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The Effects of Diltiazem and Pentoxifylline on Apoptosis of Irradiated Rat Salivary Gland (흰쥐 침샘의 방사선조사시 Apoptosis에 대한 Diltiazem과 Pentoxifylline의 효과)

  • Yang, Kwang-Mo;Suh, Hyun-Suk
    • Radiation Oncology Journal
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    • v.16 no.4
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    • pp.367-375
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    • 1998
  • Purpose : Xerostomia is a complication met by almost all patients who have radiotherapy for cancers of head and neck. Many studies for prevention of xerostomia will be necessary. Radiation-induced acute response of salivary glands has been defined as interphase death or apoptosis. Increased intracellular calcium level have an important role in radiation-induced apoptosis. Calcium channel blocker may prevent radiation-induced apoptosis of salivary glands. This study was designed to evaluate the effectiveness of diltiazem known as calcium channel blocker and pentoxifylline with inhibition of inflammatory response on the apoptosis as an acute response of radiation in rat salivary glands. Materials and Methods : Sprague-Dawley rats with about body weight 200-250 g were divided into 5 study groups : control, radiation alone, diltiazem with radiation, pentoxifylline with radiation, and diltiazem and pentoxifylline with radiation. The diltiazen and pentoxifylline were injected intraperitoneally 20 mg/kg and 50 mg/kg, 30 and 20 mimute before irradiation. respectively. Irradiation was given with a 4 MV linear accelerator. The 1600 cGy of radiation was delivered in a single fraction through a single anterior portal encompassing the entire neck. After 24 h of irradiation, rats were sacrificed and parotid and submandibular glands were removed and stained with hematoxylin and eosin. The quantification of apoptosis was performed by microscopic examination of stained tissue sections at a magnification of 200X and the percentage of apoptotic cell was calculated. Results : On parotid glands, the percentage of apoptosis by radiation alone, diltiazem with radiation, pentoxifylline with radiation, and diltiazem and pentoxifylline with radiation were 1.72$\%$ (8.35/486), 0.64$\%$ (2.9/453), 0.23$\%$ (1.2/516), and 0.28$\%$ (1.1/399), respectively. The apoptosis was markedly reduced in the groups receiving drugs compared with groups receivinge, radiation alone (p<0.05). In serous cell of submandibular glands, the percentages of apoptosis of radiation alone, diltiazem with radiation, pentoxifylline with radiation, and diltiazem and pentoxifylline with radiation were 1.94$\%$ (l1/567), 0.34$\%$ (1.9/554), 0.28$\%$ (1.8/637), and 0.22$\%$ (1.3/601), respectively. In the mucus cell of submandibular glands, the percentages of apoptosis were 0.92$\%$ (5.1/552), 0.41$\%$ (2.5/612), 0.29$\%$ (1.3/455), and 0.18$\%$ (1.0/562), respectively. The apoptosis was markedly reduced in the serous glands (p<0.05), but there was no difference in development of apoptosis in each group of mucus gland. Conclusion : These results suggest that radiation-induced apoptosis of serous cells of salivary glands may be decreased by diltiazem and pentoxifylline administration.

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A Seismic Study on Muddy Sediment Deposits in the Northern Shelf of the East China Sea (동중국해 북부대륙붕에 발달한 니질 퇴적체의 탄성파 연구)

  • Choi Dong-Lim;Lee Tae-Hee;Yoo Hae-Soo;Lim Dhong-Il;Huh Sik;Kim Kwang-Hee
    • Economic and Environmental Geology
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    • v.38 no.6 s.175
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    • pp.633-642
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    • 2005
  • We present the sedimentary sequence and distribution pattern of the late Holocene muddy deposits in the northern East China Sea shelf using the high-resolution 'Chirp' profiles. The seismic sedimentary sequence overlying acoustic basement (basal reflector-B) can be divided into two depositional units (Unit 1 and 2) bounded by erosional bounding surface (mid reflector-M). The lower Unit 1 above basal reflector-H is characterized by the acoustically parallel to subparallel reflections and channel-fill facies. The upper Unit 2, up to 7 m in thickness, shows seismically semi-transparent seismic facies and lenticular body form. On the base of sequence stratigraphic concept, these two sediment units have developed during transgression and highstand period, respectively, since the last sea-level lowstand. The transgressive systems tract (Unit 1) lie directly on the sequence boundary (reflector B) that have farmed during the last glacial maximum. The transgressive systems tract in this study consists mostly of complex of delta, fluvial, and tidal deposits within the incised valley estuary system. The maximum flooding surface (reflector M) corresponding to the top surface of transgressive systems tract is obviously characterized by erosional depression. The highstand systems tract (Unit 2) above maximum flooding surface is made up of the mud patch filled with the erosional depression. The high-stand mud deposits showing a circle shape just like a typhoon symbol locates about 140 km off the south of Cheju Island with water depth of $60\~90m$. Coverage area and total sediment volume of the mud deposits are about $3,200km^2$ and $10.7\times10^9\;m^3$, respectively. The origin of the mud patch is interpreted as a result of accumulating suspended sediments derived from the paleo-Yellow and/or Yangtze Rivers. The circular distribution pattern of the mud patch appears to be largely controlled by the presence of cyclonic eddy in the northern East China Sea.

A STUDY OF THE NORMAL & ABNORMAL OCCULSAL PATERNS IN ADULTS USING THE SUPERIMPOSED RUBBER PATTERN METHOD (Superimposed Rubber Pattern법에 의한 성인 정상 및 비정상 교합자의 교합 양상에 관한 연구)

  • Choi, Dae-Gyun;Lee, Sung-Bok;Kwon, Young-Hyuk;Choi, Boo-Byung
    • The Journal of Korean Academy of Prosthodontics
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    • v.33 no.3
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    • pp.467-491
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    • 1995
  • In order to analyze the occlusin of intercuspation with maximun bite force, fifteen healthy adult subjects with the ages 23 to 27 were studied(Group1 ; 5-normal occlusion with Angle's Class1, Group2 ; 5-Angle's Class2 malocclusion, Group3 ; 5-Angle’s Class3 malocclusion). Head Position was fixed with occlusal plane paralleling to horizontal line and occlusal registration r cord was made with polyether rubber impression material(Ramitec, ESPECo. West Germany). After all subject were trained for maximum intercuspation at least 5 times, occlusal registration procedure was repeated for this study. Lower posterior rubber occlusal registration records were sliced with 1mm thickness using precision metal sliding channel(Hitachi Ind. Co., Japan). Gross sectional drawings were traced from occluding view of upper and lower posterior teeth on the rubber slices using digitizer, and superimposed for the determination of each drawing distance(Superimposed Rubber Pattern Method). Based on superimposed rubber pattern drawings, total area of occlusal view, sum of each area of the 5 divided occlusal contact provinces and its ratio, total area and number of occlusal contact area were determined to elucidate occlusal stability in the normal and abnormal occlusion groups. The data were analysed by t-test(p=0.05) to determine statistical significance. The obtained results were as follows : 1. Group1 showed the largest standard area with occlusal view of the lower posterior teeth and Group3 showed the smallest area. There was a significant difference between Group2 and Group3(p=0.025), and Gropu1 was not statistically different for both Group2 and Group3. 2. Means and ratio of the under 2.0mm area(D) and ratio showed $197.49mm^2$, 59.76% in Group1, $188,69mm^2$, 56.10% in Group2, and $174.23mm^2$, 55.76% in Group3. The results that Group1 has the most area/ratio and Group3 has the least area/ratio can be considered Group1 is the most advantageous for masticatory effective area, and Group3 is the least adnantageous. 3. Means and ratio of the under 1.0mm area(C) were $198.96mm^2$, 42.65% in Group1, 123.06$mm^2$, 46.58% in Group2, and $92.24mm^2$, 29.52% in Group3. These data means that Group1 is the most advantageous in terms of masticatory effective area and Group3 is the least. 4. Means and ratio of the under 0.5mm area(B) were $86.68mm^2$, 26.68% in Group1, $62.98mm^2$, 18.71% in Group2, and $36.44mm^2$, 11.66% in Group3. These can also be considered Group1 is the most advantageous for masticatory effective area and occlusal stability. 5. Means and ratio of the under 0.05mm area(A) were $30.92mm^2$, 9.21% in Group1, $14.31mm^2$, 4.25% in Group2, and $7.59mm^2$, 2.43% in Group3. The area ratio of the each subject group was(4.1) : (1.9) : (1)and the data of the under 0.05mm area has the intimate relationship with inter-group and intra-group data/ratio. 6. First molar showed the most occlusal contact points in all subject group and Group1 showed somewhat uniformly distributed occlusal contact point except first premolar. In Group2, all contact point in posterior teeth showed significantly reduced distribution except first molar. Group3 showed evenly distributed contace points in first and second molars.

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Human Impact on Sedimentary Environment of Estuarine Coastal Salt Marches, Southern Coastal Region of Korea Peninsula (인위적 환경변화에 따른 해안지역 퇴적환경의 변화)

  • 박의준
    • Journal of the Korean Geographical Society
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    • v.36 no.2
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    • pp.111-125
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    • 2001
  • An estuary is semi-inclosed inlets, located between terrestrial and marine environment. Since many estuaries along south-western coasts of Korean peninsula were affected by human settlements and activities, significant changes in sedimentation environments have been observed. The research area is divided into three distinct morpho-stratigraphic units: fluvial dominated area(Area1), mixed area(Area 2), tide-dominated area(Area3). The landform of this area has been changed by reclamation and river channel change. Temporal variations affected by dam construction, periodic freshet was iterrupted. Sediments began to continuously accmulate on estuary banks by tide. Meanwhile, because of the continuous but reduced discharge of fresh water, the salinity of estuarine sediments was declined. That processes made vegetated area( Phregmites lonivalvis and Suaeda japonica) to be expanded. It indicates that the magnitude and frequency of geomorphic processes has been significantly changed.

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Development of the Holocene Sediments in Gamak Bay of the South Sea, Korea (남해 가막만의 현생퇴적층 발달특성)

  • Kim, So Ra;Lee, Gwang Soo;Choi, Dong Lim;Kim, Dae Choul;Lee, Tae Hee;Seo, Young Kyo
    • The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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    • v.19 no.2
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    • pp.131-146
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    • 2014
  • High-resolution seismic profiles coupled with sediment sampling were analyzed to investigate the acoustic characters and distribution patterns of the late Holocene sediments in Gamak Bay of the South Sea, Korea. The mean grain size of surficial sediment lies around $6.3{\sim}9.7{\Phi}$. Sediments in the bay consist of silt and clay with progressive decrease toward the inner bay. The seismic sedimentary sequence overlying the acoustic basement can be divided into two sedimentary units (GB I and II) by a prominent mid-reflector (Maximum Flooding Surface; MFS). The acoustic basement occurs at the depth between 20 m and 40 m below the sea-level and deepens gradually southward. The GB I, mostly occupying the channel-fill, is characterized by reflection-free seismic facies. It can be formed as late Transgressive System Tract (TST), interpreted tidal environment deposits. MFS appears at the depth of about 15~28 m below the sea-level and is well defined by even and continuous reflectors on the seismic profile. The GB II overlying MFS is composed of acoustically transparent to semitransparent and parallel internal reflectors. GB II is interpreted as the Highstand System Tract (HST) probably deposited during the last 6,000 yrs when the sea level was close to the present level. Especially, it is though that the GB II was subdivided into two layers (GB II-a and II-b) by a HST-reflector and this was classified by wind, sea water flux, and tidal current.

CASE REPORTS OF TREATMENT OF ERUPTION-DISTURBED MX. FIRST MOLAR BY SURGICAL EXPOSURE (맹출 장애를 가진 상악 제1대구치의 외과적 노출을 이용한 치험례)

  • Seok, Choong-Ki;Nam, Dong-Woo;Kim, Hyun-Jung;Kim, Young-Jin;Nam, Soon-Hyeun
    • Journal of the korean academy of Pediatric Dentistry
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    • v.31 no.1
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    • pp.11-18
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    • 2004
  • The eruption of permanent teeth represents the movement in the alveolar bone before appearance in oral cavity, to the occlusal plane after appearance in oral cavity, and additive movement after reaching th the occlusal plane. Tooth eruption is mostly controlled by genetic signals. The eruption stage is divided to preeruptive alveolar stage, alveolar bone stage, mucosal stage according to the process of growth and development. If the disturbance is occured in any stage of eruption, tooth does not erupt. The cause of eruption disturbance are ectopic position of the tooth germ, obstruction of the eruption path and defects in the follicle or PDL. In the treatment of eruption disturbance, surgical procedures are commonly used. There are three kind of surgical procedure ; surgical exposure, surgical repositioning, surgical exposure and traction Surgical exposure is basic procedure. This involves removal of mucosa, bone, lesion that are surrounding the teeth, dental sac when necessary to maintain a patent channel between the crown and the normal eruptive path into the oral cavity. To ensure this patency, many techniques including cementation of a celluloid crown, packing with gutta-percha or zinc oxide-eugenol, or a surgical pack, are used. When surgical exposure is conducted, operators should not expose any part of cervical root cement and not injure periodontium or root of adjunct tooth. After surgical exposure, tooth should be surrounded by keratinized gingiva. There is direct relationship between the extent of development of pathophysiologic aberrations and the intensity of the manipulative injury inflicted on the tooth by surgical treatment, so operator should consider this thing. In these cases, surgical exposure is conducted on Maxillary 1st milars that have a eruption disturbance and improve the eruption disturbance effectively.

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Estimation of the Freshwater Advection Speed by Improvement of ADCP Post-Processing Method Near the Surface at the Yeongsan Estuary (ADCP 표층유속 자료처리방법 개선을 통한 영산강 하구 표층 방류수 이류속도 산정)

  • Shin, Hyun-Jung;Kang, Kiryong;Lee, Guan-Hong
    • The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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    • v.19 no.3
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    • pp.180-190
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    • 2014
  • It has been customary to exclude top 10-20% of velocity profiles in the Acoustic Doppler Current Profiler (ADCP) measurement due to side lobe effects at the boundary. To better understand the mixing in the Yeongsan estuary, the freshwater advection speed (FAS) was recovered from highly contaminated ADCP data near the surface. The velocity profiles were measured by using ADCP at two stations in the Yeongsan estuary during August 2011: one was located in front of the Yeongsan estuarine dam and the other was deployed near Goha Island. The FAS was recovered from the ADCP data set by applying rigorous post-processing methods and compared with the sediment advection speed (SAS). The SAS was determined by the peak time difference of suspended sediment concentration between two stations in the channel, divided by the distance of two stations. The FAS and the SAS showed very similar value when the freshwater discharge was greater than $2.0{\times}10^7$ ton and the SAS was a bit greater when the freshwater discharge was smaller. Since the FAS was on average about 0.8 m/s greater than the velocity at 0.8 of water depth from the bottom, the net discharge, estimated with recovered FAS and integrated over water depth and tidal cycle, was directed seaward during the high discharge contrary to the onshore direction of the net discharge estimated with 0.8 of water depth from the bottom. Moreover, the velocity shear and Richardson number changed when the FAS was used. Thus, the importance of the true FAS is appreciated in the investigation of the surface layer stability. If currents, temperature and salinity were observed for longer time in the future, it could be possible to more accurately understand the formation and decay of stratification as well as the suspended sediment transport processes.

Studies on the Desertification Combating and Sand Industry Development(IV) - Technology Development for Sanddune Fixation and Sandy Land Conservation in China - (사막화방지(沙漠化防止) 및 방사기술개발(防沙技術開發)에 관한 연구(硏究)(IV) - 중국(中國)의 사구고정(沙丘固定) 및 방사공법분석(防沙工法分析) -)

  • Woo, Bo-Myeong;Lee, Kyung-Joon;Choi, Hyung-Tae;Lee, Sang-Ho;Park, Joo-Won;Wang, Lixian;Zhang, Kebin;Sun, Baoping
    • Journal of Korean Society of Forest Science
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    • v.90 no.3
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    • pp.277-294
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    • 2001
  • This study is aimed to analyze and to evaluate the technology development for sanddune fixation and sandy land conservation in China, resulting from the project of "Studies on the desertification combating and sand industry development". There are various types of sanddunes, including shrub-bunch type, dendritic, honey combed lattice, crescentic, parabolic, pyramid, complex and irregular types, domed, and so on. The height distribution ratios of these sanddunes are 13% of less than 5m, 17% of 6~10m, 18% of 11~25m, 14% of 26~50m, 28% of 51~100m, 10% of more than 100m, and so on. In dry land of China, shifting direction of the sanddune is mainly varying with main direction of wind, but types of shifting sanddunes have many differences in accordance with region, topography, size and shape of sanddunes. The main sanddune fixation technologies could be divided into the bio-ecological measures, physical measures and chemical measures. The bio-ecological measures include such vegetation measures as shrub-grasses measures, sandbreaks between sand dunes, sand fixation shelterblets and establishment of farmland shelterbelts, etc. The physical measures include establishment of high-sanddune stabilization walls and low-sanddune stabilization walls, sanddune fixation levees and coverage method with sediment clay, etc. The chemical measures include fixation-materials spraying and synthetical liquid spraying methods, etc. Besides, irrigation and sand settlement measures, shifting sand trapping channel, ditchsand fixation measures, etc. have been effectively applied.

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Spatial distribution of Benthic Polychaetous Communities in Deugryang Bay, Southern Coast of Korea (득량만 저서다모류군집의 공간분포)

  • Kim, Yong-Hyun;Shin, Hyun-Chool
    • The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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    • v.7 no.1
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    • pp.20-31
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    • 2002
  • This study was carried out to investigate the composition and the distribution of the benthic polychaetous communities in Deugryang Bay, semi-enclosed bays, on the southern coast of Korea and to deduce temporal changes in community with the comparison of the past studies. In Deugryang Bay, benthic polychaetous community structure was investigated on the base of the samples from 98 stations in 1996 and 1997. The main facies of surface sediment was clayey silt. The overall benthic macrofaunal density was 871 ind./m$^{2}$. The density was highest in the middle part of the bay because Musculus senhousia (Bivalvia) and cumaceans (Crustacea) had their highest densities in some stations. Benthic polychaetes were comprised of 100 species with a mean density of 138 ind./m$^{2}$. Their abundances were higher in the inner bay, in the middle bay, and in the mouth of bay, but poor community structures were established in the whole bay. The dominant species over 1.0 percentage were composed of the total 21 species, and they occupied 78.3% of the total abundance of the benthic polychaetes. The most dominant species was Lumbrineris longifolia (9.3%), followed by Eteone longa (7.3%), Heteromastus filifomis (7.1%), Sternaspis scutata (6.1%). From the cluster analysis, the study area could be divided into three station groups. Station group AI was located in the inner bay and in the shallow coastal region, and its most dominant species was Heteromastus filiformis. At the station group AII in the mouth of bay and in some channel region, its most dominant species were Lumbrineris longifolia and Eteone longa. And at the station group B located in middle part of the bay, the most dominant specis was Sternaspis scutata. In comparison with previous studies, the benthic polychaetous community experienced great change in the view of species number, density and dominant species. The dominant species were Sternaspis scutata and Eteone longa, but their densities declined greatly. Instead of these species, Lumbrineris longifolia and Heteromastus filiformis, known as the potential organic enrichment indicator species, appeared to the new dominant species even if their low densities. These facts mean that Deugryang Bay was maintained yet as little organic enriched area compared to other bays on the coast of Korea, but needed some caution of marine environmental management.

Recent Progress in Air-Conditioning and Refrigeration Research: A Review of Papers Published in the Korean Journal of Air-Conditioning and Refrigeration Engineering in 2008 (설비공학 분야의 최근 연구 동향: 2008년 학회지 논문에 대한 종합적 고찰)

  • Han, Hwa-Taik;Choi, Chang-Ho;Lee, Dae-Young;Kim, Seo-Young;Kwon, Yong-Il;Choi, Jong-Min
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
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    • v.21 no.12
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    • pp.715-732
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    • 2009
  • This article reviews the papers published in the Korean Journal of Air-Conditioning and Refrigeration Engineering during 2008. It is intended to understand the status of current research in the areas of heating, cooling, ventilation, sanitation, and indoor environments of buildings and plant facilities. Conclusions are as follows. (1) Research trends in thermal and fluid engineering have been surveyed in the categories of general fluid flow, fluid machinery and piping, new and renewable energy, and fire. Well-developed CFD technologies were widely applied in developing facilities and their systems. New research topics include fire, fuel cell, and solar energy. Research was mainly focused on flow distribution and optimization in the fields of fluid machinery and piping. Topics related to the development of fans and compressors had been popular, but were no longer investigated widely. Research papers on micro heat exchangers using nanofluids and micro pumps were also not presented during this period. There were some studies on thermal reliability and performance in the fields of new and renewable energy. Numerical simulations of smoke ventilation and the spread of fire were the main topics in the field of fire. (2) Research works on heat transfer presented in 2008 have been reviewed in the categories of heat transfer characteristics, industrial heat exchangers, and ground heat exchangers. Research on heat transfer characteristics included thermal transport in cryogenic vessels, dish solar collectors, radiative thermal reflectors, variable conductance heat pipes, and flow condensation and evaporation of refrigerants. In the area of industrial heat exchangers, examined are research on micro-channel plate heat exchangers, liquid cooled cold plates, fin-tube heat exchangers, and frost behavior of heat exchanger fins. Measurements on ground thermal conductivity and on the thermal diffusion characteristics of ground heat exchangers were reported. (3) In the field of refrigeration, many studies were presented on simultaneous heating and cooling heat pump systems. Switching between various operation modes and optimizing the refrigerant charge were considered in this research. Studies of heat pump systems using unutilized energy sources such as sewage water and river water were reported. Evaporative cooling was studied both theoretically and experimentally as a potential alternative to the conventional methods. (4) Research papers on building facilities have been reviewed and divided into studies on heat and cold sources, air conditioning and air cleaning, ventilation, automatic control of heat sources with piping systems, and sound reduction in hydraulic turbine dynamo rooms. In particular, considered were efficient and effective uses of energy resulting in reduced environmental pollution and operating costs. (5) In the field of building environments, many studies focused on health and comfort. Ventilation. system performance was considered to be important in improving indoor air conditions. Due to high oil prices, various tests were planned to examine building energy consumption and to cut life cycle costs.