• 제목/요약/키워드: Dosage strength

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Pharmacoat Coating in an Aqueous System : The Dissolution Behavior and Reduction in Coating Time

  • Sekigawa Fujio;Muto Hiroaki;Araume Kiyoshi
    • Journal of Pharmaceutical Investigation
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    • v.20 no.3
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    • pp.51-76
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    • 1990
  • It is sometimes said lately that the pH of the human gastric juice is significantly different among individuals. Thus, the dissolution behavior of coated solid dosage forms should preferably be independent of the pH of the test solution. With these points as a background, the effect of pH on the dissolution velocity of coated tablets was studied to compare that of Pharmacoat with other gastric soluble film coating materials. Three viscosity types of Pharmacoat have been available(3, 6 and 15cP) until now. the 6cP type has been considered to be the most suitable for a tablet coating amongst the three types. The 3 cP type with a low degree of polymerization, is capable of providing high concentration, but the film strength is so inferior that sometimes cracking of the film may occur. On the other hand, in the case of the 15cP type, high polymer concentration cannot be achieved because of the high dgree of polymerization, and thus it is uneconomical for coating. Now, there is a strong demand to reduce the coating time even when HPMC is used in the 6cP type in order to reduce the coating cost. In order to improve this problem, we have concentrated our attention on reducing the viscosity value of HPMC to an allowable lower limit from 6cP. As a result of this study, it was found that the reduction of the viscosity value to around 4.5cP enabled the use of a higher solution concentration and an incidental shorter coating time without giving any substantial adverse effects on the properties of coated preparations. These experiment results are presented in the later part of this presentation. Based on this study, we have added the viscosity type of 4.5cP as one of the Pharmacoat products as Pharmacoat-645.

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The Effect of Hydrogen Peroxide Bleaching on the Properties of Unbleached Hardwood Kraft Pulp Adsorbed with Birchwood Xylan

  • Li, Lizi;Lee, Sang-Hoon;Lee, Hak-Lae;Youn, Hye-Jung
    • Proceedings of the Korea Technical Association of the Pulp and Paper Industry Conference
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    • 2011.04a
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    • pp.169-169
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    • 2011
  • Xylans are polysaccharides present in large amounts in cell walls of land plants. However, during kraft cooking, a high portion of hemicelluloses including xylans are dissolved in the cooking liquor. In the current trend for a more effective utilization of biomass, attention has been paid to the exploitation of xylans as strength-enhancing additives for paper. It is believed that surface xylan adds flexibility to the cell wall/fiber surface, resulting in stronger fiber-fiber joints or greater contact area between the fibers. Accordingly, there is proposal for a new pulping process involving the extraction of xylan prior to pulping, followed by their re-adsorption on the unbleached pulp. A suitable bleaching process should be employed then, which ought to does not only improve the brightness of the pulp, but also remain the effect of the adsorption of xylan on pulp fibers. The objective of this research was to investigate the impact of hydrogen peroxide bleaching on the properties of unbleached hardwood kraft pulp pretreated with birchwood xylan by measuring optical properties (brightness, post color number, opacity) as well as physical properties (tensile index, tearing index, bulk) of handsheets made from the bleached pulp. In the meantime, the influence of process variables of peroxide bleaching including bleaching temperature, time, initial pH and $MgSO_4$ dosage were studied.

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Physical Properties of Concrete Using Shrinkage Reducing Admixture and Expansive Additive (수축저감제와 팽창재를 혼입한 콘크리트의 물리적 특성)

  • Jung, Yang-Hee;Song, Young-Chan;Kim, Yong-Ro;Han, Hyung-Sub;Kim, Ook-Jong;Lee, Do-Bum
    • Proceedings of the Korea Concrete Institute Conference
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    • 2008.11a
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    • pp.919-922
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    • 2008
  • This paper reports the physical and shrinkage properties of concrete using expansive additive(E) and three shrinkage reducing admixtures(SRA1, 2, 3) in order to reduce shrinkage of concrete. For the properties of fresh concrete, the use of SRA1, 2, 3 results in a increase in fluidity and decrease in the dosage of super plasticizer as much as 0.05$\sim$0.1%. And For the properties of hardened concrete, the use of SRA1, 2, 3 results in a decrease in compressive, tensile and flexural strength slightly. For drying shrinkage properties, the use of SRA3 is the most effective for reduction of shrinkage, and the next best way to reduce shrinkage is combination with expansive additive(E) and shrinkage reducing admixture(SRA) or the using of expansive additive(E).

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Effects of Shrinkage Reducing Agent (SRA) Type and Content on Mechanical Properties of Strain Hardening Cement Composite (SHCC) (수축저감제의 종류 및 혼입률에 따른 변형경화형 시멘트복합체의 역학적 특성)

  • Han, Seung-Ju;Jang, Seok-Joon;Khil, Bae-Su;Choi, Mu-Jin;Yun, Hyun-Do
    • Journal of the Korea Concrete Institute
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    • v.28 no.1
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    • pp.41-48
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    • 2016
  • This research investigates the effects of shrinkage reducing agent (SRA) on the mechanical behavior of strain-hardening cement composite (SHCC). SHCC material with specified compressive strength of 50 MPa was mixed and tested in this study. All SHCC mixes reinforced with volume fraction of 2.2% polyvinyl alcohol (PVA) fiber and test variables are type and dosage of shrinkage reducing agents. The shrinkage reducing materials used in this study are phase change material as the thermal stress reducing materials that have the ability to absorb or release the heat. The effect of SRA was examined based on the change in length caused by shrinkage and hardened mechanical properties, specially compressive, tensile and flexural behaviors, of SHCC material. It was noted that SRA reduces change in length caused by shrinkage at early age. SRA can also improve the tensile and flexural strengths and toughness of SHCC material used in this study.

Characteristics of Removal of Perfluorinated Compounds (PFCs) Using Magnetic Ion Exchange Resin (MIEX®) in Water (자성체 이온교환수지(MIEX®)를 이용한 수중의 과불화화합물(PFCs) 제거 특성)

  • Son, Hee-Jong;Yoom, Hoon-Sik;Kim, Kyung-A;Ryu, Sang-Weoun;Kwon, Ki-Won
    • Journal of Environmental Science International
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    • v.22 no.8
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    • pp.1009-1017
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    • 2013
  • Perfluorooctanoic acid (PFOA) and perfluorooctyl sulfonate (PFOS) is a new persistent organic pollutants of substantial environmental concern. This study investigated the potential of magnetic ion exchange resin (MIEX$^{(R)}$) as the adsorbent for the removal of PFOA and PFOS from Nakdong River water. In our batch experiments, we studied the effect of some parameters (pH, temperature, sulfate concentration) on the removal of PFOA and PFOS. The results of sorption kinetics on MIEX$^{(R)}$ show that it takes 90 min to reach equilibrium but the economical contact time and dosage were 30 min and 10 mL/L. An increase in pH (pH 6~10) leads to a decrease in PFOA (2.0%) and PFOS (3.6%) sorption on MIEX$^{(R)}$. The sorption of both PFOA and PFOS decreases with an increase in ionic strength for sulfate ion (${SO_4}^{2-}$), due to the competition phenomenon. An increase in water temperature ($8^{\circ}C{\sim}28^{\circ}C$) in water leads to a increase in PFOA (2.8%) and PFOS (4.3%) sorption on MIEX$^{(R)}$. Based on the sorption behaviors and characteristics of the adsorbents and adsorbates, ion exchange and hydrophobic interaction were deduced to be involved in the sorption, and hemi-micelles possibly formed in the intraparticle pores.

Effect of Carbon Amino Silica Black Contained Superplasticizer on the Engineering Properties and Chromaticity of Black Color Concrete (카본 아미노 실리카 블랙 기반 고성능 감수제가 블랙 컬러 콘크리트의 공학적 특성 및 발색도에 미치는 영향)

  • Han, Min-Cheol;Hong, Seok-Min
    • Journal of the Korean Recycled Construction Resources Institute
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    • v.1 no.3
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    • pp.181-188
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    • 2013
  • This paper is to investigate experimentally an effect of carbon amino silica black-superplasticizer(CASB-SP)on the engineering properties and chromaticity of black color concrete with 0.45 of W/C(water to cement). CASB-SP and carbon black were applied for pigment of the concrete. To prevent efflorescence of concrete, four different water repellent agents were also applied. As results, it was found that use of CASB-SP increased the slump and air contents. Furthermore, the use of CASB-SP increased the compressive strength. As CASB-SP dosages increased, chromaticity was well developed. For the effect of water repellent agent, the use of epoxy type was effective for protection from efflorescence. Based on test results, it was evaluated that 0.5% of CASB-SP effectively improve the concrete quality as well as enhance the chromaticity with proper dosage.

A Fundamental Study on the Superplasticized Concrete (유동화(流動化)콘크리트에 관한 기초연구(基礎研究))

  • Moon, Han Young
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.2 no.2
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    • pp.47-59
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    • 1982
  • It is well practised in the field of concrete engineering that the effort of improving the low slumped concrete and uplifting the quality of the soft concrete by adopting the superplasticizer. In this paper, an attempt is made to find out the optimum mix design of the superplasticized concrete with an unit weight of cement 400 kg and the range of $19{\pm}1cm$ of slump by variatlng the sand percentage, unit water content and the dosage of superplasticizer. As a result, the author obtained the basic idea on the optimum mix design and strength of superplasticized concrete. On the other hand, it is also considered during the research the method of preventing the slump loss of the superplasticized concrete due to the delayed time after concrete mixing.

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Reinforced fibrous recycled aggregate concrete element subjected to uniaxial tensile loading

  • Hameed, R.;Hasnain, K.;Riaz, M. Rizwan;Khan, Qasim S.;Siddiqi, Zahid A.
    • Advances in concrete construction
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    • v.9 no.2
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    • pp.195-205
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    • 2020
  • In this study, effect of recycled aggregates and polypropylene fibers on the response of conventionally reinforced concrete element subjected to tensile loading in terms of tension stiffening and strain development was experimentally investigated. For this purpose, concrete prisms of 100 × 100 mm cross section and 500 mm length having one central deformed steel re-bar were cast using fibrous and non-fibrous Recycled Aggregate Concrete (RAC) with varying percentages of recycled aggregates (0%, 25%, 50%, 75% and 100%) and tested under uniaxial tensile load. For all fibrous RAC mixes, polypropylene fibers were used at constant dosage of 3.15 kg/㎥. Effect of recycled aggregates and fibers on the compressive strength of concrete was also explored in this study. Through studying tensile load versus global axial deformation of composite and strain development in concrete and steel, it was found that replacement of natural aggregates with recycled aggregates in concrete negatively affected the cracking load, tension stiffening and strain development, and this negative effect was observed to be increased with increasing contents of recycled aggregates in concrete. The results of this study showed that it was possible to minimize the negative effect of recycled aggregates in concrete by the addition of polypropylene fibers. Reinforced concrete element constructed using concrete containing 50% recycled aggregates and polypropylene fibers exhibited cracking behavior, tension stiffening and strain development response almost similar to that of concrete element constructed using natural aggregate concrete without fiber.

Fundamental Study on Applying an Integral TiO2 Solution to Asphalt Pavement (1액형 광촉매를 아스팔트 포장에 적용하기 위한 기초연구)

  • Park, Jaeyoung;Kim, Young;Kim, Hyeok-Jung;Hwang, Yong-Kyung;Lee, Jaejun
    • International Journal of Highway Engineering
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    • v.19 no.1
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    • pp.53-62
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    • 2017
  • PURPOSES : This research was a fundamental study on the application of an integral $TiO_2$ solution to asphalt concrete pavement. The integral $TiO_2$ solution was produced in pilot production equipment; application of the integral $TiO_2$ solution to asphalt pavement was conducted to examine the pollution-reducing capability of photocatalytic compounds such as $TiO_2$. The photocatalytic $TiO_2$ reacted with air pollutants, converting them into small amounts of relatively benign molecules. METHODS : In this study, laboratory experiments were conducted using five various testing methods. Tensile strength ratio (TSR) and British pendulum test (BPT) were conducted in order to evaluate the properties of asphalt pavement subsequent to the integral $TiO_2$ solution coating. In addition, methylene blue testing, a measurement of nitrate on the coated pavement, and nitrogen oxide (NOx) reduction testing were conducted in order to evaluate photocatalytic reaction. Lastly, a UV-A lamp was used as a light source for photocatalytic reactions. RESULTS : Test results indicated no change in the properties of asphalt pavement following the integral $TiO_2$ solution coating. In order to evaluate the performance of asphalt pavement as a function of $TiO_2$, the moisture susceptibility and skid resistance were investigated. The moisture susceptibility and skid resistance satisfied there quirements related to pavement quality and safety specification. Furthermore, the effects of reduction of air pollution were significantly improved as determined via the methylene blue test and NOx reduction test. The $TiO_2$-paved asphalt specimen exhibited approximately 43% reduction of NOx. CONCLUSIONS : This study has suggested that applying $TiO_2$ rarely impacts asphalt pavement performance measures such as moisture susceptibility and skid resistance, and that its application may be a better means of reducing air pollution. Further studies, such as proper $TiO_2$ dosage rates and compatibility with various pavement types, are required to broaden and generalize its application.

Effects of Antioxidant and Thermal Treatment on the Radiation Resistance of Polypropylene (폴리프로필렌의 내방사선성에 미치는 산화방지제와 열처리의 영향)

  • Park Sung Hyun;Kim Hyung-Il;Kang Phil Hyun;Nho Young Chang
    • Polymer(Korea)
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    • v.30 no.1
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    • pp.10-13
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    • 2006
  • The effects of antioxidants and thermal treatment on the radiation resistance of the gamma-ray irradiated polypropylene (PP) were studied. The PP was blended with various antioxidants and was fabricated into a sheet. The PP sheet was irradiated with gamma-ray to a dosage of 25kGy in the nitrogen atmosphere. The differences in both color and mechanical strength were investigated for the gamma-ray irradiated PP depending on the kind and the content of antioxidant. The residual amount of free radical and the variation of oxidation index were investigated for the gramma-ray irradiated PP with thermal treatment after irradiation. The PP having phosphite antioxidant showed little difference in color after gamma-ray irradiation compared with the PP having phenolic or mine antioxidant. Sufficient amount of free radical could be removed from the gamma-ray irradiated PP by the thermal treatment at $130\;^{\circ}C$ for 30 min. Thermally treated PP showed lower oxidation index than the PP without thermal treatment.