• 대한기관식도과학회지
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• 제4권1호
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• pp.105-111
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• 1998

Double primary cancer is a rare disease in which two cancers occur in an individual independently. As prolonged survival of patients with malignant tumors is expected in the future due to advances in methods of treatment, the chance of double primary cancer will be increased. We experienced one case of double primary cancer which was developed in esophagus and chest wall. A 72 year-old male visited our hospital complaining of epigastric discomfort and right chest wall mass. We studied esophagus, chest wall, and other organs including gastrointestinal tract by various methods to exclude the cancer of other sites and could diagnose squamous cell carcinoma of mid-esophagus and adenocarcinoma of chest wall. The patient underwent esophagogastrostomy following esophagectomy and wide-resection of chest wall tumor. The postoperative course was uneventful.

• 대한종양외과학회지
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• 제14권2호
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• pp.83-88
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• 2018

Purpose: Double primary colorectal cancer (CRC) and gastric cancer (GC) represent the most common multiple primary malignant tumors (MPMT) in Korea. The recognition and screening of hidden malignancies other than the primary cancer are critical. This study aimed to investigate the clinicopathologic characteristics and survival rates in patients with synchronous or metachronous double primary CRC and GC. Methods: Between January 1994 and May 2018, 11,050 patients were diagnosed with CRC (n=5,454) or GC (n=5,596) at Gil Medical Center. MPMT and metastatic malignant tumors were excluded from this study. A total of 103 patients with double primary CRC and GC were divided into two groups: the synchronous group (n=40) and the metachronous group (n=63). The incidence, clinicopathologic characteristics, and survival rate of the two groups were analyzed. Results: The incidence of synchronous and metachronous double primary CRC and GC was 0.93%. Double primary CRC and GC commonly occurred in male patients aged over 60 years with low comorbidities and minimal previous cancer history. There were significant differences between the synchronous and metachronous groups in terms of age, morbidity, and overall survival. Metachronous group patients were 6 years younger on average (P=0.009), had low comorbidities (P=0.008), and showed a higher 5-year overall survival rate (94.8% and 61.3%, P<0.001) in contrast to synchronous group. Conclusion: When primary cancer (CRC or GC) is detected, it is important to be aware of the possibility of the second primary cancer (GC or CRC) development at that time or during follow-up to achieve early detection and better prognosis.

• 대한두경부종양학회지
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• 제32권2호
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• pp.69-72
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• 2016

Lung cancer is one of high mortality malignancy. It is known that skin metastasis from lung cancer is uncommon. We report a very rare case of finger tip metastasis from double primary cancer of the lung and lower lip. A 79 year-old man diagnosed with non small cell lung cancer presented with protruding solid mass in his lower lip. It showed central necrosis with purulent discharge. It had appeared rapidly growing features. Simultaneously, another solid mass accompanying painful swelling without skin lesion was found in his left middle finger tip. Both two solid masses were moderately differentiated squamous cell carcinomas. Lower lip mass was a primary cancer, while middle finger tip mass was diagnosed with clinically metastatic cancer from lung or lower lip, which means that it had double primary cancer origin.

• Journal of Chest Surgery
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• 제25권10호
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• pp.1087-1092
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• 1992

We underwent two surgical resection of synchronous primary esophageal squamous cell carcinoma and gastric adenocarcinoma after obtaining histologic comfirmation 74-years old male pateint was recieved esophagectomy & total gastrectomy with esophagojejunostomy and 59-years old man was recieved near total esophagectomy and total gastrectomy with esophagocolo-gejunostomy. Their was no postoperative complications. The hospital day was 15 and 21 days postoperatively. All of them started oral intake at 7 days postoperatively and possible soft diet soon. We conclude that total resection of esophagus and stomach is the recommendable methods for prolong the life of double primary cancer patients of esophagus and stomach. Also, the reconstruction of the esophagus with colon or jejunal transposition is one of the recommenable procedure for curative surgical resection of double primary cancer in esophagus and stomach. And we also wish to emphasize the importance of detailed preopertive gastric examination for detect of gastric lesion and of careful intraoperative inspection of the gastric mucosa in patients with esophageal cancer whose preoperative gastric examination provide inconclusive evidence due to the severe esophageal stenosis.

• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.6087-6091
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• 2012

Context: Patients diagnosed with a cancer have a life time risk of developing another de novo malignancy depending on various inherited, environmental and iatrogenic risk factors. Of late the detection of new primary has increased mainly due to refinement in both diagnostic and treatment modalities. Cancer victims are surviving longer and thus are more likely to develop a new metachronous malignancy. Aims: To report our observed trend of increase in prevalence of both synchronous and metachronous second malignant neoplasms among cancer victims and to review the relevant literature. Settings and Design: A hospital based retrospective collection of prospective data of patients diagnosed with second denovo malignancy. Materials and Method: The study was conducted over a 5 year period from July 2008 to June 2012. All patients diagnosed with a histologically proven second malignancy as per Warren Gate's criteria were included. Various details regarding sex, age at presentation, synchronous or metachronous, treatment and outcome were recorded. Conclusions: The occurrence of multiple primary malignancies is not rare. Awareness of the possibility alerts the clinician in evaluation of patients with a known malignancy presenting with unusual sites of metastasis. Individualizing the treatment according to the stages of the primaries will result in durable cancer control particularly in synchronous double malignancy.

• Tuberculosis and Respiratory Diseases
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• 제38권2호
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• pp.186-193
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• 1991

Three cases of double primary lung cancer occured synchronously are reported with brief review of literature. The incidence of multiple primary lung cancer relatively rare but may become increasingly prevalent as early detection techinque and cancer therapy has improved. The patients were a 67, 69, and 65-year-old men with doulbe primary lung cancer of different cell type or same cell type with other bronchus origin (squamous cell+small cell, squamous cell+squamous cell, squamous cell+bronchioloaveolar cell) were identified with flexible bronchofiberoscopic biopsies. More careful diagnostic evaluation and management are thought to be necessary.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제42권4호
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• pp.221-226
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• 2016

Spindle cell carcinoma (SpCC) is referred to as a variant of oral squamous cell carcinoma. It is also known as "sarcomatoid squamous cell carcinoma" because it consists of normal squamous carcinoma cells with spindle-shaped cells that appear similar to a sarcoma. The term, "second primary tumor" (SPT) or "double primary tumor", is proposed for a second tumor that develops independently from the first. SPTs can present as either synchronous or metachronous lesions. Synchronous SPTs are defined as tumors occurring simultaneously or within 6 months after the first tumor. The patient in this case, whose primary tumor was in the tongue, was diagnosed with SpCC with metastases to both neck lymph nodes. This case also exhibited a second primary cancer as a synchronous lesion in the thyroid gland, which is uncommon. All carcinomas, both in the tongue and thyroid gland, were removed surgically, and especially in the tongue, an anterolateral thigh free flap was performed successfully to replace the defect.

• Tuberculosis and Respiratory Diseases
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• 제41권3호
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• pp.277-288
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• 1994

연구목적 : "Field Cancerization"의 개념에 따르면, 폐암의 경우에도 여러 기관지들이 발암물질에 동시에 노출되어 다발적 암의 발생이 가능하고, 또한 암발생의 전단계인 precancerous lesion이 발견될 수 있다. 이에 저자들은 폐암의 주요 진단방법인 기관지 내시경 검사를 이용하여 방사선학적으로 나타난 병변뿐 아니라 전체 기관지에 대한 고찰을 하였다. 방법 : 1990년 4월부터 1993년 12월사이에 원자력 병원 내과에서 시행한 총 1855예의 기관지 내시경 검사상 2부위에서 이상소견이 발견되어 각각 조직검사를 시행한 총 21예를 대상으로 대상 환자의 성별, 연령별 분포, 흡연력, 각 병변의 조직학적 소견 및 방사선학적 소견, 병변위치, 치료 및 생존기간 등에 대하여 고찰하였다. 결과 : 총 21예중 14예에서 두 병변 모두 악성으로 나타났으며 이중 서로 조직학적 소견이 다른 경우는 6예, 서로 조직학적 소견이 같은 경우는 8예이었고, 총 21예 중 7예에서 한 병변은 악성, 나머지 병변은 양성으로 나타났다. 전체적으로 11예의 동시성 다발성 원발성 폐암이 있었으며 진단 당시 연령의 중앙치는 63세로 모두 남자였으며, 평균 흡연력은 40PY이었고, 조직학적 조합으로는 편평상피암의 조합이 5예, 소세포암과 편평상피암의 조합이 4예, 선암과 편평상피암의 조합이 1예, 편평상피암과 저분화암의 조합이 1예이었다. 기관지 내시경 검사상 2부위의 기관지 병변을 보인 총 21예중 15예에서 기관지 내시경 술전 방사선학적 검사상 한 병변만 나타났으며, 기관지 내시경 술전 방사선학적 검사상 두 병변 모두 나타난 6예종 5예에서 다발성 원발성 폐암이 나왔다. 결론 : 폐의 기관지 상피는 여러 발암물질에 동시에 노출되어 다발성 암의 발생 및 precancerous lesion이 생길 가능성이 높으므로, 폐암의 진단과정에 있어 방사선학적으로 나타난 병변뿐 아니라 전체 기관지에 대한 면밀한 기관지 내시경 검사 및 조직학적 확인이 필수적이다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.769-773
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• 2013

Background: A literature review on 1,104,269 cancer patients concluded that the prevalence of multiple primary malignancies (MPM) is between 0.73% and 11.7%. MPMs seem to have higher incidence than that influenced by hazard only. The purpose of this study was to investigate clinically useful information for effective screening for synchronous and metachronous second primary cancers and to identify a potential surveillance protocol. Materials and Methods: Using statistical and epidemiological indicators we evaluated the patients with MPMs (double locations) admitted to Dr. Abdurrahman Yurtarslan Ankara Oncology Education and Research Hospital between 1981 and 2010. Results: Out of the 130 cases, 24 (18.4%) were synchronous while 106 cases (81.6%) were metachronous tumours. Mean interval time from first to second primary cancers was 4.65 years (0-27 years). The most frequent malignant associations were breast-breast, breast-endometrium and breast-ovary. Both primary and secondary tumors tended to be in an advanced stage explained by the low compliance of the patients to follow-up. Conclusions: The possibility that MPMs exist must always be considered during pretreatment evaluation. Screening procedures are especially useful for the early detection of associated tumors, whereas careful monitoring of patients treated for primary cancer and a good communication between patients and medical care teams should ensure early detection of secondary tumors, and subsequent appropriate management.

• Tuberculosis and Respiratory Diseases
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• 제45권1호
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• pp.234-237
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• 1998

A 64-year-old male was admitted due to weight loss of 5kg during a month. Chest X-ray showed two large, lobulated masses on both lower lobe. Chest CT showed ill-defined, multilobulated mass on left lower lobe and irregular, relatively homogenous mass with air-bronchogram on right lower lobe. Left lower lobectomy and right lower lobectomy was performed sequentially with three months interval. Microscopic findings showed squamous cell carcinoma of both mass. It was thought that this patient had synchronous double primary lung cancer.