• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.16 no.4
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• pp.254-267
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• 2011

In order to assess structure changes of marine benthic communities in the Youngsan River Estuarine Bay for this 10-year period, we sampled macrobenthos in 2006 using the van Veen grab at the same 40 stations where a previous benthic community survey was conducted in 1995. The number of species and mean density of macrobenthos in 2006 decreased significantly than those of 1995. There were no significant differences in both the number and the density of polychaetous species between the two sampling periods, while both number and den-sity of molluscan species decreased significantly. Although the first two density-dominant species, semelid bivalve Theora fragilis and polychaete Tharyx sp. occurred as most dominant species, but the density of T. fragilis decreased significantly in many stations between 1995 and 2006. However, polychaete Tharyx sp. showed increment in density and percentage composition within community. The area dominated by T. fragilis was replaced by Tharyx sp.. Also, polychaete Poecilochaetus johnsoni and bivalve Raetellops pulchella which were pre-dominant in 1995 decreased significantly by 2006. Bivalve Yoldia johanni decreased its density and reduced its distribution area by 2006. Species diversity and rarefaction curves also revealed that overall species richness decreased. These results confirmed that the dominant species and species diversity of macrobenthic communities in the area should be changed due to anthropogenic stresses during 10 years.

• Economic and Environmental Geology
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• v.41 no.1
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• pp.93-113
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• 2008

This study presents petrochemistry and $^{40}Ar/^{39}Ar$ absolute ages of subsurface volcanic rock cores from twenty(20) boreholes in the eastern lowland (altitude loom below) of Jeju Island, Handeong-Jongdal-Udo-Susan-Samdal-Hacheon areas, and discusses topography and volcanism in the area. The subsurface volcanic rock cores are mainly basalts in composition with minor tholeiitic andesites and basaltic trachyandesites. Sequences of intercalated tholeiitic, transitional and alkalic lavas suggest that tholeiitic and transitional to alkalic lavas must have erupted contemporaneously. Especially, occurrences of trachybasalts and basaltic trachyandesites at the bases in the area imply that the volcanism in the area was initiated with slightly differentiated alkaline magma activity. The $^{40}Ar/^{39}Ar$ absolute ages of the subsurface volcanic rock cores range from $526{\pm}23ka\;to\;38{\pm}4Ka$. The lava-forming Hawaiian volcanic activities of the eastern lowland can be divided into five sequences on the basis of sediment distribution, whole rock geochemistry and $^{40}Ar/^{39}Ar$ absolute ages of the subsurface volcanic rock cores; stage I-U$(550{\sim}400Ka)$, stage II$(400{\sim}300Ka)$ and stage III$(300{\sim}200Ka)$ during syn-depositional stage of Seoguipo Formation, and stage IV$(200{\sim}100Ka)$ and stage V(younger than 100Ka) during post-depositional stage. In the eastern lowland of Jeju Island, compositional variations and local occurrences of the subsurface volcanic rocks as well as existences of various intercalated sediment layers (including hydrovolcanogenic clasts) suggest that the volcanism must have continued for long time intermittently and that the land has been progressively glowed from inland to coast by volcanic activities and sedimentation. It reveals that the subsurface volcanic rocks in the eastern lowland of Jeju Island must have erupted during relatively younger than 200Ka of stages IV and V. The results of this study are partly in contrast with those of previous studies. This study stresses the need that previous reported volcanic activities in Jeju Island based on K-Ar ages of volcanic rocks should be carefully reviewed, and that stratigraphic correlation from boreholes should be conducted by quantitative criteria combined with petrography and petrochemstry as well as radiometric studies of volcanic rock cores.

• Korean Journal of Environmental Biology
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• v.32 no.2
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• pp.138-152
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• 2014

The objective of the study survey was to determine the effect of marine sand extraction on community composition and rate of recolonization of the meiobenthos following cessation of mining activities. Because of meiobenthic distribution in nature, high abundance, intimate association with sediments, fast reproduction, benthic larva period, sensitivity to pollution and rapid life histories, meiobenthos are widely regarded as ideal organisms to study the potential ecological indicator of natural and anthropogenic stresses. The community structure of meiobenthos was studied at seven stations within sandy tidal and sub tidal zones in Jangbongdo in the Yellow Sea, Korea from Aug. 2006 to Dec. 2007. Meiobenthic samples were collected by three core samples, with a 3.6 cm in diameter, from each sediment sample taken with a Smith-McIntyre Grab. It was found that sand mining often causes complete removal of the sediment and the damage to the habitats of meiobenthos. This study in the effect showed that sand mining resulted in a reduction in total abundance and biomass of meiobenthos in mining area. The finding of this study further showed that initial restoration of abundance and biomass within one year of the cessation of sand mining.

• Bulletin of the Society of Naval Architects of Korea
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• v.25 no.4
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• pp.69-80
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• 1988

This paper proposes simple formulae for buckling and ultimate strength estimation of plates subjected to water pressure and uniaxial compression. For the construction of a formula for elastic buckling strength estimation, parametric study for actual ship plates with varying aspect ratios and the magnitude of water pressure is carried out by means of principle of minimum potential energy. Based on the results by parametric study, a new formula is approximately expressed as a continuous function of loads and aspect ratio. On the other hand, in order to get a formula for ultimate strength estimation, in-plane stress distribution of plates is investigated through large deflection analysis and total in-plane stresses are expressed as an explicit form. By applying Mises's plasticity condition, ultimate strength criterion is then derives. In the case of plates under relatively small water pressure, the results by the proposed formulae are in good agreement compared with those by other methods and experiment. But present formula overestimates the ultimate strength in the range of large water pressure. However, actual ship plates are subjected to relatively small water pressure except for the impact load due to slamming etc.. Therefore, it is considered that present formulae can be applied for the practical use.

• Archives of Pharmacal Research
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• v.28 no.3
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• pp.249-268
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• 2005

Drug metabolizing enzymes (DMEs) play central roles in the metabolism, elimination and detoxification of xenobiotics and drugs introduced into the human body. Most of the tissues and organs in our body are well equipped with diverse and various DMEs including phase I, phase II metabolizing enzymes and phase III transporters, which are present in abundance either at the basal unstimulated level, and/or are inducible at elevated level after exposure to xenobiotics. Recently, many important advances have been made in the mechanisms that regulate the expression of these drug metabolism genes. Various nuclear receptors including the aryl hydrocarbon receptor (AhR), orphan nuclear receptors, and nuclear factor-erythoroid 2 p45-related factor 2 (Nrf2) have been shown to be the key mediators of drug-induced changes in phase I, phase II metabolizing enzymes as well as phase III transporters involved in efflux mechanisms. For instance, the expression of CYP1 genes can be induced by AhR, which dimerizes with the AhR nuclear translocator (Arnt) , in response to many polycyclic aromatic hydrocarbon (PAHs). Similarly, the steroid family of orphan nuclear receptors, the constitutive androstane receptor (CAR) and pregnane X receptor (PXR), both heterodimerize with the ret-inoid X receptor (RXR), are shown to transcriptionally activate the promoters of CYP2B and CYP3A gene expression by xenobiotics such as phenobarbital-like compounds (CAR) and dexamethasone and rifampin-type of agents (PXR). The peroxisome proliferator activated receptor (PPAR), which is one of the first characterized members of the nuclear hormone receptor, also dimerizes with RXR and has been shown to be activated by lipid lowering agent fib rate-type of compounds leading to transcriptional activation of the promoters on CYP4A gene. CYP7A was recognized as the first target gene of the liver X receptor (LXR), in which the elimination of cholesterol depends on CYP7A. Farnesoid X receptor (FXR) was identified as a bile acid receptor, and its activation results in the inhibition of hepatic acid biosynthesis and increased transport of bile acids from intestinal lumen to the liver, and CYP7A is one of its target genes. The transcriptional activation by these receptors upon binding to the promoters located at the 5-flanking region of these GYP genes generally leads to the induction of their mRNA gene expression. The physiological and the pharmacological implications of common partner of RXR for CAR, PXR, PPAR, LXR and FXR receptors largely remain unknown and are under intense investigations. For the phase II DMEs, phase II gene inducers such as the phenolic compounds butylated hydroxyanisol (BHA), tert-butylhydroquinone (tBHQ), green tea polyphenol (GTP), (-)-epigallocatechin-3-gallate (EGCG) and the isothiocyanates (PEITC, sul­foraphane) generally appear to be electrophiles. They generally possess electrophilic-medi­ated stress response, resulting in the activation of bZIP transcription factors Nrf2 which dimerizes with Mafs and binds to the antioxidant/electrophile response element (ARE/EpRE) promoter, which is located in many phase II DMEs as well as many cellular defensive enzymes such as heme oxygenase-1 (HO-1), with the subsequent induction of the expression of these genes. Phase III transporters, for example, P-glycoprotein (P-gp), multidrug resistance-associated proteins (MRPs), and organic anion transporting polypeptide 2 (OATP2) are expressed in many tissues such as the liver, intestine, kidney, and brain, and play crucial roles in drug absorption, distribution, and excretion. The orphan nuclear receptors PXR and GAR have been shown to be involved in the regulation of these transporters. Along with phase I and phase II enzyme induction, pretreatment with several kinds of inducers has been shown to alter the expression of phase III transporters, and alter the excretion of xenobiotics, which implies that phase III transporters may also be similarly regulated in a coordinated fashion, and provides an important mean to protect the body from xenobiotics insults. It appears that in general, exposure to phase I, phase II and phase III gene inducers may trigger cellular 'stress' response leading to the increase in their gene expression, which ultimately enhance the elimination and clearance of these xenobiotics and/or other 'cellular stresses' including harmful reactive intermediates such as reactive oxygen species (ROS), so that the body will remove the 'stress' expeditiously. Consequently, this homeostatic response of the body plays a central role in the protection of the body against 'environmental' insults such as those elicited by exposure to xenobiotics.

• Restorative Dentistry and Endodontics
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• v.34 no.4
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• pp.324-332
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• 2009

The purpose of this study was to investigate the effect of rigidity of post core systems on stress distribution by the theoretical technique, finite element stress-analysis method. Three-dimensional finite element models simulating an endodontically treated maxillary central incisor restored with a zirconia ceramic crown were prepared and 1.5 mm ferrule height was provided. Each model contained cortical bone, trabecular bone, periodontal ligament, 4 mm apical root canal filling, and post-and-core. Six combinations of three parallel type post (zirconia ceramic, glass fiber, and stainless steel) and two core (Paracore and Tetric ceram) materials were evaluated, respectively. A 50 N static occlusal load was applied to the palatal surface of the crown with a $60^{\circ}$angle to the long axis of the tooth. The differences in stress transfer characteristics of the models were analyzed. von Mises stresses were chosen for presentation of results and maximum displacement and hydrostatic pressure were also calculated. An increase of the elastic modulus of the post material increased the stress, but shifted the maximum stress location from the dentin surface to the post material. Buccal side of cervical region (junction of core and crown) of the glass fiber post restored tooth was subjected to the highest stress concentration. Maximum von Mises stress in the remaining radicular tooth structure for low elastic modulus resin core (29.21 MPa) was slightly higher than that for high elastic modulus resin core (29.14 MPa) in case of glass fiber post. Maximum displacement of glass fiber post restored tooth was higher than that of zirconia ceramic or stainless steel post restored tooth.

• Journal of Korean Tunnelling and Underground Space Association
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• v.23 no.3
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• pp.133-149
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• 2021

This study aims to report the behavioral mechanism of steel pipe reinforcement grouting, which is being actively used to ensure the stability of the excavation surface during tunnel excavation, based on measurements taken at the actual site. After using a 12 m steel pipe attached with a shape displacement meter and a strain gauge to reinforce the actual tunnel surface, behavioral characteristics were identified by analyzing the measured deformation and stress of the steel pipe. Taking into account that the steel pipes were overlapped every 6 m, the measured data up to 7 m of excavation were used. In addition, the behavioral characteristics of the steel pipe reinforcement according to the difference in strength were also examined by applying steel pipes with different allowable stresses (SGT275 and SGT550). As a result of analyzing the behavior of steel pipes for 7 hours after the first excavation for 1 m and before proceeding with the next excavation, the stress redistribution due to the arching effect caused by the excavation relaxation load was observed. As excavation proceeded by 1 m, the excavated section exhibited the greatest deformation during excavation of 4 to 6 m due to the stress distribution of the three-dimensional relaxation load, and deformation and stress were generated in the steel pipe installed in the ground ahead of the tunnel face. As a result of comparing the behavior of SGT275 steel pipe (yield strength 275 MPa) and SGT550 steel pipe (yield strength 550 MPa), the difference in the amount of deformation was up to 18 times and the stress was up to 12 times; the stronger the steel pipe, the better it was at responding to the relaxation load. In this study, the behavior mechanism of steel pipe reinforcement grouting in response to the arching effect due to the relaxation load was identified based on the measured data during the actual tunnel excavation, and the results were reported.