• Journal of Pharmaceutical Investigation
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• 제36권1호
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• pp.19-22
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• 2006

The pharmacokinetics of nimodipine, following a single 16 mg/kg oral dose, was investigated in rabbits with hepatic failure induced by 0.5 mL/kg (mild), 1.0 mL/kg (moderate) and 2.0 mL/kg (severe) of carbon tetrachloride $(CCl_{4}$ : olive oil = 20 : 80, v/v). The plasma concentrations of nimodipine were determined by a high performance liquid chromatographic assay. The levels of sGOT and sGPT in rabbits with mild $(86.2{\pm}29.0\;and\;98.5{\pm}33.1\;unit/dL)$, moderate $(168.1{\pm}61.2\;and\;196.2{\pm}66.0\;unit/dL)$ and severe $(292.7{\pm}82.2\;and\;314.2{\pm}99.8\;unit/dL)$ hepatic failure were significantly increased compared to the control $(38.0{\pm}10.1\;and\;32.4{\pm}10.2\;unit/dL)$. The area under the plasma concentration-time curve (AUC) of nimodipine was significantly increased in mild $(131.7{\pm}28.1%)$, moderate $(168.8{\pm}32.8%)$ and severe $(204.6{\pm}58.3%)$ carbon tetrachloride-induced hepatic failure rabbits compared to the control (100%) rabbits. The volume of distribution $(V_{d})$ and the total body clearance $(CL_{t})$ of nimodipine were significantly decreased in all hepatic failure groups. The elimination rate constant $(K_{el})$ of nimodipine was significantly decreased in moderate and severe carbon tetrachloride-induced hepatic failure rabbits. There was a correlation between sGOT (y= 1.01x+241, r=0.993) or sGPT (y=0.92x +243, r=0.997) value and the AUC of nimodipine in the rabbits with hepatic failure. These findings suggest that the hepatic metabolism of nimodipine was inhibited by carbon tetrachloride-induced hepatic failure rabbits, resulting in the decrese in $V_{d}$ and $CL_{t}$ of nimodipine in the rabbits with mild, moderate and severe hepatic failure.

• Journal of Astronomy and Space Sciences
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• 제30권1호
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• pp.25-32
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• 2013

We statistically investigated the properties of low-latitude Pi2 pulsations using Bohyun (BOH, Mlat = $29.8^{\circ}$, L = 1.35) ground magnetometer data in 2008. For this 1-year interval, 582 Pi2 events were identified when BOH was in the nightside from 1800 to 0600 local times. We found the following Pi2 characteristics. (1) The occurrence distribution of Pi2s is relatively constant in local times. (2) The Pi2 frequency varies in local times. That is, Pi2 pulsations in postmidnight sector had higher frequency than in premidnight sector. (3) Pi2 power in premidnight sector is stronger than in postmidnight sector. (4) Pi2 frequency has positive correlation with solar wind speed and AE index. (5) Pi2 power has not a clear correlation with solar wind parameters. This indicates that Pi2 power is not controlled by external sources. (6) It is found that the most probable-time between Pi2 onsets is ${\Delta}t$ ~ 37.5 min: This is interpreted to be the period between Pi2 pulsations when they occur cyclically. We suggest that ${\Delta}t$ ~ 37.5 min is the occurrence rate of reconnection of open field lines in the tail lobe.

• Journal of Biosystems Engineering
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• 제42권3호
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• pp.190-198
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• 2017

Purpose: A thin-layer drying equation was developed to analyze the drying processes of soybeans (white and black beans) and investigate drying conditions by verifying the suitability of existing grain drying equations. Methods: The drying rates of domestic soybeans were measured in a drying experiment using air at a constant temperature and humidity. The drying rate of soybeans was measured at two temperatures, 50 and $60^{\circ}C$, and three relative humidities, 30, 40 and 50%. Experimental constants were determined for the selected thin layer drying models (Lewis, Page, Thompson, and moisture diffusion models), which are widely used for predicting the moisture contents of grains, and the suitability of these models was compared. The suitability of each of the four drying equations was verified using their predicted values for white beans as well as the determination coefficient ($R^2$) and the root mean square error (RMSE) of the experiment results. Results: It was found that the Thompson model was the most suitable for white beans with a $R^2$ of 0.97 or greater and RMSE of 0.0508 or less. The Thompson model was also found to be the most suitable for black beans, with a $R^2$ of 0.97 or greater and an RMSE of 0.0308 or less. Conclusions: The Thompson model was the most appropriate prediction drying model for white and black beans. Empirical constants for the Thompson model were developed in accordance with the conditions of drying temperature and relative humidity.

• 한국표면공학회:학술대회논문집
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• 한국표면공학회 2018년도 춘계학술대회 논문집
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• pp.54-54
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• 2018

To optimize the deposition parameters of diamond films, the temperature, pressure, and distance between the filament and the susceptor need to be considered. However, it is difficult to precisely measure and predict the filament and susceptor temperature in relation to the applied power in the hot filament chemical vapor deposition (HFCVD) system. In this study the temperature distribution inside the system was numerically calculated for the applied powers of 12, 14, 16 and 18 kW. The applied power needed to achieve the appropriate temperature at a constant pressure and other conditions was deduced, and applied to actual experimental depositions. The numerical simulation was conducted using the commercial computational fluent dynamics software, ANSYS-FLUENT. To account for radiative heat-transfer in the HFCVD reactor, the discrete ordinate (DO) model was used. The temperatures of the filament surface and the susceptor at different power levels were predicted to be 2512 ~ 2802 K, and 1076 ~ 1198 K, respectively. Based on the numerical calculations, experiments were performed. The simulated temperatures for the filament surface were in good agreement with experimental temperatures measured using a 2-color pyrometer. The results showed that the highest deposition rate and the lowest deposition of non-diamond was obtained at a power of 16 kW.

• 한국전기전자재료학회논문지
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• 제15권2호
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• pp.190-197
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• 2002

In this thesis, ZnO varistors with various formulation, such as A∼E, were fabricated according to ceramic fabrication method. The microstructure, electrical properties, and surge characteristics of ZnO varistors were investigated according to ZnO varistors with various formulation. In the microstructure, A∼E\`s ZnO varistor ceramics sintered at 1130$\^{C}$ was consisted of ZnO grain(ZnO), spinel phase (Zn$\_$2.33/Sb$\_$0.67/O$\_$4/), Bi-rich phase(Bi$_2$O$_3$) and intergranuler phase, wholly. Lightning impulse residual voltage of A, B, C and E\`s ZnO varistors suited standard characteristics, below 12kV at current of 5kA. On the contrary, D\`s ZnO varistor exhibited high residual voltage as high reference voltage. In the accelerated aging test, leakage current and watt loss of B, C and D\`s ZnO varistors increases abruptly with stress time under the first a.c. stress(115$\^{C}$/3.213kV/300h). Consequently, C varistor exhibited a thermal run away. On the contrary, leakage current and watt loss of A and C\`s ZnO varistors which show low initial leakage current exhibited constant characteristics. After high current impulse test, A\`s ZnO varistor has broken the side of varistor but impulse current flowed. On the contrary, E\`s ZnO Varistor exhibited good discharge characteristics which the appearance of varistor was not wrong such as puncture, flashover, creaking and other significant damage. After long duration impulse current test, E\`s ZnO varistor exhibited good discharge characteristics which the appearance of varistor was not wrong such as puncture, flashover, creaking and other significant damage. After high current impulse test and long duration impulse current test, E\`s ZnO varistor exhibited very good characteristics which variation rate of residual voltage is 1.4% before and after test.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 1984년도 학술대회지
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• pp.49-55
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• 1984

미국인삼 1년생근을 재료로 하여 각 온도조건별(-15, 0, 3, 6, 9, 12 및 $15^{\circ}C$)로 120일 이상 온도 처리한 후 온실 조건에 식부하여 성장기간동안 출아 소요일수 및 근중 증가율을 조사하였다. $0^{\circ}C$ 이하와 $9^{\circ}C$ 이상에서도 출아가 되지 않았으며 발아기능 온도 범위내에서는 온도에 따른 출아 소요일은 거의 차이가 없었다. 저장기간이 싹의 후면 타파력 및 휴면타파 종료일로부터 발아일(R = 91)까지의 기간에 큰 영향을 미쳤다. $100{\%}$의 출아를 위해서는 약 1,800시간의 저온 처리가 요구되었다. 720시간의 휴면 타파를 위한 저온 처리를 받은 인삼근의 $15{\%}$가 근관을 형성하였다. 휴면 타파가 출아에 소요되는 총 시간은 저온 처리의 온도와 관계없이 일정하게 거의 125일 (3,000시간) 이었다. 이러한 발견은 인삼재배를 위한 온도 조건을 고려한 적지 판정을 하는데 유용하게 이용될 것이다. 이는 개체군에 따라 휴면 타파를 위한 저온처리 충족요건이 유전적으로 다를 것이라는 사실을 시사해 준다.

• 태양에너지
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• 제12권3호
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• pp.37-46
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• 1992

상변화 물질로 Paraffin wax를 사용한 잠열축열 시스템의 축열성능을 실험을 통하여 조사하였다. 가열유체로는 ethylene glycol을 사용하였고 왁스로의 전열을 위해 열싸이폰을 사용하였다. 왁스의 유효열전도율을 높이기 위해 여러장의 구리망을 왁스에 넣었고 실험은 체적비 2%, 3%, 4%에 대해 유량을 변화시키며 수행하였으며 몇가지 주요결과는 다음과 같다. (1) 구리망은 열전도를 촉진시켜 왁스의 온도를 균일화 하는 역할을 한다. (2) 구리망수의 증가는 열전도를 향상시키는 반면 응해된 왁스의 대류작용을 억제한다. (3) 축열시스템에 최적인 구리망의 수가 존재하며 이 연구에서는 체적비로 나타낼 때 $3{\sim}4%$인 것으로 나타났다.

• 설비공학논문집
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• 제8권1호
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• pp.1-12
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• 1996

In lots of application to heat exchanger systems, closed two-phase thermosyphons are tilted from a horizontal. If the tilt angle, especially, is less than 30$^{\circ}$, the operational performances of thermosyphon are highly dependent on tilt angle. The present study was conducted to better understand such operational behaviors as mech-anni는 of phase change, and flow patterns inside a tilted thermosyphon. For experiment, an ethanol thermosyphon with a 35% of fill charge rate was designed and manufactured, using a copper tube with a diameter 19mm and a length 1500mm. Through a series of test, the tilt angle was kept constant at each of 4 different values in the range 10~25deg. and the heat supply to the evaporator was stepwisely increased up to 30㎾/$m^2$. When a steady state was established to the thermosyphon for each step of thermal loads, the wall temperature distribution and vapor temperature at the condenser were measured. The wall temperature distributions demonstrated a formation of dry patch in the top end zone of the evaporator, with a values of temperature 20~4$0^{\circ}C$ higher than the wetted surface for a moderate heat flux q≒20㎾/$m^2$. Inspite of the presence of hot dry patch, however, the mean values of boiling heat transfer coefficient at the evaporator wall were still in a good agreement with those predicted by Rohsenow's formula, which was based on nucleate boiling. For the condenser, the wall temperatures were practically uniform, and the measured values of condensation heat transfer coefficient were 1.7 times higher than the predicted values obtained from Nusselt's film condensation theory on tilted plate. Using those two expressions, a correlation was formulated as a function of heat flux and tilt angle, to determine the total thermal resistance of a tilted thermosyphon. The correlation formula showed a good agreement with the experimental data within 20%.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제3권5호
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• pp.187-194
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• 2014

전립선암은 전립선에 나타나는 악성 종양이다. 현재 그 발병률이 높아지고 있다. 전립선암의 구조를 가장 정확하게 확인할 수 있는 검사 방법은 MRI를 이용하는 것이나, 그 비용 때문에 모든 환자에게 적용하기는 어려운 실정이다. 그래서 많은 환자들은 가격이 저렴한 초음파검사를 이용하여 전립선암을 진단하고 있다. 전통적으로 의사들은 영상을 눈으로 확인하여 전립선의 경계를 수동으로 분할하였다. 그러나 수동으로 분할하는 과정은 시간이 많이 소요되며, 의사에 따라서 그 경계가 일정하지 않게 얻어진다. 이 문제를 해결하기 위하여 전립선의 자동 분할에 관한 연구가 되었고, 환자들에게 신뢰를 줄 수 있었다. 본 연구는 초음파 전립선 영상에서 전립선의 경계를 분할하는데 평균 형상 모델을 적용하는 것이다. 먼저, 에지 분포를 이용하여 프로브를 찾고, 프로브와 연결된 두 직선을 찾는다. 이 후에 이 정보를 이용하여 전립선 영상 위에 평균 형상을 위치시킨다.

• 약학회지
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• 제56권1호
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• pp.48-54
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• 2012

Enviromental differences in gentamicin pharmacokinetics by using population pharmacokinetic methods were compared with 20 Korean patients and 24 Korean-American appendicitis patients. Two to six blood specimens were collected from all patients at the following times : just before a regularly scheduled infusion and at 0.5 hour after the end of a 0.5 hour infusion. Nonparametric expected maximum (NPEM) algorithm for population modeling was used. The estimated parameters were the elimination rate constant (K), the slope (KS) of the relationship between K versus creatinine clearance ($C_{cr}$), the apparent volume of distribution (V), the slope (VS) of the relationship between V versus weight, gentamicin clearance (CL) and the slope (CS) of the relationship between CL versus $C_{cr}$ and the V. The output includes two marginal probability density function (PDF), means, medians, modes, variance and CV%. The mean K (KS) were $0.402{\pm}0.129\;h^{-1}(0.00486{\pm}0.00197\;[h{\cdot}ml/min/1.73\;m^2]^{-1})$ and $0.411{\pm}0.135\;h^{-1}(0.00475{\pm}0.00180\;[h{\cdot}ml/min/1.73\;m^2]^{-1})$ for Korean and Korean-American populations, respectively. The mean V (VS) were not different at $14.3{\pm}3.6l(0.241{\pm}0.0511l/kg)$ and $15.1{\pm}3.84l(0.239{\pm}0.0492l/kg)$ for Korean and Korean-American populations, respectively (p>0.2). The mean CL (CS) were $5.68{\pm}1.69l/h(0.0714{\pm}0.0222l/kg[h{\cdot}ml/min/1.73\;m^2])$ and $5.70{\pm}1.77l/h(0.0701{\pm}0.0215l/kg[h{\cdot}ml/min/1.73\;m^2])$ for Korean and Korean-American populations, respectively. There were no enviromental differences in gentamicin pharmacokinetics between Korean and Korean-American appendicitis patients.