• Journal of the Microelectronics and Packaging Society
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• v.26 no.4
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• pp.33-37
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• 2019

In this study, the graded thermal properties of composites are obtained by difference in specific gravity of fillers including Cu, h-BN and GO powders in epoxy. Relatively heavy powders such as Cu and h-BN compared to GO mostly at the bottom layer, while light GO powders were dispersed in the top layer in the composites. The thermal conductivity of composites was gradually increased from 0.55 (0.52) W/mK to 2.82 (1.37) W/mK for GO/h-BN (GO/Cu) epoxy composites from surface to bottom. On the contrary, the coefficient of thermal expansion was decreased from 51 ppm/℃ to 23 ppm/℃ and from 57 ppm/℃ to 32 ppm/℃ for GO/Cu and GO/h-BN, respectively. The variation of thermal properties in composites is attributed due to intrinsic material properties of filler including thermal conductivity, morphology and the distribution by the specific weight of fillers. This simple strategy for realizing graded thermal composites by introducing different filler materials would be effective heat transfer at interface of heterostructure with large thermal properties such as inorganic semiconductor/plastic, metal/plastic, and semiconductor/metal.

• Journal of Ginseng Research
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• v.41 no.3
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• pp.247-256
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• 2017

Background: KG-135, a standardized formulation enriched with Rk1, Rg3, and Rg5 ginsenosides, has been shown to inhibit various types of cancer cells; however, the underlying mechanisms are not fully understood. In this study, we explored its effects in A549 human lung cancer cells to investigate the induction of Forkhead Class box O3a (FOXO3a) and autophagy. Methods: Cell viability was determined by sulforhodamine B staining. Apoptosis and cell cycle distribution were analyzed using flow cytometry. The changes of protein levels were determined using Western blot analysis. Autophagy induction was monitored by the formation of acidic vesicular organelles stained with acridine orange. Results: KG-135 effectively arrested the cells in G1 phase with limited apoptosis. Accordingly, a decrease of cyclin-dependent kinase-4, cyclin-dependent kinase-6, cyclin D1, and phospho-retinoblastoma protein, and an increase of p27 and p18 proteins were observed. Intriguingly, KG-135 increased the tumor suppressor FOXO3a and induced the accumulation of autophagy hallmark LC3-II and acidic vesicular organelles without an increase of the upstream marker Beclin-1. Unconventionally, the autophagy adaptor protein p62 (sequestosome 1) was increased rather than decreased. Blockade of autophagy by hydroxychloroquine dramatically potentiated KG-135-induced FOXO3a and its downstream (FasL) ligand accompanied by the cleavage of caspase-8. Meanwhile, the decrease of Bcl-2 and survivin, as well as the cleavage of caspase-9, were also drastically enhanced, resulting in massive apoptosis. Conclusion: Besides arresting the cells in G1 phase, KG-135 increased FOXO3a and induced an unconventional autophagy in A549 cells. Both the KG-135-activated extrinsic FOXO3a/FasL/caspase-8 and intrinsic caspase-9 apoptotic pathways were potentiated by blockade of autophagy. Combination of KG-135 and autophagy inhibitor may be a novel strategy as an integrative treatment for cancers.

• Journal of Environmental Policy
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• v.9 no.1
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• pp.83-107
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• 2010

Urbanized environments are constructed to estimate peak flow and cost savings in response to possible BMP allocation at a watershed scale. The main goal is to explore the proper allocation of sub-watershed level BMPs for peak flow attenuation at a watershed scale. Since several individual site scale BMPs work as a form of aggregated BMPs at a sub-watershed scale, it is a question as to how to properly allocate the sub-watershed level BMPs at a watershed scale. The Hydrological Simulation Program-FORTRAN (HSPF) is set up for a hypothetically urbanized watershed. A peak flow is determined to be the primary variable of interest and targeted to characterize the spatial distribution of aggregated BMPs. Construction cost of a regional pond forms the basis of the economic valuation. The results indicate that when total size of BMPs is constant in the entire watershed, (1) it is most effective to have aggregated BMPs in some upper sub-watersheds while the BMPs in either the mainstem sub-watershed or a single sub-watershed are the least effective choices for peak flow attenuation at a watershed scale; (2) savings exist between allocation differences and reduced peak flow increases cost savings. The largest saving is found in the strategy of aggregated BMPs in some upper sub-watersheds. These findings, however, call for follow-up site specific case studies revisiting the watershed scale impacts of BMP allocation. Then, it will be argued that location and extent of decentralization are considerable policy variables for an alternative stormwater management policy at a watershed scale.

• Journal of Gastric Cancer
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• v.9 no.1
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• pp.14-17
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• 2009

The clinical significance of hepatic resection for gastric metastases is controversial, even though hepatic resection has been widely accepted as a modality for colorectal metastases. Very few patients with gastric hepatic metastases are good candidates for hepatic resection because of multiple bilateral metastases, extrahepatic disease, or advanced cancer progression, such as peritoneal dissemination or extensive lymph node metastases. Therefore, several authors have reported the clinical significance of hepatic resection for gastric metastases in a small number of patients. Considering the present results with previous reports. The number and distribution of tumors in hepatic metastases from gastric cancer was considered based on the present and previous reports. Several authors have reported significantly better survival in patients with metachronous metastasis than in those with synchronous disease. However, metachronous hepatic resection necessitates the dissection of adhesions between the pancreas, liver, and residual stomach to prepare for Pringle's maneuver. Patients with unilobar liver metastasis, and/or metastatic tumors <4 cm in diameter may be good candidates for hepatic resection. Synchronous metastasis is not a contraindication for hepatic resection. Most of the long-term survivors underwent anatomic hepatic resection with a sufficient resection margin. After hepatic resection, the most frequent site of recurrence was the remaining liver, which was associated with a high frequency of mortality within 2 years. A reasonable strategy for improvement in survival would be to prevent recurrence by means of adjuvant chemotherapy and careful follow-up studies.

• Korean Journal of Community Nutrition
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• v.21 no.5
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• pp.463-476
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• 2016

Objectives: Environmental, social and personal factors influence eating patterns. This study aimed to investigate the relationship between unhealthy food outlets within a residential area and obesity using nationally representative Korean survey data and data from the Census on Establishments. Methods: Data on the food intakes and socioeconomic variables of a total of 9,978 adults aged ${\geq}19$ years were obtained from the 2013-2014 Korea National Health and Nutrition Examination Survey. Geographic locations of restaurants were obtained from the 2013 Census on Establishments in Korea. Administrative area was categorized into tertiles of count of unhealthy food outlets based on the distribution of number of unhealthy food outlets among all urban (Dong) and rural (Eup or Myun) administrative districts in Korea. Multilevel logistic regressions model were used to assess the association between the number of unhealthy food outlets and obesity. Results: People living in the district with the highest count of unhealthy food outlets had higher intakes of fat (45.8 vs. 44.4 g/day), sodium (4,142.6 vs. 3,949.8 mg/day), and vitamin A (753.7 vs. $631.6 {\mu}gRE/day$) compared to those living in the district with the lowest count of unhealthy food outlets. A higher count of unhealthy food outlets was positively associated with frequent consumption of instant noodles, pizza, hamburgers and sandwiches, sweets and sour pork or pork cutlets, fried chicken, snacks, and cookies. Higher exposure to unhealthy food outlets was associated with increased odds of obesity (1st vs. 3rd tertile; OR 1.689; 95% CI 1.098-2.599). Conclusions: A high count of unhealthy food outlets within a residential area is positively associated with the prevalence of obesity in Korea. The results suggest that food environmental factors affects the health outcomes and interventions aiming to restrict the availability of unhealthy food outlets in local neighborhoods may be a useful obesity prevention strategy.

• Korean Journal of Environmental Biology
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• v.31 no.4
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• pp.370-375
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• 2013

Exotic species in aquatic ecosystem generate various problems domestically as well as globally. Largemouth bass (Micropterus salmoides) which is a well-known exotic species globally, acts as a substantial disturbance factor on the native fish communities in Korea due to the high predation pressure and hence designated as a ecologically harmful species by Ministry of Environment. In this study, we investigated the impact of largemouth bass on Korean native fish population, crucian carp (Carassius auratus), to identify responses of the prey fish. Two fish species were collected at seven reservoirs distributed at the Nakdong River catchment area, and changes in length-frequency and length-weight relationship (LWR) were analysed depending on existence of large-mouth bass. At bass absent sites, ratio of under age 1 year individuals were small, and over age two years were dominant. Conversely, normal length-frequency distribution pattern was identified at bass absent sites. The LWR of crucian carp (fish smaller than total length of 160 mm were only considered as it is frequently consumed by bass predation) was different depending upon bass existence. The value of parameter b at bass absent reservoirs was 2.909, which was smaller than that of bass present reservoirs, 3.100. Our results imply that crucian carp at bass present reservoirs presented a different strategy to survive from predation by bass, through relatively rapid growth. We propose that other native species might have similar growth strategies like crucian carp.

• Journal of Animal Science and Technology
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• v.52 no.6
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• pp.475-480
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• 2010

The bovine fatty acid binding protein 4 (FABP4) plays an important role to uptake intracellular fatty acid. It has been previously reported as a positional candidate gene for marbling score in livestock. The re-sequencing of FABP4 gene detected a polymorphic AT repeated sequence in intron II of FABP4 gene. Allelic distribution for this microsatellite marker was examined in other cattle breeds. A total of 8 alleles were detected with diverse repeat units (14 to 21 AT repeat) in Hanwoo and 7 breeds. Of the 8 alleles, the predominant alleles were $[AT]_{16}$, $[AT]_{18}$ and $[AT]_{19}$ in the Hanwoo and 7 cattle breeds. The linear mixed model for genotypic effect (3237AT) on carcass traits showed a significant effect on marbling score (MAR P=0.025) and live weight (LWT; P=0.04) in the 583 Hanwoo cattle population. Live weight (LW) was highest in the homozygous $(AT)_{17}$ genotype ($557.5{\pm}6.94$) and lowest in the heterozygous $(AT)_{16/17}$ genotype ($521.7{\pm}7.70$). On the other hand, the homozygous $(AT)_{17}$ genotype ($3.0{\pm}0.15$) has the highest effect on marbling score and the lowest effect was in homozygous (AT)$_{18}$ genotype ($2.2{\pm}0.15$). The marbling score difference between both groups was 0.8 which is around two times higher than SNP genotype effect on marbling score in Limousin $\times$ Wagyu crosses.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.8
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• pp.181-189
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• 2017

This study examines whether the variables used in the Unified Theory of Acceptance and Use of Technology(performance expectancy, effort expectancy, social influence, and facilitating conditions) is applicable to continuous usage of uTradeHub at a time of expansion in the use of uTradeHub. In addition, the role of user satisfaction(mediating effect) and CEO support(interaction effect) in the relationship is identified attempting to provide basic data to help uTradeHub management strategy establishment. A total of 101 valid responses collected through questionnaires were used for empirical analysis(using SPSS 24.0), and the results are as follows. First, for the effect of the integration technology acceptance factor on user satisfaction(H1), only performance expectancy, effort expectancy, and social influence were significant, but facilitating conditions was not significant. Second, for the effect of user satisfaction on the continued use of uTradeHub(H2), there was a significant result. Third, the mediation effect on verification of user satisfaction(H3) was full where performance expectancy, effort expectancy, and social influence prompted continuous usage through user satisfaction. Fourth, for interactive effect verification of CEO support(H4), an interaction effect was shown only in the influence relationship of performance expectancy and social influence on user satisfaction.

• Journal of Korean Society of Steel Construction
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• v.19 no.4
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• pp.367-381
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• 2007

A transmission tower was designed using the structural methodology to assume a simple truss behavior. However, there is a big difference between a simple truss behavior and a real one. A suitable explanation of structural stability is that it is a semi-rigid connection and not the assumed hinged connection. This study proposes an alternative structural-analysis modeling strategy for the transmission tower design. The element models that were considered were the truss element model, the beam element model, and the combined beam-truss element model. This study includes linear static analysis, free-vibration analysis, and elastic buckling analysis with respect to the design load. The results of the analysis indicate that the axial forces, axial stresses, and maximum displacements of the three analytical models are very similar. However, the bending moments and stresses of the beam element model and of the combined beam-truss element model are significantly high. The results of the free-vibration and elastic buckling analyses show that the beam-truss model can be conservatively used for the transmission tower design.

• Weed & Turfgrass Science
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• v.1 no.4
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• pp.6-12
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• 2012

A fact-finding survey was conducted to obtain the basic information on nation-wide weed distribution and farmer's opinions to weed control strategy in paddy field. Most respondents considered Echinochloa spp., Monochloa vaginalis, Sagittaria trifolia, and Scirpus juncoides etc. as dominate weeds in paddy fields. And herbicide resistant weed species were M. vaginalis, S. juncoides, E. oryzicola and S. pygmaea etc. Purchase guidances for herbicide selection, experience of farmers was 34.0% and dealers recommendation was 33.9% at farmer's level. And paddy field herbicides application frequence were one time 15.6% but twice 75.6%. Preferred herbicides were ranked in the following order: oxadizone 12% EC, butachlor 5% GR, butachlor 33% CS, mefenacet pyrazodulfuron-ethyl 21.42% SC, and oxadiargyl 1.7% EC etc. in paddy fields. And in most preferred foliar herbicide were bentazone MCPA 38.6% SL and bentazone cyhalop-butyl 18.5% ME, 48.5% and 22.3%, respectively.