• Radiation Oncology Journal
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• v.12 no.3
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• pp.285-293
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• 1994

Purpose : The study was designed to investigate the effect of cis-dichlorodiammineplatinum(II)(cis-DDP) on the radiation-induced cardiomyopathy in the rat. Materials and Methods : The myocardial damage was assessed by histopathologic changes. In radiation alone group, radiation dose ranged from 10-40 Gy X-ray in a single dose and in combined group, cis-dichlorodiammineplatinum(II) at a dose of 6 mg/kg was given intraperitoneally immediately after irradiation of same dose with X-ray alone group. Results : The early changes by radiation included congestion, inflammatory cell infiltrations and fibrosis in myocardial interstitium with focal myocardial necrosis, which was noted in 10 Gy group, Myocardial fibrosis was increased by increasing dose of radiation but myocardial necrosis was not Proportional to radiation dose. cis-DDP alone group showed minimal degeneration of myocardium with surrounded by inflammatory cell infiltrations. In combined group, myocardial fibrosis in 10 Gy group were similar to radiation alone group, but 30 Gy and 40 Gy groups showed severer changes. Electron microscopic examination showed disruption of Z-band and edema of mitochondria with decreased matrix density in 20 Gy radiation group which were severer in 40 Gy radiation group. Combined group showed endothelial changes and disruption of Z-band worse than radiation alone group as well as increased connective tissue, which was considered as a hallmark of late change in radiation-induced heart disease. Conclusion : This results showed minimal enhancement of the radiation-induced cardiomyopathy in rats by cis-DDP.

• Journal of Microbiology and Biotechnology
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• v.22 no.6
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• pp.793-799
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• 2012

A gene related to high pristinamycin yield in Streptomyces pristinaespiralis was selected by amplified fragment length polymorphism (AFLP) and its functions were investigated by gene disruption. First, a 561 bp polymorphic sequence was acquired by AFLP from high-yield recombinants compared with the S. pristinaespiralis ancestor ATCC25486, indicating that this approach is an effective means of screening for valuable genes responsible for antibiotic yield. Then, a 2,127 bp open reading frame of a gene designated spy1 that overlaps with the above fragment was identified and its structure and biological functions were investigated. In silico analysis of spy1 encoding a deduced 708-amino-acid-long serine/threonine protein kinase showed that it only contains a catalytic domain in the N-terminal region, which is different from some known homologs. Gene inactivation of chromosomal spy1 indicated that it plays a pleiotropic regulatory function in pristinamycin production, with a positive correlation to pristinamycin I biosynthesis and a negative correlation to pristinamycin II biosynthesis.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2013.10a
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• pp.524-525
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• 2013

동적 움직임을 가지는 노드에 대한 DTN(Delay/Disruption Tolerant Network)은 노드의 연결단절 및 불규칙적인 노드의 움직임에 의한 불안정한 상태를 해결하는 방법 중 하나이다. 특히 DTN은 재난상황 또는 움직임이 많은 노드간의 상관관계를 분석하여 노드 간 연결 확립을 보장함으로써 데이터 연결성과 전송률을 개선한다. 본 논문은 노드의 움직임에 대한 속성 정보를 기반하여 구성된 클러스터 구조의 네트워크에서 헤드노드 간의 연결 가능성을 분석하며 데이터를 목적지까지 포워딩하는 방식으로 망을 제어 유지하기 위한 방법으로 EPCM(Efficient Prediction-based Context-Awareness Matrix) 알고리즘을 제안하고자 한다. 이를 위해 적용한 상황 매트릭스는 시간에 따른 헤드노드들의 움직임과 속도 등의 상황 예측이 가능한 정보를 포함한 포워딩 분석 요소를 제공한다. EPCM 알고리즘은 노드가 주기적인 이동성을 가진다는 가정 하에 포워딩에 요구되는 상관관계를 연산 분석하여 예측 경로를 제공한다. 노드의 이동에 의해 경로가 변화하는 환경에서 EPCM 알고리즘은 상황 매트릭스를 통해 헤드노드의 연결 정보를 저장하고 관리함으로써 연결성을 보장하고 짧은 지연시간에 효율적인 전송이 가능할 것이다.

• Archives of Pharmacal Research
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• v.28 no.7
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• pp.810-815
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• 2005

Previously, we have shown that astrocytes deprived of glucose became highly vulnerable to peroxynitrite, and adenosine and its metabolites attenuated the gliotoxicity via the preservation of cellular ATP level. Here, we found that adenosine and related metabolites prevented the disruption of mitochondrial transmembrane potential (MTP) in glucose-deprived rat primary astrocytes exposed to 3-morpholinosydnonimine (SIN-1), a peroxynitrite releasing agent. Exposure to glucose deprivation and SIN-1(2h) significantly disrupted MTP in astrocytes, and adenosine prevented it in dose-dependent manner with an $EC_{50}\;of\;5.08{\mu}M$. Adenosine also partially prevented the cell death by myxothiazol, a well-known inhibitor of mitochondrial respiration. Blockade of adenosine deamination or intracellular transport with erythro-9-(-hydroxy-3-nonyl)adenosine (EHNA) or S-(4-nitrobenzyl)-6-thioinosine (NBTI), respectively, completely reversed the protective effect of adenosine. Other purine nucleos(t)ides including inosine, guanosine, ATP, ADP, AMP, ITP, and GTP also showed similar protective effects. This study indicates that adenosine and related purine nucleos(t)ides may protect astrocytes from peroxynitrite-induced mitochondrial dysfunction.

• Korean Journal of Microbiology
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• v.54 no.2
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• pp.140-145
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• 2018

The most energy-intensive processes in lipids extraction were the disruption of the cell wall of microalgae. Here, we tried to extract lipids through lysis using virus-infecting microalgae, to compare with those by the other two methods using microwave or ultrasonication. The lipids yield using viral infection was not significantly different from those using ultrasonication and microwave oven. This suggests that the same amount of lipids can be obtained with low energy and costs, as well as that microalgal lipids extraction by chlorella virus infection might provide the price competitiveness in biodiesel production even if it will be applied to mass production facilities.

• Journal of Communications and Networks
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• v.7 no.1
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• pp.76-86
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• 2005

Today's wireless access networks consist of several tiers that overlap each other. Provisioning of real time undisrupted communication to mobile users, anywhere and anytime through these heterogeneous overlay networks, is a challenging task. We extend the end-to-end approach for the handoff management in hybrid wireless data network by designing a fully mobile-controlled handoff for mobile devices equipped with dual mode interfaces. By handoff, we mean switching the communication between interfaces connected to different subnets. This mobile-controlled handoff scheme reduces the service disruption time during both horizontal and vertical handoffs and does not require any modification in the access networks. We exploit the IP diversity created by the dual interfaces in the overlapping area by simultaneously connecting to different subnets and networks. Power saving is achieved by activating both interfaces only during the handoff period. The performance evaluation of the handoff is carried out by a simple mathematical analysis. The analysis shows that with proper network engineering, exploiting the speed of mobile node and overlapping area between subnets can reduce service disruption and power consumption during handoff significantly. We believe that with more powerful network interfaces our proposal of dual interfaces can be realized.

• Bulletin of the Korean Chemical Society
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• v.19 no.4
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• pp.462-466
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• 1998

The homobimetallic anion, $({\eta}^5-MeCp)Mn(CO)_2Mn(CO)_5-M^+\; (M^+=Na^+, PPN^+$) was disrupted by $PR_3\;(R=C_6H_5,\;C_2H_5,\;OCH_3)$ in THF at various temperatures (r.t. ∼65℃) under the pseudo first order reaction conditions where excess of $PR_3$ was employed under a nitrogen atmosphere. For the reaction involving $PPN^+$ analog, Mn-Mn heterolytic cleavage occurred, leading to $PPN^+Mn(CO)_5^-\; and \;({\eta}^5-MeCp)Mn(CO)_2PR_3$ as products; however, in case of $Na^+\; analog,\; Na^+$ seems to play a novel counter ion effect on the disruption reaction by transferring one terminal CO from the $Mn(CO)_5$ moiety on to the $({\eta}^5-MeCp)Mn(CO)_2$ of the corresponding homobimetallic complex, eventually resulting in $Na^+Mn(CO)_4PR_3^-\;and\;({\eta}^5-MeCp)Mn(CO)_3$. This reaction is of overall first order with respect to [homobimetallic complex] with the activation parameters (ΔH≠=23.0±0.7 kcal/mol, ΔS≠= - 8.7±0.8 e.u. for $Na^+$ analog; ΔH≠=28.8±0.4 kcal/mol, ΔS≠=15.7±0.6 e.u. for $PPN^+$ analog reaction).

• Child Health Nursing Research
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• v.25 no.1
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• pp.9-16
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• 2019

Purpose: Childhood leukemia is a serious trauma affecting both adolescents and their parents, who experience painful process. However, adolescents with leukemia and their parents also experience positive changes, which is referred to as posttraumatic growth. We examined posttraumatic growth, core beliefs, impact of event, and event-related rumination in adolescents within 5 years of a diagnosis of childhood leukemia and their parents. Methods: The participants were 68 adolescents with childhood leukemia (aged 13~18 years) and their parents, who were recruited from C university hospital in Korea from May to September 2016. The Posttraumatic Growth Inventory, Core Belief Inventory, Impact of Event Scale-Revised, and Event-related Rumination Inventory were completed by the adolescents and their parents. The mean scores and correlations between variables were investigated for both set of participants. Results: Parents showed significantly higher levels of posttraumatic growth, disruption of core beliefs, impact of event, and invasive rumination than adolescents. Disruption of core beliefs and deliberate rumination were positively correlated with posttraumatic growth in both groups. Conclusion: Nursing intervention programs that involve modifying core beliefs and inducing a positive thought can help adolescents with leukemia and their parents grow after traumatic events.

• The Bulletin of The Korean Astronomical Society
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• v.44 no.1
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• pp.48.2-48.2
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• 2019

Tidal disruption events (TDEs) provide evidence for quiescent supermassive black holes (SMBHs) in the centers of inactive galaxies. TDEs occur when a star on a parabolic orbit approaches close enough to a SMBH to be disrupted by the tidal force of the SMBH. The subsequent super-Eddington accretion of stellar debris falling back to the SMBH produces a characteristic flare lasting several months. It is theoretically expected that the bolometric light curve decays with time as proportional to $t^{-5/3}$. However, some of the observed X-ray light curves deviate from the $t^{-5/3}$ decay rate, while some of them are overall in good agreement with the $t^{-5/3}$ law. Therefore, it is required to construct the theoretical model for explaining these light curve variations consistently. In this paper, we revisit the mass fallback rates semi-analytically by taking account of the stellar internal structure, orbital eccentricity and penetration factor. We find that the mass fallback rate is shallower than the standard $t^{-5/3}$ decay rate independently of the polytropic index, and the orbital eccentricity only changes the magnitude of the mass fallback rate. Furthermore, the penetration factor significantly can modify the magnitude and variation of mass fallback rate. We confirm these results by performing the computational hydrodynamic simulations. We also discuss the relevance of our model by comparing these results with the observed light curves.

• Resources Recycling
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• v.30 no.5
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• pp.3-9
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• 2021

In Korea, base metals such as lead, zinc, copper, tin, nickel, and aluminum have a polarized supply and demand structure. Despite the presence of world-class producers of lead, zinc, and copper, and their production is insufficient. And there are no domestic producers of tin, nickel, and aluminum, Thus, most of the domestic demand is dependent on imports. Therefore, it is necessary to prepare for the risk of supply interruption, such as the disruption of the import of base metals or interruption of domestic production. In this study, we estimated the quantity required to respond to the risk of import disruption, the quantity to which the market can respond, and the quantity to which the government needs to respond for six base metals (copper, lead, zinc, aluminum, nickel, and tin).