• 한국임상약학회지
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• 제21권2호
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• pp.74-80
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• 2011

Population pharmacokinetics for gentamicin were compared with 20 Korean patients (14 male and 6 female) and 25 Caucasian appendicitis patients (16 male and 9 female). Two to six blood specimens were collected from all patients at the following times : just before a regularly scheduled infusion and at 0.5 hour after the end of a 0.5 hour infusion. Nonparametric expected maximum(NPEM) algorithm for population modeling was used. The estimated parameters were the elimination rate constant(K), the slope(KS) of the relationship between K versus creatinine clearance(Ccr), the apparent volume of distribution (V), the slope(VS) of the relationship between V versus weight, gentamicin clearance(CL) and the slope(CS) of the relationship between CL versus Ccr and the V. The output includes two marginal probability density function(PDF), means, medians, modes, variance, skewness, kurtosis, and CV%. The mean K(KS) were$0.402{\pm}0.129hr^{-1}$ ($0.00486{\pm}0.00197[hr{\cdot}mL/min/1.73m^2]^{-1}$) and $0.425{\pm}0.137hr^{-1}$($0.00432{\pm}0.00168[hr{\cdot}mL/min/1.73m^2]^{-1}$) for Korean and Caucasian populations, respectively. The mean V(VS) were not different at $14.3{\pm}3.69L$($0.241{\pm}0.0511L/kg$) and $15.8{\pm}4.81L$($0.236{\pm}0.0531L/kg$) for Korean and Caucasian populations, respectively (P>0.2). The mean CL(CS) were $5.68{\pm}1.69L/hr$ ($0.0714{\pm}0.0222L/kg[hr{\cdot}mL/min/1.73m^2]$) and $6.29{\pm}1.84L/hr$ ($0.0629{\pm}0.0189L/kg[hr{\cdot}mL/min/1.73m^2]$) for Korean and Caucasian populations, respectively. There are no differences in gentamicin pharmacokinetics between Korean and Caucasian appendicitis patients.

• Journal of Microbiology and Biotechnology
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• 제26권3호
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• pp.503-510
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• 2016

The accumulation (internal and superficial distribution) of magnesium ions (Mg²⁺) by the green freshwater microalga Chlorella vulgaris (C. vulgaris) was investigated under autotrophic culture in a stirred photobioreactor. The concentrations of the three forms of Mg²⁺ (dissolved, extracellular, and intracellular) were determined with atomic absorption spectroscopy during the course of C. vulgaris growth. The proportions of adsorbed (extracellular) and absorbed (intracellular) Mg²⁺ were quantified. The concentration of the most important pigment in algal cells, chlorophyll a, increased over time in proportion to the increase in the biomass concentration, indicating a constant chlorophyll/biomass ratio during the linear growth phase. The mean-average rate of Mg²⁺ uptake by C. vulgaris grown in a culture medium starting with 16 mg/l of Mg²⁺ concentration was measured. A clear relationship between the biomass concentration and the proportion of the Mg²⁺ removal from the medium was observed. Of the total Mg²⁺ present in the culture medium, 18% was adsorbed on the cell wall and 51% was absorbed by the biomass by the end of the experiment (765 h). Overall, 69% of the initial Mg²⁺ were found to be removed from the medium. This study supported the kinetic model based on a reversible first-order reaction for Mg²⁺ bioaccumulation in C. vulgaris, which was consistent with the experimental data.

• 한국전기전자재료학회논문지
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• 제21권1호
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• pp.12-17
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• 2008

In this paper, an I-V characteristics of bypass diode has been studied by counting the shading effect in photovoltaic module. The shadow induces hot spot phenomenon in PV module due to the increase of resistance in the current path. Two different types of PV module with and without bypass diode were fabricated to expect maximum output power with an increasing shading rate of 5 % on the solar cell. Temperature distribution is also detected by shading the whole solar cell for the outdoor test. From the result, the bypass diode works properly over 60 % of shading per cell with constant output power. Maximum power generation in case of solar cell being totally shaded with bypass diode decreases 41.3 % compared with the one under STC(Standard Test Condition). On the other hand, the maximum output power of the module without bypass diode gradually decreases by showing hot spot phenomenon with the increase of shading ratio on the cell and finally indicates 95.5 % of power loss compared with the output under STC. Finally the module temperature measured increases around $10^{\circ}C$ higher than that under STC due to hot-spots which come from the condition without bypass diode. It has been therefore one of the main reasons for degrading the PV module and shortening the durability of the PV system.

• 한국인터넷방송통신학회논문지
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• 제18권5호
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• pp.203-208
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• 2018

본 논문에서는 지진에 의해 발생 가능한 시설물의 피해 유형 중에서 도시기반시설에 해당하는 전력시설물과 배전시설물을 선정하였고 피해 여부를 산출해내는 방식에 대해 연구를 진행하였다. 피해여부를 산출하기 위해 시설물의 유형과 종류에 따라 취약률을 산출할 수 있는 취약률 곡선 산출식을 적용시켜 피해 규모에 따른 그래프를 산출해 내었다. 산출 결과를 활용하기 위해서 도시기반시설에 지진 발생 상황을 가정하고 지진의 규모와 최대지진가속도에 따른 피해 발생 확률을 취약률 형태로 나타내었다. 또한 산출된 취약률을 정수 형태로 변환하는 방식인 취약률 정량화 방식을 적용시켜 피해 규모에 대한 상수 값을 나타내었다. 본 논문에서 적용한 방식과 같은 연구가 지속될 경우 지진 발생 시 피해를 입는 시설물의 유형을 미리 파악하고 피해를 절감하기 위한 대응을 할 수 있을 것이다.

• Composites Research
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• 제12권6호
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• pp.22-30
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• 1999

$Nb_3Sn$ 복합초전도 테이프는 금속간 화합물로서 다른 초전도 재료에 비하여 임계밀도가 높아 MRI등에 널리 이용되고 있다. 한편 $Nb_3Sn$층은 화합물이므로 bending이나 winding등의 코아 제작시 테이프 도체에 응력이 작용하면 화합물층에 취성으로 인한 크랙이 발생하여 부분적으로 파단이 일어나 임계전류 특성이 열화하며 무응력 상태에 비하여 크게 저하된다. 따라서 이와 같은 $Nb_3Sn$복합초전도 테이프의 실질적인 적용을 위해서는 선재의 제조과정 뿐만 아니라 가동 중에 기계적 응력에 대한$Nb_3Sn$복합 초전도 테이프의 미시적 거동 특성을 필히 이해하여야 할 필요가 있다. 본 연구에서는 음향방출기법(Acoustic Emission)을 이용하여 $Nb_3Sn$ 복합초전도 테이프에 대해서 일정변형속도(constant extension rate)제어로 인장하중이 작용할 경우 발생하는 AE 신호특성과 이에 대응하는 각 화합물층의 미시적 변형거동 특성과의 상관관계를 분석하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7929-7934
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• 2014

Background: The primary objective of this study was to assess the proportion of malignancies in ovarian masses during $1^{st}$ January 2002, to $31^{st}$ December 2011 at the Department of Obstetrics and Gynecology, King Chulalongkorn Memorial Hospital. A secondary objective was to evaluate associations with patients' clinical characteristics and ovarian malignancy proportion and subtypes. Materials and Methods: Retrospective descriptive study analyzed data of ovarian masses larger than 3 centimeters in maximal diameter, from the division of Gynecologic Cyto-Pathology at KCMH. SPSS software version 17 (SPSS, Inc, Chicago, IL, USA) was used. Results: A total number of 6,115 patients were included. Among the total ovarian masses studied, 13.7% were malignant. After the age of sixty, the proportion reached almost 40%. It was also above 20% in women younger than 20 years old. During premenarche period, proportion of ovarian malignancies was 50%. Only 1% of ovarian masses were found to be malignant during the pregnancy and post-partum periods. Parity decreased the probability of ovarian malignancy during postmenopausal years. Period of menopause did not have any impact on this probability. During the first two decades of life, germ cell malignancy dominated. As the age increased, the percentage of surface epithelial-stromal malignancy increased with a peak at the fifth decade. In contrast, malignant sex cord-stromal cell tumors occurred at a constant rate in each age group after the thirties. Conclusions: Proportion of ovarian cancers in each age group, menstrual and pregnancy status are similar. However there are differences in the distribution of ovarian subtypes especially for the surface epithelial-stromal category.

• 약학회지
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• 제41권2호
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• pp.195-202
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• 1997

The purpose of this study was to determine pharmacokinetic parameters of vancomycin using two point calculation(TPC) and Bayesian methods in 16 Korean normal volunteers and 15 g astric cancer patients. Nonparametric expected maximum(NPEM) algorithm for calculation of population pharmacokinetic parameter was used, and these parameters were applied for clinical pharmacokinetic parameters by Bayesian analysis. Vancomycin was administered 1.0g every 12 hrs for 3 days by IV infusion over 60 minutes. The volume of distribution(Vd), elimination rate constant(Kel) and total body clearance(CLt) of vancomycin in normal volunteers using TPC method were $0.34{\pm}0.06 L/kg,\; 0.19{\pm}0.01 hr^{-1}$ and $4.08 {\pm} 0.93 L/hr$, respectively, The Vd, Kel and CLt of vancomycin in gastric cancer patients using TPC method were $0.46 {\pm} 0.06 L/kg, 0.17{\pm}0.02 hr^{-1}$ and $4.84 {\pm} 0.57 L/hr$ respectively. There were significant differences(p<0.05) in Vd. Kel and CLt between normal volunteers and gastric cancer patients. Polpulation pharmacokinetic parameter, the slope(KS) of the relationship beetween Kel versus creatinine Clearance, and the Vd were $0.00157{\pm}0.00029(hr{\cdot}mL/min/1.73m^2)^{-1},\; 0.631 {\pm} 0.0036 L/kg$ in gastric cancer patients using NPEM algorithm respectively. The Vd and Kel were $0.63{\pm}0.005 L/kg, 0.15 {\pm}0.027 hr^{-1}$ for gastric cancer patients using Bayesian method. There were significant differences(p<0.05) in vancomycin pharmacokinetics between Bayesian and TPC methods. It is considered that the population parameter in the patient population is necessary for effective Bayesian method in clinical pharmacy practise.

• 설비공학논문집
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• 제6권3호
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• pp.237-246
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• 1994

Experimental data are reported for charging and collection of NaCl aerosols in the 0.03- to $0.2{\mu}m$-geometric-mean-diameter range in 2-stage parallel-plate electrostatic precipitators. The NaCl aerosols are generated with geometric standard deviation of about 1.74 and particle generation rate of about 10^9 particles/see by the constant output atomizer and injected into the air flow in the clean wind-tunnel. The 2-stage parallel-plate electrostatic precipitator installed in the test section of the wind-tunnel is operated with a positive corona discharge. The NaCl aerosols in the channel flow are sampled and transported to the aerosol particle number concentration measurement system by using the isoaxial sampling and transport system constructed based on the Okazaki and Willeke design. The aerosol particle number concentration measurement system measures the size distribution of submicrometer aerosols by an electrical mobility detection technique. It is confirmed from comparing the measured collection efficiencies in this study and the predicted ones by our previous theoretical analysis that the predicted collection efficiencies agree well with the experimental ones. It is also found from the comparison that below about $0.02{\mu}m$ all particles are not charged and the uncharged particles are not collected, and consequently 2-stage parallel-plate electrostatic precipitators are not suitable for that particle size range.

• 공업화학
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• 제5권3호
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• pp.385-394
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• 1994

세공분포가 서로 다른 두 종류(KHT, X-5)의 ${\gamma}$-알루미나 pellet에 아황산가스를 흡착 제거시킬 경우 반응이 진행되면서 각각의 세공벽에 반응생성층이 형성되어 반응속도 상수($K_v$), 세공률(${\varepsilon}_p$), 유효내부 확산계수($D_e$)의 변화와 세공반경이 줄어들어 세공막힘 현상이 일어나게 된다. 이들 영향을 고려하여 세공분포를 이용한 Random pore model로 최적반응온도 $450^{\circ}C$에서 산화구리의 각 담지농도(4, 6, 8, l0 wt%)와 아황산가스의 농도(1000, 2000ppm)에 대한 전환율을 수학적 모델로부터 계산하였다. 산화구리의 담지농도가 증가할수록 세공내의 유효반응 표면적과 세공률의 감소, 내부확산저항의 증가, 미세세공의 세공막힘 현상으로 전환율은 감소하였다. 총괄 전환율은 ${\gamma}$-알루미나 pallet의 표면 국부 전환율에 크게 의존하였으며 산화구리의 담지농도가 낮고 아황산가스의 농도가 클수록 증가하였다. 반응기에 유입되는 아황산가스의 유속은 반응초기 CuO의 전환율에 영향을 주었고 세공분포가 발달하여 세공율이 큰 ${\gamma}$-알루미나 pellet일수록 전환율은 높게 나타났다.

• 대한기계학회논문집B
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• 제20권12호
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• pp.4013-4026
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• 1996

A numerical simulation has been carried out for the jet impinging on a flat plate and a semi-circular concave surface. In this computation finite volume method was employed to solve the full Navier-Stokes equation based on a non-orthogonal coordinate with non staggered variable arrangement. The standard k-.epsilon. turbulent model and low Reynolds number k-.epsilon. model(Launder-Sharmar model) with Yap's correction were adapted. The accuracy of the numerical calculations were compared with various experimental data reported in the literature and showed good predictions of centerline velocity decay, wall pressure distribution and skin friction. For the jet impingement on a semi-circular concave surface, potential core length was calculated for two different nozzle(round edged nozzle and rectangular edged nozzle) to consider effects of the nozzle shape. The result showed that round edged nozzle had longer potential core length than rectangular edged nozzle for the same condition. Heat transfer rate along the concave surface with constant heat flux was calculated for various nozzle exit to surface distance(H/B) in the condition of same jet velocity. The maximum local Nusselt number at the stagnation point occurred at H/B = 8 where the centerline turbulent intensity had maximum value. The predicted Nusselt number showed good agreement with the experimental data at the stagnation point. However heat transfer predictions along the downstream were underestimated. This results suggest that the improved turbulence modeling is required.