• 제목/요약/키워드: Drug discovery

검색결과 527건 처리시간 0.034초

CV Safety & Future Generation COX-2 inhibitors

  • Shin, Song-Seok;Byun, Young-Joo;Lim, Kyung-Min;Choi, Jin-Kyu;Lee, Ki-Wha;Moh, Joo-Hyun;Kim, Jin-Kwan;Jeong, Yeon-Su;Kim, Ji-Young;Choi, Young-Hoon;Koh, Hyun-Ju;Park, Young-Ho;Oh, Young-Im
    • 대한약학회:학술대회논문집
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    • 대한약학회 2005년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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    • pp.67-68
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    • 2005
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Diaralkylthiourea Derivatives as a Novel Vanilloid Receptor Antagonist

  • Joo, Yung-Hyup;Kim, Jin-Kwan;Kim, Sun-Young;Choi, Jin-Kyu;Koh, Hyun-Ju;Jeong, Yeon-Su;Park, Young-Ho;Chung, Shin;Suh, Young-Ger;Oh, Uh-Taek;Park, Hyeung-Geun;Kim, Hee-Doo
    • 대한약학회:학술대회논문집
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    • 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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    • pp.350.1-350.1
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    • 2002
  • A series of diaralkylthiourea derivatives was prepared and tested for its antagonistic activity against vanilloid receptor. In this study we explored the possibility of selected compound type (Ⅰ) with tetrahydronaphthyl group as rigid pendant moiety. Our premise for antagonistic activity of molecules was modeled on the capsazepine. the first antagonist for vanilloid receptor. These compounds (Ⅰ) showed less potent antagonistic activity than that of capsazepine. but they were devoid of agonistic activity. (omitted)

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