• Title/Summary/Keyword: Distant Factors

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Clinical Features and the Risk Factors of Distant Metastasis in Locally Advanced Advanced Head and Neck Cancer Patients after Induction Chemotherapy Followed Locoregional Control Therapy (유도화학요법 및 국소 치료 후 원격전이를 보인 국소 진행성 두경부암 환자군의 임상 특징 및 위험인자에 관한 연구)

  • Lee, Hye-Won;Baek, Dong-Hoon;Lee, Kyung-Nam;Cho, Eun-Jung;Kim, Hyo-Jeong;Seol, Young-Mi;Song, Moo-Kon;Choi, Young-Jin;Shin, Ho-Jin;Chung, Joo-Seop;Cho, Goon-Jae
    • Korean Journal of Head & Neck Oncology
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    • v.27 no.2
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    • pp.177-182
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    • 2011
  • Backgrounds : Head and neck cancer is one of the most prevalent cancers in the world. It tends to remain localized at the primary site and regional lymph nodes, but if distant metastasis occurs, it has a poor prognosis. This study was performed to evaluate the prevalence of distant metastasis and to determine the risk factor in locally advanced head and neck cancer after induction chemotherapy followed locoregional control therapy. Methods : A retrospective review was performed in 420 patients with locally advanced head and neck cancer who treated with induction chemotherapy followed locoregional control therapy from January 2001 to December 2010. Among them, 31 patients who had distant metastasis as first relapse within 2 years after termination of therapy were analyzed for clinical features and the risk factors of distant metastasis. Results : The overall incidence of distant metastasis was 7.3%. The bone, lung, and liver were the most frequent metastatic organs. In univariate analysis, nodal stage, nasopharyngeal cancer, laryngeal cancer, G3/G4 neutropenia during induction chemotherapy, and concurrent chemoradiotherapy were the influencing factors for distant metastasis. In multivariate analysis, advanced N stage and nasopharynx were the risk factors of distant metastasis, and grade 3/4 neutropenia during induction chemotherapy was considered to decrease distant metastasis. Conclusion : This study suggests that the advanced N stage is the risk factor of distant metastasis and Grade 3/4 neutropenia during induction chemotherapy can be beneficial against distant metastasis in locally advanced head and neck cancer patients treated with induction chemotherapy followed locoregional control therapy.

Clinical Factors Predictive of Metastases from Renal Cell Carcinomas

  • Widia, Fina;Hamid, Agus Rizal AH;Mochtar, Chaidir A;Umbas, Rainy
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.9
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    • pp.4503-4506
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    • 2016
  • Background: Lymph node and distant metastases are known as the prognostic factor in renal cell carcinoma (RCC). Clinical parameters are needed to predict metastases preoperatively. The aim of this study was to assess clinical predictive factors for lymph node and distant metastases. Materials and Methods: We collected RCC data from January 1995 until December 2015 at Cipto Mangunkusumo hospital in Jakarta. We only reviewed data that had renal cell carcinoma histopathology by operation or biopsy. Clinical information such as patient age, gender, hemoglobin (Hb), erythrocyte sedimentation rate (ESR), and tumor size (clinical T stage) were reviewed and analyzed by Chi-squre and logistic regression to establish clinical predictive value. Results: A total of 102 patients were reviewed. There were 32 (31.4%) with lymph node metastases and 27 (26.5%) with distant metastases. Age, Hb and clinical T staging were associated with nodal metastases. However, only Hb and clinical T staging were found to be associated with distant metastases. By logistic regression, we found T3-4 in clinical T-stage to be the only predictor of nodal metastases (OR 5.14; 1.87 - 14.09) and distant metastases (OR 3.42; 1.27 - .9.23). Conclusions: Clinical T-stages of T3 and T4 according to The AJCC TNM classification could be used as independent clinical predictive factors for lymph node or distant metastases in patients with RCC.

Substitution analysis among production factors of distant longline fisheries in IATTC waters using a translog cost function (초월대수 비용함수 추정을 통한 IATTC 해역 원양연승어업의 생산요소 간 대체성 분석)

  • Jo, Heon-Ju;Kim, Do-Hoon;Kim, Doo-Nam;Lee, Sung-Il;Lee, Mi-Kyung
    • Ocean policy research
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    • v.34 no.2
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    • pp.1-28
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    • 2019
  • The purpose of this study is to analyze the substitution among production factors of Korean distant water longline fisheries in IATTC waters. In the analysis, the translog function which have one output variable of total cost and input variables of labor, fuel, fishing gear, and capital was established and it was transformed into simultaneous equations by each cost. Then, variables of equations were estimated by SUR (seemingly unrelated regression) model. Since distant water longline fisheries is a fishing type with high fuel usage, substitution of fuel with other factors was mainly analyzed. Results showed a substitute relation between fuel and labor as well as fuel and fishing gear, while a complementary relation between fuel and capital. In addition, it was analyzed that magnitude of fuel elasticity with other factors would be inelastic.

The Prognosis of Patients with Stage IV Gastric Carcinoma without Distant Metastasis (원격전이를 동반하지 않은 4기 위암 환자의 예후)

  • Lee Jun Ho;Noh Sung Hoon;Choi Seung Ho;Min Jin Sik
    • Journal of Gastric Cancer
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    • v.1 no.2
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    • pp.100-105
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    • 2001
  • Purpose: In the UICC staging system, stage IV contains not only those patients with distant metastasis but also patients with far advanced T and N status but without distant metastasis. We investigated the prognostic factors of stage IV gastric carcinoma patients without distant metastasis after curative resection. Materials and Methods: 190 stage IV gastric carcinoma patients without distant metastasis were reviewed after curative resection. Results: Male sex, distal third location, Borrmann type III, IV and histologically undifferentiated type were common. 5 year survival rate of the 190 patients was $22.2\%$. Depth of invasion and lymph node metastasis did not influence survival. The lymph node ratio (positive lymph node / retrieved lymph node) and combined resection affected survival by univariate and multivariate analysis. Conclusion: Combined resection and positive lymph node ratio were the independent prognostic factors in the patients with stage IV gastric carcinoma who underwent curative resection.

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Surgery and Prognostic Consideration in Differentiated Thyroid Cancer(DTC) (분화 갑상선암의 수술 및 예후에 대한 고찰)

  • Byun, Kyung-Do;Ha, Tae-Kwun;Ryu, Sung-Mock;Kim, Tae-Hyun;Kim, Sang-Hyo
    • Korean Journal of Head & Neck Oncology
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    • v.25 no.2
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    • pp.132-137
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    • 2009
  • Purpose : For the past 10 years, the incidence of thyroid cancer has been rapidly increased in female population showing current incidence of 12,000 new thyroid cancer patients annually in Korea. Though differentiated thyroid cancer is known to show favorable prognosis and excellent long-term survival from slow growth and late distant metastasis, we re-evaluated prognostic factors of recurrence and mortality following surgical procedures based on our cases. Material and Methods : 954 Patients of DTC surgically treated at Department of Surgery, Inje University Busan Paik Hospital between 1980 and 2004 were reviewed in the aspects of the surgical procedures, clinical staging, risk factors, recurrence and their outcome through median follow-up period of 10.5 years. Results : Recurrence in remnant thyroid, cervical nodes, and distant metastasis were observed in 84 paients(8.8%), and 31 patients were confirmed to be died of locoregional recurrence of cancer and distant metasasis. Regarding the risk factors to recurrence, tumor size, extrathyroidal extension, nodal metastasis, and capsular invasion were significant predictors(p<0.05). Local recurrence and distant metastasis had no statistical signiicance according to age, sex, pathology, surgery, and lymphovascular invasion. Overall 10-year survival rate was 92.4%, but low, intermediate, and high-risk patient showed 100%, 94.4%, and 70.5% respectively. Conclusion : The significant factors influencing local recurrence and distant metastasis were tumor size, extrathyroidal exension, LN metastasis, capsular invasion. In order to improve survival rate of high-risk group, appropriate and aggressive management should be recommended.

Multivariate Analysis of the Prognosis of 37 Chondrosarcoma Patients

  • Yang, Zheng-Ming;Tao, Hui-Min;Ye, Zhao-Ming;Li, Wei-Xu;Lin, Nong;Yang, Di-Sheng
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.4
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    • pp.1171-1176
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    • 2012
  • Objective: The current study aimedto screen for possible factors which affect prognosis of chondrosarcoma. Methods: Thirty seven cases were selected and analyzed statistically. The patients received surgical treatment at our hospital between December 2005 and March 2008. All of them had complete follow-up data. The survival rates were calculated by univariate analysis using the Kaplan-Meier method and tested by Log-rank. ${\chi}^2$ or Fisher exact tests were carried out for the numeration data. The significant indexes after univariate analysis were then analyzed by multivariate analysis using COX regression model. Based on the literature, factors of gender, age, disease course, tumor location, Enneking grades, surgical approaches, distant metastasis and local recurrence were examined. Results: Univariate analysis showed that there were significant differences in Enneking grades, surgical approaches and distant metastasis related to the patients' 3-year survival rate after surgery (P<0.001). No significant difference was not found in gender, age, disease course, tumor location or local recurrence (P>0.05). Multivariate analysis showed that Enneking grade (P=0.007) and surgical approaches (P=0.010) were independent factors affecting the prognosis of chondrosarcoma, but distant metastasis was not (P=0.942). Conclusion: Enneking grades, surgical approaches and distant metastasis are risk factors for prognosis of chondrosarcoma, among which the former two are independent factors.

Republic of Korea Navy's Long-Term Development Plan to Acquire Operational Capabilities at Distant Ocean - Focused on Introduction of Aircraft Carrier and Nuclear-powered Submarine - (원양 작전 능력 확보를 위한 한국 해군의 장기(長期) 발전 방안 - 항공모함 및 원자력 잠수함 도입제안을 중심으로 -)

  • Kim, Jae-Yeop
    • Strategy21
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    • s.34
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    • pp.149-177
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    • 2014
  • Today distant oceans around the world are regarded as a major 'global commons' for international trade and transportation. Korea is not an exception, because Korea hugely depends on sea lines of communication (SLOC) for supplying vital commodities such as food and energy resource. As a result, assuring a free and safe use of distant ocean beyond territory is also an important agenda for Korea's maritime security. However there are a number of challenges for Korea to enjoy a free and safe use of distant ocean; dangers of regional maritime conflict in East Asia, naval arms race of China and Japan, and concerns on possible decline of U.S naval presence and power projection capabilities. These factors provide a reasonable basis for Republic of Korea Navy (ROKN) to pursue capabilities for major naval operations at distant ocean in a long-term perspective toward the year 2030. The introduction of aircraft carrier and nuclear-powered submarine is a key requirement for achieving this goal. ROKN needs to acquire a 'multi-role strategic landing platform' type of light aircraft carrier, which takes a role to escort naval task force by providing air superiority at distant ocean. Additionally nuclear-powered submarine will offer ROKN a formidable power to carry out offensive missions effectively at distant ocean.

Clinicopathological Factors and Gastric Cancer Prognosis in the Iranian Population: a Meta-analysis

  • Somi, Mohammad Hossein;Ghojazadeh, Morteza;Bagheri, Masood;Tahamtani, Taraneh
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.3
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    • pp.853-857
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    • 2015
  • Background: Gastric cancer is the most common cancer in the Iranian population. The aim of this study was to determine the effect of clinicopathological factors on prognosis by meta-analysis. Materials and Methods: A literature search was conducted using MEDLINE, EMBASE and Cochrane library and extensive literature search using the Persian databases until February 2011. Prospective follow up studies with multivariate analysis of overall survival of the patients with gastric cancer were included in this review. The data were analyzed by CMA.2. Publication bias are checked by funnel plot and data are shown as Forest plots. Results: From a total of 63 articles, 14 retrospective studies which examined 5 prognostic factors and involving 10,500 patients were included. Tumor size (>35mm) was the main significant factor predicting an unfavorable prognosis for the patients with gastric cancer (RR=1.829, p<0.001) followed by presence of distant metastases (RR=1.607, p<0.001), poor differentiation (RR=1.408, p<0.001) and male sex (RR=1.194, p<0.001). Lymph node metastases (RR=1.058, p=0.698) and moderate differentiation (RR=0.836, p=0.043) were not statistically significant as prognostic factors. Conclusions: This meta-analysis suggests that tumor size>35mm, poor differentiation, presence of distant metastasis and male gender are strongly associated with a poor prognosis in Iranian patients with gastric cancer.

Fishing efficiency by vessel capacity of Korean tuna purse seiners operating in the western and central Pacific Ocean (태평양 수역 우리나라 다랑어선망어업의 선박 역량에 따른 조업 효율성 분석)

  • LEE, Mi Kyung;LEE, Sung Il;KIM, Doo Nam;KU, Jeong Eun;KWON, Youjung
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.53 no.2
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    • pp.169-176
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    • 2017
  • Tuna purse seine fishery in the western and central Pacific Ocean (WCPO) has been rapidly developed since early 1980s due to massive investment of major distant water fishing nations, and catch by purse seine fishery operating in the WCPO accounts for nearly half of the world's tuna total catch. As fishing efficiency is reflected by not only improving of individual vessel's capacity but also increasing number of active vessel, it is essential to understand vessel capacity for reliable assessment result on how fishery affects stock status of target species. In this study, fishing efficiency was analyzed by main factors which are representative of vessel capacity using fishing data and vessel information related to Korean tuna purse seine fishery operating in the western and central Pacific Ocean from 1992 to 2014. It showed that fishing efficiency of vessel tends to be higher when having larger vessel tonnage, higher engine power, lower vessel age and larger length of vessel. As for fishing efficiency by set type, CPUE of associated set with floating objects was generally higher than that of free school set, and CPUE of free school set seemed to have a greater effect on engine power and vessel age compared to other factors.

A Study on the Facilities Distribution based on the Choice Model of the Outdoor Leisure-Facilities in a Neighbourhood Unit of the Megalopolis Citizens. -In terms of the Comparison of Choice Models and the Limitations of Use Areas between the Megalopolis- (대도시 주민의 근린옥외여가시설 선택모형을 기초로 한 시설지 배분에 관한 연구)

  • 최기수;김한배;진양교;진상철;허미선
    • Journal of the Korean Institute of Landscape Architecture
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    • v.23 no.1
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    • pp.123-139
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    • 1995
  • The megalopolis citizens are reevaluating the expectant value and the perception of leisure aceording to increasing the level of their incomes, The leisure of citizens is increasing in the aspect of quantity and quality of life nowadays In the site planning of leisure, the concrete understanding about people's choice of a leisure site will be the most important thing, not only for the aspect of improvement of the quality of life but also efficiencies of the land use The purposes of chi study are firstly, to find out the factors which are influenced on a choice of Outdoor leisure facilities in neighbourhood unit and to Compare the Characteristics Of Choice models between the three metropolitan areas, secondly, to predict a limitation of use areal according to the change of a needed time based on the metropolitan's standard choice model For the choice model establishment this research used Logit Model which has been used in the field of the traffic, the tourism and the economics. This research made the results which find out the influencing variables with needed times, the accessibility and the percentage of facilities. The lindtations of use areas come out the results which are predicted according to the change of needed times as a most influencing factors. The range of each preferred leisure facility is about 956 meter distant in the neighbourhood park about 644 meter distant in the pocket park about 604 meter distant in the recreation center, about 628 meter distant in the tennis court about 974 meter distant in the private hob by facility and about 528 meter distant in the library from the apartment unit The recreation center and the library are nearer facilities than the other facilities. But these facilities are surveyed to be more or less influenced by an interesting progran, a context of events and the level of useful facilities, etc.

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