• Asian Pacific Journal of Cancer Prevention
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• v.16 no.1
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• pp.41-44
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• 2015

Based on genome-wide association studies (GWAS) a linkage between several variants such as single nucleotide polymorphisms (SNPs) in intron 3 of SMAD7 (mothers against decapentaplegic homolog7) were, rs12953717, rs4464148 and rs4939827 has been noted for susceptibility to colorectal cancer (CRC). In this study we investigated the relationship of rs12953717 and rs4464148 with risk of CRC among 487 Iranian individuals based on a case-control study. Genotyping of SNPs was performed by PCR-RFLP and for confirming the outcomes, 10% of genotyping cases were sequenced with RFLP. Comparing the case and control group, we have found significant association between the rs4464148 SNP and lower risk of CRC. The AG genotype showed decreased risk with and odds ratio of 0.635 (adjusted OR=0.635, 95% CI: 0.417-0.967, p=0.034). There was no significant difference in the distribution of SMAD7 gene rs12953717 TT genotype between two groups of the population evaluated (adjusted OR=1.604, 95% CI: 0.978-2.633, p=0.061). On the other hand, rs12953717 T allele showed a statistically significant association with CRC risk (adjusted OR=1.339, 95% CI: 1.017-1.764, p=0.037). In conclusion, we found a significant association between CRC risk and the rs4464148 AG genotype. Furthermore, the rs12953717 T allele may act as a risk factor. This association may be caused by alternative splicing of pre mRNA. Although we observed a strong association with rs4464148 GG genotype in affected women, we did not detect the same association in CRC male patients.

• Journal of the Korean Society for Geothermal and Hydrothermal Energy
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• v.12 no.4
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• pp.40-46
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• 2016

In order to improve air quality of indoor environment, studies of the underfloor air distribution (UFAD) system for application in buildings are actively in progress based on temperature and air flow distribution. However, although the age of air is the major evaluation parameter, there has been very little study on this parameter for the UFAD system. In this study, we investigated the age of air to reach the air diffuser, which is installed at the bottom of the interior by the UFAD system. Computational fluid dynamics simulations showed no regular pattern to the maximum value of the age of air in accordance with air flow rate and the velocity at air diffuser. These factors can be deduced from air movement by considering that air emitted from air conditioners was rotated according to the bottom shape of the floor, and then, the age of air in the rotation center was increased. The average age of air of internal interior was reduced considerably as the flow velocity at the underfloor air diffuser was increased from 0.5 m/s to 1.0 m/s However, the age of air was not substantially affected with change in the air volume. Moreover, when the flow velocity at the underfloor air diffuser was higher than 1.0 m/s, the age of air showed no significant difference with change in air volume or height of measurement. These results imply that indoor air quality is more substantially influenced by flow velocity than air volume, and the appropriate flow velocity is 1 m/s or more.

• Progress in Medical Physics
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• v.32 no.4
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• pp.153-158
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• 2021

Purpose: This study evaluated the features of a pressure mapping system for patient motion monitoring in radiation therapy. Methods: The pressure mapping system includes an MS 9802 force sensing resistor (FSR) sensor with 2,304 force sensing nodes using 48 columns and 48 rows, controller, and control PC (personal computer). Radiation beam attenuation caused by pressure mapping sensor and signal perturbation by 6 and 10 mega voltage (MV) photon beam was evaluated. The maximum relative pressure value (mRPV), average relative pressure value (aRPV), the center of pressure (COP), and area of pressure distribution were obtained with/without radiation using the upper body of an anthropomorphic phantom for 30 minutes with 15 MV. Results: It was confirmed that the differences in attenuation induced by the FSR sensor for 6 and 10 MV photon beams were small. The differences in mRPV, aRPV, area of pressure distribution with/without radiation are about 0.6%, 1.2%, and 0.5%, respectively. The COP values with/without radiation were also similar. Conclusions: The characteristics of a pressure mapping system during radiation treatment were evaluated on the basis of attenuation and signal perturbation using radiation. The pressure distribution measured using the FSR sensor with little attenuation and signal perturbation by the MV photon beam would be helpful for patient motion monitoring.

• Journal of Radiation Protection and Research
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• v.15 no.2
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• pp.41-49
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• 1990

$^{88}SrCl_2$ was injected to the tail vein of Wistar rats and investigated its distribution and clearance in the tissues and blood. We also measured the changes in Sr binding to the blood plasma protein by administrating chelating agents and organic acids. For the blood, 60% of the Sr occurred in the plasma and 40% on the cell membrane. Fifty percent of Sr in the blood plasma was bound to plasma protein. Sr on the cell membrane seemed to be bound loosely. The binding in the lymphocyte was higher than in the erythrocyte .and granulocyte. Within one hour Sr was quickly disappeared from the blood stream, to be accumulated in the bone. Twenty four hours after the injection, Sr decreased rapidly in the organs of soft tissue, but slowly in the bone. The binding of Sr to plasma protien decreased from 57% of the control to 27-33% in the group treated with chelating agents, EDTA, EGTA and DTPA and to 19% and 40% in the groups treated with organic acids, citrate and oxalate, respectively.

• Journal of Welding and Joining
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• v.9 no.1
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• pp.40-47
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• 1991

The most fatigue tests carried out under the either stress or strain control, but machines and structures had taken variable stress. This variable stress was treated as statistics based on p-type distributions. In this paper, the cumulative fatigue damage of SM45C round bar specimens having a center hole resulting from block loading with p-distributions in rotating bending conditions, is presented. The value of p was changed in the range from 0.25 to 1; 0.25, 0.5, 0.75, 1. The following conclusions were obtained through the constant stress amplitude experiments and the block loading experiments. (1) In constant loading test, fatigue life was affected by cyclic rate. From experimental data, N$_{f}$ (100cpm)/N$_{f}$(3000cpm)equal to 0.56. (2) In case of the cyclic rate 100cpm and 3000cpm, at the high stress amplitude level the crack propagation life N$_{*}$f is longer than the low stress amplitude level. (3) Miner's hypothesis may be valid for p=0.75 and prediction of fatigue life by Haibach's method agree with experimental data well for the case p=0.5, while the modified Miner's method agree with experimental data well for the case p=0.25.5.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.15 no.1
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• pp.1-7
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• 2016

In the dentistry field, an ultrasonic surgery unit is widely used in bone cutting and scaling to reduce operation time and minimize hemorrhage. The purpose of this study was to evaluate bone cutting and the effect of a specimen's temperature on the two-type ultrasonic surgery unit using a handpiece moving system(HMS). A HMS, which can cut the bone, was developed to perform the experimental procedure with precision of motion control. Bone specimens were prepared from a combination of epoxy-hardener and cortical bone of bovine leg. Through the bone-cutting experiment, the cutting depth was evaluated by not only scanning electron microscopy, but also Vernier calipers. Also, the temperature distribution was measured by a thermo-graphic camera. This study may be applied methodically in various experimental evaluations on a performance test by a HMS.

• Proceedings of the KSRS Conference
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• v.1
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• pp.475-478
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• 2006

Total primary production resulting from the photosynthetic process can be defined as the amount of organic matter produced in a given period of time. It is proportional to the chlorophyll-a (chl-a) values in the surface layer of the ocean. The MODIS board on Aqua satellite measures visible and infrared radiation in 36 wavebands, providing simultaneous images of chl-a concentration and sea surface temperature (SST) in the upper layer of the sea. The seasonal distribution of chl-a concentration during one year from April 2005 to March 2006 was examined. Light has a role of starting the seasonal cycle. The Kuroshio Current in this area induces many oceanographical features affecting to the change of seasonal control. The chl-a concentration is also seasonal, which is low in summer and high in winter. In summer, the meandering of Kuroshio Current induces strong eddies and increases the chl-a concentration. In autumn, the delayed small autumn bloom occurred until last December due to the Kuroshio Current. When the Kuroshio axis moves far from the coast, the coastal water dominates and increases the concentration even in the winter. The spring bloom starts early at the beginning of March and decreases during the spring.

• The Journal of Engineering Research
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• v.6 no.1
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• pp.75-81
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• 2004

To solve the urban flood problems, it must get the enough channel conveyances and pumping capacities. It needs set up the detention system to control the flow over the channel capacity. Inspite of this detention system, the peak flow may increased by rainfall distribution and the delay of flow. This shows a design model of detention system which can consider the time problems from mutual connections of the detention storages and pumping flow using IDP(Incremental Dynamic Programming) method.

• 제어로봇시스템학회:학술대회논문집
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• 1988.10b
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• pp.885-890
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• 1988

This is a successive study of the development and application of an electronic safeguard system for elderly men (senile dementia patients) who wander without purpose because of declined mental capability, while retaining their physical ability. The new safeguard system is designed with some additional functions on the basis of the previously developed system. Firstly, alarms are designed not to disturb other patients at night, so that informations about doors from which the patients go out may be transmitted to helpers individually by radio paging system. Secondly, the system hardware can be set up anywhere without laying particular signal transmission cables, provided that there exist AC power distribution lines for the utilization as a transmission line of signals to alarm indicators. Thirdly, it is possible to have a grasp of the whole states of the safeguard systems at the center of operation by monitoring the operational state of each system with a necessary data acquisition according to its instruction through telecommunication network. Thus, each safeguard system can be economically supplied to the special nursing homes and the helpers are ensured more released from physical and psychological burdens so that they can devote themselves to the care of senile elderly men, thereby improving their patients' comfort and human dignity.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.26 no.3
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• pp.328-336
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• 2017

The exit surface of a lens is designed using a three-dimensional free-form expression in order to easily modify a curved surface. This enables the design of numerical values and mathematical things using three-dimensional free-form expression, and enhances precision because it can be fine-tuned via numerical control. The standard of "Classification of Luminaire Light Distribution" for outdoor lighting fixtures by IESNA is adopted in order to examine the correlation between three-dimensional free-form surface expression and lighting performance. The variation of light distribution type and range is analyzed using the values of maximum light intensity and 50% light intensity. The actual tolerance occurs owing to parameters such as the thickness of the lens, the distance between LEDs, and the movement of the center of the incident surface; the effects of changes in these parameters on the performance are compared and analyzed.