• 한국운동역학회지
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• 제26권4호
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• pp.433-441
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• 2016

Objective: The purpose of this study was to understand the injury mechanism and to provide quantitative data to use in prevention or posture correction training by conducting kinematic and kinetic analyses of risk factors of lower extremity joint injury depending on the change of direction at different angles after a landing motion. Method: This study included 11 men in their twenties (age: $24.6{\pm}1.7years$, height: $176.6{\pm}4.4cm$, weight: $71.3{\pm}8.0kg$) who were right-leg dominant. By using seven infrared cameras (Oqus 300, Qualisys, Sweden), one force platform (AMTI, USA), and an accelerometer (Noraxon, USA), single-leg drop landing was performed at a height of 30 cm. The joint range of motion (ROM) of the lower extremity, peak joint moment, peak joint power, peak vertical ground reaction force (GRF), and peak vertical acceleration were measured. For statistical analysis, one-way repeated-measures analysis of variance was conducted at a significance level of ${\alpha}$ <.05. Results: Ankle and knee joint ROM in the sagittal plane significantly differed, respectively (F = 3.145, p = .024; F = 14.183, p = .000), depending on the change of direction. However, no significant differences were observed in the ROM of ankle and knee joint in the transverse plane. Significant differences in peak joint moment were also observed but no statistically significant differences were found in negative joint power between the conditions. Peak vertical GRF was high in landing (LAD) and after landing, left $45^{\circ}$ cutting (LLC), with a significant difference (F = 9.363, p = .000). The peak vertical acceleration was relatively high in LAD and LLC compared with other conditions, but the difference was not significant. Conclusion: We conclude that moving in the left direction may expose athletes to greater injury risk in terms of joint kinetics than moving in the right direction. However, further investigation of joint injury mechanisms in sports would be required to confirm these findings.

• 한국운동역학회지
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• 제22권3호
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• pp.315-324
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• 2012

The purpose of current study was to investigate the effects of the heights on the lower extremities, torso and neck segments for energy dissipation during single-leg drop landing from different heights. Twenty eight young healthy male subjects(age: $23.21{\pm}1.66yr$, height: $176.03{\pm}4.22cm$, weight: $68.93{\pm}5.36kg$) were participated in this study. The subjects performed the single-leg drop landing from the various height(30, 45 & 60 cm). Force plates and motion-capture system were used to capture ground reaction force and kinematics data, respectively. The results were as follows. First, the ROM at the ankle, knee, hip and trunk was increased with the increased heights but the ROM at the neck was increased in the 60cm. Second, the angular velocity, moment and eccentric work at the ankle, knee, hip, trunk, and neck was increased with the increased heights. Third, the contribution to total work at the knee joint was not significantly different, while the ankle joint rate was decreased and hip and neck rate was increased in the 60cm, and trunk rate was increased with the increased heights. Lastly, the increase in landing height was able to augment the level of energy dissipation not only at the lower extremities but also at the trunk and neck. The findings showed that drop landing affect trunk and neck with lower extremity joints. Therefore, we need to consider that trunk and neck strengthening including stability should be added to reduce sports injury during prevention training.

• 한국운동역학회지
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• 제22권2호
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• pp.237-242
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• 2012

The purpose of this study was (a) to develop carbon nanotube-based shock absorbers for reducing potentially harmful impact forces and excessive foot pronation, and (b) to briefly determine how the effects of carbon nanotube-based shock absorbers on biomechanical variance during drop landing. A university student(age: 24.0 yrs, height: 176.2 cm, weight: 679.5 N) who has no musculoskeletal disorder was recruited as the subject. Hardness, specific gravity, tensile strength, elongation, 100% modulus, tear strength, split tear strength, compression set, resilience, vertical GRF, and loading rate were determined for each material. For each dependent variable, a descriptive statistics was used for different conditions. The property test results showed that tensile strength, tear strength, split tear strength, compression set, and resilience in carbon nanotube-based shock absorbers were greater than general Ethylene Vinyl Acetate(EVA). These indicated that resistance against variable strength in developed carbon nanotube-based shock absorbers were greater than general EVA. In vertical GRF of CNTC was less than those of EVA during drop landing and loading rate of CNTC was greater than EVA. It seems that the use of CNT can be a effective way of reducing and controlling shock from impact.

• Journal of Korean Neurosurgical Society
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• 제57권6호
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• pp.445-454
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• 2015

Objective : In the present study we analyzed neuroprotective and antiapoptotic effect of the difumarate salt S-15176, as an anti-ischemic, an antioxidant and a stabilizer of mitochondrial membrane in secondary damage following spinal cord injury (SCI) in a rat model. Methods : Three groups were performed with 30 Wistar rats; control (1), trauma (2), and a trauma+S-15176 (10 mg/kg i.p., dimethyl sulfoxide) treatment (3). SCI was performed at the thoracic level using the weight-drop technique. Spinal cord tissues were collected following intracardiac perfusion in 3rd and 7th days of posttrauma. Hematoxylin and eosin staining for histopatology, terminal deoxynucleotidyl transferase dUTP nick end labeling assay for apoptotic cells and immunohistochemistry for proapoptotic cytochrome-c, Bax and caspase 9 were performed to all groups. Functional recovery test were applied to each group in 3rd and 7th days following SCI. Results : In trauma group, edematous regions, diffuse hemorrhage, necrosis, leukocyte infiltration and severe degeneration in motor neurons were observed prominently in gray matter. The number of apoptotic cells was significantly higher (p<0.05) than control group. In the S-15176-treated groups, apoptotic cell number in 3rd and 7th days (p<0.001), also cytochrome-c (p<0.001), Bax (p<0.001) and caspase 9 immunoreactive cells (p<0.001) were significantly decreased in number compared to trauma groups. Hemorrhage and edema in the focal areas were also noticed in gray matter of treatment groups. Results of the locomotor test were significantly increased in treatment group (p<0.05) when compared to trauma groups. Conclusion : We suggest that difumarate salt S-15176 prevents mitochondrial pathways of apoptosis and protects spinal cord from secondary injury and helps to preserve motor function following SCI in rats.

• The Journal of Korean Physical Therapy
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• 제7권1호
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• pp.1-8
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• 1995

The purpose of this study was to determine the effects of high voltage pulsed current(HVPC) and low voltage pulsed current(LVPC) on posttraumatic edema formation in frog hind limbs In this study, 16 bullfrogs(Rana Catesbeiana), weighting 189g to 340g were used. Limb 16 anesthetized bullfrogs were systemically injuried by weight drop. One hind limb of each frogs was randomly selected to receive continuous 120 pps HVPC and 100 pps LVPC at $90\%$ of motor threshold(HVPC : 33.3v, LVPC : 0.2-1mA). The opposite hind was remained as a control. A series of six 30-minute treatment(interrupted by 30-minute rest) was begun minutes after injury. The results were as follows. 1. Cathodal HVPC has heed shown to be effective in curbing posttraumatic edema formation in frogs, but anodal HVPC did not effect. 2. Volumes of hind limbs treated with LVPC were not significantly different over time from those of untreated hind limbs. 3. Therefore, waveform(HVPC versus LVPC) seems to influence the efficacy of electrotherapy for edema control. 4. Electrical stimulation were not increased edema formation on frog hind limbs.

• 한국운동역학회지
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• 제21권2호
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• pp.173-179
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• 2011

This study aims to analyse difference in biomechanical factors between dominant legs and recessive ones according to muscular imbalance during drop landing targeting talented children in sports. The subjects of the study were ten primary students who are attending to Sports Program for Talented Children organized by C university (age: $12.28{\pm}0.70$ year, height: $1.52{\pm}0.11$ m, and weight: $45.2{\pm}4.9$ kg). Strength legs were classified into dominant side and strengthless legs were classified into non-dominant legs. For three-dimensional analyses of the data collected, 6 video cameras(MotionMaster200, Visol, Korea) were used. To analyse ground reaction force, two force platforms(AMTI ORG-6, MA) were used and to analyse electromyograghy a 8-channeled wireless Noraxon Myoresearch made in USA was used at 1000 Hz for sampling. As a result, it was discovered that the dominants legs controlled knee bending motions more stably than strengthless legs as the maximum vertical ground reaction force was significantly high in dominant legs(p<.05), and joint moment of knee joints of the dominant legs was high(p<.05). Therefore, this study suggested that injury prevention program focusing on muscular balance as well as the existing sports programs for talented children should be developed based on results of the study and it is expected that the results will be useful for improvement of sports programs for talented children.

• 한국운동역학회지
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• 제22권4호
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• pp.429-435
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• 2012

The purpose of this study was to determine the biomechanical effect of wearing carbon nanotube-based insole on cushioning and muscle tuning during drop landing. Twenty male university students(age: $21.2{\pm}1.5yrs$, height: $175.4{\pm}4.7cm$, weight: $70.2{\pm}5.8kg$) who have no musculoskeletal disorder were recruited as the subjects. Average axial strain, average shear strain, inversion angle, linear velocity, angular velocity, vertical GRF and loading rate were determined for each trial. For each dependent variable, a one-way analysis of variance(ANOVA) with repeated measures was performed to test if significant difference existed among different three conditions(p<.05). The results showed that Average axial strain of line 4 was significantly less in CNT compared with EVA and PU during IP phase. The average shear strain was less in CNT compared with EVA and PU during other phases. The inversion angle was increased in CNT compared with EVA and PU during all phase. In linear velocity, angular velocity, vertical GRF and loading rate, there were no significant difference between the three groups. This result seems that fine particle of carbon nanotube couldn't make geometric form which can absolve impact force by increasing density through eliminating voids of forms. Thus, searching for methods that keep voids of forms may play a pivotal role in developing of insole. This has led to suggestions of the need for further biomechanical analysis to these factors.

• Journal of Korean Neurosurgical Society
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• 제29권4호
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• pp.461-470
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• 2000

Objective : Many investigators have demonstrated the protective effects of hypothermia following traumatic brain injury(TBI) in both animals and humans. It has long been recognized that mild to moderate hypothermia improves neurologic outcomes as well as reduces histologic and biochemical sequelae after TBI. In this study, two immunohistochemical staining using terminal deoxynucleotidyl-transferase-mediated biotin dUTP nick end labeling(TUNEL), staining of apoptosis, and ${\beta}$-amyloid precursor protein(${\beta}$-APP), a marker of axonal injury, were done and the authors evaluated the protective effects of hypothermia on axonal and neuronal injury after TBI in rats. Material and Method : The animals were prepared for the delivery of impact-acceleration brain injury as described by Marmarou and colleagues. TBI is achieved by allowing of a weight drop of 450gm, 1 m height to fall onto a metallic disc fixed on the intact skull of the rats. Fourty Sprague-Dawley rats weighing 400 to 450g were subjected to experimental TBI induced by an impact-acceleration device. Twenty rats were subjected to hypothermia after injury, with their rectal temperatures maintained at $32^{\circ}C$ for 1 hour. After this 1-hour period of hypothermia, rewarming to normothermic levels was accomplished over 30-minute period. Following 12 hours, 24 hours, 1 week and 2 weeks later the animals were killed and semiserial sagittal sections of the brain were reacted for visualization of the apoptosis and ${\beta}$-APP. Results : The density of ${\beta}$-APP marked damaged axons within the corticospinal tract at the pontomedullary junction and apoptotic cells at the contused cerebral cortex were calculated for each animal. In comparison with the untreated controls, a significant reduction in ${\beta}$-APP marked damaged axonal density and apoptotic cells were found in all hypothermic animals(p<0.05). Conclusion : This study shows that the posttraumatic hypothermia result in substantial protection in TBI, at least in terms of the injured axons and neurons.

• 한국산학기술학회논문지
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• 제19권3호
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• pp.423-429
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• 2018

연구목적 본 연구의 목적은 전신진동운동(whole body vibration exercise)이 드랍랜딩점프(drop landing jump) 동작에 미치는 영향을 규명하는 것으로 진동운동그룹(n=5, VEG, Vibration Exercise Group)과 단순운동그룹(n=5, OEG, Only Exercise Group)을 4주 동안 트레이닝 시킨 후 운동 전과 운동 4주 후 변화를 비교 분석하였다. 실험방법 3차원 영상 데이터는 10개의 적외선카메라(Vicon, UK)를 샘플링 율, 100 Hz.를 사용하여 획득하였으며, 하지 관절의 파워는 2대의 지면반력기(AMTI, USA)를 샘플링 율 1000Hz.로 데이터를 획득 하였다. 연구결과 첫째, 무게중심의 변동성은 하강국면에서 가장 크게 나타나 점프 후 착지 시 상해위험성이 큰 것으로 나타났다. 둘째, 진동운동그룹은 훈련기간에 관계없이 단순운동그룹보다 점프높이가 증가하였다. 셋째, 운동그룹간의 관절파워가 4주 훈련 후 엉덩관절 P1(굴곡)과 무릎관절 P2(신전)에서 통계적으로 유의한 차이를 보였으나, 훈련기간에 따른 하지의 관절파워는 모든 국면과 운동그룹에 관계없이 통계적으로 유의한 차이를 보이지 않았다. 결론 훈련기간에 관계없이 진동과 운동을 병행한 진동운동그룹이 운동만을 수행한 단순운동그룹보다 점프높이에 증가를 가져왔으나 점프높이와 하지의 관절 파워와의 일관성 규명할 수 없었다.

• The Korean Journal of Physiology and Pharmacology
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• 제19권6호
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• pp.491-497
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• 2015

Traumatic brain injury (TBI) is a major cause of mortality and long-term disability, which can decrease quality of life. In spite of numerous studies suggesting that Epigallocatechin-3- gallate (EGCG) has been used as a therapeutic agent for a broad range of disorders, the effect of EGCG on TBI remains unknown. In this study, a weight drop model was established to evaluate the therapeutic potential of EGCG on TBI. Rats were administered with 100 mg/kg EGCG or PBS intraperitoneally. At different times following trauma, rats were sacrificed for analysis. It was found that EGCG (100 mg/kg, i.p.) treatment significantly reduced brain water content and vascular permeability at 12, 24, 48, 72 hour after TBI. Real-time PCR results revealed that EGCG inhibited TBI-induced IL-$1{\beta}$ and TNF-${\alpha}$ mRNA expression. Importantly, CD68 mRNA expression decreasing in the brain suggested that EGCG inhibited microglia activation. Western blotting and immunohistochemistry results showed that administering of EGCG significantly inhibited the levels of aquaporin-4 (AQP4) and glial fibrillary acidic protein (GFAP) expression. TBI-induced oxidative stress was remarkably impaired by EGCG treatment, which elevated the activities of SOD and GSH-PX. Conversely, EGCG significantly reduced the contents of MDA after TBI. In addition, EGCG decreased TBI-induced NADPH oxidase activation through inhibition of $p47^{phox}$ translocation from cytoplasm to plasma membrane. These data demonstrate that EGCG treatment may be an effective therapeutic strategy for TBI and the underlying mechanism involves inhibition of oxidative stress.