• Nuclear Engineering and Technology
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• 제54권4호
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• pp.1414-1420
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• 2022

High dose rate (HDR) brachytherapy treatment planning usually involves optimization methods to deliver uniform dose to the target volume and minimize dose to the healthy tissues. Four optimizations were used to evaluate the high-risk clinical target volume (HRCTV) coverage and organ at risk (OAR). Dose-volume histogram (DVH) and dosimetric parameters were analyzed and evaluated. Better coverage was achieved with PGO (mean CI = 0.95), but there were no significant mean CI differences than GrO (p = 0.03322). Mean EQD₂ doses to HRCTV (D₉₀) were also superior for PGO with no significant mean EQD₂ doses than GrO (p = 0.9410). The mean EQD₂ doses to bladder, rectum, and sigmoid were significantly higher for NO plan than PO, GrO, and PGO. PO significantly reduced the mean EQD₂ doses to bladder, rectum, and sigmoid but compromising the conformity index to HRCTV. PGO was superior in conformity index (CI) and mean EQD₂ doses to HRCTV compared with the GrO plan but not statistically significant. The mean EQD₂ doses to the rectum by PGO plan slightly exceeded the limit from ABS recommendation (mean EQD₂ dose = 78.08 Gy EQD₂). However, PGO can shorten the treatment planning process without compromising the CI and keeping the OARs dose below the tolerance limit.

• Journal of Radiation Protection and Research
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• 제28권2호
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• pp.137-143
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• 2003

Annual radiation dose limit to radiation worker was substantially lowered in Korea by the adoption of 1990 recommendations of the International Commission on Radiation Protection (ICRP 60) in its legislation. On the other hand, radiation management environment in nuclear power plants is getting more worse because of the accumulation of radiation sources inside the system and the frequent need for maintenance according as the operation years of nuclear power plants increase. Therefore, Korea Hydro & Nuclear power Co., Ltd. (KHNP) has established a long-term 10 years plan from 2001 to 2010 for the reduction of radiation dose to workers. The plan is aimed for the reduction of annual dose per unit averaged over 5 years from 0.9 man-Sv in 2001 to 0.75 man-Sv in 2010 by radiation source reduction, equipment/tool improvement or new equipment development for easy maintenance, and the improvement of administration and system.

• Biomolecules & Therapeutics
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• 제12권1호
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• pp.43-48
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• 2004

The present study was carried out to investigate the potential acute toxicity of CKD-602 by a single intravenous dose in Sprague-Dawley rats. Ten males females were used in each test groups: a vehicle control, 34.7, 4l.7, 50.0, 60.0 and 72.0 mg/kg groups, and were given different single intravenous doses of CKD-602 to the test animals. Mortalities, clinical findings, and body weight changes were monitored for the 14-day period following the administration. At the end of l4-day observation period, all animals were sacrificed and complete gross postmortem examinations were performed. One, 1, 2, 8 and 9 cases of deaths occurred in the male dose groups of 34.7, 41.7, 50.0, 60.0 and 72.0 mg/kg, respectively, and 1, 5 and 9 cases in the female dose groups 50.0, 60.0 and 72.0 mg/kg, respectively. An increase in the incidence of clinical signs such as alopecia, skin pallor skin ulcerations, emaciation and change of fecal material was found in the both sexes of all treatment groups. A decrease or Suppression in the body weight was also observed in a dose-dependent manner. In autopsy, male and/or female rats of the treatment groups showed treatment-related gross findings such as splenomegaly, atrophy of the testis, epididymis, seminal vesicles, ovary, uterus and thymus which were dose-dependent in incidence and severity. Based on these results, it was concluded that a single intravenous injection of CKD-602 to rats caused significant toxicities in gastrointestinal, hematopoietic, and reproductive systems. The $LD_{50}$ value was 53.8 (95% confidence limit: 48.5~60.6) mg/kg for males and 60.l (95% confidence limit: 55.3~65.8) mg/kg for females. The $LD_{10}$ value was 39.9 (95% confidence limit: 3l.7~44.8) mg/kg for males and 50.3 (95% confidence limit: 40.6~54.8) mg/kg for females.

• Journal of Radiation Protection and Research
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• 제47권1호
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• pp.1-7
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• 2022

Background: In Japan, new regulations that revise the dose limit for the lens of the eye (hereafter the lens), operational quantities, and measurement positions for the lens dose were enforced in April 2021. Based on the international safety standards, national guidelines, the results of the Radiation Safety Research Promotion Fund of the Nuclear Regulation Authority, and other studies, the Working Group of Radiation Protection Standardization Committee, the Japan Health Physics Society (JHPS) developed a guideline for radiation dose monitoring for the lens. Materials and Methods: The Working Group of the JHPS discussed the criteria of non-uniform exposure and the management criteria set not to exceed the dose limit for the lens. Results and Discussion: In July 2020, the JHPS guideline was published. The guideline consists of three parts: main text, explanations, and 26 examples. In the questions, the corresponding answers were prepared, and specific examples were provided to enable similar cases to be addressed. Conclusion: With the development of the guideline on radiation dose monitoring of the lens, radiation managers and workers will be able to smoothly comply with revised regulations and optimize radiation protection.

• Nuclear Engineering and Technology
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• 제52권9호
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• pp.2085-2091
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• 2020

The license for Kori-1, the first commercial reactor in Busan, Korea, was terminated in June 2017; therefore, preparations are being made for its decommissioning. Because the radioactivity of Bio-shield varies greatly throughout the structure, the doses received by the workers depend on the location, order, and duration of dismantling operations. Thus, a model for evaluating the worker external dose during the dismantling of the Kori-1 bio-shield was developed, and work scenarios for dose assessment were designed. The Dose evaluation code VISIPLAN was used for dose assessment. The dose rate around the bio-shield was evaluated and the level of exposure to the operator was evaluated according to the work scenario. The maximum annual external dose was calculated as 746.86 mSv for a diamond wire saw operator under dry cutting conditions, indicating that appropriate protective measures, such as changing dismantling sequence, remote monitoring, shield installation, and adjustment of work team are necessary for the safe dismantling of the bio-shield. Through these protective measures, it was found that the worker's dose could be below the dose limit.

• Journal of Radiation Protection and Research
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• 제42권4호
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• pp.222-228
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• 2017

Background: On June 18, 2017, Korea's first commercial nuclear reactor, the Kori Nuclear Power Plant No. 1, was permanently suspended, and the capacity of nuclear power generation facilities will be adjusted according to the governments denuclearization policy. In these circumstances, it is necessary to assess the quality of radiation safety management in nuclear power plants in Korea by evaluating the radiation dose associated with them. Materials and Methods: The average annual radiation dose per unit, the annual radiation dose per person, and the annual dose distribution were analyzed using the radiation dose database of nuclear reactors for the last 5 years. The results of our analysis were compared to the specifications of the Nuclear Safety Act and Medical Law in Korea. Results and Discussion: The annual average per unit radiation dose of global major nuclear power generation was 720 man-mSv, while that of Korea's nuclear power plants was 374 manmSv. No workers exceeded 50 mSv per year or 100 mSv in 5 years. The individual radiation dose according to occupational exposure was 0.59 mSv for nuclear workers, 1.77 mSv for non-destructive workers, and 0.8 mSv for diagnostic radiologists. Conclusion: The radiation safety management of nuclear power plants in Korea has achieved the best outcomes worldwide, which is considered to be the result of the as-low-as-reasonably-achievable (ALARA) approach and strict radiation safety management. Moreover, the occupational exposures were also very low.

• Toxicological Research
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• 제18권1호
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• pp.73-77
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• 2002

The single dose toxicity of Hwangiaegongjinbo, an invigorator developed by Korea Medical Science Institute was evaluated in ICR mice and Sprague-Dawley rats. The aqueous solution of freeze-dried powder of Hwangiaegongjinbo or its original solution was once administrated orally to both sexes of mice and rats at dose of 2000 mg/kg, the recommended upper limit dose for acute toxicity. Water was administered to another group as control. after single adminstration, sign of toxicity were observed every hour for the first 6 hours and every day for 14 days. Neither sign그cant toxic sign nor death was observed during the observation period. In addition, no pathological changes were noticed in macroscopic examination at necropsy in those treated group. These results indicated that $LD_{50}$ of Hwangiaegongjinbo is greater than 2000 mg/kg in ICR mice and Sprague-Dawley rats.

• 동국한의학연구소논문집
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• 제11권
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• pp.66-73
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• 2008

Objectives: The study was designed to evaluate the single dose toxicity of modified Bo-yang-Hwan-o-Tang (mBHT) in Sprague-Dawley (SD) rats. Methods: The mBHT was once administrated orally to both sexes of rats at dose 2,000 mg/kg body weight which are the recommended maximum limit dose for acute toxicity. We recorded clinical signs of toxicity, body weight, gross and histological changes in target organs for all rats. Results: Neither significant changes of body weight not death was observed during the observation period in mBHT-administrated rats. Neither significant toxic signs not histopathological changes were shown during the observation period. There were not observed significant gross abnormality between the control and mBHT-administrated rats. Conclusions: These results indicated that the toxicity of mBHT is greater than 2,000 mg/kg body weight in SD rats.

• 방사성폐기물학회지
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• 제21권2호
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• pp.183-191
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• 2023

The potential impact of hypothetical accidents that occur during the immediate and deferred dismantling of the Kori Unit 1 steam generator has been comprehensively evaluated. The evaluation includes determining the inventory of radionuclides in the Steam Generator based on surface contamination measurements, assuming a rate of release for each accident scenario, and applying external and internal exposure dose coefficients to assess the effects of radionuclides on human health. The evaluation also includes calculating the atmospheric dispersion factor using the PAVAN code and analyzing three years of meteorological data from Kori NPP to determine the degree of diffusion of radionuclides in the atmosphere. Overall, the effective dose for residents living in the Exclusion Area Boundary (EAB) of Kori NPP is predicted, an it is found that the maximum level of the dose is 0.034% compared to the annual dose limit of 1 mSv for the general public. This implies that the potential impact of hypothetical accidents on human health discussed above is within acceptable limits.

• 방사성폐기물학회지
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• 제21권2호
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• pp.255-269
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• 2023

Compared to operational wastes, nuclear power plant (NPP) decommissioning wastes are generated in larger quantities within a short time and include diverse types with a wider range of radiation characteristics. Currently used 200 L drums and IP-2 type transport containers are inefficient and restrictive in packaging and transporting decommissioning wastes. Therefore, new packaging and transport containers with greater size, loading weight, and shielding performance have been developed. When transporting radioactive materials, radiological safety should be assessed by reflecting parameters such as the type and quantity of the package, transport route, and transport environment. Thus far, safety evaluations of radioactive waste transport have mainly targeted operational wastes, that have less radioactivity and a smaller amount per transport than decommissioning wastes. Therefore, in this study, the possible radiation effects during the transport from NPP to disposal facilities were evaluated to reflect the characteristics of the newly developed containers and decommissioning wastes. According to the evaluation results, the exposure dose to transport workers, handling workers, and the public was lower than the domestic regulatory limit. In addition, all exposure dose results were confirmed, through sensitivity analysis, to satisfy the evaluation criteria even under circumstances when radioactive materials were released 100% from the container.