• Journal of Distribution Science
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• v.18 no.11
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• pp.91-103
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• 2020

The recent Covid-19 outbreak has caused severe disruption of the global supply chain, which tests firms' ability to survive and build resilience. The concept of adaptive supply chain management (A-SCM) has never been tested against a severe supply chain disruption, such as a pandemic. Purpose: The aim of this study is to examine how firms in Indonesia develop resilience through the implementation of components of adaptive supply chain management, namely risk management, resource reconfiguration and supply chain flexibility, in order to survive severe supply chain disruption. Research design, data and methodology: A qualitative method and PLS-SEM were used to analyze 120 data collected from Indonesian manufacturing firms in various industries. Results: The findings show that risk management, resource reconfiguration, and supply chain flexibility are important components that make up A-SCM. However, only risk management contributes to help build firm resilience in the presence of severe supply chain disruption. Conclusions: The components of A-SCM have been empirically tested. The implication is that managers should carefully use RM to prepare firms for different scenarios to develop contingency strategies. This research contributes to the supply chain management body of knowledge in the context of pandemic-level disruption and broadens the dynamic capabilities perspective.

• Industrial Engineering and Management Systems
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• v.12 no.2
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• pp.103-111
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• 2013

This paper discusses how to manage supply chain disruption risks from natural disasters or other low-likelihood-high-impact risk drivers. After the catastrophic earthquake in Eastern Japan and the severe flood in Thailand, most companies have been attempting to re-establish the business continuity plan to prevent their supply chain from disruption. However, the challenges for managers and individual risks are often interrelated, and thus, actions that mitigate one risk can end up being no contribution as a whole. In this paper, we describe a framework for assessing how much impact individual mitigation strategies have on the entire supply chain protection against disruption, using network reliability. We propose three categories of risk-mitigation approaches: Stabilization, Absorption, and Duplication. We analyze the situation under which each of these strategies is the best suitable. With a clear understanding of relations between these mitigation strategies and the entire supply chain risks, managers can select effective risk-reduction approaches to their supply chain.

• Industrial Engineering and Management Systems
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• v.12 no.2
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• pp.74-84
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• 2013

Modern companies have been facing devastating impacts from unexpected events such as demand uncertainties, natural disasters, and terrorist attacks due to the increasing global supply chain complexity. This paper proposes a multi stage logistic network model under disruption risk. To formulate the problem practically, we consider the effect of continuity rate, which is defined as a percentage of ability of the facility to provide backup allocation to customers in the abnormal situation and affect the investments and operational costs. Then we vary the fixed charge for opening facilities and the operational cost according to the continuity rate. The operational level of the company decreases below the normal condition when disruption occurs. The backup source after the disrup-tion is recovered not only as soon as possible, but also as much as possible. This is a concept of the business continuity plan to reduce the recovery time objective such a continuity rate will affect the investments and op-erational costs. Through numerical experiments, we have shown the proposed idea is capable of designing a resilient logistic network available for business continuity management/plan.

• Resources Recycling
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• v.30 no.5
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• pp.3-9
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• 2021

In Korea, base metals such as lead, zinc, copper, tin, nickel, and aluminum have a polarized supply and demand structure. Despite the presence of world-class producers of lead, zinc, and copper, and their production is insufficient. And there are no domestic producers of tin, nickel, and aluminum, Thus, most of the domestic demand is dependent on imports. Therefore, it is necessary to prepare for the risk of supply interruption, such as the disruption of the import of base metals or interruption of domestic production. In this study, we estimated the quantity required to respond to the risk of import disruption, the quantity to which the market can respond, and the quantity to which the government needs to respond for six base metals (copper, lead, zinc, aluminum, nickel, and tin).

• Sleep Medicine and Psychophysiology
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• v.13 no.1
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• pp.5-10
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• 2006

Alcohol has extensive effects on sleep and daytime sleepiness. Alcohol has a sleep inducing effect and the effect of increased non-REM sleep and suppressed REM sleep during the first half portion of night sleep, but alcohol induces the effect of decreased non-REM sleep and increased light sleep and frequent awakenings and REM rebound during the second half portion of night sleep. Alcohol provokes chronobiological change such as the changes of amplitude or the phase shifts of hormones or core body temperature. The sleep disruption resulting from alcohol drinking may lead to daytime fatigue and sleepiness. The elderly are at particular in the increased risk of alcohol-related sleep disorders because they achieve higher levels of alcohol in the blood and brain than do younger adults after consuming an equivalent dose. Bedtime alcohol consumption among older adults may lead to unsteadiness if walking is attempted during the night, with increased risk of falls and injuries. Continued alcohol use for sleep induction often induces aggravation of insomnia, alcoholism or sleep related breathing disorders such as obstructive sleep apnea. Alcohol should not be used as substitution of sleep pill because of the dependence and tolerance for sleep inducing effect, and the sleep disruption produced by alcohol withdrawal.

• Management & Information Systems Review
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• v.27
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• pp.149-172
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• 2008

Since the 9/11 terror attack, the event which caused supply chain disruption, supply chain security has becomes more important than ever before. Furthermore, such company's logistics strategies conflicting supply chain security as increased global sourcing, JIT manufacturing are increasing supply chain vulnerability. It could burden for global companies to strengthen supply chain security because not only it requires additional investment cost but also changes of companiy's global logistics strategy. However, on the other hand, supply chain visibility and resilience can be improved through supply chain security. In addition, it allows companies to stabilize supply chain structure as well as rapid and flexible response to market demand. The key issue is balancing between efficiency and supply chain security. To do this, identifying risk elements under the supply chain and assessing vulnerability of each supply chain components should be performed before developing efficient supply chain security management system without obstructing supply chain efficiency.

• The Korean journal of internal medicine
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• v.39 no.4
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• pp.563-576
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• 2024

The detection of early colorectal cancer (CRC) is increasing through the implementation of screening programs. This increased detection enhances the likelihood of minimally invasive surgery and significantly lowers the risk of recurrence, thereby improving patient survival and reducing mortality rates. T1 CRC, the earliest stage, is treated endoscopically in cases with a low risk of lymph node metastasis (LNM). The advantages of endoscopic treatment compared with surgery include minimal invasiveness and limited tissue disruption, which reduce morbidity and mortality, preserve bowel function to avoid colectomy, accelerate recovery, and improve cost-effectiveness. However, T1 CRC has a risk of LNM. Thus, selection of the appropriate treatment between endoscopic treatment and surgery, while avoiding overtreatment, is challenging considering the potential for complete resection, LNM, and recurrence risk.

• Toxicological Research
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• v.26 no.4
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• pp.301-313
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• 2010

Growth promoters including hormonal substances and antibiotics are used legally and illegally in food producing animals for the growth promotion of livestock animals. Hormonal substances still under debate in terms of their human health impacts are estradiol-$17\beta$, progesterone, testosterone, zeranol, trenbolone, and melengestrol acetate (MGA). Many of the risk assessment results of natural steroid hormones have presented negligible impacts when they are used under good veterinary practices. For synthetic hormonelike substances, ADIs and MRLs have been established for food safety along with the approval of animal treatment. Small amounts of antibiotics added to feedstuff present growth promotion effects via the prevention of infectious diseases at doses lower than therapeutic dose. The induction of antimicrobial resistant bacteria and the disruption of normal human intestinal flora are major concerns in terms of human health impact. Regulatory guidance such as ADIs and MRLs fully reflect the impact on human gastrointestinal microflora. However, before deciding on any risk management options, risk assessments of antimicrobial resistance require large-scale evidence regarding the relationship between antimicrobial use in food-producing animals and the occurrence of antimicrobial resistance in human pathogens. In this article, the risk profiles of hormonal and antibacterial growth promoters are provided based on recent toxicity and human exposure information, and recommendations for risk management to prevent human health impacts by the use of growth promoters are also presented.

• Earthquakes and Structures
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• v.13 no.4
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• pp.421-427
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• 2017

Seismic safety evaluation of weir structure is significant considering the catastrophic economical consequence of operational disruption. In recent years, the seismic probabilistic risk assessment (SPRA) has been issued as a key area of research for the hydraulic system to mitigate and manage the risk. The aim of this paper is to assess the seismic probabilistic risk of weir structures employing the seismic hazard and the structural fragility in Korea. At the first stage, probabilistic seismic hazard analysis (PSHA) approach is performed to extract the hazard curve at the weir site using the seismic and geological data. Thereafter, the seismic fragility that defines the probability of structural collapse is evaluated by using the incremental dynamic analysis (IDA) method in accordance with the four different design limit states as failure identification criteria. Consequently, by combining the seismic hazard and fragility results, the seismic risk curves are developed that contain helpful information for risk management of hydraulic structures. The tensile stress of the mass concrete is found to be more vulnerable than other design criteria. The hazard deaggregation illustrates that moderate size and far source earthquakes are the most likely scenario for the site. In addition, the annual loss curves for two different hazard source models corresponding to design limit states are extracted.

• Journal of Environmental Health Sciences
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• v.36 no.5
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• pp.418-434
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• 2010

As concerns regarding water pollution grow, the need increases for a fast and accurate assessment of ecological risk. In this context, many studies have been conducted to identify biomarkers which can sensitively indicate exposure to and effects of various contaminants in a water environment. However, the utility of most such biomarkers in the real water environment is not yet validated. In this paper, we conducted a thorough review of publications that were related to developing or evaluating molecular and biochemical biomarkers of freshwater fish in ecological risk assessment, and evaluated whether these biomarkers of interest could link to the effects on higher biological levels, such as histopathology and above. Biomarkers of interest included those associated with metabolism, oxidative stress, reproduction and endocrine disruption, genotoxicity, and defense against heavy metal exposure. We found that, when used alone, most molecular and biochemical biomarkers are not sufficient to understand the effects of toxic substances in higher biological levels, due to defense or acclimation mechanisms of organisms. Moreover, some biomarkers respond not only to hazardous substances but also to the changes in water quality and disease outbreak. Molecular and biochemical biomarkers may be most useful in understanding the potential biological effects of toxic compounds when used in parallel with relevant endpoints of higher biological levels.