• Journal of Korea Society of Industrial Information Systems
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• v.26 no.3
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• pp.9-22
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• 2021

This study proposes a supply chain network (SCN) model considering supply disruption in assembly industry. For supply disruption, supplier disruption and its route disruption are simultaneously taken into consideration in the SCN model. With the simultaneous consideration, the SCN model can achieve its flexibility and efficiency. A mathematical formulation is suggested for representing the SCN model, and a proposed hybrid genetic algorithm (pro-HGA) is used for implementing the mathematical formulation. In numerical experiment, the performance of the pro-HGA approach is compared with those of some conventional approaches using the SCN models with various scales, and a sensitivity analysis considering the change of the numbers of suppliers and backup routes is done. Experimental results show that the performances of the pro-HGA approach are superior to those of the conventional approaches, and the flexibility and efficiency of the SCN model considering supply disruption are proved. Finally, the significance of this study is summarized and a potential future research direction is mentioned in conclusion.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.20 no.8
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• pp.33-41
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• 2021

Recently, many studies have been conducted on substituting fossil fuels with bio-refineries in existing industrial systems using biomass. Among the various bio-refineries, microalgae have received wide attention because it uses inorganic compounds to produce useful substances, which are extracted by a cell disruption process. Although numerous cell disruption methods exist, cell disruption efficiency has been studied by ultrasonic treatment. Ultrasound is a high-frequency (20 kHz or higher) sound wave and causes cell disruption by cavitation when passing through a solvent. In this study, we used the microalgal species Chlorella sp., which was cultured in a plate-type photobioreactor. The experiment was conducted using a continuous low-frequency processing device. The reduction of cells with time due to cell disruption was fitted using a logistic model, and optimum conditions for highly efficient cell disruption were determined by conducting experiments under multiple conditions.

• Journal of Environmental Health Sciences
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• v.39 no.1
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• pp.1-18
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• 2013

Objectives: Although a great body of knowledge is available on the toxicity of bisphenol A (BPA), little is known about that of BPA alternatives, such as bisphenol analogues (BPs) or $Tritan^{TM}$ copolyesters. This review provides a summary of the available information on the toxicity of BPs and three components of $Tritan^{TM}$, with a special focus on endocrine disruption. Methods: We collected from the literature a battery of in vitro and in vivo assay data developed to assess endocrine disruption of four BPs (bisphenol AF, B, F, and S) and three major components of $Tritan^{TM}$ ((di-methylterephthalate (DMT), 1,4-cyclohexanedimethanol (CHDM), and 2,2,4,4-tetramethyl-1,3-cyclobutanediol (TMCD)). Results: Several alternative compounds were identified as possessing comparable or even greater endocrinedisrupting effects than BPA in in vitro and in vivo studies. Conclusions: Potential endocrine disruption of BPA alternatives requires further studies on health consequences in experimental animals and in humans following longer term exposure.

• Journal of Distribution Science
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• v.18 no.11
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• pp.91-103
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• 2020

The recent Covid-19 outbreak has caused severe disruption of the global supply chain, which tests firms' ability to survive and build resilience. The concept of adaptive supply chain management (A-SCM) has never been tested against a severe supply chain disruption, such as a pandemic. Purpose: The aim of this study is to examine how firms in Indonesia develop resilience through the implementation of components of adaptive supply chain management, namely risk management, resource reconfiguration and supply chain flexibility, in order to survive severe supply chain disruption. Research design, data and methodology: A qualitative method and PLS-SEM were used to analyze 120 data collected from Indonesian manufacturing firms in various industries. Results: The findings show that risk management, resource reconfiguration, and supply chain flexibility are important components that make up A-SCM. However, only risk management contributes to help build firm resilience in the presence of severe supply chain disruption. Conclusions: The components of A-SCM have been empirically tested. The implication is that managers should carefully use RM to prepare firms for different scenarios to develop contingency strategies. This research contributes to the supply chain management body of knowledge in the context of pandemic-level disruption and broadens the dynamic capabilities perspective.

• Proceedings of the Korean Society of Toxicology Conference
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• 2002.05a
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• pp.132-132
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• 2002

Effects of antioxidant vitamins were investigated in di(2-ethylhexyl) phthalate (DEHP)-induced endocrine disruption toxicity. After rats were treated with DEHP, and vitamin C and vitamin E were supplemented for 30 days.(omitted)

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.19 no.2
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• pp.111-118
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• 2020

Recently, bioenergy research using microalgae, one of the most promising biofuel sources, has attracted much attention. Cell disruption, which can be classified as physical or chemical, is essential to extract functional ingredients from microalgae. In this study, we investigated the cell disruption efficiency of Chlorella sp. using low-frequency non-focused ultrasound (LFNFU). This is a continuously physical method that is superior to chemical methods with respect to environmental friendliness and low processing cost. A flat panel photobioreactor was employed to cultivate Chlorella sp. and its growth curve was fitted both with Logistic and Gompertz models. The temporal change in cell reduction by cell disruption using LFNFU was fitted with a Logistic model. The experimental conditions that were investigated were the initial concentration of microalgal cells, relative amplitude of output ultrasound waves, processing volume of microalgal cells, and initial pH value. The optimal conditions for the most efficient cell disruption were determined through the various tests.

• Korean Journal of Adult Nursing
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• v.17 no.2
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• pp.310-319
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• 2005

Purpose: The purpose of the study is to investigate the degree of fatigue and its related factors in patients with breast cancer. Method: The subjects of this study consisted of 62 breast cancer patients receiving chemotherapy. The Revised Piper Fatigue Scale, Disruption of Usual Activity Scale, Linear Analogue Self Assessment Scale and Self-Care Diary Scale were employed to measure fatigue, disruption of usual activity, mood state and physical symptom respectively. Collected data were analyzed using SPSS-PC to obtain summary statistics for the descriptive analysis, Pearson Correlation, and Stepwise Multiple Regression. Result: The results are as follows. 1. The mean score of the degree of fatigue was 4.82 points indicating moderate level. 2. The mean score of the degree of disruption of usual activity, mood state and physical symptom were 2.66, 5.00, and 4.69 points. 3. Fatigue of the subjects was significantly correlated with disruption of usual activity(r=.517, p<.01), mood state(r=.420, p<.01) and physical symptom(r=.463, p<.01). 4. With the result of stepwise multiple regression, disruption of usual activity, mood state and physical symptom being the three variables which could explain fatigue by 39.1%. The results of this study suggest that comprehensive intervention strategy for fatigue should be developed to maintain quality of life during and following chemotherapy considering these factors.

• Journal of Yeungnam Medical Science
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• v.8 no.1
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• pp.238-245
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• 1991

The disc internal disruption syndrome is not well known to us, but the following hypothesis is widely accepted in clinical practice. The disc internal disruption syndrome may develop intractable back pain with aggrevated of pain, loss of spinal motion with any physical exercise, leg pain, loss of energy, marked weight loss, and profound depression. The patient with this syndrome will be found to have normal plain roentgenograms, myelograms, CT scans, results of blood examination and neurologic findings. For these reasons, this syndrome was frequently diagnosed by abnormal discographic findings. We had experience with two cases of disc internal disruption syndrome with clinical, roentgenographic and discographic evaluations. Thus We present these cases with a brief review of the concerned literature.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.16
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• pp.6547-6552
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• 2014

Background: Cancer is a major life event that imposes huge economic and mental burdens on patients and families. In addition, the diagnosis of cancer also causes significant family discordance that can lead to marital problems such as divorce or separation. The aim of this study was to investigate the association and any related gender differences between cancer diagnosis and marital disruption among cancer survivors. Materials and Methods: We used the recent cross-sectional Korea National Health and Nutrition Examination Survey ($4^{th}$ and $5^{th}$; Years 2008-2012). The study participants were 623 married cancer survivors over the age of 19. A multivariate logistic regression analysis was conducted to estimate odds ratios. Results: After adjusting for socioeconomic status and health-related behaviors, the odds ratio of marital disruption among female cancer survivors compared with male cancer survivors was 3.94 (95%CI 1.30-11.94; p=0.02). The odds ratio of marital disruption for the below-average economic level compared with the above-average economic level was 5.64 (95%CI: 1.03-31.02; p=0.05). When compared with the non-smoking cancer survivors, the smoking cancer survivors had an OR of marital disruption equal to 2.94 (95%CI: 1.08-8.00; p=0.03). Conclusions: The findings of this study suggest that the odds of marital disruption among female cancer survivors are higher than those among their male couterparts. Medical practitioners should be sensitive to early signs of marital discord in couples affected by a cancer diagnosis. Early identification and psychosocial intervention might reduce the frequency of divorce and separation and thus improve quality of life and quality of care for cancer survivors.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.26 no.1
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• pp.1-5
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• 2017

This study investigated the mechanical tearing of a cell membrane using a nanostructured alumina filter for easy and quick mechanical cell disruption. Nanostructured alumina filters were prepared by a multi-step aluminum anodizing process and nanopore etching process. Six different types of nanostructures were formed on the surface of the nanoporous alumina filters to compare the mechanical cell disruption characteristics according to the shape of the nanostructure. The prepared alumina filter was assembled in a commercial filter holder, and then, NIH3T3 fibroblast cells in a buffer solution were passed through the nanostructured alumina filter at a constant pressure. By measuring the concentration of proteins and DNA, the characteristics of mechanical cell disruption of the nanostructured alumina filter were investigated.