• 제목/요약/키워드: Double-blind

검색결과 538건 처리시간 0.031초

The effects of pomegranate peel added bread on anthropometric measurements, metabolic and oxidative parameters in individuals with type 2 diabetes: a double-blind, randomized, placebo-controlled study

  • Ozlem Ozpak Akkus;Ugurcan Metin;Zeynep Camlik
    • Nutrition Research and Practice
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    • 제17권4호
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    • pp.698-716
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    • 2023
  • BACKGROUND/OBJECTIVES: The aim of this study was to evaluate the sensory properties of antioxidant-rich bread made by adding pomegranate peels and their effects on anthropometric measurements and metabolic and oxidative parameters of individuals with type 2 diabetes after consumption. SUBJECTS/METHODS: This randomized, double-blind, placebo-controlled study was conducted with 22 individuals aged between 19 and 64 years who had been diagnosed with type 2 diabetes for at least 5 years, used only metformin, did not lose more than 10% of their body weight in the last 6 months, and had a body mass index of ≥ 25.0 kg/m2. While the study group (n = 11) consumed bread containing 500 mg pomegranate peel daily for 8 wk, the control group (n = 11) consumed standard bread. Anthropometric measurements and metabolic and oxidative parameters of individuals were evaluated at the beginning and end of the study. RESULTS: Decreases were detected in the waist circumference, waist/hip and waist/height ratios, body fat percentages, blood pressure, and serum insulin, triglyceride, and total cholesterol levels in the individuals in the treatment group, compared with those in the control group (P < 0.05). CONCLUSIONS: Pomegranate peel consumption by individuals with type 2 diabetes may have positive effects on anthropometric measurements and glycemic and lipid parameters.

기능경기대회에 출제된 한복분야 바느질법 분석 (An Analysis of the Questions about Sewing Methods of Hanbok in Korea Skills Competition)

  • 김지현;송정아
    • 한국의류산업학회지
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    • 제16권6호
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    • pp.927-934
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    • 2014
  • Today Hanbok, the symbol of our nation's culture, has been preserved as cultural heritage despite natural and social environmental changes over years. This study is analyzing Hanbok which were taken in the National Skills Competition from 2000 to 2013; it presents our traditional stitching methods and clarifies the pride the Hanbok artisans have as inheriting the traditional heritage. Therefore this paper contributes to continuous and proper development of the culture of Hanbok and being loved by many people. The assignments about Hanbok featured in the National Skills Competition were categorized by national and local competition, time required to produce assignments, required amount of fabric, type of stitching, unlined and lined clothes depending on the type of assignment; according to the classification, methods for sewing were analyzed in detail. First, the national tournament presented 12 kinds of sewing techniques; especially hand-sewn stitching method appeared in common. Second, the unlined and lined clothes depending on the type of assignments had applied different sewing methods; double-stitching, flat fell seam, french seam, roll over sewing, blind stitch, right angle blind stitch, decorative saddle stitching, darning, etc. were used. Sewing methods in the 21st century has not changed over the years; the shape of clothes was changed upon trends. Sewing became easier than before by the invention of sewing machine, we should carry on our traditional sewing techniques. Through this analysis on sewing methods of the National Skills Competition, I hope to support competition participants for studying Hanbok and indicate proper sewing techniques.

A double-blind placebo-controlled heart rate variability investigation to evaluate the quantitative effects of the organic nanoscale aeon patch on the autonomic nervous system

  • Nazeran, Homer
    • 셀메드
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    • 제5권1호
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    • pp.5.1-5.5
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    • 2015
  • In this first double-blind-placebo-controlled investigation of the Aeon Patch, electrocardiographic data were acquired from 50 well-hydrated volunteers [21 females and 29 males, age: 19-79, weight: 117-334 lbs, height: 5'-6',3"], under 3 different conditions for a total duration of 15 min (5 min/condition). Condition1: Control (C) - while wearing no Patch, Condition 2: Placebo (P) or Active (A) - after wearing either the Placebo or the Aeon Patch for 20 min, and Condition 3: Active (A) or Placebo (P) - after wearing either the Aeon or the Placebo Patch for 20 min. There was a washout period of 15 min between Conditions 2 and 3. All involved in the investigation were blind to the (A) and (P) Patches as they looked exactly the same and were assigned in a random fashion. The hypothesis to be tested was: Wearing the Aeon Patch for 20 min reduces stress. Data were first quality assured and those subjects who showed a parasympathetic response after wearing the Patch within 20 min were identified as early responders. Thirty subjects (60%) achieved a relaxed state after wearing the Aeon Patch as early as 20 min. Statistical analysis (one-sample inference) was used to compare the spectral features of the responders. The normalized LF/HF decreased significantly ($24%{\pm}9%$ after 20 min) in condition (A) compared to condition (P) with a p-value < 0.047 (n = 30) in responders. Therefore, the hypothesis that wearing the Aeon Patch for 20 min reduces stress was accepted as true.

Attenuating effect of Lactobacillus brevis G101 on the MSG symptom complex in a double-blind, placebo-controlled study

  • Kim, Dong-Hyun;Choi, Yeji;Park, Sun-Sung;Kim, Se-Young;Han, Myung Joo
    • Nutrition Research and Practice
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    • 제9권6호
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    • pp.673-676
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    • 2015
  • BACKGROUND/OBJECTIVES: Lactobacillus brevis G101 suppresses the absorption of monosodium glutamate (MSG) from the intestine into the blood in mice. Therefore, the attenuating effect of orally administered G101 on monosodium glutamate (MSG) symptom complex was investigated in humans MATERIALS/METHODS: Capsules (300 mg) containing Lactobacillus brevis G101 ($1{\times}10^{10}CFU/individual$) or maltodextrin (placebo) was orally administered in 30 respondents with self-recognized monosodium glutamate (MSG) symptom complex for 5 days and the rice with black soybean sauce containing 6 g MSG (RBSM) was ingested 30 min after the final administration. Thereafter, the MSG symptom complex (rated on a 5-point scale: 1, none; 5, strong) was investigated in a double blind placebo controlled study. The intensity of the MSG symptom complex was significantly reduced in respondents of the G101 intake group ($2.87{\pm}0.73$) compared to that in those treated with the placebo ($3.63{\pm}1.03$) (P = 0.0016). Respondents in the placebo group exhibited more of the various major conditions of the MSG symptom complex than in the G101 intake group. Although there was no significant difference in the appearance time of the MSG symptom complex between subjects orally administered G101 and those administered the placebo, its disappearance in < 3 h was observed in 69.9% of subjects in the G101 treatment group and in 38.0% of subjects in the placebo group (P = 0.0841). CONCLUSIONS: Oral administration of Lactobacillus brevis G101 may be able to reduce the intensity of the MSG symptom complex.

An Offline Electronic Payment System Based on an Untraceable Blind Signature Scheme

  • Kutubi, Md. Abdullah Al Rahat;Alam, Kazi Md. Rokibul;Tahsin, Rafaf;Ali, G.G. Md. Nawaz;Chong, Peter Han Joo;Morimoto, Yasuhiko
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • 제11권5호
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    • pp.2628-2645
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    • 2017
  • This paper proposes a new offline electronic payment (e-payment) system that satisfies the major security requirements of e-payment, i.e. anonymity, unlinkability, unforgeability, double spending control, conditional traceability, and fraud prevention. The central idea is the use of Hwang et al.'s RSA-based untraceable blind signature (BS), which disables the link between the e-coin and its owner and ensures the anonymity of both the customer and the merchant. It attaches an expiration, a deposit and the transaction dates to each e-coin in order to manage the database of the bank effectively, to correctly calculate the interest on the e-coin and to aid arbitration if a dishonest customer attempts to double-spend the coin. It also ensures the anonymity of the customer as long as the coin is spent legitimately. Only when a fraudulent e-coin transaction is detected can the bank, with the help of the central authority (a trusted entity), determine the identity of the dishonest customer. The system is referred to as offline since the bank does not need to be concurrently involved in transactions between a customer and a merchant. Finally, analyses of the performance of the prototype and the primary security requirements of the proposed system are also presented.

공기식 집열창 시스템이 설치된 건물의 동적부하 해석 (Time Dependent Thermal Load Analysis of the Building with an Airflow Window System)

  • 조성환;박상동
    • 설비공학논문집
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    • 제4권2호
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    • pp.82-95
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    • 1992
  • It has been known that the application of an airflow window system reduces the energy consumption compared with conventional double pane window in a building. But how to analyze thermal load in a building with an airflow window system has not been well known. so two kinds of method (Mode 1 and Mode 2) to analyze time dependent thermal load of the building with an airflow window system are presented in this study. The results of load analysis about the model building(total area : $4521m^2$, 3 floors) by Mode 2 show that the maximum cooling and heating load in a building with an airflow window system are decreased about 12-17% and about 19.5% than with double pane glass window, and yearly energy consumption with an airflow window system is saved about about 20% than with double pane glass window.

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베네시안 블라인드가 적용된 오피스 건물의 외피 투과체 계획을 위한 열·빛 환경 평가에 대한 연구 (Evaluation of Thermal and Visual Environment for the Glazing and Shading Device in an Office Building with Installed of Venetian Blind)

  • 김철호;김강수
    • KIEAE Journal
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    • 제15권6호
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    • pp.101-109
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    • 2015
  • Purpose: Glazing and shading devices influence a lot on the thermal and visual environment in office buildings. Solar heat and daylight are contrary concept, therefore proper arrangement of thermal and optical performance is needed when designing a glazing and shading devices. The purpose of this study is to examine the conditions of the glazing and shading devices available for promoting the reduction of cooling loads + lighting loads and the improvement in thermal comfort and visual comfort for the summer season in an office building installed with venetian blind. Method: This study established 12 simulation cases which have different glazings and the positions of venetian blind for evaluating different thermal and optical performance. And by using EnergyPlus v8.1 and Window v7.2 program, we quantitatively analyzed cooling loads + lighting loads, thermal comfort and visual comfort in an office building installed with the glazing and shading devices. Result: Consequently, Case 9(Double Low-E+Exterior Blind) is the best arrangement of solar heat gain and daylight influx, thereby becomes the most excellent case of reducing cooling+lighting loads(46.8%) and simultaneously becomes the enhancement case in thermal comfort. Also, DGI(Daylight glare index) under clear sky conditions in summer was evaluated to be 19.6, and thereby satisfied the recommendation level of allowing visual comfort.

다양한 기후조건에 대응하는 이중외피시스템 개발에 관한 실험적 연구 (Experimental Study on Developing of Double Facade System dealing with the various climatic Conditions)

  • 이건호;김현수;장대희;문수영
    • KIEAE Journal
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    • 제5권2호
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    • pp.19-26
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    • 2005
  • Every site has a different given geometrical and climatic condition, which influenced not only the lifestyle of the humanbeings but also the regional architecture. For example, on a cold region, the reduction of the energy loss is necessary, like an igloo, which has a littlest energy loss at hemisphere. Or on a warm region, the house must be protected thermally from the overheating at the sunshining. like a huge shading. An architectural interpretation in the (extreme) moderate climate, like Korea, has always tried to satisfy the both opposite demands simultaneously. A facade, which divides out- and inside, has an ideal position to lead the regulated regional climatic conditions into the room. The Double Facade System(DFS) is well known as an innovative solution in the european countries, like Germany. It provides an reasonable alternative, which can achieve these goals at the same time. A Double Facade System provides an effective sunshade, which means a cooling energy reduction at the warm season. In addition, it enables a natural ventilation at the cold season with the preheating at the system as well as spring and autumn. An ordinary Single Facade System with a inside or outside sun blind provides a solution just for a specified season, like a summer or winter. But the Double Facade System can deal with the various climatic conditions in the moderate climate.

Herbal anti-inflammatory immunomodulators as host modulators in chronic periodontitis patients: a randomised, double-blind, placebo-controlled, clinical trial

  • Deore, Girish D.;Gurav, Abhijit N.;Patil, Rahul;Shete, Abhijeet R.;Naiktari, Ritam S.;Inamdar, Saurabh P.
    • Journal of Periodontal and Implant Science
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    • 제44권2호
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    • pp.71-78
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    • 2014
  • Purpose: Host modulatory therapy has been proposed as a treatment for periodontal diseases. A class of herbal medicines, known to be immunomodulators, alters the activity of immune function through the regulation of informational molecules such as cytokines. In the current study, we tested the hypothesis that herbal immunomodulator drugs act as an adjuvant to scaling and root planing (SRP) in alleviating periodontal inflammation by improving clinical and biochemical parameters. Methods: Sixty healthy subjects (30 in each group) with moderate and severe chronic periodontitis were enrolled in a double-blind, placebo-controlled, double-masked randomised controlled trial. The control group was treated with SRP and a placebo, whereas the test group was treated with SRP followed by dietary supplementation of Septilin for 3 weeks. Periodontal clinical parameters and serum C-reactive protein (CRP) levels were evaluated for all patients at the baseline, 3 weeks, and 6 weeks. Results: Improved gingival index scores found in the test group as compared to the control group were found to be statistically significant only after 3 weeks (P<0.001). In contrast, the decrease in the sulcus bleeding index and pocket depth scores was statistically highly significant in the test group as compared to the control group after 3 weeks and 6 weeks (P<0.001). However, reduced clinical attachment level and CRP scores, as reflected in the test group as compared to the control group, were not found to be statistically significant after both 3 weeks (P>0.05) and 6 weeks (P>0.05). Conclusions: The results of this clinical-biochemical study suggest that dietary supplementation with herbal immunomodulatory agents may be a promising adjunct to SRP and may aid in improving periodontal treatment outcomes.

혈중지질에 대한 진피추출물의 유효성 평가를 위한 인체적용시험 : 무작위배정, 이중맹검 (Clinical Trial to Evaluate the Efficacy of Extract of Citri Pericarpium on Serum Lipid Profiles in Subjects: a Randomized, Double-blind)

  • 이진상;도은주;곽민아;박현진;하일도;성기준;김미려
    • 대한본초학회지
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    • 제26권1호
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    • pp.125-132
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    • 2011
  • Objectives : This study was performed to evaluate the efficacy of extract from Citri Pericarpium (CP) on lipid-lowering effect in semi-healthy subjects with increased serum levels of total cholesterol and triglyceride. Methods : A experimental group (n=45) and placebo group (n=46) were randomly established based on the plasma lipid profiles (triglyceride, total cholesterol etc.) in the semi-healthy subjects, then all subjects randomly took experimental or placebo capsules, which contain 1,200 mg of CP or the same dose of soluble starch per day with regular meals for 8 weeks by double-blind method. Results : One-hundred forty (140) subjects were screened, then 91 subjects enrolled in the study. No serious adverse events were reported for trial period. The CP treatment showed statistically significant decrease in serum levels of triglyceride both at 4-weeks (p<0.01) and at 8-weeks (p=0.0001). Futhermore, there was significant difference in the triglyceride levels between CP-treated and placebo group. The CP-treated but not placebo group, experienced decrease in serum levels of total cholesterol at 8-weeks. Then there was no significant difference in the total cholesterol levels between the two groups. In addition, statistically significant difference of AST, ALT, ${\gamma}$-GT serum levels wasn't shown before and after trial in two groups. Conclusion : These results demonstrate that CP can significantly suppress the elevated triglyceride but not total cholesterol level. Therefore, CP may play a role in the improvement of blood lipid levels, as an effective functional food.