• 제어로봇시스템학회논문지
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• 제10권11호
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• pp.1100-1106
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• 2004

In this report, a self-organizing fuzzy neural network is proposed to control chemical feeding, which is one of the most important problems in water treatment process. In the case of the learning according to raw water quality, the self-organizing fuzzy network, which can be driven by plant operator, is very effective, Simulation results of the proposed method using the data of water treatment plant show good performance. This algorithm is included to chemical feeder, which is composed of PLC, magnetic flow-meter and control valve, so the intelligent control of chemical feeding is realized.

• Biotechnology and Bioprocess Engineering:BBE
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• 제3권2호
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• pp.91-95
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• 1998

Camptothecin productoin was increased with elicitors, methyl jasmonate, jasmonic acid, yeast extract elicitor, and ferulic acid in suspension cultures of Camptotheca acuminata. Jasmonic acid was found to be the most efficient elicitor. Camptothecin production increased 11 times by using the optimum dosing concentration of jasmonic acid which was 50 ${\mu}$M. The kinetics of camptothecin accumulation in response to the treatment with jasmocin acid showed that the comptothecin accumulation reached the maximum value at 4 days after jasmonic acid dosing and then a rapid decrease in camptothecin accumulation was observed.

• 상하수도학회지
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• 제7권2호
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• pp.39-46
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• 1993

In this experimental study, it is concerned to develop a simple equation using jar-test results in order to predict the optimum dosage of coagulant, PAC(polyaluminum chloride). Considering the relationships with the reactions of coagulation and flocculation, the four independent variables (e.g. turbidity, temperature, pH and alkalinity) are selected out of many parameters and they are put into calculations to develop an equation by means of multi-regression method. As the result, the dosing rate of PAC is proportional to turbidity, pH and alkalinity, but in inverse to temperature. And the developed equation is as follow, $$D_c=\frac{3.2{\cdot}T^{0.37}{\cdot}A^{0.04}{\cdot}P^{0.5}}{t^{0.1}},\;(R^2=0.9443)$$ And also, comparing between the estimated value from the equation and the real dosing rate in the plant, Kwangam and Tdukdo, during 1988~1991, it is represented an agreement having a relative error of 16.4%, 17.8%, respectively.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2006년도 춘계종합학술대회
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• pp.319-323
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• 2006

공공정보의 온라인서비스는 이제 공공기관이 일방적으로 제공하는 민원서비스의 하나에서 탈피하여 시민이 가장 많이 방문하는 최대의 대 시민 접점공간이 되어버렸다. 시민들의 온라인을 통한 서비스 수준은 기관이 보유한 대안보다 훨씬 복잡하고 다양하다고 할 수 있다. 바야흐로 u-City 시대, 정보문명 속에서 더욱 다양해신 시민들의 Life Style, 더욱 많아진 정보전달 수단들, 이 모든 생활환경에 맞는 공공기관의 온라인서비스 방법에 대한 문제점과 대안을 제시하였다.

• 대한약학회:학술대회논문집
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• 대한약학회 2000년도 NEW STRATEGY FOR DRUG DEVELOPMENT IN POST-GENOMIC ERA(대한약학회)
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• pp.282-282
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• 2000

• Asian-Australasian Journal of Animal Sciences
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• 제18권12호
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• pp.1746-1751
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• 2005

The objective of this study was to evaluate the effects of sarsaponin on methane production, ruminal fermentation, nutrient digestion and blood metabolites using three Holstein steers in a 3${\times}$3 Latin Square design. The steers were fed Sudangrass hay plus concentrate mixture at a ratio 1.5:1 twice daily, and sarsaponin (0, 0.5 and 1% of DM), which was given at 09:00 and 17:00 h daily by mixing with concentrate. Rumen samples were collected 0, 2, and 5 h after morning dosing. Ruminal pH was numerically decreased and numbers of protozoa were decreased linearly (p<0.01) by treatment. Ruminal ammonia-N was reduced (linear; p<0.05) and total VFA was increased (quadratic; p<0.05) at 2 and 5 h after sarsaponin dosing. The molar proportion of acetate was decreased (quadratic; p<0.05) and propionate was increased (linear; p<0.01) at all sampling times. Blood plasma glucose was increased and urea-N was decreased (linear; p<0.05) at 2 and 5 h after dosing. Methane was decreased by approximately 12.7% (linear; p<0.05). The apparent digestibility of DM and NDF were decreased (quadratic; p<0.05) and that of CP remained unchanged due to the sarsaponin. The numbers of cellulolytic bacteria were decreased (quadratic; p<0.05), while numbers of total viable bacteria remained unchanged due to the sarsaponin. These results show that sarsaponin can partially inhibit rumen methanogenesis in vivo and improve ruminal fermentation, which supports our previous in vitro results.

• 한국자동차공학회논문집
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• 제20권1호
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• pp.95-105
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• 2012

The selective catalytic reduction (SCR) system is a highly-effective aftertreatment device for NOx reduction of diesel engines. Generally, the ammonia ($NH_3$) was generated from reaction mechanism of SCR in the SCR system using the liquid urea as the reluctant. Therefore, the precise urea dosing control is a very important key for NOx and $NH_3$ slip reduction in the SCR system. This paper investigated NOx and $NH_3$ emission characteristics of urea-SCR dosing system based on model-based control algorithm in order to reduce NOx. In the map-based control algorithm, target amount of urea solution was determined by mass flow rate of exhaust gas obtained from engine rpm, torque and $O_2$ for feed-back control NOx concentration should be measured by NOx sensor. Moreover, this algorithm can not estimate $NH_3$ absorbed on the catalyst. Hence, the urea injection can be too rich or too lean. In this study, the model-based control algorithm was developed and evaluated on the numerical model describing physical and chemical phenomena in SCR system. One channel thermo-fluid model coupled with finely tuned chemical reaction model was applied to this control algorithm. The vehicle test was carried out by using map-based and model-based control algorithms in the NEDC mode in order to evaluate the performance of the model based control algorithm.

• 한국임상수의학회지
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• 제28권4호
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• pp.375-386
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• 2011

Polygoni Multiflori Radix (PMR), a dried root tuber of Polygonum multiflorum Thunberg with bioactivities in bone metabolism is one of the most famous tonic traditional medicines. To observe in vivo anti-osteoporotic efficacy of PMR extracts, we orally administered once a day for 28 days (Qd ${\times}$ 28) to bilateral ovariectomized (OVX)-induced osteoporosis ddY mice after 1 week of recovery periods at 125, 250 and 500 mg/kg (of body weight). A positive control drug, Alendronate (FOSA) 10 mg/kg-dosing group was added. As results of OVX-induced osteoporotic process, estrogen-deficient osteoporotic changes were also dramatically decreased in all PMR extracts-dosing groups. Especially middle dosage of PMR extracts, 250 mg/kg constantly and significantly (p < 0.01 or p < 0.05) inhibited the loss of bone strength and bone quality. Based on the results, it was concluded that PMR extracts (125, 250 or 500 mg/kg; orally dosing) has relatively good favorable effect to prevention and/or treatment of OVX-induced osteoporosis. Therefore, although the efficacy was slighter than that of Alendronate on the inhibition of bone loss, it is expected that PMR extracts will be promising as a new anti-osteoporotic agents for prevent the fracture induced in osteoporotic patients because natural herbal medicine origin PMR extracts will be dose not show serious side effects especially the problem in upper alimentary irritation by bisphosphonate and hypercalcaemia of parathyroid hormone analogs.

• Biomolecules & Therapeutics
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• 제11권3호
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• pp.178-182
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• 2003

The clinical use of once daily aminoglycoside (ODA) dosing has been increased because of the potential therapeutic advantages of this dosing regimen. To evaluate the optimal sampling times of ODA dosing method in a clinical setting, the study was prospectively conducted in a total of 28 patients with UTI. All of the patients were intravenously administered gentamicin at a dose of 7 mg/kg over 60 minutes and randomly divided into two groups. Blood was collected at 0, 2, and 6 hours in Group A and at 1, 2, and 6 hours in Group B after the end of 1-hour infusion. The pharmacokinetic parameters (Ke, Vd and Cmax) obtained using the 0, 6 hour levels and 2, 6 hour levels in Group A were statistically different while those of 1, 6 hour levels and 2, 6 hour levels in Group B were similar. This finding indicated that the distributional phase of ODA is completed within 1 hour following the end of the I-hour infusion. If we are allowed to collect only two blood samples in ODA considering patients comfort and the analytical cost of drug, the first one should be drawn after 1 hour following the end of infusion to obtain adequate pharmacokinetic information.

• Journal of Nutrition and Health
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• 제38권5호
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• pp.335-343
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• 2005

쥐에게 콩과 콩나물, 순수한 genistein을 함유되어 있는 genistein함량을 기준으로 동일하게 급여 (20mg/kg) 시켰을 때, 체내에서 흡수가 되는 속도는 soy, soy sprout, pure genistein군의 순이며 일반소화율은 soy sprout, pure genistein, soy군의 순이었다. 이로써 soy의 genistein은 쉽게 흡수되고 배설되며, 또한 전혀 흡수되지 않고 배설분으로 나오는 양도 세 그룹 중 가장 많은 것을 알 수 있었다. 이는 담즙 등으로 재순환되지 않는 양이 다른 그룹보다 많기 때문이라고 추정되었다. 따라서 생리기능상의 목적으로 isoflavone을 섭취하고자 할 때에는 콩보다는 콩나물형태로의 섭취가 타당할 것으로 생각되며 정확한 결과를 위해서도 사람이 섭식하는 상태의 콩과 콩나물의 isoflvones의 흡수율을 조사할 필요성이 있을 것으로 생각되었다.