• 대한방사선치료학회지
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• 제13권1호
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• pp.38-46
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• 2001

Purpose : The aim of this study is to investigate the effect of tissue inhomogeneities when appling to contrast medium among Homogeneous, Batho and ETAR dose calculation method in RTP system. Method and Material : We made customized heterogeneous phantom it filled with water or contrast medium slab. Phantom scan data have taken PQ 5000 (CT scanner, Marconi, USA) and then dose was calculated in 3D RTP (AcQ-Plan, Marconi, USA) depends on dose calculation algorithm (Homogeneous, Batho, ETAR). The dose comparisons were described in terms of 2D isodose distribution, percent depth dose data, effective path length and monitor unit. Also dose distributions were calculated with homogeneous and inhomogeneous correction algorithm, Batho and ETAR, in each patients with different clinical sites. Results : Result indicated that Batho and ETAR method gave rise to percent depth dose deviation $1.5{\sim}2.7\%,\;2.3{\sim}3.5\%$ (6MV, field size $10{\times}10cm^2$) in each status with and without contrast medium. Also show that effective path lengths were more increase in contrast status (23.14 cm) than Non-contrast (22.07 cm) about $4.9\%$ or 10.7 mm (In case Hounsfield Unit 270) and these results were similary showned in each patient with different clinical site that was lung. prostate, liver and brain region. Concliusion : In conclusion we shown that the use of inhomogeneity correction algorithm for dose calculation in status of injected contrast medium can not represent exact dose at GTV region. These results mean that patients will be more irradiated photon beam during radiation therapy.

• 대한방사선치료학회지
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• 제26권2호
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• pp.171-176
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• 2014

목 적 : Lung SABR plan 에서 AAA의 calculation grid를 변화시켜 선량변화를 분석하고 그에 따른 영향을 연구하여 적절한 적용 방안에 대해 고찰한다. 대상 및 방법 : 모든 plan에 이용된 4D CT image는 Brilliance Big Bore CT(Philips, Netherlands)에서 촬영되었으며 10 건의 Lung SABR plan($Eclipse^{TM}$ ver 10.0.42, Varian, the USA)에서 anisotropic analytic algorithm (AAA, ver. 10, Varian Medical Systems, Palo Alto, CA, USA)을 이용하여 각각 1.0, 3.0, 5.0 mm의 calculation grid로 계산하였다. 결 과 : 10 건의 Lung SABR plan에서 1.0 mm calculation grid를 사용한 경우 $V_{98}$이 각각 처방선량의 약 $99.5{\pm}1.5%$ 였으며 Dmin이 각각 처방선량의 약 $92.5{\pm}1.5%$ 였고 Homogeneity Index(HI)는 약 $1.0489{\pm}0.0025$로 나타났다. 3.0 mm calculation grid를 사용한 경우 $V_{98}$이 각각 처방선량의 약 $90{\pm}4.5%$였으며, Dmin이 각각 처방선량의 약 $87.5{\pm}3%$ 였고 HI가 약 $1.07{\pm}1$로 나타났다. 5.0 mm calculation grid를 사용한 경우 $V_{98}$이 각각 처방선량의 약 $63{\pm}15%$ 였으며, Dmin이 각각 처방선량의 약 $83{\pm}4%$ 였고 HI가 약 $1.13{\pm}0.2$로 나타났다. 결 론 : 1.0 mm calculation grid의 계산 시간이 3.0 mm, 5.0 mm 보다 오래 걸렸지만 grid의 간격이 좁을수록 상대적으로 작은 PTV를 갖는 plan의 정확성을 향상시키는 것으로 나타났다. 또한 Lung과 같이 비교적 넓게 퍼져 있으며 밀도가 낮은 장기의 작은 PTV를 치료해야 하는 경우에는 1.0 mm의 calculation grid를 사용하는 것이 좋을 것으로 사료된다.

• Nuclear Engineering and Technology
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• 제56권7호
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• pp.2659-2665
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• 2024

This study proposes an algorithm that combines a Kalman Filter method with effective decay constant correction to improve the accuracy of predicting radiation dose rate distribution during emergencies. The algorithm addresses the limitations of relying solely on measurement data by incorporating calculation data and refining the estimations. The effectiveness of algorithm was assessed using hypothetical test scenarios, which demonstrated a significant improvement in the accuracy of dose rate prediction compared to the model predictions. The estimates generated by the algorithm showed a good agreement with the measured data, and the discrepancies tend to decrease over time. Furthermore, the application of the effective decay constant correction accelerated the reduction of prediction errors. In conclusion, it was confirmed that the combined use of the Kalman filter method and effective decay constant correction is an effective approach to improve the accuracy of dose rate prediction.

• Journal of Radiation Protection and Research
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• 제26권2호
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• pp.93-99
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• 2001

해부학적으로 단순한 수학적인형팬텀의 한계를 극복하기 위한 voxel 머리팬텀을 제작하고 BNCT(Boron Neutron Capture Therapy) 시행 시 선량분포를 계산하였다. 일반목적 몬테칼로 코드인 MCNP4B의 반복구조 알고리즘을 이용하여 voxel 몬테칼로 계산체계를 수립하였고 두 가지 물질로 구성된 예시적 voxel 팬텀과 기하체조합팬텀의 계산값 비교를 통해 계산체계를 검증하였다. 미국 NLM(National Library of Medicine)에서 제공하는 VHP man 인체단층사진에 대한 분할 및 색인작업을 통해 voxel 머리팬텀을 제작하여 AP 및 PA 방향에서 입사하는 넓고 평행한 광자 및 중성자빔에 대한 선량값을 MIRD 팬텀의 계산값과 비교한 결과 중성자빔 AP 방향조사 시 MIRD 팬텀에서는 볼 수 없는 안구로 인한 중성자 감쇠현상을 확인할 수 있었다. 3차원 정밀계산이 필요한 BNCT 시술시 선량분포계산을 위해 뇌 중앙에 직경 5cm의 구형 뇌종양 체적을 정의하고 뇌와 종양의 붕소 함량을 조정하여 10keV 및 40keV 상부입사 중성자에 의한 장기별 흡수선량을 계산한 결과 종양에 $30{\mu}g/g$, 정상세포에 $3{\mu}g/g$의 붕소를 주입한 경우 붕소함량이 없을 때에 비해 2배 가량 큰 선량을 보였다. 본 연구를 통해 voxel몬테칼로기법을 이용한 선량평가체계를 수립하였고 정밀한 선량계산을 필요로 하는 치료방사선분야 선량계산에 실제 인체에 가까운 voxel팬텀의 응용가능성을 제시하였다.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2002년도 Proceedings
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• pp.68-73
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• 2002

In standard teletherapy, a treatment plan is generated with the aid of a treatment planning system, but it is common to perform an independent monitor unit verification calculation (MUVC). In exact analogy, we propose and demonstrate that a simple and accurate MUVC in Intensity Modulated Radiotherapy (IMRT) is possible. We introduce a concept of Modified Clarkson Integration (MCI). In MCI, we exploit the rotational symmetry of scattering to simplify the dose calculation. For dose calculation along a central axis (CAX), we first replace the incident IMRT fluence by an azimuthally averaged fluence. Second, the Clarkson Integration is carried over annular sectors instead of over pie sectors. We wrote a computer code, implementing the MCI technique, in order to perform a MUVC for IMRT purposes. We applied the code to IMRT plans generated by CORVUS. The input to the code consists of CORVUS plan data (e.g., DMLC files, jaw settings, MU for each IMRT field, depth to isocenter for each IMRT field), and the output is dose contribution by individual IMRT field to the isocenter. The code uses measured beam data for Sc, Sp, TPR, (D/Mu)$\_$ref/ and includes effects from MLC transmission, and radiation field offset. On a 266 MHZ desktop computer, the code takes less than 15 sec to calculate a dose. The doses calculated with MCI algorithm agreed within +/- 3% with the doses calculated by CORVUS, which uses a 1cm x 1cm pencil beam in dose calculation. In the present version of MCI, skin contour variations and inhomogeneities were neglected.

• Journal of Radiation Protection and Research
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• 제48권3호
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• pp.117-123
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• 2023

Background: We investigated the impact of 0.35 T magnetic field on dose calculation for non-small cell lung cancer (NSCLC) stereotactic ablative radiotherapy (SABR) in the ViewRay system (ViewRay Inc.), which features a simultaneous use of magnetic resonance imaging (MRI) to guide radiotherapy for an improved targeting of tumors. Materials and Methods: Here, we present a comprehensive analysis of the effects induced by the 0.35 T magnetic field on various characteristics of SABR plans including the plan qualities and dose calculation for the planning target volume, organs at risk, and outer/inner shells. Therefore, two SABR plans were set up, one with a 0.35 T magnetic field applied during radiotherapy and another in the absence of the field. The dosimetric parameters were calculated in both cases, and the plan quality indices were evaluated using a Monte Carlo algorithm based on a treatment planning system. Results and Discussion: Our findings showed no significant impact on dose calculation under the 0.35 T magnetic field for all analyzed parameters. Nonetheless, a significant enhancement in the dose was calculated on the skin surrounding the tumor when the 0.35 T magnetic field was applied during the radiotherapy. This was attributed to the electron return effect, which results from the deviation of the electrons ejected from tissues upon radiation due to Lorentz forces. These returned electrons re-enter the tissues, causing a local dose increase in the calculated dose. Conclusion: The present study highlights the impact of the 0.35 T magnetic field used for MRI in the ViewRay system for NSCLC SABR treatment, especially on the skin surrounding the tumors.

• Journal of Radiation Protection and Research
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• 제24권3호
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• pp.143-154
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• 1999

Panasonic UD-809P 알비도 중성자 열형광선량계를 팬텀에 장착시켜 원자력발전소에서 중성자 개인선량당량을 측정하였다. 측정된 판독값으로부터 Panasonic 사의 사용자 매뉴얼에 제시되어 있는 방법을 이용하여 열중성자와 초열중성자 및 속중성자로 인한 개인선량당량을 평가하였다. 그 결과 열중성자 성분의 비율이 높은 원자력발전소에서는 속중성자로 인한 개인선량당량을 적절하게 평가할 수 없는 것으로 확인되었는데, 이는 열중성자로 인한 알비도 성분이 열형광선량계로 재입사 되는 양이 이론적인 값과 상당한 차이가 나기 때문인 것으로 추정되었다. 따라서 원자력발전소와 같이 열중성자 성분의 비율이 높은 조건에서 속중성자로 인한 중성자 개인선량당량을 평가하기 위하여 중성자 성분을 열중성자와 속중성자로 구분한 새로운 중성자 선량계산 알고리즘을 제안하였으며, 각각의 성분에 대한 개인선량당량과 교정인자, 민감도 인자 평가공식을 유도하였다.

• 한국의학물리학회지:의학물리
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• 제34권2호
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• pp.15-22
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• 2023

This study compared the dose calculated using the electron Monte Carlo (eMC) dose calculation algorithm employing the old version (eMC V13.7) of the Varian Eclipse treatment-planning system (TPS) and its newer version (eMC V16.1). The eMC V16.1 was configured using the same beam data as the eMC V13.7. Beam data measured using the VitalBeam linear accelerator were implemented. A box-shaped water phantom (30×30×30 cm³) was generated in the TPS. Consequently, the TPS with eMC V13.7 and eMC V16.1 calculated the dose to the water phantom delivered by electron beams of various energies with a field size of 10×10 cm². The calculations were repeated while changing the dose-smoothing levels and normalization method. Subsequently, the percentage depth dose and lateral profile of the dose distributions acquired by eMC V13.7 and eMC V16.1 were analyzed. In addition, the dose-volume histogram (DVH) differences between the two versions for the heterogeneous phantom with bone and lung inserted were compared. The doses calculated using eMC V16.1 were similar to those calculated using eMC V13.7 for the homogenous phantoms. However, a DVH difference was observed in the heterogeneous phantom, particularly in the bone material. The dose distribution calculated using eMC V16.1 was comparable to that of eMC V13.7 in the case of homogenous phantoms. The version changes resulted in a different DVH for the heterogeneous phantoms. However, further investigations to assess the DVH differences in patients and experimental validations for eMC V16.1, particularly for heterogeneous geometry, are required.

• 대한방사선기술학회지:방사선기술과학
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• 제45권6호
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• pp.553-560
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• 2022

The purpose of this study is to evaluate the clinical risk according to the applicator heterogeneity, mislocation, and tissue heterogeneity correction through a dose verification program during brachytherapy of cervical cancer. We performed image processing with MATLAB on images acquired with CT simulator. The source was modeled and stochiometric calibration and Monte-Carlo algorithm were applied based on dwell time and location to calculate the dose, and the secondary cancer risk was evaluated in the dose verification program. The result calculated by correcting for applicator and tissue heterogeneity showed a maximum dose of about 25% higher. In the bladder, the difference in excess absolute risk according to the heterogeneity correction was not significant. In the rectum, the difference in excess absolute risk was lower than that calculated by correcting applicator and tissue heterogeneity compared to the water-based calculation. In the femur, the water-based calculation result was the lowest, and the result calculated by correcting the applicator and tissue heterogeneity was 10% higher. A maximum of 14% dose difference occurred when the applicator mislocation was 20 mm in the Z-axis. In a future study, it is expected that a system that can independently verify the treatment plan can be developed by automating the interface between the treatment planning system and the dose verification program.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2002년도 Proceedings
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• pp.291-293
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• 2002

Accurate dose calculation in radiation treatment planning is most important for successful treatment. Since human body is composed of various materials and not an ideal shape, it is not easy to calculate the accurate effective dose in the patients. Many methods have been proposed to solve the inhomogeneity and surface contour problems. Monte Carlo simulations are regarded as the most accurate method, but it is not appropriate for routine planning because it takes so much time. Pencil beam kernel based convolution/superposition methods were also proposed to correct those effects. Nowadays, many commercial treatment planning systems, including Pinnacle and Helax-TMS, have adopted this algorithm as a dose calculation engine. The purpose of this study is to verify the accuracy of the dose calculated from pencil beam kernel based treatment planning system Helax-TMS comparing to Monte Carlo simulations and measurements especially in inhomogeneous region. Home-made inhomogeneous phantom, Helax-TMS ver. 6.0 and Monte Carlo code BEAMnrc and DOSXYZnrc were used in this study. Dose calculation results from TPS and Monte Carlo simulation were verified by measurements. In homogeneous media, the accuracy was acceptable but in inhomogeneous media, the errors were more significant.