• The Korean Journal of Pesticide Science
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• v.10 no.2
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• pp.153-156
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• 2006

As an ongoing research program for the development of environmentally friendly new herbicide, several hydantoin derivatives 5a - 5i possessing amide subgroup were synthesized and shown to have interesting herbicidal activities exhibiting symptoms as Protoporphyrinogen IX oxidase inhibitor under postemergence upland greenhouse screening. Among derivatives tested, compound 5h showed superior herbicidal activity against upland problem weed, digitaria sanguinalis and aeschynomene indica to reference compound fluthiacet-methyl.

• Journal of Korea Port Economic Association
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• v.26 no.1
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• pp.1-19
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• 2010

This paper focuses measuring the efficiency of container yards on container terminals in Busan (Gasungdae, Shinsundae, Gamman, New Gamman, Uam, Gamchon, PNC) and Gwangyang(GICT, KEC, Dongbu, KIT) using Data Envelopment Analysis(DEA) approach. Container terminals in Busan and Gwangyang play an important role in the region's economic development. The results show that Shinsundae was an efficient DMU during the period of 2007 to 2009, while Gamman, New Gamman and PNC were efficient terminals in 2009. The very inefficient terminals were shown to be GICT, KEC, Dongbu and KIT. GICT(2009), KEC(2009), Dongbu(2008-2009), KIT(2009) on Gwangyang Port were found to be relatively the inefficient terminals in terms of the returns to scale. This study also finds that the efficiency of Shinsundae terminal was so high as to be abel to keep its efficiency in spite of the additional increase of the inputs from 2007 to 2009. Gamman terminal was in the decreasing returns to scale in 2009, while the other terminals were in the increasing returns to scale. It means that we are able to improve the efficiency of the Gamman terminal with increasing returns to scale through enlarging the scale.

• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.2
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• pp.38-45
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• 2014

This paper proposes a characterization method based on the reference memory to characterize memory compiler quickly and accurately. In order to maintain the accuracy of the memory complier and to minimize characterization time, the proposed method models the trends of the generated memories by selecting the reference memories after analyzing the timing trends of the memory compiler. To validate the proposed method, we characterized the 110nm memory compiler derived from 130nm memroy compiler. The average error rate of the characteristics of the memories generated by the proposed method and SPICE simulation is lower than ${\pm}0.1%$. Furthermore, we designed memory BIST test chips at 110nm and 180nm processes and the results of the function test show that the yield is 98.8% and 98.3%, respectively. Therefore, the proposed method is useful to characterize the memory compiler.

• The Korean Journal of Pesticide Science
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• v.10 no.3
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• pp.201-209
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• 2006

Antifungal activities of 43 different plant oils were evaluated against different phytopathogenic fungi. Thyme oil showed highest antifungal activity among the tested oils. The major of thyme oil were found to be thymol, carvacrol, bomeol, p-cymene and linalool. Thymol and carvacrol were found to be responsible for thyme's antifungal activity. The spore germination assay was conducted on Alternaria mail and Botrytis cinerea. Thymol and carvacrol strongly inhibited spore germination in the fungi test. In addition, thymol and carvacrol showed a curative effectiveness to gray mold disease on cucumber crop. The antifungal activities of alkylphenol and alkylaniline compounds, which has similar molecular structure to that of thymol or cavacrol, were also tested. It was found that alkylphenol compounds also show higher inhibition to spore germination. Thus, thymol, carvacrol and alkylphenol compounds can be used an potent antifungal agents.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.36 no.4
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• pp.355-360
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• 2012

Cold drawn(CD) bars feature superb surface roughness, dimensional precision, and straightness. They are used in the manufacture of automotive parts and home electrical appliances. Two cross-roll straighteners have been used to manufacture CD bars for these industries. This study investigated the variation of the gap size between the two cross-rolls. It was found that changes in the gap size have a large influence on the residual stress and plastic deformation. Finite element method(FEM) simulations were performed to study the influence of the gap size on the residual stress in CD bars, and experiments were performed to verify the FEM results. The residual stresses were measured with X-ray diffraction in both the axial and the hoop directions.

• Korean Journal of Plant Resources
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• v.18 no.2
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• pp.309-314
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• 2005

This study was carried out to obtain the basic informations on the flowering habit, pollination patterns and seed setting in Hosta plantaginea Aschers. Flowers came out in the night with white color. Almost fertilization seemed to be out by wind in early and full flowering. But bearing pods by insects and fertilization rate by wind were increased by interval of flowering and particular scent slowly decreased in after flowering. Bearing pods and seeds setting rate were $65.0\%,\;40.9\%$ per peduncle after artificial pollination, and also $33.3\%,\;24.3\%$ in natural pollination, respectively. The flowering times was all around seven to eight o'clock at night and optimum temperature for pollination was $25{\sim}28^{\circ}C$.

• Archives of Pharmacal Research
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• v.27 no.2
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• pp.239-245
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• 2004

KR-31543, (2S,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(2 -methyl-2H-tetrazol-5-ylmethyl) amino]-3,4-dihydro-2-dimethoxymethyl-3-hydroxy-2-methyl-2H-1-benzopyran, is a new neuroprotective agent for preventing ischemia-reperfusion damage. This study was performed to identify the metabolic pathway of KR-31543 in human liver microsomes and to characterize cytochrome P450 (CYP) enzymes that are involved in the metabolism of KR-31543. Human liver microsomal incubation of KR-31543 in the presence of NADPH resulted in the formation of two metabolites, M1 and M2. M1 was identified as N-(4-chlorophenyl)-N-(2-methyl-2H-tetrazol-5-ylmethyl)amine on the basis of LC/MS/MS analysis with a synthesized authentic standard, and M2 was suggested to be hydroxy-KR-31543. Correlation analysis between the known CYP enzyme activities and the rates of the formation of M 1 and M2 in the 12 human liver microsomes have showed significant correlations with testosterone 6$\beta$-hydroxylase activity (a marker of CYP3A4). Ketoconazole, a selective inhibitor of CYP3A4, and anti-CYP3A4 monoclonal antibodies potently inhibited both N-hydrolysis and hydroxylation of KR-31543 in human liver microsomes. These results provide evidence that CYP3A4 is the major isozyme responsible for the metabolism of KR-31543 to M1 and M2.

• Journal of IKEEE
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• v.17 no.2
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• pp.208-213
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• 2013

In this paper, we proposed the novel SCR-based ESD protection circuit with high holding voltage for power clamp. In order to increase the holding voltage, the floating p+ and n+ to n-well and p-well, respectively, in the conventional SCR. The resulting increase of the holding voltage of the our proposed ESD circuit enables the high latch-up immunity. The electrical characteristics including ESD robustness of the proposed ESD circuit have been simulated using Synopsys TCAD simulator. According to the simulation result, the proposed device has higher holding voltage of 4.98 V than that of the conventional SCR protection circuit. Moreover, it is confirmed that the device could have the holding voltage of maximum 13.26 V with the size variation of floated diffusion area.

• Archives of Pharmacal Research
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• v.28 no.12
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• pp.1358-1364
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• 2005

In this study, we investigated whether a novel anti-ischemic $K_{ATP}$ opener KR-31378 [(2S,3S,4R)­N'-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2 -methly-2-dimethoxymethly-2H-benzopyran-4-yl)­N'-benzylguanidine] has protective effect against oxidative stress-induced death in heart-derived H9c2 cells. Cell death was induced by BSO, butionine sulfoximine, which inhibits GSH synthesis and subsequently increases reactive oxygen species (ROS) level. Cell death was quantitatively determined by measuring lactate dehydrogenase (LDH) activity and stained by Hoechst 33258. BSO-induced ROS production and mitochondrial membrane potential (MMP) were measured using 2',7'-dichlorofluorescein diacetate oxidation and rhodamine 123, respectively. Both the LDH release and the ROS elevation induced by treatment of H9c2 cells with 10 mM BSO, were significantly decreased by KR-31378. These protective effect and antioxidant effect of KR-31378 appeared to be independent on $K_{ATP}$ channel opening. Cells exposed to BSO showed an early reduction in MMP, and this reduction in MMP was significantly reversed by treatment with KR-31378. Caspase-3 activity in BSO treated H9c2 cells was remarkably increased, and this increased caspase-3 activity was significantly reversed by KR-31378. In conclusion, our results suggest that KR-31378 can produce cardioprotective effect against oxidative stress-induced cell death through antioxidant mechanism.

• Journal of Korea Water Resources Association
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• v.54 no.6
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• pp.381-393
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• 2021

As part of the National Disaster Management Research Institute's Official Development Assistance (ODA) projects for transferring new technologies in the field of disaster-safety management, a flood forecasting and warning system was established in 2019 targeting the Borikhan in the Namxan River Basin in Bolikhamxai Province, Laos. In the target area, which is an ungauged small and medium river basin, observation stations for real-time monitoring of rainfall and runoff and alarm stations were installed, and a software that performs real-time data management and flood forecasting and warning functions was also developed. In order to establish a flood warning standard and develop a nomograph for flood prediction, hydraulic and hydrological analysis was performed based on the 30-year annual maximum daily rainfall data and river morphology survey results in the target area. This paper introduces the process and methodology used in this study, and presents the results of the system's applicability review based on the data observed and collected in 2020 after system installation.