature. In each experiment, the drying capacity have showed over 500 kg/hr. A drying efficiency of the ratio of drying consumption energy to input energy was 33.46%, lower than the average of 57.76% for the 157 conventional dryers. Because developed dryer must have a drying time of less than one hour, it is considered that the dry efficiency has been reduced due to the loss of wind volume during drying. If waste heat from incineration plant is used as a direct heat source, the dry air temperature is expected to be at least 160℃, greatly improving the drying capacity.

• Journal of Animal Environmental Science
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• v.8 no.3
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• pp.177-182
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• 2002

Drying process is very important for commercialization of velvet antlers. So far, artificial drying has mostly depended on experience of farmers resulting in low efficiency of drying, deterioration during drying, and contamination by dust and bacteria. Various drying techniques for high-quality production have currently been commercialized in some developed countries, and one of them is a drying technique using microwave. In this study, application of the technique using an electronic (microwave) oven for drying of velvet antler was investigated. The results of this study are as follows. 1. It was found that the drying period was significantly affected by cornification of velvet antlers. Accordingly, it can be assumed that the velvet antlers should partly be sliced to save drying period and required drying energy. 2. It was also found that the drying speed was changeable according to tempering period and even with same drying period. The tempering period should be controlled according to processing rate. 3. The results indicated that a repeated drying of 2-min drying and 3-min tempering is the most effective when a microwave oven was used. 4. The results also showed that the drying technique using microwave of electronic oven can be effectively used for drying of velvet antlers. 5. Only drying and tempering periods were examined in this study, however, ingredient change of deer antler after drying is necessary to be investigated in the future.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.20 no.5
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• pp.547-552
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• 2011

Drying process, corresponding to a final process in the area of food engineering, requires a lot of heat energy. Thus, the energy efficiency is very important for dryers. Since the energy efficiency of heat pump dryers is much higher compared to that of electric dryers or other types of dryers, most of large-capacity dryers are adopting heat pump. In this study, shapes, positions and number of air-circulating fans, guide vanes, air inlet, outlet and top separator were varied for optimization of the flow of a large-capacity heat pump dryer. In addition, fans were modelled with performance curves and porous media were assumed for foods and heat exchangers. The simulation results were applied to the 12-ton dryer and the velocity distributions were experimentally examined. Finally, uniform drying in time was successfully accomplished through frozen pepper experiment.

• Korean Journal of Optics and Photonics
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• v.2 no.2
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• pp.89-95
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• 1991

High diffraction efficiency holographic gratings in silver halide emulsion were fabricated by using reversal bleaching process. The diffraction efficiencies of gratings were improved greatly by applying rapid drying procedure with isopropyl alcohol after bleaching with optimized developers. The dependency of diffraction efficiencies on the different groups of developers, the concentration of bleaching solutions, and the drying methods are investigated experimentally and the results were analyzed theoretically. Same as usual reversal bleaching process, the fabricated gratings showed very low scttering compared to those made by conventional bleach process. The maximum diffraction efficiency was 88%.

• Korean Journal of Optics and Photonics
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• v.3 no.3
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• pp.148-154
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• 1992

With nonhardening fixer, dichromated bleacher and alcohol drying, the diffraction efficiency of over 71o/c has been achie'{ed for holographic phase gratings in silver halide emulsion. The swollen emulsion of Agfa 8E75 HD film is identified by scanning electron microscope (SEM) after chemical processing. Dichromated bleacher and rapid dehydration using alcohol drying make a strong modulation so that diffraction efficiency is. increased over 20%. The principal characteristic parameters in coupled wave theory are investigated and new modified parameter values are presented by computer simulation. Controlling the emulsion thickness has an important role as a potential source for high diffraction efficiency.ciency.

• Proceedings of the Korea Technical Association of the Pulp and Paper Industry Conference
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• 2007.05a
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• pp.83-125
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• 2007

Increasing energy costs have caused profitability problems for paper suppliers. Therefore unprofitable lines are being closed down. The actions aiming for improved profits are focused either on cost savings or on increasing the capacity of the remaining machines. The runnability of a paper machine and its total efficiency have a significant effect on energy consumption. Producing one ton of waste paper consumes at least as much energy as producing the same amount of sellable end product. New automation solutions enable significant cost-effective improvements to the total efficiency of a line without large investment projects. The measures focus on minimizing changes, interruptions, interruption recovery times and grade change times. Newest actuators, online quality measurements and wet end analysators create an improvement potential, which can be optimally implemented with the latest machine direction control solutions, based on model predictive control concepts. Equally, drying management is significant to the energy consumption. The newest control strategies optimize the use of various drying actuators for different situations; either by responding to changes as efficiently as possible or by using only the cheapest energy sources in stable situations. An even steam supply, which is vital for paper machines, is achieved with control for the power plant steam network. This makes possible to avoid the delays upon starting the paper machine and assure an even steam supply for the drying section and the actuators. This document describes means which have brought significant energy and raw material savings for paper machines. Metso Automation has provided efficiency improvement packages, which are usually based on optimized control of dry weight and drying in all running conditions. The solutions are based on performance analysis, on which the estimations for improvement potential and the necessary actions are based on. Typically benefits on an annual level have been from hundreds of thousands of euros to over one million euro. For example, variations in dry weight have been decreased more than 50%. The results are presented with a few examples. Additionally, the analysis models, adjustment solutions and the changes in running methods with which the results were achieved, are presented.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.30 no.2
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• pp.40-46
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• 1998

This study was aimed to investigate any improvement of dewatering and energy saving on the papermaking process when the various types of fillers were used, i.e., clay, talc and grounded calcium carbonate (GCC). Cationic polyelectrolyte and alum coagulants neutralized the surface charge of the filler particles and the filler particles were coagulated. The rates of dewatering and drying were investigated. The results indicated that clay tended to intense anion, while talc and GCC tended to anion trend nearly to neutrality. Clay and talc added with EPI-DMA, P-DADMAC and alum respectively as optimum levels showed a significant efficiency on the dewatering and the turbidity dissipation. However, the turbidity and dewatering rate of GCC decreased, when GCC was added with EPI-DMA and P-DADMAC respectively Drying rate of clay was increased when coagulant added. However drying rates of talc and GCC were not affected by coagulant, while the apprarent drying time of talc and GCC in the absence of any coagulant was shorter than the clay in the presence of a coagulant. The result confirmed that talc or GCC was more efficient than clay on the dewatering and drying, which is consistent with a general knowledge in the collodal science.

• Resources Recycling
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• v.6 no.1
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• pp.40-46
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• 1997

Sludgc d~sposal has been a major challenge in the wastewater treatment. Drying is operation which is separated fromsewage sludge to solid and liquid by heating. Drying needs to pretreatment process for effective "thation, incinerationand dispaal The objective of this work was to the drying dewatered sewage sludge by microwave heating, and tocompare the experimental rcsults with thcorctical rcsults. Microwave drylng is fast and has a high efficiency. In thepresent \ark, an unsteady state analysis of one dunensional drying, with microwave heating, is carried out. In drying ratecurve, moisture movement at falling rate period occured by dfision. A good agreement was abtamed between the modcland the experimental results using the slab sample of 0.2cm thickness. 0.2cm thickness.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.6
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• pp.37-45
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• 2018

An electric vehicle is an environmentally friendly vehicle because there is no exhaust gas, unlike gasoline automobiles. On the other hand, because the electric vehicle is driven by electric power charged in batteries, the distance to go through a single charge depends on the energy density of the batteries. Therefore, a lithium-ion battery with a high energy density is a good candidate for batteries in electric vehicles. Because the electrode is an essential component that governs the efficiency of a lithium-ion battery, the electrode manufacturing process plays a vital role in the entire production process of lithium-ion batteries. In particular, the drying process during the electrode manufacturing process is a critical process that has a significant influence on the performance. This paper proposes an innovative process for improving the efficiency and productivity of the drying process in electrode manufacturing and describe the equipment design method and development results. In particular, the design procedure and development method for enhancing the electrode adhesion power, atmospheric pressure superheated steam drying technology, and drying furnace slimming technologies are presented. As a result, high-speed drying technology was developed for battery electrodes through the world's first turbo dryer technology for mass production using open/integrated atmospheric pressure superheated steam. Compared to the conventional drying process, the drying furnace improved the productivity (Dry Lead Time $0.7min{\rightarrow}0.5min$).