• 제목/요약/키워드: Drug Shelf-life

검색결과 29건 처리시간 0.026초

Effects of a Gelatin Coating on the Shelf Life of Salmon

  • Heu, Min-Soo;Park, Chan-Ho;Kim, Hyung-Jun;Lee, Dong-Ho;Kim, Jin-Soo
    • Fisheries and Aquatic Sciences
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    • 제13권2호
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    • pp.89-95
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    • 2010
  • This study was conducted to investigate the efficacy of using a coating of gelatin extracted from refiner discharge to extend the shelf life of salmon during cold storage ($5^{\circ}C$). Relative percentage of moisture loss in gelatin-coated salmon during cold storage was less than that of uncoated salmon. The treatment of salmon with gelatin reduced volatile basic nitrogen (VBN) formation throughout the entire storage period. Measurements of the peroxide value (POV), fatty acid composition, and (20:5n-3+22:6n-3)/16:0 ratio during cold storage indicated that the coating of salmon with gelatin from refiner discharge effectively suppressed lipid oxidation over the entire storage period. The extent of sensory color change during cold storage was less in the gelatin-coated than in the uncoated salmon. From the results of chemical measurements, such as relative moisture content, VBN, POV, fatty acid composition, (20:5n-3+22:6n-3)/16:0 ratio, and sensory color change, the conclusion was made that the coating treatment of salmon with refiner discharge gelatin effectively suppressed moisture loss, lipid oxidation, and color deterioration over the entire storage period.

Development of Antimicrobial Edible Film from Defatted Soybean Meal Fermented by Bacillus subtilis

  • KIM , HYUNG-WOOK;KIM, KYUNG-MI;KO, EUN-JUNG;LEE, SI-KYUNG;HA, SANG-DO;SONG, KYUNG-BIN;PARK, SANG-KYU;KWON, KI-SUNG;BAE, DONG-HO
    • Journal of Microbiology and Biotechnology
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    • 제14권6호
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    • pp.1303-1309
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    • 2004
  • In order to extend shelf-life of the packaged or coated foods, an antibacterial edible film was developed. Antimicrobial activities of 9 bacteriocin-like substance (BLS)­producing strains were evaluated after growing them on defatted soybean meal medium (DSMM). Bacillus subtilis was selected among those, because it showed the biggest inhibition zone against 6 problem bacteria in food. The antimicrobial edible film, containing $0.32\%$ of BLS, was produced from the fermented soybean meal with B. subtilis at the optimum condition of pH 7.0-7.5 and $33^{\circ}C$ for 33 h. The antimicrobial activity of the film was over $50\%$ of the maximum activity after film production with heat treatment at $90^{\circ}C$ and pH adjustment to 9. When the soy protein film with BLS was applied on the agar media containing E. coli, the growth inhibition was much higher than the ordinary soy protein film. These results indicate that the soy protein film with BLS from B. subtilis can be used as a new packaging material to extend the shelf-life of foods.

Physicochemical Properties and Stability Study of BR-8702-2, a New Anticancer Drug

  • Lee, Ho-Bum;Lee, Joong-Bok;Lee, Sang-Jin;Shin, Hyun-Jong;Paik, Woo-Hyun
    • 한국응용약물학회:학술대회논문집
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    • 한국응용약물학회 1996년도 춘계학술대회
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    • pp.276-276
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    • 1996
  • 합성한 BR-8702-2의 시험결과 원소분석에서는 이론치와 실험치가 잘 일치하였고, 구조확인을 위한 FT-IR 및 FT-NMR(H$^1$)등의 시험에서도 구조와 일치하는 결과치를 나타내었다. 합성물질의 정량법을 HPLC 및 구성원소인 P와 N을 이용한 정량법에서도 유의성있는 결과를 얻을 수 있었다. 또한 분말상태인 이 물질의 안정성은 고온 고습하에서도 양호하였으며, 각종 완충수용액에서 pH가 분해에 미치는 영향을 pH-rate profile로 나타낸 결과 pH7, 8, 9에서 안정하였고 pH8에서 k=1.3$\times$$10^{-4}$day으로 가장 안정하여 shelf life는 807일이었다. 광에 대해서도 k=5.8$\times$$10^{-4}$day로 매우 안정하였다.

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의약품(醫藥品)의 품질평가(品質評價)에 관(關)한 연구(硏究) (제 2 보)(第 2 報) -프레드니솔론 정제(錠劑)의 용출(溶出)에 관한 연구(硏究)- (Quality Evaluation of Pharmaceutical Preparations( II ) -Dissolution of Prednisolone Tablets-)

  • 김형국;김재백
    • Journal of Pharmaceutical Investigation
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    • 제14권3호
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    • pp.122-130
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    • 1984
  • The dissolution profiles of the seven branded prednisolone tablets were determined by means of available compendium. Those tablets were stored at $40^{\circ}C,\;50^{\circ}C\;and\;60^{\circ}C$ for 15, 30 and 60 days respectively. Under the stress conditions, the dissolution efficiency showed significant changes. It is considered that the determination of shelf life of drug from these aging effects is possible because the dissolution data followed a logarithmic distribution. There were no substantial differences of dissolution between two prednisolone formulations with different particle size not larger than $100\;{\mu}m$. The effect of two starches (corn and potato) on the rate of dissolution of prednisolone from dosage form was also investigated. All marketed tablets met the requirement of the established compendium.

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탁주의 유통기간 산정을 위한 저장온도 및 기간별 품질특성 (Quality Characteristics at Different Storage Temperatures and Periods for Shelf Life Evaluation of Takju)

  • 장귀영;이상훈;;김성태;이지현;강태수;이주연;이준수;정헌상
    • 한국식품영양학회지
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    • 제28권1호
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    • pp.104-110
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    • 2015
  • 비살균 탁주의 유통기간 산정을 위하여 저장기간에 따른 온도별 품질특성을 살펴보았다. 품질특성은 알코올 함량, 총균수, 효모수, 총산도, pH, 메탄올, 알데히드 함량 및 관능특성을 분석하였다. 모든 저장조건에서 알코올 함량, pH, 총균수 및 효모수는 저장기간이 길어짐에 따라 감소하였으며, 알데히드 함량과 총산도는 저장기간이 증가함에 따라 증가하였다. 관능평가 결과 모든 저장조건에서 저장기간이 증가함에 따라 향, 맛 및 전반적 기호도가 감소하였다. 알코올 함량, 총균수, 효모수, 총산도, pH, 알데히드 함량 및 관능특성과 같은 품질지표는 저장온도가 높을수록 변화가 빨랐다. 관능특성에 영향을 미치는 요인은 알코올 함량, 총균수, 효모수, 총산도, pH 및 알데히드 함량이었다. 식품규격에 따라 품질유지기한은 $5^{\circ}C$에서는 55일, $10^{\circ}C$에서는 26일 그리고 $20^{\circ}C$에서는 3일까지 섭취가 가능할 것으로 판단된다.

항균 필름과 저장 온도의 고등어 저장성 및 미생물학적 안정성에 대한 병행 효과 (Combined Effects of Antibacterial Film and Storage Temperature on Shelf-life and Microbiological Safety of Mackerel)

  • 하지형;이유시;허선경;배동호;박상규;황선순;하상도
    • 한국식품위생안전성학회지
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    • 제22권4호
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    • pp.317-322
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    • 2007
  • 본 연구는 고흡습성 필름에 고추냉이 추출물을 첨가하여 제작한 항균흡습필름의 고등어 중 존재하는 식품위해 미생물에 대한 살균효과를 확인하고자 하였다. 총호기성균 및 식품위해미생물인, Escherichia coli O157:H7, Listeria monocytogenes Vibrio parahaemolyticus를 점 접종하여 항균흡습필름으로 포장한 후 저장온도, 기간별 및 항균 필름의 코팅 횟수가 균의 성장 및 사멸에 미치는 영향을 관찰하였다. $5^{\circ}C$에서 총균수, Escherichia coli O157:H7, Listeria monocytogenes의 성장 억제 효과는 $10^{\circ}C,\;15^{\circ}C$에서 보다 우수하였다. 특히 Usrio Vibrio parahaemolyticus는 $5^{\circ}C$에서 저온에 민감한 반응을 보이면서 모든 시료에서 1일, 4일 후 각각 약 $1\;log_{10}cfu/g\;and\;1.80\;log_{10}cfu/g$ 정도 감소하다가 7일 후에는 검출한계 아래로 모두 사멸하였다. 고추냉이 추출 물질이 함유된 흡습필름은 $10^{\circ}C,\;15^{\circ}C$에서 보다 $5^{\circ}C$ 에서 우수한 항균효과를 보였다. 세 가지 농도별 항균효과는 $5^{\circ}C$ 에서 두드러진 농도별 항균효과 차이를 보였으며 코팅 횟수가 늘어날수록 항균효과가 컸다. 이는 항균필름, 한 가지로만은 저장기간 향상에 한계가 있고 냉장저장이라는 hurdle을 동시에 적용하여 항미생물 synergy 효과를 보인다는 증거가 된다.

저장조건에 따른 기능성표시제도가 도입된 검은콩 선식 제품의 식이섬유 및 칼슘 함량 변화 관찰 (Investigating the Impact of Storage Conditions on Dietary Fiber and Calcium Contents of Black Soybean Sunsik to Develop a Functional Labelling System)

  • 이강표;인예원;임지현;이옥환;이부용
    • 한국식품위생안전성학회지
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    • 제38권4호
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    • pp.273-278
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    • 2023
  • 본 연구에서는 검은콩 선식 및 기능성 표시 검은콩 선식의 저장온도(25℃, 35℃, 50℃) 및 저장기간(0개월, 6개월, 12개월)에 따른 식이섬유 및 칼슘함량 변화를 관찰하였다. 이후 Arrhenius 반응식을 통해 품질한계기한을 산출하여 소비기한을 예측하였다. 식이섬유 분석 결과 BS 및 BSN 모두 저장 12개월에서 저장초기에 비해 증가하는 경향을 나타내었으며, 이는 저장 중 선식에 함유된 phytate의 분해로 인하여 양이온이 방출되고, 양이온은 pectic acid와 Middle Lamella에서 새로운 가교결합을 형성하여 결과적으로 저장 중 식이섬유 함량이 증가될 수 있다. 반면에 BS와 BSN의 칼슘함량은 저장기간에 따라 감소하였다. 이러한 결과를 바탕으로 품질한계기한을 예측한 결과 BS 15.65 개월, BSN 28.34 개월 이었으며, 난소화성 말토덱스트린 및 젖산칼슘을 첨가한 검은콩 선식을 제조하였을 때 기능성 표시 제도를 도입할 수 있을 뿐만 아니라 품질한계기한을 연장시킬 수 있을 것으로 판단된다.

천연물 성분을 이용한 환경 유해미생물의 biofilm 생성 저해능 비교에 관한 연구 (Comparison of In vitro Anti-Biofilm Activities of Natural Plant Extracts Against Environment Harmful Bacteria)

  • 강은진;박지헌;진슬;김영록;도형기;양웅석;이재용;황철원
    • 한국환경과학회지
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    • 제28권2호
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    • pp.225-233
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    • 2019
  • In this study, we investigated the in vitro anti-biofilm activities of plant extracts of chives (Allium tuberosum), garlic (Allium sativum), and radish (Raphanus sativus L.) against environment harmful bacteria (gram-positive Staphylococcus aureus and, gram-negative Salmonella typhimurium and Escherichia coli O157:H7). In the paper disc assay, garlic extracts exhibited the highest anti-biofilm activity. The Minimal Inhibitory Concentration (MIC) of all plant extracts was generally higher for gram-negative bacteria than it was for gram-positive bacteria. Gram-negative bacteria were more resistant to plant extracts. The tetrazolium dye (XTT) assay revealed that, each plant extract exhibited a different anti-biofilm activity at the MIC value depending on the pathogen involved. Among the plant extracts tested, garlic extracts (fresh juice and powder) effectively reduced the metabolic activity of the cells of food-poisoning bacteria in biofilms. These anti-biofilm activities were consistent with the results obtained through light microscopic observation. Though the garlic extract reduced biofilm formation for all pathogens tested, to elucidate whether this reduction was due to antimicrobial effects or anti-biofilm effects, we counted the colony forming units of pathogens in the presence of the garlic extract and a control antimicrobial drug. The garlic extract inhibited the E. coli O157:H7 biofilm effectively compared to the control antimicrobial drug ciprofloxacin; however, it did not inhibit S. aureus biofilm significantly compared to ciprofloxacin. In conclusion, garlic extracts could be used as natural food preservatives to prevent the growth of foodborne pathogens and elongater the shelf life of processed foods.

인체에 미치는 트랜스지방의 위해와 규제현황 (Hazardous Effect of Dietary Trans Fats on Human Health and Regulations)

  • 길복임;노정해
    • 한국식품조리과학회지
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    • 제23권6호
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    • pp.1015-1024
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    • 2007
  • Trans-fatty acids (TFAs) are defined as the sum of all unsaturated fatty acids that contain one or more non-conjugated double bonds in a trans configuration. Dietary trans- fatty acids originate from commercially hydrogenated oils and from dairy and meat fats. From the perspective of the food industry, partially hydrogenated vegetable oils are attractive because of their long shelf life, stability during deep-frying, and semisolidity, which can be customized to enhance the palatability of baked goods and fried foods. Although no definite differences have been documented so far between the metabolic and health effects of industrial and ruminant TFAs, the intake of industrially produced TFA has declined, and in Europe, the majority of TFAs are of ruminant origin. Due to the scientific evidence associating TFA intake with increased risk of coronary heart disease (CDH), the Korea Food and Drug Administration (KFDA) issued a final rule that requires the amount of trans fat present in foods to be declared on the nutrition label, by December 1, 2007. In addition, many food manufacturers who use partially hydrogenated oils in their products have developed, or are considering ways, to reduce or eliminate trans-fatty acids from certain food products.

감마선을 조사한 시판 도토리묵의 저장 중 품질 특성 (Quality Characteristics of Gamma Irradiated Commercial Arcon Starch Gel during Storage)

  • 김민희;김현주;허옥순;이주운;변명우;김미리
    • 동아시아식생활학회지
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    • 제17권6호
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    • pp.816-821
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    • 2007
  • The physical properties and sensory characteristics of acorn starch gels (Dotori Mook), which were gamma-irradiated up to 3 kGy, were evaluated during storage at $4^{\circ}C$. Even at the dose of 2 kGy, the gamma irradiation decreased total bacteria in the Dotori Mook during 5 days of storage, to lower than the detection limit $(10^2CFU/g)$. The hardness of the control sample increased according to the days of storage, while the gamma irradiated samples had decreased hardness according to the irradiation dose. The sample irradiated at 3 kGy maintained the same hardness as the control at day 0 of storage. Irradiation did not affect the Hunter color values. No significant differences were observed in off-odor, color, springiness, and overall acceptability (p<0.05) at the irradiation dose of 2 kGy. It can be concluded that the irradiation of Dotori Mook, up to 2 kGy, does not affect the quality of the Mook during storage, with regard to texture and sensory characteristics. Moreover, the irradiated Mook was superior in maintaining hardness and had prolonged shelf-life time by sanitation.

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