• Title/Summary/Keyword: Dithiocarbamate Chitosan

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A Study on the Effect of Chitin, Chitosan and Dithiocarbamate Chitosan on the Cadmium Accumulation in Liver of Rats (Chitin 및 Chitosan이 생체내 카드뮴 축적에 미치는 영향 -Chitin, Chitosan 및 Dithiocarbamate Chitosan이 흰쥐 간내 카드뮴 축적에 미치는 영향-)

  • 유일수;류문희;이종섭
    • Journal of Environmental Health Sciences
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    • v.24 no.2
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    • pp.47-56
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    • 1998
  • When rats are exposed to cadmium in their diet, the cadmium accumulates in the liver. This study was carried out to investigate the effect of chitin, chitosan and dithiocarbamate chitosan on the cadmium accumulation in liver of rats. For this experiment, 10 male Sprague-Dawley were used. The experimental groups were divided into four independent groups which were one control group and three experimental groups by cadmium alone treatment or chitin, chitosan and dithiocarbamate chitosan with cadmium. In order to investigate the eliminative effect of chitin, chitosan and dithiocarbamate chitosan on the cadmium accumulation in liver of rats, the cadmium concentration, the metallothionein level and the enzyme activitys were measured. The results obtained revealed the eliminative effect of cadmium in liver of rats by chitin, chitosan and dithiocarbamate chitosan. The effect of chitin on the cadmium elimination was less than that of chitosan and dithiocarbamate chitosan. Also it shows that the eliminative effect of cadmium by dithiocarbamate chitosan was the highest.

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A Study on the Effect of Chitin, Chitosan and Dithiocarbamate Chitosan against Cadmium Accumulation in Liver and Kidney of Catfish (Chitin 및 Chitosan이 생체내 카드뮴 축적에 미치는 영향 -키틴, 키토산 및 Dithiocarbamate Chitosan이 메기 간장과 신장내 카드뮴 축적에 미치는 영향-)

  • 유일수;류문희;신철호
    • Journal of Environmental Health Sciences
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    • v.24 no.3
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    • pp.107-113
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    • 1998
  • This study was performed to investigate the effects of chitin, chitosan and dithiocarbamate chitosan on the cadmium accumulation in liver and kidney of catfish. The experimental groups were divided into four independent groups which were one control group and three experimental groups by cadmium alone treatment or chitin, chitosan and dithiocarbamate chitosan which cadmium. in order to investigate the effects of chitin, chitosan and dithiocarbamate chitosan on the cadmium accumulation in liver and kidney of catfish, the cadmium concentration, the metallothionein level were measured. The results obtained were as follows: 1. The cadmium concentrations in liver and kidney of catfish in cadmium alone treatment group were similar to that of the chitin treatment group, but chitosan and dithiocarbamate chitosan treatment groups were significantly decreased. 2. The metallothionein levels in liver and kidney of catfish alone treatment group were similar to that of the chitin treatment group, but chitosan and dithiocarbamate chitosan treatment groups were significantly increased. In conclusion, this study revealed the effect of chitin, chitosan and dithiocarbamate chitosan against cadmium accumulation in liver and kidney of catfish. It exhibited the highest effect at dithiocarbamate chitosan treatment group.

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A Study on the Effect of Chitin, Chitosan and Dithiocarbamate Chitosan against Cadmium Accumulation in Scapharca subcrenata (키틴 및 키토산이 생체내 카드뮴 축적에 미치는 영향)

  • 유일수;유문희;소진탁
    • The Korean Journal of Malacology
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    • v.13 no.1
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    • pp.65-70
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    • 1997
  • This strdy was performed to investigate the effect of chitin, chitosan and dithiocarbamate chitosan against cadmium accumulation. The Scapharca subcrenata were divided into four independent groups which were one control and three experimintal groups by camium alone treatmint or chitin, chitosan and dithsan and dithiocabamate chitosan which cadmium. Samples were analyzed by Varian 30/40 atomic absorption spectrophotometer. The results obtained were as follows;1. The cadmium concentration in water were isgnificantly decreased in three experimental group compared with that of control group (P<0.05)2. The cadmium concentration in muscle of S. srbcrenata in cadmium alone treatment group were similar to that of the chitin treatmint group, but chitosan and dithiocarbamate chitosan treatmint groups were significantly decreased (P<0.05)In conclusion, this study revealed the effect of chitin chitosan and dithiocarbamate chitosan against cadmium accumulation. It exhibited the highest effect at dithiocarbamate chitosan treatment group.

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A Study on the Effect of Chitin, Chitosan and Dithiocarbamate Chitosan on the Nickel Toxicity in Rat liver

  • Yoo, Il-Sou;Choi, Kyung-Soon;Ryu, Mun-Hee
    • Journal of Environmental Health Sciences
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    • v.34 no.4
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    • pp.285-291
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    • 2008
  • This study was performed to investigate the effects of Chitosan on the nickel poisoning in rats. In the study, 150 male Sprague-Dawley were used. The experimental groups were divided into four: A (30 mg/L nickel), B (30 mg/L nickel+0.2% Chitin, Chitosan and Dithiocarbamate Chitosan), C (30 mg/L nickel+0.4% Chitin, Chitosan and Dithiocarbamate Chitosan), D (30 mg/L nickel+0.8%Chitin, Chitosan and Dithiocarbamate Chitosan). The results were as flows; 1. The nickel concentration in the livers of the control group (A) was $0.153{\sim}0.186\;mg/kg$ but the nickel concentration in the livers of the experimental decreased during the experimental period (P<0.05). 2. Metallothionenin levels in rat liver were $2.77{\sim}3.25\;ug/g$ wet,wt in control group (A), but were $2.89{\sim}3.51\;ug/g$ wet,wt (B), $2.97{\sim}3.62\;ug/g$ wet,wt (C), $2.68{\sim}3.68\;ug/g$ wet,wt (D). Respectively in the experimental groups. The experimental groups were inclined to increase compare to the control group (P<0.05). In conclusion, this study revealed a preventive effect of Chitin, Chitosan and Dithiocarbamate Chitosan against nickel toxicity.

Development of Polymeric Drugs Utilizing Dithiocarbamate Chitosan: Formation and Antimicrobial Activities of Dithiocarbamate Chitosan-Ca(II)-Tetracycline Complex (Dithiocarbamate Chitosan을 Matrix로 이용한 고분자 약물의 개발 : Dithiocarbamate Chitosan-Ca(II)-Tetracycline Complex 의 생성 및 항균성)

  • 김윤택;김영미;한석규;정연진;유종호
    • YAKHAK HOEJI
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    • v.39 no.1
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    • pp.48-54
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    • 1995
  • Coupling of tetracycline(Tc) to dithiocarbamate chitosan(DTCC) via chelate bond was investigated varying reaction time, concentration, temperature, pH, and Ca(II)/Tc ratio. The amount of Tc bound to matrix increased to give a maximum and decreased as the reaction proceeded. The degree and rate of dissociation of Tc complex were affected by the reaction temperature, and pH. By running the reaction at low temperature and pH, the degree of dissociation was greatly diminished. Properties of drug-release from DTCC-Ca(II)-Tc complex were studied by batch- and flow-method and release of Tc and CA(II) by flow method followed nearly zero-order. DTCC-Ca(II)-Tc showed very prolonged antimicrobial activity compared to that of free Tc.

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Development of Polymeric Drugs Utilizing Dithiocarbamate Chitosan: Formation and Antimicrobial Activities of Dithiocarbamate Chitosan-Mg(II)-Tetracycline Complex (디치오카바메이트 키토산을 지지체로 이용한 고분자 약물의 개발 : 디치오카바메이트 키토산-Mg(II)-테트라사이클린 복합체의 생성 및 항균성)

  • 김윤택;유종호;정연진;이정수;김영미
    • YAKHAK HOEJI
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    • v.39 no.4
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    • pp.373-379
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    • 1995
  • Coupling of tetracycline (Tc) to dithiocarbamate chitosan(DTCC) via chelate bond was carried out in the presence of Mg (II) ion by one- and two-bath process. In one-bath process, DTCC was treated with Mg(II)-Tc solution. In two-bath process, DTCC was treated with Mg(II) to produce DTCCMg(II), which was isolated and treated in turn with Tc solution. The effect of pH and temperature on binding of Tc, was investigated varying the pH of the solution from 2.6 to 3.2 at 10 and $30^{\circ}C$. Binding of Tc was not affected greatly by such variations in pH and temperature. Amount of Tc bound to 1 gm of matrix reached to 180 mg. Release of Tc from DTCC-Mg(II)-Tc was investigated by batch and flow method, and the amount of Tc released against time followed by flow method exhibited near linear relationship. DTCC-Mg(II)-Tc showed very prolonged antimicrobial activity compared to that of free Tc when it was tested against Escherichia coli TG-1 and Bacillus subtilis NA-1.

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