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Clinical Factors Predictive of Metastases from Renal Cell Carcinomas  

Widia, Fina (Department of Urology Faculty of Medicine University of Indonesia - Cipto Mangunkusumo Hospital)
Hamid, Agus Rizal AH (Department of Urology Faculty of Medicine University of Indonesia - Cipto Mangunkusumo Hospital)
Mochtar, Chaidir A (Department of Urology Faculty of Medicine University of Indonesia - Cipto Mangunkusumo Hospital)
Umbas, Rainy (Department of Urology Faculty of Medicine University of Indonesia - Cipto Mangunkusumo Hospital)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.17, no.9, 2016 , pp. 4503-4506 More about this Journal
Abstract
Background: Lymph node and distant metastases are known as the prognostic factor in renal cell carcinoma (RCC). Clinical parameters are needed to predict metastases preoperatively. The aim of this study was to assess clinical predictive factors for lymph node and distant metastases. Materials and Methods: We collected RCC data from January 1995 until December 2015 at Cipto Mangunkusumo hospital in Jakarta. We only reviewed data that had renal cell carcinoma histopathology by operation or biopsy. Clinical information such as patient age, gender, hemoglobin (Hb), erythrocyte sedimentation rate (ESR), and tumor size (clinical T stage) were reviewed and analyzed by Chi-squre and logistic regression to establish clinical predictive value. Results: A total of 102 patients were reviewed. There were 32 (31.4%) with lymph node metastases and 27 (26.5%) with distant metastases. Age, Hb and clinical T staging were associated with nodal metastases. However, only Hb and clinical T staging were found to be associated with distant metastases. By logistic regression, we found T3-4 in clinical T-stage to be the only predictor of nodal metastases (OR 5.14; 1.87 - 14.09) and distant metastases (OR 3.42; 1.27 - .9.23). Conclusions: Clinical T-stages of T3 and T4 according to The AJCC TNM classification could be used as independent clinical predictive factors for lymph node or distant metastases in patients with RCC.
Keywords
Renal cell carcinoma; metastases; factors; age/gender; hemoglobin; erythrocyte sedimentation; stage;
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1 Adibi M, Karam JA, Wood CG (2015). Reporting geographic and temporal trends in renal cell carcinoma: why is this important? Eur Urol, 67, 531-2.   DOI
2 Belldegrun AS (2007). Renal Cell Carcinoma: Prognostic Factors and Patient Selection. European Urology Supplements, 6, 477-83.   DOI
3 Choueiri TK, Rini B, Garcia JA, et al (2007). Prognostic factors associated with long-term survival in previously untreated metastatic renal cell carcinoma. Ann Oncol, 18, 249-55.
4 Cohen HT, McGovern FJ (2005). Renal-cell carcinoma. N Engl J Med, 353, 2477-90.   DOI
5 Ljungberg B, Campbell SC, Choi HY, et al (2011). The epidemiology of renal cell carcinoma. Eur Urol, 60, 615-21.   DOI
6 Lam JS, Shvarts O, Leppert JT, et al (2005). Renal cell carcinoma 2005: new frontiers in staging, prognostication and targeted molecular therapy. J Urol, 173, 1853-62.   DOI
7 Leibovich BC, Blute ML, Cheville JC, et al (2003). Prediction of progression after radical nephrectomy for patients with clear cell renal cell carcinoma: a stratification tool for prospective clinical trials. Cancer, 97, 1663-71.   DOI
8 Ljungberg B, Bensalah K, Canfield S, et al (2015). EAU guidelines on renal cell carcinoma: 2014 update. Eur Urol, 67, 913-24.   DOI
9 Ficarra V, Galfano A, Verhoest G, et al (2007). Prognostic Factors and Staging Systems for Renal Cell Carcinoma. European Urol Supplements, 6, 623-9.   DOI
10 Cross BW, Johnson TV, DeRosa AB, et al (2012). Preoperative Erythrocyte Sedimentation Rate Independently Predicts Overall Survival in Localized Renal Cell Carcinoma following Radical Nephrectomy. Int J Surgical Oncol, 6.
11 Furniss D, Harnden P, Ali N, et al (2008). Prognostic factors for renal cell carcinoma. Cancer Treat Rev, 34, 407-26.   DOI
12 Guethmundsson E, Hellborg H, Lundstam S, et al (2011). Metastatic potential in renal cell carcinomas   DOI
13 Hutterer GC, Patard JJ, Perrotte P, et al (2007). Patients with renal cell carcinoma nodal metastases can be accurately identified: external validation of a new nomogram. Int J Cancer, 121, 2556-61.   DOI
14 Karakiewicz PI, Trinh QD, Bhojani N, et al (2007). Renal cell carcinoma with nodal metastases in the absence of distant metastatic disease: prognostic indicators of disease-specific survival. Eur Urol, 51, 1616-24.   DOI
15 Motzer RJ, Mazumdar M, Bacik J, et al (1999). Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol, 17, 2530-40.   DOI
16 Masuda H, Kurita Y, Suzuki K, et al (1997). Predictive value of serum immunosuppressive acidic protein for staging renal cell carcinoma: comparison with other tumour markers. Br J Urol, 80, 25-9.   DOI
17 Miyata Y, Koga S, Nishikido M, et al (2001). Relationship between serum ferritin levels and tumour status in patients with renal cell carcinoma. BJU Int, 88, 974-7.
18 Motzer RJ, Bacik J, Mazumdar M (2004). Prognostic factors for survival of patients with stage IV renal cell carcinoma: Memorial Sloan-Kettering Cancer Center experience. Clin Cancer Res, 10, 6302-3.   DOI
19 Procopio G, Verzoni E, Iacovelli R, et al (2012). Prognostic factors for survival in patients with metastatic renal cell carcinoma treated with targeted therapies. Br J Cancer, 107, 1227-32.   DOI
20 Naito S, Kinoshita H, Kondo T, et al (2013). Prognostic factors of patients with metastatic renal cell carcinoma with removed metastases: a multicenter study of 556 patients. Urol, 82, 846-51.   DOI
21 Rampersaud EN, Klatte T, Bass G, et al (2014). The effect of gender and age on kidney cancer survival: younger age is an independent prognostic factor in women with renal cell carcinoma. Urol Oncol, 32, 9-13.
22 Sengupta S, Lohse CM, Cheville JC, et al (2006). The preoperative erythrocyte sedimentation rate is an independent prognostic factor in renal cell carcinoma. Cancer, 106, 304-12.   DOI
23 Sidharth, Luitel BR, Gupta DK, et al (2011). Pattern of renal cell carcinoma - a single center experience in Nepal. Kathmandu Univ Med J (KUMJ), 9, 185-8.
24 Znaor A, Lortet-Tieulent J, Laversanne M, et al (2015). International variations and trends in renal cell carcinoma incidence and mortality. Eur Urol, 67, 519-30.   DOI
25 Toyoda Y, Shinohara N, Harabayashi T, et al (2007). Survival and prognostic classification of patients with metastatic renal cell carcinoma of bone. Eur Urol, 52, 163-8.   DOI
26 Umbas R, Safriadi F, Mochtar CA, et al (2015). Urologic cancer in Indonesia. Jpn J Clin Oncol, 45, 708-12.   DOI
27 Yap NY, Ng KL, Ong TA, et al (2013). Clinical prognostic factors and survival outcome in renal cell carcinoma patients--a Malaysian single centre perspective. Asian Pac J Cancer Prev, 14, 7497-500.   DOI