• Title/Summary/Keyword: Drug Shelf-life

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Effects of a Gelatin Coating on the Shelf Life of Salmon

  • Heu, Min-Soo;Park, Chan-Ho;Kim, Hyung-Jun;Lee, Dong-Ho;Kim, Jin-Soo
    • Fisheries and Aquatic Sciences
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    • v.13 no.2
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    • pp.89-95
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    • 2010
  • This study was conducted to investigate the efficacy of using a coating of gelatin extracted from refiner discharge to extend the shelf life of salmon during cold storage ($5^{\circ}C$). Relative percentage of moisture loss in gelatin-coated salmon during cold storage was less than that of uncoated salmon. The treatment of salmon with gelatin reduced volatile basic nitrogen (VBN) formation throughout the entire storage period. Measurements of the peroxide value (POV), fatty acid composition, and (20:5n-3+22:6n-3)/16:0 ratio during cold storage indicated that the coating of salmon with gelatin from refiner discharge effectively suppressed lipid oxidation over the entire storage period. The extent of sensory color change during cold storage was less in the gelatin-coated than in the uncoated salmon. From the results of chemical measurements, such as relative moisture content, VBN, POV, fatty acid composition, (20:5n-3+22:6n-3)/16:0 ratio, and sensory color change, the conclusion was made that the coating treatment of salmon with refiner discharge gelatin effectively suppressed moisture loss, lipid oxidation, and color deterioration over the entire storage period.

Development of Antimicrobial Edible Film from Defatted Soybean Meal Fermented by Bacillus subtilis

  • KIM , HYUNG-WOOK;KIM, KYUNG-MI;KO, EUN-JUNG;LEE, SI-KYUNG;HA, SANG-DO;SONG, KYUNG-BIN;PARK, SANG-KYU;KWON, KI-SUNG;BAE, DONG-HO
    • Journal of Microbiology and Biotechnology
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    • v.14 no.6
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    • pp.1303-1309
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    • 2004
  • In order to extend shelf-life of the packaged or coated foods, an antibacterial edible film was developed. Antimicrobial activities of 9 bacteriocin-like substance (BLS)­producing strains were evaluated after growing them on defatted soybean meal medium (DSMM). Bacillus subtilis was selected among those, because it showed the biggest inhibition zone against 6 problem bacteria in food. The antimicrobial edible film, containing $0.32\%$ of BLS, was produced from the fermented soybean meal with B. subtilis at the optimum condition of pH 7.0-7.5 and $33^{\circ}C$ for 33 h. The antimicrobial activity of the film was over $50\%$ of the maximum activity after film production with heat treatment at $90^{\circ}C$ and pH adjustment to 9. When the soy protein film with BLS was applied on the agar media containing E. coli, the growth inhibition was much higher than the ordinary soy protein film. These results indicate that the soy protein film with BLS from B. subtilis can be used as a new packaging material to extend the shelf-life of foods.

Physicochemical Properties and Stability Study of BR-8702-2, a New Anticancer Drug

  • Lee, Ho-Bum;Lee, Joong-Bok;Lee, Sang-Jin;Shin, Hyun-Jong;Paik, Woo-Hyun
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1996.04a
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    • pp.276-276
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    • 1996
  • 합성한 BR-8702-2의 시험결과 원소분석에서는 이론치와 실험치가 잘 일치하였고, 구조확인을 위한 FT-IR 및 FT-NMR(H$^1$)등의 시험에서도 구조와 일치하는 결과치를 나타내었다. 합성물질의 정량법을 HPLC 및 구성원소인 P와 N을 이용한 정량법에서도 유의성있는 결과를 얻을 수 있었다. 또한 분말상태인 이 물질의 안정성은 고온 고습하에서도 양호하였으며, 각종 완충수용액에서 pH가 분해에 미치는 영향을 pH-rate profile로 나타낸 결과 pH7, 8, 9에서 안정하였고 pH8에서 k=1.3$\times$$10^{-4}$day으로 가장 안정하여 shelf life는 807일이었다. 광에 대해서도 k=5.8$\times$$10^{-4}$day로 매우 안정하였다.

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Quality Evaluation of Pharmaceutical Preparations( II ) -Dissolution of Prednisolone Tablets- (의약품(醫藥品)의 품질평가(品質評價)에 관(關)한 연구(硏究) (제 2 보)(第 2 報) -프레드니솔론 정제(錠劑)의 용출(溶出)에 관한 연구(硏究)-)

  • Kim, Hyung-Kook;Kim, Jae-Baek
    • Journal of Pharmaceutical Investigation
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    • v.14 no.3
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    • pp.122-130
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    • 1984
  • The dissolution profiles of the seven branded prednisolone tablets were determined by means of available compendium. Those tablets were stored at $40^{\circ}C,\;50^{\circ}C\;and\;60^{\circ}C$ for 15, 30 and 60 days respectively. Under the stress conditions, the dissolution efficiency showed significant changes. It is considered that the determination of shelf life of drug from these aging effects is possible because the dissolution data followed a logarithmic distribution. There were no substantial differences of dissolution between two prednisolone formulations with different particle size not larger than $100\;{\mu}m$. The effect of two starches (corn and potato) on the rate of dissolution of prednisolone from dosage form was also investigated. All marketed tablets met the requirement of the established compendium.

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Quality Characteristics at Different Storage Temperatures and Periods for Shelf Life Evaluation of Takju (탁주의 유통기간 산정을 위한 저장온도 및 기간별 품질특성)

  • Jang, Gwi Yeong;Lee, Sang Hoon;Li, Meishan;Kim, Sung Tae;Lee, Ji Hyun;Kang, Tae Su;Lee, Ju Yeon;Lee, Junsoo;Jeong, Heon Sang
    • The Korean Journal of Food And Nutrition
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    • v.28 no.1
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    • pp.104-110
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    • 2015
  • This study was performed to investigate the changes in quality characteristics of Takju under different storage temperatures (5, 10 and $20^{\circ}C$) and length of shelf life. Under all storage conditions, alcohol content, pH, total bacteria and yeast counts of Takju decreased with increasing storage period. However, aldehyde content and total acidity increased. In sensory evaluation, flavor, taste and overall satisfaction of Takju under all storage conditions decreased with increasing storage period and temperature. Quality characteristics such as alcohol content, total bacteria count, yeast count, total acidity, pH, aldehyde content and overall satisfaction at high storage temperature changed faster than low storage temperature. Alcohol content, total bacteria count, yeast count, total acidity, pH and aldehyde content had high correlations among factors affecting sensory characteristics (p<0.01). based on the results from this study, expected expiration dates of Takju are 55, 26 and 3 days at 5, 10 and $20^{\circ}C$, respectively.

Combined Effects of Antibacterial Film and Storage Temperature on Shelf-life and Microbiological Safety of Mackerel (항균 필름과 저장 온도의 고등어 저장성 및 미생물학적 안정성에 대한 병행 효과)

  • Ha, Ji-Hyoung;Lee, Yu-Si;Heo, Sun-Kyung;Bae, Dong-Ho;Park, Sang-Kyu;Hwang, Sun-Soon;Ha, Sang-Do
    • Journal of Food Hygiene and Safety
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    • v.22 no.4
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    • pp.317-322
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    • 2007
  • The purpose of this study was to investigate the antibacterial effect of films on shelf-life and microbiological safety of mackerel. Effects of antimicrobial films against total aerobic bacteria, Escherichia coli O157:H7, Listeria monocytogenes, Vibrio parahaemolyticus in mackerel were evaluated during storage of 5-14 days at $5^{\circ}C,\;10^{\circ}C\;and\;15^{\circ}C$. Antimicrobial films were developed with addition of a natural substance, wasabi extracts (Wasabia japonica). At $5^{\circ}C$ storage, growth of total aerobic bacteria, Escherichia coli O157:H7, Listeria monocytogenes were inhibited higher than at 10 and $15^{\circ}C$. Especially, the numbers of V. parahaemolyticus were decreased gradually at $5^{\circ}C$ even in the control sample, and about $1\;log_{10}cfu/g\;and\;1.8\;log_{10}cfu/g$ reductions were observed at 1 and 4 days, respectively. After 7 days, V. parahaemolyticus in all samples were not detected. There is a limit of a single treatment of antimicrobial film to prolong shelf-life of mackerel. The synergistic effect of antimicrobial film were shown by addition of $5^{\circ}C$ refrigeration.

Investigating the Impact of Storage Conditions on Dietary Fiber and Calcium Contents of Black Soybean Sunsik to Develop a Functional Labelling System (저장조건에 따른 기능성표시제도가 도입된 검은콩 선식 제품의 식이섬유 및 칼슘 함량 변화 관찰)

  • Kang-Pyo Lee;Ye-Won In;Ji-Hyun Im;Ok-Hwan Lee;Boo-Yong Lee
    • Journal of Food Hygiene and Safety
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    • v.38 no.4
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    • pp.273-278
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    • 2023
  • This study aimed to predict the shelf life of black soybean Sunsik to develop a functional labeling system for the product. The Arrhenius equation was used to calculate the shelf life by examining alterations in the dietary fiber and calcium levels of black soybean Sunsik stored at 25, 35, and 50℃ for 0, 6, and 12 months. Dietary fiber and calcium analyses were performed according to the experimental methods specified in the Food Code of the Ministry of Food and Drug Safety. Both black soybean Sunsik (BS) and black soybean Sunsik containing nondigestible maltodextrin and calcium lactate (BSN) exhibited an upward trend in dietary fiber content after 12 months of storage, compared to their initial levels. During storage, the phytate in Sunsik degraded, releasing cations that facilitated the formation of new cross-links between pectic acid and middle lamella, which ultimately increased dietary fiber content. Conversely, the calcium contents of both BS and BSN decreased with prolonged storage. Based on these findings, the expected shelf life of BS and BSN was calculated as 15.65 and 28.34 months, respectively.

Comparison of In vitro Anti-Biofilm Activities of Natural Plant Extracts Against Environment Harmful Bacteria (천연물 성분을 이용한 환경 유해미생물의 biofilm 생성 저해능 비교에 관한 연구)

  • Kang, Eun-Jin;Park, Ji Hun;Jin, Seul;Kim, Young-Rok;Do, Hyung-Ki;Yang, Woong-Suk;Lee, Jae-Yong;Hwang, Cher-Won
    • Journal of Environmental Science International
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    • v.28 no.2
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    • pp.225-233
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    • 2019
  • In this study, we investigated the in vitro anti-biofilm activities of plant extracts of chives (Allium tuberosum), garlic (Allium sativum), and radish (Raphanus sativus L.) against environment harmful bacteria (gram-positive Staphylococcus aureus and, gram-negative Salmonella typhimurium and Escherichia coli O157:H7). In the paper disc assay, garlic extracts exhibited the highest anti-biofilm activity. The Minimal Inhibitory Concentration (MIC) of all plant extracts was generally higher for gram-negative bacteria than it was for gram-positive bacteria. Gram-negative bacteria were more resistant to plant extracts. The tetrazolium dye (XTT) assay revealed that, each plant extract exhibited a different anti-biofilm activity at the MIC value depending on the pathogen involved. Among the plant extracts tested, garlic extracts (fresh juice and powder) effectively reduced the metabolic activity of the cells of food-poisoning bacteria in biofilms. These anti-biofilm activities were consistent with the results obtained through light microscopic observation. Though the garlic extract reduced biofilm formation for all pathogens tested, to elucidate whether this reduction was due to antimicrobial effects or anti-biofilm effects, we counted the colony forming units of pathogens in the presence of the garlic extract and a control antimicrobial drug. The garlic extract inhibited the E. coli O157:H7 biofilm effectively compared to the control antimicrobial drug ciprofloxacin; however, it did not inhibit S. aureus biofilm significantly compared to ciprofloxacin. In conclusion, garlic extracts could be used as natural food preservatives to prevent the growth of foodborne pathogens and elongater the shelf life of processed foods.

Hazardous Effect of Dietary Trans Fats on Human Health and Regulations (인체에 미치는 트랜스지방의 위해와 규제현황)

  • Gil, Bog-Im;Rho, Jeong-Hae
    • Korean journal of food and cookery science
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    • v.23 no.6
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    • pp.1015-1024
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    • 2007
  • Trans-fatty acids (TFAs) are defined as the sum of all unsaturated fatty acids that contain one or more non-conjugated double bonds in a trans configuration. Dietary trans- fatty acids originate from commercially hydrogenated oils and from dairy and meat fats. From the perspective of the food industry, partially hydrogenated vegetable oils are attractive because of their long shelf life, stability during deep-frying, and semisolidity, which can be customized to enhance the palatability of baked goods and fried foods. Although no definite differences have been documented so far between the metabolic and health effects of industrial and ruminant TFAs, the intake of industrially produced TFA has declined, and in Europe, the majority of TFAs are of ruminant origin. Due to the scientific evidence associating TFA intake with increased risk of coronary heart disease (CDH), the Korea Food and Drug Administration (KFDA) issued a final rule that requires the amount of trans fat present in foods to be declared on the nutrition label, by December 1, 2007. In addition, many food manufacturers who use partially hydrogenated oils in their products have developed, or are considering ways, to reduce or eliminate trans-fatty acids from certain food products.

Quality Characteristics of Gamma Irradiated Commercial Arcon Starch Gel during Storage (감마선을 조사한 시판 도토리묵의 저장 중 품질 특성)

  • Kim, Min-Hee;Kim, Hyun-Joo;Heo, Ok-Soon;Lee, Ju-Woon;Byun, Myung-Woo;Kim, Mee-Ree
    • Journal of the East Asian Society of Dietary Life
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    • v.17 no.6
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    • pp.816-821
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    • 2007
  • The physical properties and sensory characteristics of acorn starch gels (Dotori Mook), which were gamma-irradiated up to 3 kGy, were evaluated during storage at $4^{\circ}C$. Even at the dose of 2 kGy, the gamma irradiation decreased total bacteria in the Dotori Mook during 5 days of storage, to lower than the detection limit $(10^2CFU/g)$. The hardness of the control sample increased according to the days of storage, while the gamma irradiated samples had decreased hardness according to the irradiation dose. The sample irradiated at 3 kGy maintained the same hardness as the control at day 0 of storage. Irradiation did not affect the Hunter color values. No significant differences were observed in off-odor, color, springiness, and overall acceptability (p<0.05) at the irradiation dose of 2 kGy. It can be concluded that the irradiation of Dotori Mook, up to 2 kGy, does not affect the quality of the Mook during storage, with regard to texture and sensory characteristics. Moreover, the irradiated Mook was superior in maintaining hardness and had prolonged shelf-life time by sanitation.

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