• The Journal of Korean Society for Radiation Therapy
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• v.31 no.2
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• pp.25-31
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• 2019

Purpose: Metals induce metal artifact during CT-image for therapy planning, and it occurs images distortion, which affects the volumetric measurement and radiation calculation. In the case of using megavoltage computed tomography(MVCT), the volume of metals can be measured as similar to true volume due to minimal metal artifact outcome. In this study, radiation assessment was conducted by comparing teeth volume from images of kVCT and MVCT of head and neck cancer patients, then assigning to kVCT image to calculate radiation after obtaining the similar volume of true teeth volume from MVCT. Also, formal IR image was able to verify the accuracy of radiation calculation. Material and method: 5 head and neck cancer patients who had intensity-modulated radiation therapy from Radixact^® Series were of the subject in this study. Calculations of radiation when constraining true teeth volume out of kVCT image(A-CT) and when designated specific HU after teeth assigned using MVCT image were compared with formal IR image. Treatment planning was devised at the same constraints and mean dose was measured at the radiation assess points. The points were anterior of the teeth, between PTV and the teeth, the interior of PTV near the teeth, and the teeth where 5cm distance from PTV. Result: A difference of metals volume from kVCT and MVCT image was mean 3.49±2.61cc, maximum 7.43cc. PTV was limited to where the internal teeth were fully contained. The results of PTV dose evaluation showed that the average CI value of the kVCT treatment planning without the artifact correction was 0.86, and the average CI value of the kVCT with the artifact correction using MVCT image was 0.9. Conclusion: When the Treatment Planning was made without correction of metal artifacts, the dose of PTV was underestimated, indicating that dose uncertainty occurred. When the computerized treatment plan was made without correction of metal artifacts, the dose of PTV was underestimated, indicating that dose uncertainty occurred.

• The Journal of Korean Society for Radiation Therapy
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• v.25 no.1
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• pp.1-8
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• 2013

Purpose: A selection of proper energy in treatment planning is very important because of having different dose distribution in body as photon energy. In generally, the low energy photon has been used in intensity-modulated radiation therapy (IMRT) for head and neck (H&N) cancer. The aim of this study was to evaluate the effect of partially used high energy photon at posterior oblique fields on IMRT plan for H&N cancer. Materials and Methods: The study was carried out on 10 patients (nasopharyngeal cancer 5, tonsilar cancer 5) treated with IMRT in Seoul National University Bundang Hospital. CT images were acquired 3 mm of thickness in the same condition and the treatment plan was performed by Eclipse (Ver.7.1, Varian, Palo Alto, USA). Two plans were generated under same planing objectives, dose volume constraints, and eight fields setting: (1) The low energy plan (LEP) created using 6 MV beam alone, (2) the partially used high energy plan (PHEP) created partially using 15 MV beam at two posterior oblique fields with deeper penetration depths, while 6 MV beam was used at the rest of fields. The plans for LEP and PHEP were compared in terms of coverage, conformity index (CI) and homogeneity index (HI) for planning target volume (PTV). For organs at risk (OARs), $D_{mean}$ and $D_{50%}$ were analyzed on both parotid glands and $D_{max}$, $D_{1%}$ for spinal cord were analyzed. Integral dose (ID) and total monitor unit (MU) were compared as addition parameters. For the comparing dose to normal tissue of posterior neck, the posterior-normal tissue volume (P-NTV) was set on the patients respectively. The $D_{mean}$, $V_{20Gy}$ and $V_{25Gy}$ for P-NTV were evaluated by using dose volume histogram (DVH). Results: The dose distributions were similar with regard to coverage, CI and HI for PTV between the LEP and PHEP. No evident difference was observed in the spinal cord. However, the $D_{mean}$, $D_{50%}$ for both parotid gland were slightly reduced by 0.6%, 0.7% in PHEP. The ID was reduced by 1.1% in PHEP, and total MU for PHEP was 1.8% lower than that for LEP. In the P-NTV, the $D_{mean}$, $V_{20Gy}$ and $V_{25Gy}$ of the PHEP were 1.6%, 1.8% and 2.9% lower than those of LEP. Conclusion: Dose to some OARs and a normal tissue, total monitor unit were reduced in IMRT plan with partially used high energy photon. Although these reduction are unclear how have a clinical benefit to patient, application of the partially used high energy photon could improve the overall plan quality of IMRT for head and neck cancer.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4777-4781
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• 2012

Objective: To investigate the relationship between the efficacy and safety of different doses of thalidomide (Thal) plus dexamethasone (Dex) as the initial therapy in elderly patients with newly diagnosed multiple myeloma (MM). Methods: Clinical data of 28 elderly patients with newly diagnosed MM who underwent the TD regimen as the initial therapy were analyzed retrospectively. The patients were divided into two groups according to the maximal sustained dose of Thal: lower dose (group A) and higher dose (group B). The overall response rate (ORR), progression free survival (PFS), overall survival (OS), and adverse events (AES) were compared between the two groups. Results: A total of 28 patients were followed up with a median of 18 months. The ORR was 60.1%. The median response time and PFS were 2.0 and 17.0 months, respectively. The mean sustained dose of Thal in group B was significantly higher than group A (292.9 mg v 180.4 mg, P=0.01). There was no significantly difference in ORR (57.1% v 64.3%, P=1.00) and PFS (9.63months v 17.66 months, P=0.73) between groups A and B. During the follow up, only five patients died (<40%) and, therefore, median OS values were not available. It is estimated, however, that the mean survival time in the two groups was 35.6 and 33.4 months (P>0.05), respectively. All of the patients tolerated the treatment well. The incidence of AES in patients with a grading above 3 in group B was significantly higher than in group A (P=0.033). Conclusions: The TD regimen results in a high response rate and manageable AES as the initial therapy in elderly patients with MM. TD should be considered as the front line regimen for the treatment of elderly patients with MM in areas with financial constraints. The clinical response can be achieved at a low dose Thal with minimal toxicity.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.38A no.11
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• pp.919-927
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• 2013

In this paper, we present a perception-based tone mapping technique using histogram modification for displaying high dynamic range image. HDR (high dynamic range) tone mapping algorithms are used to display HDR image on LDR (low dynamic rnage) devices. Although perception-based tone mapping methods provides better performance, it dose not always produce good results for a wide variety of images. The proposed method reduces dynamic range by using the perception-based tone mapping function and histogram modification. A derivative of perception-based tone mapping function is used as constraint function of histogram and additional compensation process is performed. This method not only improves contrast by adopting different constraints on each pixel value, but also preserves more visual details. In order to prevent over enhancement, histogram modification technique is applied. Furthermore, it can control the rate of image contrast using control parameters. Subjective and objective evaluations show that proposed algorithm is better than existing algorithms.

• Proceedings of the Korea Information Processing Society Conference
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• 2014.04a
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• pp.807-810
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• 2014

로봇 시스템의 제어 및 이를 이용한 환경 인식에는 많은 전자 광학 소자들이 사용되고 있다. 로봇 제어회로에 사용되고 있는 Si CMOS 공정의 CPU, ASIC, FPGA 소자는 고 선량의 감마선에 취약하다. 환경정보 수집용으로 로봇에 탑재되는 CMOS/CCD 카메라의 관측영상에는 고선량 감마선으로 인한 speckle (백색잡음, white noise) 들이 나타나며, 이들이 카메라의 관측성능을 저하시킨다. 후쿠시마 원자력발전소 사고와 같이 원자력시설에서 제어불능의 심각한 사고가 발생되면 고선량 감마선이 방출된다. 이러한 고선량 감마선방출은 사람에 의한 사고수습을 불가능하게 하며, 사고 수습을 위해서는 로봇의 활용이 불가피하다. 그러나, 방출되는 고선량 감마선의 세기(선량율)가 지나치게 높을 경우, 로봇 전자회로가 장애를 일으키기 때문에 로봇의 적절한 임무수행이 가능한 감마선 세기에 대한 고려가 필요하다. 본 논문에서는 고선량 감마선 환경하에서의 로봇 탑재 CCD/CMOS 카메라의 관측 성능을 고려하여 100 Gy/h 를 감마선 선량율 제한조건으로 설정한다. 그리고, 재 가동 승인심사를 받기 위해 일본의 원전 운영자들이 제시한 PWR (가압경수로) 원전의 중대사고 대책 적합성 평가문서에 나타난 노심용융개시 시점의 원자로 격납건물내 감마선 선량율 추이 계산결과를 활용하여 로봇의 대응시간을 계산하였다. 문서 (PDF) 에 표현된 감마선 선량율 추이 그래프를 영상 판독하여, 격납건물내 감마선 선량율이 100 Gy/h 제한조건에 도달하는 시간을 계산하였다. 이를 로봇의 대응시간으로 설정한다.

• Nuclear Engineering and Technology
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• v.55 no.9
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• pp.3150-3163
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• 2023

To improve the performance of blanket: maximizing the tritium breeding rate (TBR) for tritium self-sufficiency, and minimizing the Dose of backplate for radiation protection, most previous studies are based on manual corrections to adjust the blanket structure to achieve optimization design, but it is difficult to find an optimal structure and tends to be trapped by local optimizations as it involves multiphysics field design, which is also inefficient and time-consuming process. The artificial intelligence (AI) maybe is a potential method for the optimization design of the blanket. So, this paper aims to develop an intelligent optimization method based on an improved multi-objective NSGA-III algorithm and an adaptive BP neural network to solve these problems mentioned above. This method has been applied on optimizing the radial arrangement of a conceptual design of CFETR HCSB blanket. Finally, a series of optimal radial arrangements are obtained under the constraints that the temperature of each component of the blanket does not exceed the limit and the radial length remains unchanged, the efficiency of the blanket optimization design is significantly improved. This study will provide a clue and inspiration for the application of artificial intelligence technology in the optimization design of blanket.

• Radiation Oncology Journal
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• v.20 no.1
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• pp.81-90
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• 2002

Purpose : To establish and verify the proper and the practical IMRT (Intensity--modulated radiation therapy) patient QA (Quality Assurance). Materials and Methods : An IMRT QA which consists of 3 steps and 16 items were designed and examined the validity of the program by applying to 9 patients, 12 IMRT cases of various sites. The three step OA program consists of RTP related QA, treatment information flow QA, and a treatment delivery QA procedure. The evaluation of organ constraints, the validity of the point dose, and the dose distribution are major issues in the RTP related QA procedure. The leaf sequence file generation, the evaluation of the MLC control file, the comparison of the dry run film, and the IMRT field simulate image were included in the treatment information flow procedure QA. The patient setup QA, the verification of the IMRT treatment fields to the patients, and the examination of the data in the Record & Verify system make up the treatment delivery QA procedure. Results : The point dose measurement results of 10 cases showed good agreement with the RTP calculation within $3\%$. One case showed more than a $3\%$ difference and the other case showed more than $5\%$, which was out side the tolerance level. We could not find any differences of more than 2 mm between the RTP leaf sequence and the dry run film. Film dosimetry and the dose distribution from the phantom plan showed the same tendency, but quantitative analysis was not possible because of the film dosimetry nature. No error had been found from the MLC control file and one mis-registration case was found before treatment. Conclusion : This study shows the usefulness and the necessity of the IMRT patient QA program. The whole procedure of this program should be peformed, especially by institutions that have just started to accumulate experience. But, the program is too complex and time consuming. Therefore, we propose practical and essential QA items for institutions in which the IMRT is performed as a routine procedure.