• Title/Summary/Keyword: Double Blind

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Amiodarone Versus Propafenone to Treat Atrial Fibrillation after Coronary Artery Bypass Grafting: A Randomized Double Blind Controlled Trial

  • Nemati, Mohammad Hassan;Astaneh, Behrooz
    • Journal of Chest Surgery
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    • v.49 no.3
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    • pp.177-184
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    • 2016
  • Background: Atrial fibrillation (AF) is one of the most common complications after cardiac surgery. Several therapeutic and preventive strategies have been introduced for postoperative AF, but the treatment and prophylaxis of AF remain controversial. We aimed to compare the efficacy of intravenous amiodarone and oral propafenone in the treatment of AF after coronary artery bypass grafting (CABG). Methods: This was a randomized controlled trial performed in two hospitals in Shiraz, Iran from 2009 to 2012. We included all patients who underwent elective CABG and developed AF postoperatively. The patients were randomly assigned to receive propafenone or amiodarone. The duration of AF, the success rate of the treatment, the need for cardioversion, the frequency of repeated AF, and the need for repeating the treatment were compared. Results: The duration of the first (p=0.361), second (p=0.832), and third (p=0.298) episodes of AF, the need for cardioversion (p=0.998), and the need to repeat the first and second doses of drugs (p=0.557, 0.699) were comparable between the study groups. Repeated AF was observed in 17 patients (30.9%) in the propafenone group and 23 patients (34.3%) in the amiodarone group (p=0.704). Conclusion: Oral propafenone and intravenous amiodarone are equally effective in the treatment and conversion of recent-onset AF after CABG.

A Performance Measurement of Multi-channel Audio codec for HDTV Satellite Broadcasting (고선명 TV 위성 방송을 위한 멀티 채널 오디오의 성능 평가)

  • 김성한;장대영;홍진우
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.1 no.1
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    • pp.71-76
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    • 1997
  • In this paper, we describe simulation results of subjective assessments with bit rate variation of multi-channel audio codec system for the services of HDTV satellite broadcasting services. Based on this experiment results, we also describe the specification and subjective performance results for 4-channel audio codec. For multi-channel, bit rates are 384,320,256,128kbps and the results show that 320kbps bit rate is needed to compare with the original and the reproduced signal. Based on this, for 384kbps for 4-channel audio codec, three items that achieve a diffgrade worse than -0.5 are due to the noise of analog output module. This system is satisfied for the audio codec of the HDTV system.

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A Case Study on Thermal Performance for Transparent Glazing Space Considering Solar Radiation in Summer (여름철 일사를 고려한 투명 투과체 공간의 열환경 특성에 관한 사례연구)

  • Ryu, Young-Hee;Seo, Hye-Soo;Lee, Min-Jung;Nam, Ji-yeon;Song, Mi-Na;Chun, Chung-Yoon
    • KIEAE Journal
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    • v.3 no.1
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    • pp.31-36
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    • 2003
  • Recently, buildings with transparent glazing on exterior walls have increased. The transparent glazing on exterior walls gives an impression of opening through introducing external environment's elements to inside of the building, and has various merits and so on, but has defects in controling indoor environments. Especially, the excess of solar radiation in summer increases cooling load causing discomforts to occupants providing radiant environment with high temperature. Cooling load mainly depends on electricity comparing to heating load and intents to centralize specific time. So it is necessary to work out a countermeasure. In this study, showed P building with transparent glazing on exterior walls as a case, investigated indoor thermal performance, numerical analysis of P building in summer through comparing dry-sauna which is represented as radiant environment with high temperature. In the results of this study, transparent glazing space has radiant environment with high temperature such as dry-sauna because of the excess of solar radiation. Accordingly countermeasures are considered in building planning. As concrete methods, there are adiabatic effects using double glazing, use of sunscreen, blind, ventilation facilitation using natural draft, decrease of surface temperature through evaporation cooling and cooling coils.

Intracoronary Radiation Therapy Using Re-188 after percutaneous Coronary Angioplasty (경피적 관동맥혈관성형술 후 Re-188을 이용한 혈관 내 방사선조사요법)

  • Chae, In-Ho;Lee, Myoung-Mook;Lee, Dong-Soo
    • 대한핵의학회:학술대회논문집
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    • 1999.05a
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    • pp.228-241
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    • 1999
  • Percutaneous coronary angioplasty is well established therapeutic modality in the management of coronary artery disease. However, the high restenosis rate of 30 to 50% limits its usefulness. The principal mechanism of restenosis, intimal hyperplasia, is the proliferative response of vessel wall to injury, which consists largely of smooth muscle cells. A large body of animal investigations and a limited number of clinical studies have established the ability of ionizing radiation to reduce neointimal proliferation and restenosis rate significantly. Human studies have been reported that intravascular radiation after first restenosis inhibits a second restenosis. Encouraged by these reports, we are also conducting a double blind, placebo-controlled, randomized trial to evaluate this new therapeutic modality in patients with coronary artery stenosis. The objective of our trial is to determine the safety and efficacy of catheter-based solutional beta emitting radioisotope system in preventing restenosis after angioplasty. This review describes the vascular brachytherapy systems and isotopes that have been utilized in the initial clinical trials performed in this area of post PTCA coronary restenosis. The results of many worldwide ongoing clinical trials will determine whether this new technology will change the future practice of vascular intervention.

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Effect of Vitamin K2 (Menaquinone-7) in Cheongukjang Powder on Bone Health Circulation in Postmenopausal Women (비타민 K2(Menaquinone-7) 함유 청국장 분말의 섭취가 폐경기 여성의 뼈건강 개선에 미치는 효과)

  • Bang, Seon-Ok;Kim, Kum-Suk;Jeong, Min-Hong
    • The Korean Journal of Food And Nutrition
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    • v.29 no.6
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    • pp.978-984
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    • 2016
  • Osteoporosis is a disease that often occurs in postmenopausal women. The purpose of this study was to examine the positive effects of Cheongukjang powder containing menaquinone-7 (MK-7) on bone health circulation in postmenopausal women. Fifty-six postmenopausal women were recruited into a randomised double-blind placebo-controlled trial. The participants were randomly assigned into two groups. For 12 weeks, one group received $800{\mu}g$ MK-7 in the form of Cheongukjang packs (CMK-7), and the other group received the same amount of identical-looking placebo packs containing barley meal for 12 weeks. Femoral bone mineral density (BMD), bone-specific alkaline phosphatase (ALP), deoxypyridinoline (DPD), osteocalcin (OSC), serum Ca, and serum P were measured at baseline (0 weeks) and 12 weeks. After 12 weeks in the CMK-7 group, it was found that BMD, serum Ca, and serum P had increased above the baseline (p<0.0001, p=0.0028, p<0.0001), whereas bone-specific ALP, DPD, and OSC had decreased below the baseline (p=0.0003, p<0.0001, p<0.0001). Therefore, MK-7 taken as Cheongukjang is expected to prevent osteoporosis in postmenopausal women.

A Performance Assessment of Real-time Multichannel Audio Codec

  • Kim, Sunghan;Jang, Daeyoung;Hong, Jinwoo
    • The Journal of the Acoustical Society of Korea
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    • v.16 no.3E
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    • pp.56-61
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    • 1997
  • In this paper, we describe a real-time implementation of a multi-channel auido codec system that is based on the MPEG-1 audio algorithm. The major feature of this system is that it has a flexible multi-DSP system that can be adapted for various applications with using up to four TMS320C40 DSPs. The purpose of this paper is to present the problems of the system and is to describe the optimized methods to solve the problems in the view of hardware and software. Our audio codec is composed of an encoder an a decoder system and the bit rate of bitstream is up to 384 kbps. Fast input/output interfaces, DSP overloads, and inter-DSP communications methods with high speed are considered in multi-DSP H/W. Also, to run real-time in S/W, optimizing methods of algorithm are considered. After implementation of system, the subjective assessment method, and 'triple stimulus/hidden reference/double blind' that recommended by ITU-R TG10/3 is adopted for the quality of our system. All test items except one are awarded difference grades(diffgrade) better than 1-. Form the results, multi-channel audio system can be used for HDTV service.

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A Study for Reducing Pain from Injection of Lidocaine Hydrochloride (염산 Lidocaine 주입으로 초래되는 통증을 줄이는 방법에 대한 연구)

  • Jeong, Jae-Ho;Lee, Kyung-Ho
    • Journal of Yeungnam Medical Science
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    • v.11 no.1
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    • pp.30-34
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    • 1994
  • Local anesthetics produce pain during infiltration into skin. The relationship between local anesthetic-induced pain and pH of the local anesthetic solution has not been fully investigated. Commercial preparation of local anesthetics are prepared as acidic solutions of the salts to promote solubility and stability. And the acidity of local anesthetic solition may be related with the pain during infiltration of the solutione. So, we tried to neutralize the lidocaine hydrochloride solution which is one of the most frequently used local anesthetic agent. Sodium bicarbonate was used for neutralization. Sodium bicarbonate was mixed with lidocaine hydrochloride until the resulting pH of the solution become 7.4 which is identical to the acidity of body fluid. To identify the effect of neutralized lidocaine solution, we had a course of double blind test to 6 volunteers. Both forearm of each volunteer were injected with neutralized lidocaine and plain one, and the degree of pain was estimated by each volunteers. According to subjective description by the volinteers, everyone felt neutralized lidocaine injection site was less painful than plain lidocaine. We concluded that we could reduce pain from infiltration of lidocaine hydrochloride by neutralization of the anesthetic solution with sodium bicarbonate.

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Efficacy of proton pump inhibitors and H2 blocker in the treatment of symptomatic gastroesophageal reflux disease in infants

  • Azizollahi, Hamid Reza;Rafeey, Mandana
    • Clinical and Experimental Pediatrics
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    • v.59 no.5
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    • pp.226-230
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    • 2016
  • Purpose: Gastroesophageal reflux disease (GERD) occurs in pediatric patients when reflux of gastric contents presents with troublesome symptoms. The present study compared the effects of omeprazole and ranitidine for the treatment of symptomatic GERD in infants of 2-12 months. Methods: This study was a clinical randomized double-blind trial and parallel-group comparison of omeprazole and ranitidine performed at Children Training Hospital in Tabriz, Iran. Patients received a standard treatment for 2 weeks. After 2 weeks, the patients with persistent symptoms were enrolled in this randomized study. Results: We enrolled 76 patients in the present study and excluded 16 patients. Thirty patients each were included in group A (ranitidine) and in group B (omeprazole). GERD symptom score for groups A and B was $47.17{\pm}5.62$ and $51.93{\pm}5.42$, respectively, with a P value of 0.54, before the treatment and $2.47{\pm}0.58$ and $2.43{\pm}1.15$, respectively, after the treatment (P=0.98). No statistically significant differences were found between ranitidine and omeprazole in their efficacy for the treatment of GERD. Conclusion: The safety and efficacy of ranitidine and omeprazole have been demonstrated in infants. Both groups of infants showed a statistically significant decrease in the score of clinical variables after the treatment.

The Study of Correlation between Serum Vitamin K Concentration and Bone Metabolism in Postmenopausal Women (폐경후 여성에서 비타민 K와 골대사와의 상관성에 관한 연구)

  • 홍주영
    • Journal of Nutrition and Health
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    • v.32 no.3
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    • pp.287-295
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    • 1999
  • This study was conducted to observe the effect of vitamin K on bone metabolism in postmenopausal women. Twenty-four healthy postmenopausal women recruited for this one-month, double-blind controlled study. Before and after daily administration of 1.0mg of phylloquinone the levels of serum vitamin K, osteocalcin, under-carboxylated osteocalcin, and urinary deoxy-phyidinoline were measured. The serum vitamin K concentration of Koran women as well as the average dietary intake of vitamin K was shown to be higher than the average levels of foreign women. However, no correlation between serum vitamin K concentration and vitamin K intake was found. Also, serum vitamin K concentration showed no special correlation with either bone mineral density or bone turnover markers in the study group. However, women with low serum vitamin K concentration(vitamin K-low group)had lower bone mineral density levels. After supplementation with 1.0mg/day of vitamin K, there were no changes in the levels of serum vitamin K, osteocalcin, ucOC, or u-DPD. Vitamin K supplementation did not seem to have any positive effects on bone metabolism through carboxylation. It can, however, be expected that vitamin K supplementation has a positive effect on bone metabolism in postmenopausal women with especially low serum vitamin K concentrations.

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The Effect of Low Level Laser Therapy on Pressure Pain Threshold in Patients with Temporomandibular Disorders : A Double-blind Study (저출력레이저 조사가 측두하악장애환자의 압력통각역치에 미치는 영향)

  • Cho, Kyung-Ah;Park, June-Sang;Ko, Myung-Yun
    • Journal of Oral Medicine and Pain
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    • v.24 no.3
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    • pp.281-300
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    • 1999
  • 측두하악장애환자와 정상대조군의 두경부 근육에 있어서 실제 또는 위약 치료에 따른 저출력 레이저의 효과와 측두하악장애환자에서 저출력 레이저의 효과적인 치료기간을 평가하기 위하여, 측두하악장애를 가진 부산대학교 치과대학생 19명과 측두하악장애의 병력이나 증상이 없는 부산대학교 치과대학생 20명을 대상으로 치료전, 치료 2주 및 치료 4주에 구외촉진이 가능한 32 근골격 촉진점의 압력통각역치와 각각의 동통정도와 두개하악지수를 측정하여 다음과 갈은 결론을 얻었다, 1. 치료전 환자군의 압력통각역치는 정상대조군 압력통각역치보다 낮았다(p<0.05), 2. 환자군의 압력통각역치는 유의하게 증가하였으며 (p<0.05) 레이저 조사 환자군의 증가된 압력통각역치는 레이저 모의조사-환자군의 증가된 압력통각역치보다 더 크게 나타났다. 3. 대조군에서는 레이저 조사나 모의 조사에 의해 압력통각역치와 변화가 없었다. 4. 레이저 조사-환자군의 압력통각역치가 안면근육에서는 치료2주부터 유의하게 증가하였고 경부근육에서는 치료4주부터 유의하게 증가하였다(p<0.05) 5. 레이저 조사-환자군에서 동통의 정도와 두개하악지수는 유의하게 감소하였다(p<0.05).

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