• 제목/요약/키워드: Down type ladder

검색결과 2건 처리시간 0.022초

In vivo anti-metastatic action of Ginseng Saponins is based on their intestinal bacterial metabolites after oral administration

  • Saiki, Ikuo
    • Journal of Ginseng Research
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    • 제31권1호
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    • pp.1-13
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    • 2007
  • We found that the main bacterial metabolite M1 is an active component of orally administered protopanxadiol-type ginsenosides, and that the anti-metastatic effect by oral administration of ginsenosides may be primarily mediated through the inhibition of tumor invasion, migration and growth of tumor cells by their metabolite M1. Pharmacokinetic study after oral administration of ginsenoside Rb1 revealed that M1 was detected in serum for 24 h by HPLC analysis but Rb1 was not detected. M1, with anti-metastatic property, inhibited the proliferation of murine and human tumor cells in a time- and concentration-dependent manner in vitro, and also induced apoptotic cell death (the ladder fragmentation of the extracted DNA). The induction of apoptosis by M1 involved the up-regulation of the cyclin-dependent kinase(CDK) inhibitor $p27^{Kip1}$ as well as the down-regulation of a proto-oncogene product c-Myc and cyclin D1 in a time-dependent manner. Thus, M1 might cause the cell-cycle arrest (G1 phase arrest) in honor cells through the up/down-regulation of these cell-growth related molecules, and consequently induce apoptosis. The nucleosomal distribution of fluorescence-labeled M1 suggests that the modification of these molecules is induced by transcriptional regulation. Tumor-induced angiogenesis (neovascularization) is one of the most important events concerning tumor growth and metastasis. Neovascularization toward and into tumor is a crucial step for the delivery of nutrition and oxygen to tumors, and also functions as the metastatic pathway to distant organs. M1 inhibited the tube-like formation of hepatic sinusoidal endothelial (HSE) cells induced by the conditioned medium of colon 26-L5 cells in a concentration-dependent manner. However, M1 at the concentrations used in this study did not affect the growth of HSE cells in vitro.

고층건축물의 피난기구 도입 필요성에 관한 연구 - 승강식피난기를 중심으로 - (A Study on the Necessity of Introducing Evacuation Instrument in High-rise Buildings - Focusing on Elevator Type Evacuation Instrument -)

  • 최규출;나판주;설영미
    • 한국화재소방학회논문지
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    • 제28권3호
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    • pp.10-19
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    • 2014
  • 고층건물화재에서는 화재층에서 피난층까지 신속한 대피가 이루어져야만 인명피해를 최소화할 수 있다. 현행 국가화재안전기준(NSFC 301)이 정하는 적응성 있는 피난기구 중 고층건축물에 적용이 가능한 피난기구를 선정하여 현장 적응시험을 통한 11층 이상에서 적용 가능성을 분석하였다. 현장 시험결과 현재 11층 이상에서 제한하고 있는 피난기구의 문제점을 보완하여 신기술로 개발된 신개념 승강식피난기는 소방기관의 안정성 검사와 성능인증시험을 마친 제품으로 고층건축물 피난기구로 도입하여도 문제가 없다는 분석결과를 얻었다. 전력을 사용하지 않고 피난자의 체중(體重)을 이용하는 승강식피난기는 고층건축물 화재시 짧은 시간에 많은 인원의 피난이 가능한 피난기구임을 확인하였다. 특히 장애인이나 중증환자 등이 이용하는 건물에서 이용자 특성을 고려한 피난기구로는 무동력으로 작동되는 승강식피난기가 맞춤형 피난기구로 적응성이 있음을 확인하였다.