• Archives of Pharmacal Research
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• v.23 no.6
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• pp.633-636
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• 2000

Translationally controlled tumor protein (TCTP), also known as IgE-dependent histamine-releasing factor, is a growth-related tumor protein. Although the primary sequence of rat TCTP does not reveal any recognizable $Ca^{2+}$ -binding motif, previous studies have demonstrated that rat TCTP consisting of 172 amino acids is a $Ca^{2+}$ -binding protein. However. the region of TCTP required for $Ca^{2+}$ interaction has not been mapped to the molecule. Here, we reported that the $Ca^{2+}$ binding region of TCTP which was mapped by using a combination of deletion constructs of rat TCTP and $^{45}Ca^{2+}$-overlay assay. was confined to amino acid residues 81-112. This binding domain did not show any peculiar loop of calcium- binding motif such as CaLB domain and EF hand motif and it seems to be constituted of random coil regions neighboring the a helix. Thus, our data confirm that TCTP is a novel family of $Ca^{2+}$ -binding protein.

• Journal of the Korean Society for information Management
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• v.22 no.4 s.58
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• pp.97-109
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• 2005

To build the consistency among different metadata systems and to increase the interoperability of that systems even among different domains, naming rules and glossaries for the data elements are necessary. This study provides discussion of naming and identification of the data element concept, data element, conceptual domain, value domain, and its meta model. This study also describes example naming conventions based on ontology derived from the combination with object, properties, and representation of data elements. The naming principles and rules described in this study use I-R analysis, DC metadata set, and SHOE 1.0 as an example of the scientific documents. This study would be a guideline to build the naming rules of metadata based on ontology in various domains.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2005.09a
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• pp.243-248
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• 2005

도메인 조합에 기반한 단백질 상호작용 예측 기법은 효모와 같은 특정 종에 대하여 우수한예측 정확도를 보이는 것으로 알려졌으나, 인간과 같은 고등 생명체의 단백질에 대한 상호작용 예측을 수행하기 위하여는 여러종에 대한 기법의 적절성검증과 최적의 학습집단 구성 방안에 대한 연구가 선행되어야 한다. 본 논문에서는, 초파리 단백질을 이용한 예측 정확도 검증으로 도메인 조합 기법의 일반화 가능성을 타진 하고 이종간의 상호작용 예측실험 및 정확도 검증을 통하여 비교적 연구가 덜 되어진 종의 단백질 상호작용 예측을 위한 학습집단 구성 방법에 대하여 기술한다. 초파리 실험에서는 10351개의 상호작용이 있는 단백질 쌍 가운데, 80%와 20%를 각각 학습집단 및 실험집단으로 사용하였으며, 상호작용이 없는단백질 쌍의 학습집단은 1배에서 5배까지 변화시키면서 예측 정확도를 관찰하였다. 이 결과77.58%의 민감도와 92.61%의 특이도를 확인하였다. 이종간의 상호작용 예측 실험은 효모, 초파리, 효모, 초파리에 해당하는 학습집단 각각을 바탕으로 Human, Mouse, E. coli, C. elegans 등의 단백질 상호작용 예측을 수행하였다. 실험 곁과 학습집단의 도메인이 실험집단의 도메인과 많이 겹칠수록 높은 정확도를 보여주었으며, 도메인 집단간의 유사도를 나타내기 위해 고안한 Domain Overlapping Rate(DOR) 는 상호작용 예측 정확도의 중요한 요소임을 찾아내었다.

• Structural Engineering and Mechanics
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• v.59 no.6
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• pp.1037-1054
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• 2016

Structural parameter evaluation and external force estimation are two important parts of structural health monitoring. But the structural parameter identification with limited input information is still a challenging problem. A new simultaneous identification method in time domain is proposed in this study to identify the structural parameters and evaluate the external force. Each sampling point in the time history of external force is taken as the unknowns in force evaluation. To reduce the number of unknowns for force evaluation the time domain measurements are divided into several windows. In each time window the structural excitation is decomposed by orthogonal polynomials. The time-variant excitation can be represented approximately by the linear combination of these orthogonal bases. Structural parameters and the coefficients of decomposition are added to the state variable to be identified. The extended Kalman filter (EKF) is augmented and selected as the mathematical tool for the implementation of state variable evaluation. The proposed method is validated numerically with simulation studies of a time-invariant linear structure, a hysteretic nonlinear structure and a time-variant linear shear frame, respectively. Results from the simulation studies indicate that the proposed method is capable of identifying the dynamic load and structural parameters fairly accurately. This method could also identify the time-variant and nonlinear structural parameter even with contaminated incomplete measurement.

• Journal of Life Science
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• v.11 no.2
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• pp.133-137
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• 2001

The molecular taxonomic relationship of nine species in the genus Moniliella Stolk & Dakin and Trichosporonoides Haskins & Spencer and six species of other yea나-like fungi was examined by sequencing analysis of large subunit rDNA D1/D2 variable domain. The fifteeen species fell into two major groups corresponding with their genetic relationships. The nine species of the genus Moniliella and Trichosporonoides were placed at the same cluster. similarity values based on the D1/D2 domain sequences were 45.4-100% among species of genus Moniliella, 45.2-84.4% among genus Trichosporonoides species, and 45.6-90.1% among species of genus Moniliella and Trichosporonoides. Identical sequence similarity was observed between M. suaveolens var. nigra and M. suaveolens. A colse relationship of M. mellis. and M. acetoabutens is observed. The result of this study provided and insight into the genetic origins of genus Moniliella and Trichosporonoides species as well as their genetic relationships. Genus Moniliella and Trichosporonoides are closely related to each other based on sequence analysis of the large subunit rDNA D1/D2 region and we suggest combination of the genus Moniliella and Trichosporonoides to single genus.

• Atmosphere
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• v.22 no.3
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• pp.345-356
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• 2012

The UK Met Office Unified Model at the KMA has been operationally utilized as the next generation numerical prediction system since 2010 after it was first introduced in May, 2008. Researches need to be carried out regarding various physical processes inside the model in order to improve the predictability of the newly introduced Unified Model. We first performed a preliminary experiment for the domain ($170{\times}170$, 10 km, 38 layers) smaller than that of the operating system using the version 7.4 of the UM local model to optimize its physical processes. The result showed that about 7~8% of the improvement ratio was found at each stage by integrating four factors (u, v, th, q), and the final improvement ratio was 25%. Verification was carried out for one month of August, 2008 by applying the optimized combination to the domain identical to the operating system, and the result showed that the precipitation verification score (ETS, equitable threat score) was improved by 9%, approximately.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1994.10a
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• pp.571-576
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• 1994

In recent years, ultrasonic has been widely applied in measurement and industrial fields and its application range has been expanded as a result of continuous research and development. Wire Bonding Machine, an instrument fabricating semi-conductor, makes use of ultrasonic bonding method. In order to improve the currently used wire bonding machine using ultrasonic energy, technical accumulation is needed steadily through development of exciting device of ultrasonic composed of piezoelectic vibrator and horn. This study investigates the design conditions affecting the dynamic characteristics through the theoretical and experimental analysis of piezoelectric vibrator and horn, The study conducts separately the system identification of piezoelectric vibrator in time domain and the modal analysis of horn in frequency domain. In theoretical model, the integrated modeling is conducted via a combination of dynamic identification of piezoelectric vibrator and theoretical analysis of horn. Hence comparison is made for theoretical and experimental results of the dynamic characteristics of the ultrasonic transducer composed of piezoelectric vibrator and horn. Form the results of this study we develop the design technique of ultrasonic transducer using dynamic characteristic analysis and propose the possibility of ultrasonic welding considering the optimal condition of the natural frequency and vibration mode of horn.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.10 no.2
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• pp.180-186
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• 1999

Conformal methods such as staircase approximation and effective medium theory have been used to model arbitrary dielectric surfaces in Cartesian FDTD(finite-difference time-domain) grids. However, the staircase approximation doesn't guarantee accurate results and the effective medium theory cannot be applied for frequency dispersive medium. In this paper, a simple conformal method is introduced for analyzing arbitrary dielectric surfaces. These arbitrarily shaped dielectric surfaces make nonuniformly filled FDTD cells. E(H)-field in a nonuniformly filled FDTD cell is calculated by considering the cell as the combination of two kinds of uniformly filled cells whose material boundaries are normal and parallel to the E(H)-field in the cell. TM scattering from a rotated 2-D dielectric and a ferrite square cylinder is analyzed to show the accuracy of the proposed method.

• Korean Medical Education Review
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• v.24 no.1
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• pp.35-45
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• 2022

Needs for public healthcare have recently increased. This paper proposes education topics for competency development in public healthcare in line with the needs of the times. In Korea, various lifelong education providers have already provided public health-related education. For example, the Research Institute for Health Policy (RIHP) under the Korean Medical Association provided an "executive course for physicians' public health care competencies" in 2019 and 2020. At the end of the course, the RIHP published a comprehensive report, entitled "Curricular development and evaluation for doctors' public healthcare competencies." This article is based on a summary of that report. To develop a curriculum for public healthcare, the RIHP adopted the following methodologies for a needs analysis; reviewing already-existing education subjects, evaluating end-of-course reports, and conducting in-depth focused group interviews and questionnaire surveys with doctors at public healthcare-related institutions. The results from the needs analysis can be categorized into two domains of education topics for public healthcare. The first domain includes education subjects related to the theory and practice of public healthcare, as follows: a general overview, community or population health, organizational administration, planning and evaluation, budget and finance, responses to disasters such as infectious diseases, health policy, and the legal system. The second domain contained education topics related to general professional competencies: leadership, communication, cooperation, teamwork, and professionalism. In conclusion, the curricular content for public healthcare will be an appropriate combination of competencies specific to public healthcare and core competencies for health professionals.

• Journal of Korea Society of Industrial Information Systems
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• v.16 no.4
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• pp.27-35
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• 2011

Multicarrier-Direct Sequence/Code Division Multiple Access(MC-DS/ CDMA) which is a combination of Orthogonal Frequency Division Multiplexing(OFDM) and DS/CDMA has been of significant interest as a means to take such advantages as bandwidth efficiency, high bit rate and robustness against multipath fading. In this paper we study a reduced-complexity multiuser detection aided multirate MC-DS/CDMA with time(T)-domain and frequency(F)-domain spreading. The one- dimensional orthogonal variable spreading factor(1D OVSF) code extracted from 2D OVSF code are used as a spreading code in T/F-domain. The proposed system will use code grouping interference cancellation(CGIC) receiver to reduce Multiuser Interference(MUI). The CGIC receiver uses code grouping by the correlation properties of 1D OVSF code and dose not requires the code information and activity of other user. The multiuser detector with CGIC receiver will be analyzed in Time- and Frequency-domain separately(jointly). The system performance is analytically derived in Additive White Gaussian Noise(AWGN) channel and we also compare the system performance between proposed system and T/F spreaded single(multi) rate multiuser MC-DS/CDMA system. In the computer simulation results, the proposed receiver of demonstrated huge performance improvement over conventional matched filter receiver.