With the development of the chemical industry, the chemical accident is increasing every year, thereby increasing the risk of accidents caused by chemicals. The Ministry of Environment provides the criteria for determining shelter-in-place or outdoor evacuation by material, duration of accident, and distance from the toxic substance leak. However, it is hard to say that the criteria for determining the transition point are not clear. Transition point mean the time that evacuation method is switched from shelter-in-place to outdoor evacuation. So, the purpose of this study was to calculate appropriate transition point by comparing the cumulative toxic load. Namdong-gu in Incheon Metropolitan City was finally selected as the target area, considering the current status of the population of Incheon Metropolitan City in 2016 and the statistical survey of chemicals in 2016. The target materials were HCl, HF, and NH3. Modeling was simulated by ALOHA and performed assuming that the entire amount would be leaked for 10 min. Residents' evacuation scenarios were assumed to be shelter-in-place, immediate outdoor evacuation, and outdoor evacuation at an appropriate time after shelter-in-place. Based on the above method, the appropriate transition point from residents located in A(800 m away), B(1,200 m away), C(1,400 m away) and D(2,200 m away) was identified. In HCl, appropriate transition point was after 15 min, after 16 min, after 17 min, after 20 min in order by A, B, C and D. In HF, appropriate transition point was before 1 min or after 16 min, before 4 min or after 19 min, before 5 min or after 20 min, before 14 min or after 26 min in order by A, B, C and D. In NH3, appropriate transition point at A was before 4 min or after 16. Others are not in chemical cloud. This study confirmed the transition point to minimize the cumulative toxic load can be obtained by quantitative method. Through this, it might be possible to select evacuation method quantitatively that cumulative toxic load are minimal. In addition, if the shelter-in-place is maintained without transition to outdoor evacuation, the cumulative toxic load will increase more than outdoor evacuation. Therefore, it was confirmed that actions to reduce the concentration of chemicals in the room were necessary, such as conducting ventilation after the chemical cloud passed through the site.