• 한국의학물리학회지:의학물리
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• 제29권2호
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• pp.73-80
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• 2018

Accelerated partial breast irradiation (APBI) is a new treatment delivery technique that decreases overall treatment time by using higher fractional doses than conventional fractionation. Here, a quantitative analysis study of CyberKnife-based APBI was performed on 10 patients with left-sided breast cancer who had already finished conventional treatment at the Inha University Hospital. Dosimetric parameters for four kinds of treatment plans (3D-CRT, IMRT, VMAT, and CyberKnife) were analyzed and compared with constraints in the NSABP B39/RTOG 0413 protocol and a published CyberKnife-based APBI study. For the 10 patients recruited in this study, all the dosimetric parameters, including target coverage and doses to normal structures, met the NSABP B39/RTOG 0413 protocol. Compared with other treatment plans, a more conformal dose to the target and better dose sparing of critical structures were observed in CyberKnife plans. Accelerated partial breast irradiation via CyberKnife is a suitable treatment delivery technique for partial breast irradiation and offers improvements over external beam APBI techniques.

• 한국의학물리학회지:의학물리
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• 제35권1호
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• pp.10-15
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• 2024

Purpose: This study aimed to comprehensively investigate the diverse characteristics of a novel commercial bolus, CLEANBOLUS-WHITE (CBW), to ascertain its suitability for clinical application. Methods: The evaluation of CBW encompassed both physical and biological assessments. Physical parameters such as mass density and shore hardness were measured alongside analyses of element composition. Biological evaluations included assessments for skin irritation and cytotoxicity. Dosimetric properties were examined by calculating surface dose and beam quality using a treatment planning system (TPS). Additionally, doses were measured at maximum and reference depths, and the results were compared with those obtained using a solid water phantom. The effect of air gap on dose measurement was also investigated by comparing measured doses on the RANDO phantom, under the bolus, with doses calculated from the TPS. Results: Biological evaluation confirmed that CBW is non-cytotoxic, nonirritant, and non-sensitizing. The bolus exhibited a mass density of 1.02 g/cm³ and 14 shore 00. Dosimetric evaluations revealed that using the 0.5 cm CBW resulted in less than a 1% difference compared to using the solid water phantom. Furthermore, beam quality calculations in the TPS indicated increased surface dose with the bolus. The air gap effect on dose measurement was deemed negligible, with a difference of approximately 1% between calculated and measured doses, aligning with measurement uncertainty. Conclusions: CBW demonstrates outstanding properties for clinical utilization. The dosimetric evaluation underscores a strong agreement between calculated and measured doses, validating its reliability in both planning and clinical settings.

• 한국의학물리학회지:의학물리
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• 제27권3호
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• pp.111-116
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• 2016

This study is to evaluate the dosimetric impact of dosimetric leaf gap (DLG) and transmission factor (TF) at different measurement depths and field sizes for high definition multileaf collimator (HD MLC). Consequently, its clinical implication on dose calculation of treatment planning system was also investigated for pancreas stereotactic body radiation therapy (SBRT). The TF and DLG were measured at various depths (5, 8, 10, 12, and 15 cm) and field sizes ($6{\times}6$, $8{\times}8$, and $10{\times}10cm^2$) for various energies (6 MV, 6 MV FFF, 10 MV, 10 MV flattening filter free [FFF], and 15 MV). Fifteen pancreatic SBRT cases were enrolled in the study. For each case, the dose distribution was recomputed using a reconfigured beam model of which TF and DLG was the closest to the patient geometry, and then compared to the original plan using the results of dose-volume histograms (DVH). For 10 MV FFF photon beam, its maximum difference between 2 cm and 15 cm was within 0.9% and it is increased by 0.05% from $6{\times}6cm^2$ to $10{\times}10cm^2$ for depth of 15 cm. For 10 MV FFF photon beam, the difference in DLG between the depth of 5 cm and 15 cm is within 0.005 cm for all field sizes and its maximum difference between field size of $6{\times}6cm^2$ and $10{\times}10cm^2$ is 0.0025 cm at depth of 8 cm. TF and DLG values were dependent on the depth and field size. However, the dosimetric difference between the original and recomputed doses were found to be within an acceptable range (<0.5%). In conclusion, current beam modeling using single TF and DLG values is enough for accurate dose calculation.

• Radiation Oncology Journal
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• 제14권4호
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• pp.323-332
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• 1996

목적 : 방사선 치료에 있어서 조직내 등선량 분포곡선을 변형시킬 목적으로 쐐기 차폐물이 사용되고 있는데 최근 기존의 고정 쐐기와는 다르게 비대칭적인 콜리메이터인 Independent Jaw에 의해 등선량 분포곡선을 변형시키는 동적 쐐기 기법이 실용화 되고 있으나 아직 그 방사선 물리학적인 특성에 대해서는 잘 알려져 있지 않다. 이에 본 저자는 기존의 고정 쐐기와 비교하여 조직내 방사선량 분포의 특성을 알아보고자 본 연구를 계획하였다. 대상 및 방법 : 물 판톰, 폴리 스타이린 판톰, 평균 유방 모형 판톰을 대상으로 전리함, 필름, TLD 등을 이용하여 동적 쐐기와 고정 쐐기의 선량 분포를 측정하여 비교하였다. 방사선원은 선형 가속기의 6MV x선을 사용하였고 $15{\times}15$ 조사면에서 15, 30, 45도 쐐기를 이용하였다 조직내선량 분포는 전리함과 필름 선량계를 사용하였고, 유방 접선 치료방식에서의 반대편 유방 조사선량은 TLD를 사용하였다. 결과 : 1) 조직내 $\%$심도 선량은 고정 쐐기의 경우 심도 선량 깊이가 깊어지는 방사선의 경화 현상이 뚜렷하였으나 동적 쐐기의 경우에는 발견할 수 없었으며 그 $\%$심도선량은 개방 조사면과 유사하였다. 2) 조직내 등선량 분포 곡선을 보면 동적 쐐기의 경우 고정 쐐기와는 달리 원하는 깊이, 원하는 조사면에서 원하는 쐐기 각도를 얻을 수 있었으며 쐐기 각도를 이루는 등선량 분포 곡선이 고정 쐐기에 비해 더욱 직선적이었다. 3) 산란선량은 동적 쐐기의 경우 개방 조사면과 그 양이 거의 동일하였으며 유방보존술에서의 접선 조사방식의 방사선치료에서 고정 쐐기 대신에 동적 쐐기를 사용함으로써 반대측 유방으로의 피폭선량을 감소시킬 수 있었다. 결론적으로 동적 쫴기 기법은 단순히 고정 쐐기를 대체할 수 있을 뿐만 아니라 고정 쐐기의 단점을 보완해 줄 수 있으며 향후 방사선 치료에 있어서 더 다양한 유용성을 가질 수 있으리라 생각한다.

• 한국방사선학회논문지
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• 제16권7호
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• pp.863-870
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• 2022

DLG (Dosimetric Leaf Gap)와 투과계수는 방사선치료계획 시스템에서 MLC 모델링의 중요 매개변수이다. 본 연구에서는 측정 용적이 다른 검출기를 이용하여 HD-MLC의 DLG와 투과계수를 측정하였고, DLG의 최적화를 통해 방사선 치료계획의 정확성을 평가하였다. 용적이 작은 Semiflux3D, MicroDiamond 검출기로 Dynamic Sweeping Gap 방법을 통해 DLG를 측정하였다. 측정된 DLG 값을 최적화할 수 있도록 10개의 방사선치료계획을 생성하고 QA결과와 비교하였다. 6, 8, 10 MV에서 Semiflux3D로 측정한 DLG는 0.76, 0.83, 0.85 mm 였고, MicroDiomond로 측정한 DLG는 0.78. 0.86, 0.9 mm 였다. 방사선치료계획 시스템에서 검출기로 측정한 DLG와 최적화된 DLG 값으로 생성한 10개의 치료계획을 Postal dosimetry로 QA하여 감마분석 하였다. 6 MV 광자선의 감마분석결과 2 mm/2% 기준에서 DLG 0.78 mm는 평균 94.3%였고, DLG 1.15 mm는 평균 98.4%였다. 10 MV 광자선에서도 DLG 0.9 mm는 평균 91.2%, DLG 1.25 mm는 97.6%였다. HD-MLC의 사용은 방사선치료계획 시스템에 정확한 모델링이 완성되어야 한다. DLG 값을 검출기로 측정하여 임상에 사용할 수 있지만, DLG 값의 최적화가 이루어진다면 환자에게 더 유용한 방사선 치료를 전달할 수 있을 것이다.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 2002년도 추계학술발표회요약집
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• pp.356.2-356
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• 2002

• 대한방사선치료학회지
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• 제5권1호
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• pp.115-119
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• 1992

The beam characteristics and dosimetric measurements of the 6MV X-ray and 6MeV electron beam from a ML-6M linear accelerator are examined. The Percent Depth Dose(PDD) table and the tissue Maximum Ratio(TMR) table are taken from measurement as a function of the field size and the depth. The calculated TMR table from PDD table is compared with those from measurement. Other beam characteristics such as output factor, beam profile(including flatness, symmetry and penumbra), wedge, and the variation of Dmax are presented. All of these dosimetric measurements sufficiently characterized the beam to permit safe clinical use.

• 한국전자파학회:학술대회논문집
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• 한국전자파학회 2005년도 종합학술발표회 논문집 Vol.15 No.1
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• pp.425-428
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• 2005

A variety of wireless devices are commercially available now. Most of studies, however, have been directed to the biological effects of mobile-phone EMF. In this study, dosimetric analysis for wireless devices of head-mounted display type and a wristwatch type were made to investigate possible biological effects of these devices. SAR (Specific Absorption Rate) distributions were calculated using FDTD (Finite Difference Time Domain) method, for adult human models such as standard Korean human model and VHP(Visible Human Project) model, as well as scaled models. Measurements were also performed for SAM phantom wearing a simplified prototype for a wireless device for validation of the simulation results. It has been found that children are more vulnerable to such exposure, and these devices could cause some biological effects for relatively lower power compared to conventional mobile pones.

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 2001년도 제40차 춘계학술대회 및 연수교육
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• pp.4-10
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• 2001

The radionuclide therapy is a protocol for tumor control by administering radionuclides as the cytotoxic agents. Radionuclides concentrated at the site of cancerous lesion are expected to kill the cancerous cells with minimal injury to the normal tissue. The efficacy of every radionuclide treatment can be evaluated by examining the toxicity to the lesion differentiated from that to the normal tissue. Radiation dosimetry is the procedure of quantitating the energy absorbed by target volumes of interest. Dosimetric information plays an indicator of the expected radiation damage and thus the therapeutic efficacy. This paper summarizes the dosimetric aspects in radionuclide therapy in terms of radionuclides of use, radiation dosimetry methodology and considerations for each treatment in practical use.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2006년도 제33회 추계학술대회 발표논문집
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• pp.120-120
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• 2006