YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Development of Polymeric Drugs Utilizing Dithiocarbamate Chitosan: Formation and Antimicrobial Activities of Dithiocarbamate Chitosan-Mg(II)-Tetracycline Complex

디치오카바메이트 키토산을 지지체로 이용한 고분자 약물의 개발 : 디치오카바메이트 키토산-Mg(II)-테트라사이클린 복합체의 생성 및 항균성

  • Published : 1995.08.01
Download PDF
⟨ Previous Next ⟩

Abstract

Coupling of tetracycline (Tc) to dithiocarbamate chitosan(DTCC) via chelate bond was carried out in the presence of Mg (II) ion by one- and two-bath process. In one-bath process, DTCC was treated with Mg(II)-Tc solution. In two-bath process, DTCC was treated with Mg(II) to produce DTCCMg(II), which was isolated and treated in turn with Tc solution. The effect of pH and temperature on binding of Tc, was investigated varying the pH of the solution from 2.6 to 3.2 at 10 and $30^{\circ}C$. Binding of Tc was not affected greatly by such variations in pH and temperature. Amount of Tc bound to 1 gm of matrix reached to 180 mg. Release of Tc from DTCC-Mg(II)-Tc was investigated by batch and flow method, and the amount of Tc released against time followed by flow method exhibited near linear relationship. DTCC-Mg(II)-Tc showed very prolonged antimicrobial activity compared to that of free Tc when it was tested against Escherichia coli TG-1 and Bacillus subtilis NA-1.

Keywords

References

  1. J. Bioact. and Compat. Polym. v.6 no.April Synthetic Polymers with intrinsic anticancer activity Seymour,L.
  2. Bioactive Polymeric Systems Gebelein,C.G.;Carraher,C.E.(ed.)
  3. Anionic Polymeric Drugs Donamura,L.G.;Ottenbreite,R.M.;Vogl,O.(ed.)
  4. Drug Design v.Ⅹ Polymeric Drug Delivery System Kim,S.W.;Peterson,R.V.;Fejica,J.;Ariens,E.J.(ed.)
  5. Proceedings of the controlled Release of Bioactive Materials Symposium Polymers Containing Pendent Insecticides Meyer,W.E.;Lewis,D.H.;Vandemeer,R.K.;Lofgren,C.S.
  6. Controlled Release of Biologically Active Agents Controlled Release Pesticides : Concepts and Realization Neogi,A.N.;Allan,G.G.;Tanguary,A.C.(ed.);Lacey,R.E.(ed.)
  7. J. of Environmental Studies, Pusan National University v.2 Synthesis of dithiocarbamate wool as an absorbent for removal of heavy metals in industrial waste waters Han,S.K.;Kim,J.K.;Kim,Y.M.;Yun,I.
  8. Bulletin of College of Pharmacy v.15 Development of heavy-metal adsorbent utilizing dithiocarbamate wool Han,S.K.;Lee,K.H.;Kim,Y.M.;Yun,I.
  9. Bulletin of College of Pharmacy v.20 Synthesis and metal binding properties of xanthate cotton and cotton fabrics Kim,Y.M.;Lee,K.J.;Han,S.K.
  10. Bulletin of College of Pharmacy v.22 Active insolubilized antibiotics based on cotton xanthate-zirconium complex Kim,Y.M.;Lee,K.J.;Jung,Y.J.
  11. Arch. Pharm. Res. v.12 Development of cotton fabrics with prolonged antimicrobial action Kim,Y.M.;Han,S.K.;Lee,K.J.;Kim,Y.T.
  12. Applied Bioactive Polymeric Materials Development of polymers with anti-infectious properties Jansen,B.;Peters,G.;Schareina,S.;Steinhauser,H.;Schumacher-Perdreau,F.;Pulverer,G.;Charles G. Gebelein;Charles E. Carraher,Jr.;Van R. Foster(ed.)