• Biotechnology and Bioprocess Engineering:BBE
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• v.10 no.1
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• pp.85-90
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• 2005

A downstream process was developed for the production of yeast extract from brewer's yeast cells. Various downstream processing conditions including clarification, debittering, and the Maillard reaction were considered in the development of the process. This simple and economic clarification process used flocculating agents, specifically calcium chloride ($1\%$). After the clarification step, a Maillard reaction is initiated as a flavor-enhancing step. By investigating the effects of several operation parameters, including the type of sugar added, sugar dosage, glycine addition, and temperature, on the degree of browning (DB), giucose addition and reaction temperature were found to have significant effects on DB. A synthetic adsorption resin (HP20) was used for the debittering process, which induced a compositional change of the hydrophobic amino acids in the yeast hydrolysate, thereby reducing the bitter taste. The overall dry matter yield and protein yield for the entire process, including the downstream process proposed for the production of brewer's yeast extract were 50 and $50\%$, respectively.

• Korean Management Science Review
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• v.34 no.3
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• pp.1-14
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• 2017

This study empirically analyzes the impact of inventory management performance on the energy efficiency in Korean petrochemical companies. The concept of the distance function is used to define the energy efficiency and the estimation of the distance function is performed using the stochastic frontier analysis. The inventory turnover is selected as the variable indicating the inventory management performance of the company. The main results of this study are as follows. First, the inventory turnover has a positive impact on energy efficiency. Second, during the period over 2011~2015, while the gap in energy efficiency among the companies expanded, the average energy efficiency decreased. Third, the average energy efficiency in upstream process companies was greater than downstream process companies and the gap in energy efficiency among downstream process companies was greater than upstream process companies. Fourth, the average marginal effect of inventory turnover on energy efficiency increased gradually from 2011 to 2015. Finally, the average marginal effect of inventory turnover in downstream process companies was greater than upstream process companies, and the gap in the marginal effect of inventory turnover among downstream process companies was greater than upstream process companies. These results together imply the importance of inventory management in terms of energy efficiency.

• Proceedings of the Korea Water Resources Association Conference
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• 2011.05a
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• pp.17-17
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• 2011

As a method of countermeasure to bed degradation and armoring phenomena of bed material in the downstream area of dam reservoirs, sediment augmentation (replenished sediment) has been carried out in many Japanese rivers. In general, bed of the replenished sediment site is composed of rocks, because the site is located in the downstream area of the dams and sediment supply is very small. Bed deformation process has been researched by many researchers. As a method of countermeasure to bed degradation and armoring phenomena of bed material in the downstream area of dam reservoirs, sediment augmentation (replenished sediment) has been carried out in many Japanese rivers. In general, bed of the replenished sediment site is composed of rocks, because the site is located in the downstream area of the dams and sediment supply is very small. Bed deformation process has been researched by many researchers. However, most of them can treat movable bed only and cannot be applied to the bed deformation process of sediment on rocks. If the friction angle between the sediment and the bed surface is assumed to be the same as the friction angle between the sediment and the sediment, sediment transport rate must be smaller without sediment deposition layer on the rocks. As a result, the reproduced bed geometry is affected very well. In this study, non-equilibrium transport process of non-cohesive sediment on rigid bed is introduced into the horizontal two dimensional bed deformation model and the model is applied to the erosion process of replenished sediment on rock in the Nakagawa, Japan. Here, the Japanese largest scale sediment augmentation has been performed in the Nakagawa. The results show that the amounts of the eroded sediment and the remained sediment reproduced by the developed numerical model are $56300m^3$ and $26800m^3$, respectively. On the other hand, the amounts of the eroded sediment and the remained sediment measured in the field after the floods are $56600m^3$ and $26500m^3$, respectively. The difference between the model and field data is very small. Furthermore, the bed geometry of the replenished sediment after the floods reproduced by the developed model has a good agreement with the measured bed geometry after the floods. These results indicate that the developed model is able to simulate the erosion process of replenished sediment on rocks very well. Furthermore, the erosion speed of the replenished sediment during the decreasing process of the water discharge is faster than that during the increasing process of the water discharge. The replenished sediment is eroded well, when the top of the replenished sediment is covered by the water. In general, water surface level is kept to be high during the decreasing process of the discharge during floods, because water surface level at the downstream end is high. Hence, it is considered that the high water surface level during the decreasing process of the water discharge affects on the fast erosion of the replenished sediment.

• International conference on construction engineering and project management
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• 2022.06a
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• pp.590-598
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• 2022

Benchmarking is an important tool to assess the performance of capital projects in the construction industry. Incorporating cost-related metrics into a benchmarking system requires an effective cost normalization process to enable meaningful comparisons among projects that were executed at different locations and times. Projects in the downstream and chemicals sector have unique characteristics compared to other types of construction projects, they require a distinctive cost normalization framework to be developed to benchmark their absolute cost performance. The purpose of this study is to develop such a framework to be used for the case of benchmarking the downstream and chemical projects for their performance assessment. The research team started with a review of existing cost normalization methodologies adopted in benchmarking systems and conducted 7 interviews to identify the current cost normalization practices used by industrial professionals. A panel of 12 experts was then convened and it held 6 review sessions to accomplish the framework development. The cost normalization framework for benchmarking downstream and chemical projects was established as a three-step procedure and it adopts a 4-element cost breakdown structure to accommodate projects submitted by both owners and contractors. It also incorporated 5 published cost indexes that are compatible with downstream and chemical projects and they were embedded into 2 options to complete the normalization process. The framework was then pilot-tested on 4 completed projects to validate its functional practicality and the downstream and chemical use case in the benchmarking system.

• Electrical & Electronic Materials
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• v.9 no.9
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• pp.918-924
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• 1996

A downstream oxygen plasma is generated by capacitively coupled RF power and applied to photoresist stripping. Stripping rate (ashing rate) is measured in terms of RF power, chamber pressure, oxygen flow rate and temperature. Ashing reaction is thermally activated and depends on oxygen radical density. The ashing process is optimized to have the high ashing rate, good uniformity and minimal plasma damage using a statistical method.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.22 no.6
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• pp.1018-1024
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• 2013

In the process of draw die design for stamping automotive press panels, the addendum surfaces generated in metal forming simulation software cannot be used in downstream processes such as machining and making draw dies because simulation tools use simple discrete models for the surface geometry. The downstream processes require more precise and continuous geometric models such as NURBS surfaces. Generally, automotive die engineers manually regenerate the addendum surface geometry using the discrete model. This paper presents an automated geometric modeling process for generating addendum surfaces using draft surface models. The design parameters of the section curve for the addendum surfaces are extracted automatically from the draft geometry. Using the extracted design parameters, smooth addendum surfaces are generated automatically as NURBS surfaces. The generated surfaces are $G^1$ continuous with the part surface and the binder surface, and can be used in downstream processes.

• Journal of the Society of Naval Architects of Korea
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• v.48 no.5
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• pp.414-420
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• 2011

Decades of studies of geophysical flow have unveiled that the flow downstream of obstacles in stratified flow consists of attached wake and strong gravity waves, or separated, fluctuating wake and persistent late wakes. Among unique and interesting characteristics of the stratified flow past obstacles is the generation of coherent vortex in the late wake far downstream of the object. Unlike in homogeneous fluid, the flow field downstream self-develops coherent vortex even after diminishing of the near wake, no matter how small the stratification is. This paper present a computational approach to simulate the generation of the coherent vortex structure in the late wake of a moving sphere submerged in weakly stratified fluid. The results are in consistent with several experimental observations and the vortex stretching mechanism is employed to explain the process of coherence.

• Proceedings of the KSME Conference
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• 2003.04a
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• pp.1863-1868
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• 2003

Decades of studies of geophysical flow have unveiled that the flow downstream of obstacles in stratified flow consists of attached wake and strong internal waves, or separated, fluctuating wake and persistent late wakes. Among unique and interesting characteristics of the stratified flow past obstacles is the generation of coherent vortex the late wake far downstream of the object. Unlike in homogeneous fluid, the flow field downstream self-develops coherent vortex even after diminishing of the near wake, no matter how small the stratification is. This paper present a computational approach to simulate the generation of the coherent vortex structure in late wake of a moving sphere submerged in weakly stratified fluid. The results are in consistent with several experimental observations and the vortex stretching mechanism is employed to explain the process of coherence.

• Membrane Journal
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• v.30 no.6
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• pp.373-384
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• 2020

Antibody-based therapeutics have been receiving great attention as a representative biopharmaceutical, in which many researches are also carried out for its commercialization. The downstream process is considered an important part of the manufacturing processes of antibody-based therapeutics since it directly affects the performance and stability of products. Ultrafiltration/diafiltration (UF/DF), mostly performed in final step during downstream process, are used for the final concentration and formulation of antibody-based therapeutics. This paper reviewed the major products of the UF membrane, process characteristics, and recent research trends in UF/DF.

• Journal of Technology Innovation
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• v.14 no.2
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• pp.143-165
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• 2006

By analyzing five in-depth case studies of suppliers in newly emerging Vietnam's motorcycle industry, this paper explores the differences in patterns and processes of capability improvement of suppliers who participate in different kinds of supplier-assembler network with different structures. The paper finds the correlation between the kinds of suppliers' capabilities improved and the structure of networks they participate in. While suppliers in arm-length networks can improve more upstream capabilities (structure design, process desist), suppliers in embedded networks can improve more downstream capabilities (process design, process setup, process maintenance and delivery control). Two capability improvement patterns of firms in newly emerging economy are indicated. The first pattern is asymmetrical improvement, either upstream or downstream capabilities, by participating in either arm-length or embedded networks. This pattern obstructs the suppliers to meet the requirements of new buyers rho come from different kinds of network. The second pattern is symmetrical improvement by joining both arm-length and embedded networks.