• Title/Summary/Keyword: Drug

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Effect of capsaicin on melanoma growth and metastasis

  • Kim, Ok-Hee;Jun, Hye-Seung;Han, Beom-Seok;Song, Chi-Won;Lee, Chang-Ki;Park, Mi-Sun;Eom, Mi-Ok;Jee, Seung-Wan;Ryeom, Tai-Kyung;Kang, Ho-Il
    • Proceedings of the Korea Environmental Mutagen Society Conference
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    • 2002.11a
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    • pp.143-143
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    • 2002
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CORRELATION BETWEEN SKIN IRRITATION AND CYTOTOXICITY OF ANTI-WRINKLE AGENTS

  • Lee, Eun-Hee;Hong, Jin-Tae;Lee, Jong-Kwon;Kim,Yong-Kyu;Park, Ki-Sook;Jung, Kyoung-Mi;Kwan, Jung-Hai;Lee, Sun-Hee;Yang, Ki-Hwa;Chung, Soo-Youn
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2001.05a
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    • pp.110-110
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    • 2001
  • To compare skin irritation and cytotoxicity of anti-wrinkle agents, we examined skin irritation of six anti-wrinkle agents (ascorbic acid, glycolic acid, all trans-retinoic acid, ginseng extract, retinol, EB) in New Zeland white rabbit.(omitted)

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Drug Safety Evaluation in the United States of America

  • Yoon, Young-H.;Johnson, Charles A.;Soltys, Randolph A.;Sibley, Peter L.
    • Korean Journal of Veterinary Pathology
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    • v.1 no.2
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    • pp.91-96
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    • 1997
  • General steps in the discovery and development of novel drugs in the United States are presented. The first step is the discovery of novel drugs. Brief histories and mechanisms of a few novel drugs in the American market are outlined. In this presentation preclinical animal toxicologic studies (drug safety evaluateion) are emphasized in regard to drug development. When preclinical animal studies have defined the toxicity and the doses at which it occurs an Investigational new Drug Application (IND) is submitted to the Food and Drug Administration (FDA) An IND notifies the FDA the intention to begin testing a novel drug in human subjects.

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Drug allergy in children: what should we know?

  • Park, Ji Soo;Suh, Dong In
    • Clinical and Experimental Pediatrics
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    • v.63 no.6
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    • pp.203-210
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    • 2020
  • The drug allergy "label" may have a lifetime of consequences for a child. Many children with alleged drug allergies are proven to be tolerant to the culprit medication when challenged. The field of drug hypersensitivity is a recently evolving field of research, but studies on its epidemiology and diagnostic tools are lacking in children. Clinical history is significant in the diagnosis and classification of drug hypersensitivity in children. Diagnostic tools have been evaluated in a limited number of children; therefore, the guidelines are mainly in line with those for adults. Here, we review the clinical characteristics, main drugs, risk factors, and diagnosis of drug hypersensitivity to aid in its accurate diagnosis in children.