• Title/Summary/Keyword: Drug Discovery

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CV Safety & Future Generation COX-2 inhibitors

  • Shin, Song-Seok;Byun, Young-Joo;Lim, Kyung-Min;Choi, Jin-Kyu;Lee, Ki-Wha;Moh, Joo-Hyun;Kim, Jin-Kwan;Jeong, Yeon-Su;Kim, Ji-Young;Choi, Young-Hoon;Koh, Hyun-Ju;Park, Young-Ho;Oh, Young-Im
    • Proceedings of the PSK Conference
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    • 2005.04a
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    • pp.67-68
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    • 2005
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Diaralkylthiourea Derivatives as a Novel Vanilloid Receptor Antagonist

  • Joo, Yung-Hyup;Kim, Jin-Kwan;Kim, Sun-Young;Choi, Jin-Kyu;Koh, Hyun-Ju;Jeong, Yeon-Su;Park, Young-Ho;Chung, Shin;Suh, Young-Ger;Oh, Uh-Taek;Park, Hyeung-Geun;Kim, Hee-Doo
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.350.1-350.1
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    • 2002
  • A series of diaralkylthiourea derivatives was prepared and tested for its antagonistic activity against vanilloid receptor. In this study we explored the possibility of selected compound type (Ⅰ) with tetrahydronaphthyl group as rigid pendant moiety. Our premise for antagonistic activity of molecules was modeled on the capsazepine. the first antagonist for vanilloid receptor. These compounds (Ⅰ) showed less potent antagonistic activity than that of capsazepine. but they were devoid of agonistic activity. (omitted)

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