• Structural Engineering and Mechanics
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• v.33 no.1
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• pp.47-66
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• 2009

Radiation damping due to wave propagation in unbounded domains may cause a significant reduction of structural vibrations when excited near resonance. Here a novel matrix-valued algebraic Pad$\acute{e}$-like stiffness formulation in the frequency-domain and a corresponding state equation in the time domain are elaborated for a soil-structure interaction problem with a layered soil excited in a transient manner by a flexible rotor during startup and shutdown. The contribution of radiation damping caused by a soil-layer upon a rigid bedrock is characterized by the corresponding amount of critical damping as it is used in structural dynamics.

• Korean Journal of Computational Design and Engineering
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• v.18 no.3
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• pp.155-166
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• 2013

We present recent human-vehicle interaction (HVI) research conducted in the area of defense and military application. Research topics discussed in this paper include: training simulation for overland navigation tasks; expertise effects in overland navigation performance and scan patterns; pilot's perception and confidence on an overland navigation task; effects of UAV (Unmanned Aerial Vehicle) supervisory control on F-18 formation flight performance in a simulator environment; autonomy balancing in a manned-unmanned teaming (MUT) swarm attack, enabling visual detection of IED (Improvised Explosive Device) indicators through Perceptual Learning Assessment and Training; usability test on DaViTo (Data Visualization Tool); and modeling peripheral vision for moving target search and detection. Diverse and leading HVI study in the defense domain suggests future research direction in other HVI emerging areas such as automotive industry and aviation domain.

• Biomedical Science Letters
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• v.26 no.1
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• pp.47-50
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• 2020

Recently, decades of robust researches on degenerative brain disorder have been highlighted on the interactive connection of gut and brain. In terms of inflammatory cytokine production, others have shown that Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) is involved with Leucine-Rich Repeat Kinase 2 (LRRK2). HEK293T cells were transiently co-transfected with Myc-tagged LRRK2 and Flag-tagged NOD2 and then followed by co-immunoprecipitation assay. In this study, we provide the novel finding of physical protein-protein interaction between NOD2 and LRRK2. G2019S variant has shown stronger interactions against NOD2 than those of wild type LRRK2. In an axis of NOD2-LRRK2 communication, it is believed to pave a new way in the understanding of the bidirectional molecular mechanism of brain disorder, including Parkinson's disease into gut inflammatory disease, including Crohn's disease.

• Coupled systems mechanics
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• v.1 no.1
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• pp.99-113
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• 2012

We present a monolithic semi-implicit algorithm for solving fluid-structure interaction problem at small structural displacements. The algorithm uses one global mesh for the fluid-structure domain obtained by gluing the fluid and structure meshes which are matching on the interface. The continuity of velocity at the interface is automatically satisfied and the continuity of stress does not appear explicitly in the global weak form due to the action and reaction principle. At each time step, we have to solve a monolithic system of unknowns velocity and pressure defined on the global fluid-structure domain. Numerical results are presented.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.5 no.3
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• pp.92-98
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• 2006

In this study, the behavior characteristics of a hydrostatic thrust bearing used in hydraulic equipment was analyzed using a commercial finite element program, ADINA. The solid domain was modeled with the fluid domain simultaneously to solve the fully coupled problem, because this is a problem where a fully coupled analysis is needed in order to model the fluid-structure interaction(FSI). The results such as bearing deformation, stress, film thickness and lifting bearing force were obtained through FSI analysis, and then they were compared with the results calculated from the classical method, a single step sequential analysis. It was found that the result difference between two analyses was increased according to the injection pressure. Therefore, in case of high pressure loading, it is desirable to conduct the FSI analysis to examine the deformation characteristics of a hydrostatic slipper bearing.

• Journal of the Korean Ceramic Society
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• v.53 no.3
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• pp.312-316
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• 2016

The energetics of defects in the presence of domain walls in $LiNbO_3$ are characterized using density-functional theory calculations. Domain walls show stronger interactions with antisite defects than with interstitial defects or vacancies. As a result, antisite defects act as a strong pinning center for the domain wall in $LiNbO_3$. Analysis of migration behavior of the antisite defects across the domain wall shows that the migration barrier of the antisite defects is significantly high, such that the migration of antisite defects across the domain wall is energetically not preferable. However, further study on excess electrons shows that the migration barrier of antisite defects can be lowered by changing the charge states of the antisite defects. So, excess electrons can enhance the migration of antisite defects and thus facilitate domain wall movement by weakening the pinning effect.

• BMB Reports
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• v.32 no.4
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• pp.405-408
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• 1999

The transactivation potential of HIV-1 Vpu was identified from the yeast two-hybrid screening process. The helix II domain of HIV-1 Vpu protein and mutant Vpu protein lacking the transmembrane domain exhibited transactivation of the LacZ and Leu2 reporter genes carrying LexA upstream activating sequences, but full-length HIV-1 Vpu and the helix I domain of HIV-1 Vpu did not. The helix II domain of HIV-1 Vpu consists of a number of acidic amino acids, and is especially rich in glutamic acid, a characteristic of many transcription factors. This result suggests that protein-protein interaction may occur through the acidic helix II domain of HIV-1 Vpu.

• Journal of Photoscience
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• v.7 no.3
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• pp.79-86
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• 2000

Phytochromes are red and far-red light absorbing photoreceptors for photomorphogenesis in plants. The red/far wavelength reversible biliproteins are made up of two structural domains. The light-perceiving function of the photoreceptor resides in the N-terminal domain, whereas the signal transducing regulatory function is located within the C-terminal domain. The characteristic role of the phytochromes as phtosensory molecular switches is derived from the phototransformation between two distinct spectral forms, the red light absorbing Pr and the far-red light absorbing Pfr forms. The photoinduced Pr Pfr phototransformation accompanies subtle conformational changes throughout the phytochrome molecule. The conformational signals are subsequently transmitted to the C-terminal domain through various inter-domain crosstalks and induce the interaction of the activated C-terminal domain with phytochrome interacting factors. Thus the inter-domain crosstalks play critical roles in the photoactivation of the phytochromes. Posttranslational modifications, such as the phosphorylation of Ser-598, are also involved in this process through conformational changes and by modulating inter-domain signaling.

• Proceedings of the Microbiological Society of Korea Conference
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• 2002.10a
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• pp.159-161
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• 2002

Bacteriophage lambda integrase carries out the site-specific recombination of lambda. Integrase contains two DNA binding domains with distinct sequence specificity, namely arm-type binding and core-type binding domains. The amino-terminal arm-binding domain is structurally related to the three-stranded $\beta-sheet$ family of DNA-binding domains. Integrase binding to the high affinity arm-type site by the amino-terminal domain facilitates Int binding to the low affinity core-type site, where the cleavage and strand exchange occurs. The amino-terminal domain of Int also modulates the core-binding and catalysis through intramolecular domain-domain interaction and/or intermolecular interactions between Int monomers. In addition, the amino-terminal domain interacts cooperatively with excisionase during excision. This indicates that amino-terminal domain of Int plays an important role in formation of proper higher-order nucleoprotein structure required for lambda site-specific recombination.

• Journal of The Korean Association For Science Education
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• v.33 no.7
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• pp.1450-1470
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• 2013

The purpose of this study was to develop elementary science programs that used multi-level instruction and to analyze verbal interaction patterns in science classes that applied these programs. For this study, the 27 children from the fifth grade at B elementary school, located in Gyeonggi-do, were selected and separated into heterogeneous groups of four students. Verbal interactions occuring in two groups during each class were recorded using video. Elementary science programs using multi-level instruction were developed to target a fifth grade second semester 'Lesson 1. Human Body'. This program provided a mission form for each group and evaluation form for each child. A mission form depending on the children's level has different colors and levels of difficulty for questions. The evaluation form is composed of questions suitable for a child's level in reaching the goal with key concepts. The verbal interaction was mostly categorized into the cognitive domain and the affective domain for analysis. The cognitive domain was subdivided into question, response, making solution, receiving opinion, and the affective domain was divided into behavioral participation and students' attitude. Results of study showed that the frequency of the cognitive domain was higher than the frequency of the affective domain. In the cognitive domain, the median-level was of highest frequency in the children. In the affective domain, high-level was of highest frequency in the children. In terms of both the cognitive and affective domains of children, low-level exhibited the lowest frequency. Verbal interaction frequency was no difference between high-level and median level in cognitive and affective aspects, so median-level children were actively participating in activities similarly with high-level children. There were more types of interactions question, response, making solution, students' attitude in the median-low level children's verbal interaction than high-median level children's verbal interaction.