• Radiation Oncology Journal
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• 제9권2호
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• pp.337-342
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• 1991

방사선 선량의 표준측정법 (한국의학 물리학회 1990) 및 TG-21, $C_{\lambda}/C_E$ 방법을 비교 연구하였다. 방사선 치료에서 사용되는 광자선과(4MV-l5MV) 전자선(6MeV-20MeV)을 세 종류의 전리함으로 물팬틈속에서 측정, 평가한 결과를 비교하였다. TG-21과 방사선 선량의 표준 측정법 비교에서는1$\%$ 이내의 작은 차이만을 보여주었으며 그 차이는 주로 $N_{D}-N_{gas}$ 차이에서 나오는 것으로 평가되었다. 그러나 $C_{\lambda}/C_E$ 방법과의 비교에서는 광자선의 경우 $-1.9{\pm}0.6\%$ (방사선 선량의 표준 측정에 의한 결과가 높게 나옴) 전자선의 경우 $3.3{\pm}1\%$(방사선 선량의 표준측정법에 의한 결과가 낮게 나옴)의 차이를 보였다.

• 한국의학물리학회지:의학물리
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• 제29권2호
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• pp.73-80
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• 2018

Accelerated partial breast irradiation (APBI) is a new treatment delivery technique that decreases overall treatment time by using higher fractional doses than conventional fractionation. Here, a quantitative analysis study of CyberKnife-based APBI was performed on 10 patients with left-sided breast cancer who had already finished conventional treatment at the Inha University Hospital. Dosimetric parameters for four kinds of treatment plans (3D-CRT, IMRT, VMAT, and CyberKnife) were analyzed and compared with constraints in the NSABP B39/RTOG 0413 protocol and a published CyberKnife-based APBI study. For the 10 patients recruited in this study, all the dosimetric parameters, including target coverage and doses to normal structures, met the NSABP B39/RTOG 0413 protocol. Compared with other treatment plans, a more conformal dose to the target and better dose sparing of critical structures were observed in CyberKnife plans. Accelerated partial breast irradiation via CyberKnife is a suitable treatment delivery technique for partial breast irradiation and offers improvements over external beam APBI techniques.

• Nuclear Engineering and Technology
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• 제55권1호
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• pp.270-277
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• 2023

Exposure to ionizing radiation induces free radicals in human nails. These free radicals generate a radiation-induced signal (RIS) in electron paramagnetic resonance (EPR) spectroscopy. Compared with the RIS of tooth enamel samples, that in human nails is more affected by moisture and heat, but has the advantages of being sensitive to radiation and easy to collect. The fingernail as a biological sample is applicable in retrospective dosimetry in cases of localized hand exposure accidents. In this study, the dosimetric characteristics of fingernails were analyzed in fingernail clippings collected from Korean donors. The dose response, fading of radiation-induced and mechanically induced signals, treatment method for evaluation of background signal, minimum detectable dose, and minimum detectable mass were investigated to propose a fingernail-EPR dosimetry protocol. In addition, to validate the practicality of the protocol, blind and field experiments were performed in the laboratory and a non-destructive testing facility. The relative biases in the dose assessment result of the blind and field experiments were 8.43% and 21.68% on average between the reference and reconstructed doses. The results of this study suggest that fingernail-EPR dosimetry can be a useful method for the application of retrospective dosimetry in cases of radiological accidents.

• Asian Pacific Journal of Cancer Prevention
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• 제13권3호
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• pp.985-989
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• 2012

Objective: To make sure the feasibility with $^{18F}FDG$ PET/CT to guided dynamic intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma patients, by dosimetric verification before treatment. Methods: Chose 11 patients in III~IVA nasopharyngeal carcinoma treated with functional image-guided IMRT and absolute and relative dosimetric verification by Varian 23EX LA, ionization chamber, 2DICA of I'mRT Matrixx and IBA detachable phantom. Drawing outline and making treatment plan were by different imaging techniques (CT and $^{18F}FDG$ PET/CT). The dose distributions of the various regional were realized by SMART. Results: The absolute mean errors of interest area were $2.39%{\pm}0.66$ using 0.6cc ice chamber. Results using DTA method, the average relative dose measurements within our protocol (3%, 3 mm) were 87.64% at 300 MU/min in all filed. Conclusions: Dosimetric verification before IMRT is obligatory and necessary. Ionization chamber and 2DICA of I'mRT Matrixx was the effective dosimetric verification tool for primary focal hyper metabolism in functional image-guided dynamic IMRT for nasopharyngeal carcinoma. Our preliminary evidence indicates that functional image-guided dynamic IMRT is feasible.

• 한국의학물리학회지:의학물리
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• 제21권4호
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• pp.354-359
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• 2010

뇌하수체 종양의 치료 계획 시 다양한 영상 융합 프로토콜이 실제 PTV (planning target volume) coverage 및 OAR (organ at risk) 보호에 미치는 선량학적 영향을 확인하고자 하였다. 선량 체적 히스토그램(DVH, dose volume histogram)을 이용하여 각 프로토콜 별 실제 PTV의 coverage 및 그 변화 그리고 시각경로(optic pathway) 및 뇌간(brainstem)의 최대 흡수 선량과 임계 선량을 초과한 체적을 획득하였고 축상면(axial plane)과 관상면(coronal) 영상을 함께 사용하여 S-I (superior-inferior) 방향의 불확정도를 보정한 영상 융합 프로토콜이 축상면 만을 이용한 경우보다 시각경로 및 뇌간의 최대 흡수 선량과 임계 선량을 초과한 체적 모두 감소된 수치를 보임을 확인 하였다. 본 case에 한해 축상면 그리고 관상면 영상을 함께 사용하는 것이 OARs 보호에 가중치를 둔 방사선 수술 치료 계획 수립에 도움을 줄 수 있다.

• 대한방사선기술학회지:방사선기술과학
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• 제47권4호
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• pp.271-278
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• 2024

This study aimed to evaluate the impact of changes in beam arrangement and arc counts on dosimetric factors in volumetric modulated arc therapy (VMAT) inverse radiation therapy planning for hippocampal-avoidance whole brain radiation therapy (HA-WBRT) by using the Elekta Monaco radiation therapy planning system (RTPs). For coplanar VMAT, both the arc per beam (APB) method and the beam determined arc(BDA) method, which is determined by the number of beams, were applied. For non-coplanar VMAT, the BDA method was utilized, and a total of 9 treatment plans were established by varying the arc counts. All radiation therapy plans met the radiation oncology group (RTOG) 0933 protocol standards, and 14 dosimetric factors were compared and analyzed. The results showed that the BDA-NC VMAT method demonstrated superior performance in terms of planning target volume (PTV) coverage and protection of normal organs, while APB-VMAT was advantageous in terms of hippocampal protection, monitor unit and delivery time. This study is expected to contribute to the efficient establishment of HA-WBRT plans considering the changes in beam arrangement and rotation arc numbers in Monaco RTPs.

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 2001년도 제40차 춘계학술대회 및 연수교육
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• pp.4-10
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• 2001

The radionuclide therapy is a protocol for tumor control by administering radionuclides as the cytotoxic agents. Radionuclides concentrated at the site of cancerous lesion are expected to kill the cancerous cells with minimal injury to the normal tissue. The efficacy of every radionuclide treatment can be evaluated by examining the toxicity to the lesion differentiated from that to the normal tissue. Radiation dosimetry is the procedure of quantitating the energy absorbed by target volumes of interest. Dosimetric information plays an indicator of the expected radiation damage and thus the therapeutic efficacy. This paper summarizes the dosimetric aspects in radionuclide therapy in terms of radionuclides of use, radiation dosimetry methodology and considerations for each treatment in practical use.

• Asian Pacific Journal of Cancer Prevention
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• 제17권11호
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• pp.4935-4937
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• 2016

Objective: To compare dosimetric parameters of 3 dimensional conformal radiotherapy (3 DCRT) and intensity modulated radiotherapy (IMRT) in terms of target coverage and doses to organs at risk (OAR) in the management of rectal carcinoma. Methods: In this prospective study, conducted between August 2014 and March 2016, all patients underwent CT simulation along with a bladder protocol and target contouring according to the Radiation Therapy Oncology Group (RTOG) guidelines. Two plans were made for each patient (3 DCRT and IMRT) for comparison of target coverage and OAR. Result: A total of 43 patients were recruited into this study. While there were no significant differences in mean Planning Target Volume (PTV) D95% and mean PTV D98% between 3 DCRT and IMRT, mean PTV D2% and mean PTV D50% were significantly higher in 3 DCRT plans. Compared to IMRT, 3 DCRT resulted in significantly higher volumes of hot spots, lower volumes of cold spots, and higher doses to the entire OAR. Conclusion: This study demonstrated that IMRT achieves superior normal tissue avoidance (bladder and bowel) compared to 3 DCRT, with comparable target dose coverage.

• 한국의학물리학회지:의학물리
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• 제9권4호
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• pp.267-276
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• 1998

팬톰내에 삽입되는 전리함은 전자 플루언스의 교란을 최소화하는 기하학적 구조를 갖는 것이 바람직한데 평행평판형 전리함은 다른 어떤 전리함보다도 이러한 조건을 잘 만족시킨다. 이러한 이유로 IAEA 표준측정법에서는 표면 평균 에너지가 10 MeV 이하인 전자선 측정시 평행평판형 전리함의 사용을 권고하고 있으나 일반적으로 편의상 원통형 전리함을 많이 사용하고 있는 실정이다. 본 연구에서는 네 가지 다른 표준 측정법 즉 1)원통형 전리함을 사용한 IAEA 표준 측정법 2)원통형 전리함을 사용한 TG-21 표준 측정법 3)평행평판형 전리함을 사용한 Markus 측정법 4)평행평판형 전리함을 원통형 전리함에 대하여 교정한 TG 39 측정법을 사용하여 서로 다른 측정법과 전리함의 차이에 의한 선량 값의 변화를 알아보고자 한다. Siemens KD-2 선형가속기에서 발생하는 고에너지 전자선(6,9,12,15,18 MeV)을 이용하여 3차원 전산화 물팬톰과 0.125 cc 전리함을 사용하여 각 에너지별로 l0$\times$10 $cm^2$ cone size의 심부선량백분율을 구하였다. 고체 물팬톰내에서 Farmer type 0.6cc 원통형 전리함을 사용하여 IAEA 표준 측정법과 TG-21 표준 측정법에 의해서 각 에너지별로 흡수선량을 측정하였다. 평행평판형 전리함(Markus Chamber)을 사용하여 Markus 측정법에 의해서 각 에너지별로 흡수선량을 측정하였다. 전자선 에너지 18 MeV를 사용하여 원통형 전리함에 대한 평행평판형 전리함의 교정계수를 얻고 TG 39 측정법에 의해서 각 에너지별로 흡수선량을 측정하였다. Cone size 는 l0$\times$10 $cm^2$ 이었고 측정점의 깊이는 d$_{max}$ 이었다. IAEA 표준 측정법과 TG 21 표준 측정법은 18 MeV 에 대하여 0.9 % 의 차이가 나타났고 그 외의 에너지 영역에서 0.7% 이내로 비교적 잘 일치하였다. Markus 측정법과 TG 39 측정법은 18 MeV 와 6 MeV 에 대하여 각각 $\pm$0.8 % 의 차이가 나타났고 그 외의 에너지 영역에서 0.5 % 이내로 잘 일치하였다. 원통형 전리함과 평행평판형 전리함을 이용한 측정법간의 차이는 18 MeV 에서 1.6 % 까지 나타나므로 주의를 요하며 TG 39 측정법에서 제시한 다른 측정방법을 사용하여 측정을 하여 교정계수를 얻을 필요가 있을 것으로 생각된다.다.

• Nuclear Engineering and Technology
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• 제54권2호
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• pp.429-436
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• 2022

Investigations of retrospective dosimetry have shown that components of mobile phones are suitable as emergency dosimeters in case of radiological incidents. For physical dosimetry, components can be read out using optically stimulated luminescence (OSL), thermoluminescence (TL) and phototransferred thermoluminescence (PTTL) methods to determine the absorbed dose. This paper deals with a feasibility study of display glass from modern mobile phones that are measured by thermally assisted (Ta) optically stimulated luminescence. Violet (VSL, 405 nm) and infrared (IRSL, 850 nm) LEDs were used for optical stimulation and two protocols (Ta-VSL and Ta-IRSL) were tested. The aim was to systematically investigate the luminescence properties, compare the results to blue stimulated Ta-BSL protocol (458 nm) and to develop a robust measurement protocol for the usage as an emergency dosimeter after an incident with ionizing radiation. First, the native signals were measured to calculate the zero dose signal. Next, the reproducibility and dose response of the luminescence signals were analyzed. Finally, the signal stability was tested after the storage of irradiated samples at room temperature. In general, the developed Ta-IRSL and Ta-VSL protocols indicate usability, however, further research is needed to test the potential of a new protocol for physical retrospective dosimetry.