• Bulletin of the Korean Chemical Society
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• 제34권11호
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• pp.3295-3300
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• 2013

Acrolein (ACR) is a well-known carbonyl toxin produced by lipid peroxidation of polyunsaturated fatty acids, which is involved in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease (AD). In Alzheimer's brain, ACR was found to be elevated in hippocampus and temporal cortex where oxidative stress is high. In this study, we evaluated oxidative modification of cytochrome c occurring after incubation with ACR. When cytochrome c was incubated with ACR, protein aggregation increased in a dose-dependent manner. The formation of carbonyl compounds and the release of iron were obtained in ACR-treated cytochrome c. Reactive oxygen species scavengers and iron specific chelator inhibited the ACR-mediated cytochrome c modification and carbonyl compound formation. Our data demonstrate that oxidative damage of cytochrome c by ACR might induce disruption of cyotochrome c structure and iron mishandling as a contributing factor to the pathology of AD.

• 고무기술
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• 제5권2호
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• pp.94-103
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• 2004

The present work describes modification of dual phase filler by electron beam irradiation in presence of multifunctional acrylates like trimethylol propane triacrylate (TMPTA) or silane coupling agent like bis (3-triethoxysilylpropyltetrasulphide) and in-fluence of the modified fillers on the physical properties of styrene-butadiene rubber (SBR) vulcanizates. Modulus at 300 % elongation increases whereas the tensile strength decreases with increase in radiation dose for the dual phase filler loaded styrene-butadiene rubber vulcanizates (SBR). However, modulus and tensile strength significantly increase, which is more, pronounced at higher filler loadings for TMPTA modified dual phase filler loaded SBR. These changes in properties are explained by the equilibrium swelling data and Kraus plot interpreting the polymer-filler interaction. Electron beam modification of the filler results in a reduction of tan ${\delta}$ at $70^{\circ}C$, a parameter for rolling resistance and increase in tan ${\delta}$ at $0^{\circ}C$, a parameter for wet skid resistance of the SBR vulcanizates. Finally, the influence of modified fillers on the properties like abrasion resistance, tear strength and fatigue failure and the improvement in the properties have been explained in terms of polymer-filler interaction.

• BMB Reports
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• 제45권3호
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• pp.147-152
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• 2012

Methylglyoxal (MG) was identified as an intermediate in non-enzymatic glycation and increased levels were reported in patients with diabetes. In this study, we evaluated the effects of MG on the modification of ferritin. When ferritin was incubated with MG, covalent crosslinking of the protein increased in a time- and MG dose-dependent manner. Reactive oxygen species (ROS) scavengers, $N-acetyl-_L-cysteine$ and thiourea suppressed the MG-mediated ferritin modification. The formation of dityrosine was observed in MG-mediated ferritin aggregates and ROS scavengers inhibited the formation of dityrosine. During the reaction between ferritin and MG, the generation of ROS was increased as a function of incubation time. These results suggest that ROS may play a role in the modification of ferritin by MG. The reaction between ferritin and MG led to the release of iron ions from the protein. Ferritin exposure to MG resulted in a loss of arginine, histidine and lysine residues. It was assumed that oxidative damage to ferritin caused by MG may induce an increase in the iron content in cells, which is deleterious to cells. This mechanism, in part, may provide an explanation or the deterioration of organs under diabetic conditions.

• Journal of Ginseng Research
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• 제34권4호
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• pp.264-273
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• 2010

While ginseng is reported to have a wide array of applications, there is growing evidence for its indications in diabetes and vascular disease. A clear connection, however, has not been established between ginseng's composition, dose and its targeted efficacy in humans. We therefore developed and initiated the Korean Red Ginseng Clinical Testing Program for diabetes and vascular function which is an efficacy and safety-based clinical screening model for ginseng. The most efficacious sources, ginsenoside profiles, doses, and modes of administration were examined in sequential, acute, followed by long term, randomized-controlled trials to investigate the efficacy and safety profiles. This review discusses the current state of the clinical research of Korean red ginseng program conducted in Toronto, paving the way for the use of clinically selected ginseng and its ginsenoside fractions in the management of diabetes and vascular diseases.

• 한국환경보건학회지
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• 제26권4호
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• pp.49-57
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• 2000

This study was carried out to find the optimal condition to treat refractory organic matter which can’t treat clearly with biological treatment and to find the optimal division dosage and division dose timing in the modification of Fenton oxidation which is used resolve the problem that hydrogen peroxide is too expensive. The results are following; 1. The highest TOC removal efficiency was 41% and color removal efficiency was 64% when the dilution magnitude of leachate is fold. This suggests that dilution is efficiency when high concentration of leachate is treated. 2. The removal efficiency of TOC and color increased up to the molar ratio between ferrate and hydrogen peroxide was 1:1. However above that ratio, removal efficiency hardly increased. The highest removal efficiency of TOC and color were 38% and 71% when the mole ratio of ferrate to hydrogen peroxide was 1.5:1. 3. When the mole ratio between ferrate and hydrogen peroxide was fixed, the removal efficiency of TOC and color increased as the dosage of hydrogen peroxide increased. 4. pH of samples were adjusted at pH 3, 5, 7, 9, 11. After oxidation reaction, pH of samples were dropped to 2.59, 2.54, 5.34, 6.36 and 9.68. The highest color removal efficiency was 75.7% when initial pH was at pH 7. 5. The removal of TOC and color was ended within 10. min. and the removal efficiency increased logarithmically within 10min. However after 10 min., the removal efficiency of hardly increased. 6. The color removal efficiency was higher with modification of fentone oxidation than that with fentone oxidation by 5%. Optimal division dosage ratio was 1:1 and optimal dose timing ratio was 2:1. However the TOC removal efficiency was not higher with modification of Fenton oxidation than that with Fenton oxidation.7. The CO $D_{Mn}$ /BO $D_{5}$ Ratio decreased with the time went by. It meant bioresolution increased as time went by. However, after 15 min., the CO $D_{Mn}$ /BO $D_{5}$ Ratio did not decrease any more. 8. In the case of $H_2O$$_2$ Divisiom Dose experiment, the increase of bioresolution was highest at the $H_2O$$_2$ Division dosage Ratio of 3:7.3:7.

• 대한전자공학회논문지
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• 제17권1호
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• pp.23-30
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• 1980

C.T.(전산화 단층 영상 처리) 영상재구성의 경우, 투사되는 광양자(X-ray, positron 등)가 적을 때는 잡음에 의한 효과가 증폭되어 재구성된 화면은 거의 알아 볼 수 없게 된다. 그 경우 화질을 높이깅 nl해서는 재구성 필터를 사영 데이터(projection data)의 신호대잡음비에 따라 수정시켜야 할 필요성이 생긴다. 이 논문에서는 사영 데이터에서 얻은 정보를 사용하여 재구성 필터를 수정하는 방법에 관하여 고찰하고 그에 대한 시뮬레이션을 행하였다. 시뮬레이션의 결과, 이 방법은 재구성 화상에서의 잡음을 줄여, 그 분해능력을 크게 향상시킬 수 있음이 판명되었다. 또한 이 필터를 근사적으로 구현하는 방법에 관하여도 논하고, 그 근사 필터의 회귀적 구성(recursive implementation)의 가능성에 관하여도 언급하였다.

• Preventive Nutrition and Food Science
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• 제11권2호
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• pp.146-154
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• 2006

Structural modification of corn starch by gamma irradiation was evaluated for under dry conditions at varied intensities from 0 to 40 kGy. Under scanning electron microscopy, the granule shape of corn starch was not significantly affected by the irradiation up to 40 kGy. In addition, X-ray diffraction and melting patterns of the irradiated starches were similar to those of the native starch, indicating that crystalline regions in the starch granules were not changed by irradiation. However, the pattern of gel permeation column chromatography showed a significant increase in partial hydrolysis of gamma irradiated starch samples. The degree of polymerization and the paste viscosity of irradiated starch samples dose-dependently decreased significantly with irradiation, and increased solubility and clarity were observed in the irradiated starch solution. In addition, the degree of retrogradation decreased as irradiation dose increased. Irradiation of corn starch has advantages over the ordinary acid or the enzyme hydrolysis modification methods. It does not affect the granular shape and crystalline phase of starch during hydrolysis, and the process can be carried out in dry state.

• 한국재료학회지
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• 제16권6호
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• pp.367-372
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• 2006

Polytetrafluoroethylene (PTFE) surface was modified for improving hydrophilicity by ion irradiation in environmental gas of $N_2$ and $NH_3$, respectively. The water contact angle onto the PTFE surface increased from $104{\circ}$ to over $140{\circ}$ by Ar ion irradiation in $N_2$ gas. In the case of $NH_3$ as environmental gas, there were a slight increase of contact angle from ion dose of $1{\times}10^{15}\;to\;5{\times}10^{15}\;ions/cm^2$, and its dramatic decrease to the value of 35o at the conditions of ion dose higher than $1{\times}10^{16}\;ions/cm^2$. It was found from SEM results that the surface morphology of PTFE was changed into one with filament structure after Ar ion irradiation in $N_2$ gas environments. On the contrary, Ar ion irradiation in $NH_3$ gas condition induced the PTFE surface with network structure. Hydrogen ion irradiation resulted in a little change of PTFE surface morphology, comparing with the case of Ar ion irradiation. The water contact angle of hydrogen ion irradiated PTFE surface in reactive gas decreased with increment of ion dose. Hydrogen ion irradiation could improve hydrophilicity with little change of surface morphology. It might be considered from FT-IR results that the improvement in wettability of PTFE surface by ion irradiation in $N_2$ and $NH_3$ gases could be due to the hydrophilic groups of NHx bonds.

• 한국진공학회지
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• 제8권3B호
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• pp.262-268
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• 1999

Polycarbonate (PC) and Polymethylmethacrylate (PMMA) surface was modified by ion assisted reaction (IAR) technique to obtain the hydrophilic functional groups and improve the wettability. In conditions of ion assisted reaction, ion beam energy was changed from 500 to 1500eV, and ion dose and oxygen gas blown rate were fixed $1\times10^{16}$ ions/$\textrm{cm}^2$ and 4ml/min, respectively. Wetting angle of water on PC and PMMA surface modified by $Ar^+$ ion without blowing oxygen at 4ml/mon showed $5^{\circ}$ and $10^{\circ}$. Changes of wetting angle with oxygen gas and $Ar^+$ ion irradiation were explained by considering formation of hydrophilic group due to a reaction between irradiated polymer chain by energetic ion irradiation and blown oxygen gas. X-ray photoelectron spectroscopy analysis shows that hydrophilic groups such as -C-O, -(C=O)- and -(C=O)-O- are formed on the surface of polymer by chemical interaction. The polymer surface modification using ion assisted reaction only changed the surface physical properties and sept the bulk properties. In comparison with other modification methods, the surface modification by IAR treatment was chemically stable and enhanced the adhesion between metal and polymer surface. The applications of various kinds of polymer surface modification methods, metal and polymer surface. The applications of various kinds of polymer surface modification could be appled to the new materials about hydrophilic surface properties by IAR treatment. The adhesion between metal film and polymer measured by Scotch tape test whether the hydrophilic surfaces could improve the adhesion strength or not.

• 한국통신학회논문지
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• 제38A권11호
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• pp.919-927
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• 2013

본 논문에서는 HDR (high dynamic range) 영상 렌더링을 위한 히스토그램 변형 기법을 이용한 인지기반 톤 맵핑(tone mapping) 기법을 제안한다. HDR 톤 맵핑 알고리듬은 넓은 동적 영역을 갖는 영상을 LDR (low dynamic range) 영상 장치에 표현하기 위해 사용된다. 인간의 시각특성을 이용한 톤 맵핑 알고리듬은 상당히 효과적이지만 고정된 형태의 맵핑 함수를 사용하기 때문에 모든 영상에서 동일한 성능을 얻지 못한다. 제안하는 방법은 인지기반 톤 맵핑 함수와 히스토그램 변형기법을 적용하여 HDR 영상의 동적 영역을 압축한다. 인지기반 톤 맵핑 함수를 이용해서 원 영상의 히스토그램을 제한하고 보상과정을 통해서 적응적인 톤 맵핑 함수를 얻을 수 있다. 이는 화소값에 따라 서로 다른 제약조건들을 사용함으로써 contrast를 향상시킬 뿐만 아니라 원 영상의 디테일도 보존한다. 또한, 히스토그램 변형기법을 사용함으로써 과도한 히스토그램 평활화로 인한 왜곡을 개선할 수 있고, 더욱이 제어파라미터를 이용하여 영상의 contrast를 조정할 수 있다. 시뮬레이션 및 실험을 통해 주관적 및 객관적 성능을 비교하고 기존 방법에 비해 제안한 방법이 우수함을 입증한다.