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Antiosteoporotic Effects of Polygoni Multiflori Radix (PMR) in Ovariectomized (OVX)-Induced Osteoporosis ddY Mice  

Do, Yoon-Jung (National Institute of Animal Science)
Ku, Sae-Kwang (College of Oriental Medicine, Daegu Haany University)
Kim, Hong-Tae (Busan Metropolitan City Institute of Health & Environment)
Oh, Tae-Ho (College of Veterinary Medicine, Kyungpook National University)
Cho, Young-Moo (National Institute of Animal Science)
Kim, Sung-Woo (National Institute of Animal Science)
Ryu, Il-Sun (National Institute of Animal Science)
Lee, Keun-Woo (College of Veterinary Medicine, Kyungpook National University)
Publication Information
Journal of Veterinary Clinics / v.28, no.4, 2011 , pp. 375-386 More about this Journal
Abstract
Polygoni Multiflori Radix (PMR), a dried root tuber of Polygonum multiflorum Thunberg with bioactivities in bone metabolism is one of the most famous tonic traditional medicines. To observe in vivo anti-osteoporotic efficacy of PMR extracts, we orally administered once a day for 28 days (Qd ${\times}$ 28) to bilateral ovariectomized (OVX)-induced osteoporosis ddY mice after 1 week of recovery periods at 125, 250 and 500 mg/kg (of body weight). A positive control drug, Alendronate (FOSA) 10 mg/kg-dosing group was added. As results of OVX-induced osteoporotic process, estrogen-deficient osteoporotic changes were also dramatically decreased in all PMR extracts-dosing groups. Especially middle dosage of PMR extracts, 250 mg/kg constantly and significantly (p < 0.01 or p < 0.05) inhibited the loss of bone strength and bone quality. Based on the results, it was concluded that PMR extracts (125, 250 or 500 mg/kg; orally dosing) has relatively good favorable effect to prevention and/or treatment of OVX-induced osteoporosis. Therefore, although the efficacy was slighter than that of Alendronate on the inhibition of bone loss, it is expected that PMR extracts will be promising as a new anti-osteoporotic agents for prevent the fracture induced in osteoporotic patients because natural herbal medicine origin PMR extracts will be dose not show serious side effects especially the problem in upper alimentary irritation by bisphosphonate and hypercalcaemia of parathyroid hormone analogs.
Keywords
Polygoni Multiflori Radix(PMR); anti-osteoporotic effect; osteoporosis; Alendronate (FOSA); ovariectomized(OVX);
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