• 한국콘텐츠학회논문지
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• 제18권6호
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• pp.193-203
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• 2018

본 연구는 결혼이주여성의 종교성향과 결혼적응과의 관계에서 종교적 문제해결의 매개효과를 검증하고자 하였다. 연구대상은 도시(서울), 농촌(경북) 지역 그리스도인 302명(개신교 185명, 천주교 117명)을 대상으로 종교성향, 종교적 문제해결, 결혼적응검사를 사용하여 설문조사를 실시하였다. 자료 분석은 SPSS 25.0을 사용하였다. 연구 결과는 다음과 같다. 첫째, 결혼이주여성의 종교성향, 결혼적응, 종교적 문제해결 모두 상관이 있는 것으로 나타났다. 둘째, 종교성향과 결혼적응과의 관계에서 종교적 문제해결은 부분매개효과가 있는 것으로 나타났다. 본 연구는 지금까지 결혼이주여성의 종교성에 대한 연구가 거의 이루어지지 않았다는 상황에서 종교성향과 종교적 문제해결이 결혼적응에 미치는 영향력을 실증적으로 검증하였다는 데 의의가 있다. 후속연구에서는 결혼이주여성의 적응에 영향을 미치는 종교성 요인에 대하여 질적 분석을 통해 결혼이주여성의 종교적 삶을 입체적으로 조망할 필요가 있겠다.

• 약학회지
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• 제28권4호
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• pp.207-215
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• 1984

Effects of Ssang Wha Tang (SWT), a blended Chinease traditional medicine, on the pharmacokinetics of sulfobromophthalein (BSP) in the rats of hepatic failure induced by carbon tetrachloride were examined. The disposition of plasma BSP in carbon tetrachloride-treated rats (Group I) and in carbon tetrachloride+SWT-treated rats (Group II) followed a three-compartment model, while those in control group followed two-compartment model. GOT, GPT level and some pharmacokinetic paramiters like plasma clearance but except distribution volume (Vdss) recovered in Group II compared to Group I. Therefore, SWT seemed to have an apparent restoring effect of hepatic function damaged by carbon tetrachloride treatment. From the fact that Vdss of BSP in Group II was considered as an one of the probable mechanisms. More intensive increase in BSP-free fraction ($f_p$) in Group II than that in Group I might also explain the increases of BSP clearance and Vdss in Group II compared to Group I. Assuming no changes in hepatic plasma flow(Q) in each group, hepatic intrinsic clearance($CL^h_{int}$) decreased in Group I did not recovered not at all in Group II. Therefore SWT seemed not to have any restoring effect of true hepaticfunction to biotransform and excrete BSP, and the apparent restoring effect of SWT might be due only to the replacement of BSP-plasma protein binding. Whether $f_p$ is actually higer in Group II than in Group I, and Q is constant in each group are being examined in our laboratory. The changes of Q, which might lead to another conculusions, also should be taken into consideration to clarify the apparent hepatorestoring effect of SWT.

• 융합정보논문지
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• 제9권3호
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• pp.36-43
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• 2019

본 연구의 목적은 간호대학생의 직소모형과 플립러닝 융합교육의 효과를 확인하기 위함이며 비동등성 대조군 전 후 설계 실험연구이다. 연구대상자는 J지역에 소재한 간호학과 3학년 통합실습II를 수강한 81명의 학생으로 자료는 설문지를 이용하여 융합교육 전 후에 수집되었다. 연구결과, 직소모형과 플립러닝 융합교육이 학습만족도(t=-3.783, p=.001)에서 유의하게 나타났다. 따라서 직소모형과 플립러닝 융합교육을 교수학습방법으로 활용하면 학습만족도를 향상시켜 학습성과를 극대화 시킬 수 있을 것으로 사료되며, 본 연구는 그 기초자료로 의의가 있다. 이러한 연구결과를 토대로 직소모형과 플립러닝을 융합한 후속연구와 교수학습 프로그램 개발 및 적용이 필요하다.

• 한국식품위생안전성학회지
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• 제5권4호
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• pp.229-236
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• 1990

SPF wistar계 랫트를 이용하여 Vitamin A(VA)의 과잉 투여 ($40{\times}10^4IU/kg$)에 의한 최기형성 대하여 ethanol(E) 2g/kg을 임신 9일부터 임신 11일까지 3일간 경구로 병용 투여한 결과 다음과 같은 결과를 얻었다. 1.임신 모체의 영향에 있어서 $VA{\times}E$ 병용 투여군이 대조군 및 VA 단독투여군에 비해 유의한 체중증가의 억제를 보였다. 2. 태자 사망율은 VA+E 병용 투여군이 VA 단독 투여군에 비해 유의하게 증가되었고 (p<0.05), 태자의 평균 체중은 VA+E 병용 투여군에 대조군에 비해 유의하게 감소되었으며(p<0.01), VA 단독 투여군과의비교에서도 유의한 감소를 보였다. (p<0.05). 3. 외표기형의 발생율은 VA 단독투여군에 비해 VA+E 병용투여군이 증가되어 나타났다. 발현된 기형의 특징은 귀위치이상, 부이(복이), 안검개존, 소구증, 단악증, 구개열 등이다. 이상의 경과에서 Vitamin A의 과잉투여에 의한 최기형성에 ethanol이 상승적으로 작용함을 알 수 있다.

• 한국콘텐츠학회논문지
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• 제17권7호
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• pp.332-343
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• 2017

본 연구는 개인의 이타적 성향과 메시지 프레이밍의 상호작용이 국제기아 돕기 캠페인의 효과에 미치는 영향에 대하여 조사하였다. 이타적 성향은 고통 받는 타인에게 연민을 느끼고, 관심을 갖는 정도를 나타내는 공감적 관심을 선정하였고, 프레이밍은 도움을 주었을 때의 긍정적 결과 혹은 도움을 주지 않았을 때의 부정적 결과를 강조하는 대비 방식을 이용하였다. 실험은 175명을 대상으로 실행되었으며, 2단계로 나누어서 실행되었다. 1단계에서는 참여자들의 이타적 성향과 관여도에 관한 설문을 진행하였고, 2단계에서는 긍정적 혹은 부정적으로 유형화된 메시지를 제시한 후 나타나는 반응을 측정하였다. 연구 결과, 긍정적 프레이밍에서 공감적 관심이 높은 사람들이 낮은 사람들에 비하여 더 높은 행위 의도와 친밀감을 보여주었고, 부정적 프레이밍은 차별적 반응을 이끌어 내지 않은 것으로 나타났다. 그리고 인지된 친밀감은 행위 의도에 대한 상호작용을 매개하는 것으로 나타났다.

• The Korean Journal of Physiology and Pharmacology
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• 제18권3호
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• pp.233-239
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• 2014

The present study was designed to investigate the effect Hypericum Perforatum (HP), on behavioral changes, corticosterone, TNF-${\alpha}$ levels and tryptophan metabolism and disposition in bilateral ovariectomized rats compared to $17{\alpha}$-ethinylestradiol. Behavioral analysis by measuring immobility time in forced swimming test and open field test, serum and hippocampal corticosterone and TNF-${\alpha}$ along with hippocampal kynurenine/tryptophan ratio were determined in mature ovariectomized rats treated orally either by HP at three different doses 125, 250, and 500 mg/kg/day or by $17{\alpha}$-ethinylestradiol $30{\mu}g/kg/day$ for 30 days. Ovariectomized rats showed significant increase in immobility time in the forced swimming test. Along with elevation in serum and hippocampal TNF-${\alpha}$ and corticosterone levels associated with significant increase in hippocampal kynurenine/tryptophan ratio. Immobility time in the forced swimming test was decreased in rats treated by different doses of HP in a dose dependent manner and $17{\alpha}$-ethinylestradiol with no concomitant changes in the open field test. Only Rats treated with HP exhibited significant decrease in the elevated serum and hippocampal TNF-${\alpha}$ and corticosterone, which couldn't explain the associated insignificant effect on hippocampaus kynurenine/tryptophan ratio in comparison to ovariectomized untreated rats. It is concluded that increased tryptophan metabolism toward kynurenine secondary to elevated corticosterone and TNF-${\alpha}$ might be one of the pathohphysiological mechanisms that could explain depression like state observed in this rat model. Further, the observed attenuating effect of HP on TNF-${\alpha}$ and corticosterone could contribute in its antidepressant effect in this animal model by other ways than their effects on tryptophan-kynurenine metabolism pathway.

• 한국유통학회지:유통연구
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• 제11권4호
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• pp.97-124
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• 2006

본 연구에서는 소매전문점에서의 관계마케팅요인(고객화, 전문성, 커뮤니케이션, 유대)이 관계품질(신뢰, 만족) 및 점포충성도에 미치는 영향을 실증적으로 검정하였다. 그 결과 커뮤니케이션을 제외한 모든 관계마케팅요인이 관계품질에 긍정적인 영향을 미치고 있고 그 가운데 고객화가 관계품질 형성에 가장 높은 영향을 미치는 것으로 나타났다. 또한 소비자 특성변수(성별과 거래경험 및 다양성 추구성향)에 따른 조절효과에서는 관계마케팅요인에 따라 중요도에 차이는 있으나, 커뮤니케이션을 제외한 모든 관계마케팅요인이 관계품질에 긍정적인 영향을 미쳐 최종적으로 점포충성도를 형성하는 것을 확인할 수 있었다. 소매전문점은 고객과의 관계형성에 있어 대형점포보다는 유리한 조건에 있다. 그러므로 개별 고객들의 성향을 면밀히 파악하여 맞춤식 서비스를 제공하는 고객화와 고객들과의 관계형성을 위한 종업원의 전문성 및 유대관계가 소매전문점 고객의 점포충성도를 형성하는 중요한 요인임이 확인되었다.

• 약학회지
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• 제54권4호
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• pp.252-257
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• 2010

The aim of this study was to investigate the effect of resveratrol on the pharmacokinetics of nifedipine in rats. The pharmacokinetic parameters of nifedipine were measured after the oral administration of nifenipine (6 mg/kg) in the presence or absence of resveratrol (0.5, 2.5 and 10 mg/kg, respectively). The effect of resveratrol on the P-glycoprotein (Pgp), CYP 3A4 activity was also evaluated. Resveratrol inhibited CYP3A4 enzyme activity in a concentration-dependent manner with 50% inhibition concentration ($IC_{50}$) of 0.94 ${\mu}M$. In addition, resveratrol significantly enhanced the cellular accumulation of rhodamine 123 in MCF-7/ADR cells overexpressing P-gp. Compared to the control groups, the presence of 2.5 mg/kg and 10 mg/kg of resveratrol significantly (p<0.05, p<0.01) increased the area under the plasma concentrationtime curve (AUC) of nifedipine by 49~75%, and the peak concentration ($C_{max}$) of nifedipine by 48~66%. The absolute bioavailability (AB%) of nifedipine was significantly (p<0.05) increased by 22.9-34.8% compared to the control (19.8%). The terminal half-life ($T_{1/2}$) of nifedipine was significantly (p<0.05) increased compared to the control. While there was no significant change in the time to reach the peak plasma concentration ($T_{max}$) of nifedipine in the presence of resveratrol. It might be suggested that resveratrol altered disposition of nifedipine by inhibition of both the CYP3A and P-glycoprotein efflux pump in the small intestine of rats. In conclusion, the presence of resveratrol significantly enhanced the oral bioavailability of nifedipine, suggesting that concurrent use of resveratrol or resveratrol-containing dietary supplenment with nifedipine should require close monitoring for potential drug interation.

• 가정과삶의질연구
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• 제30권3호
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• pp.179-192
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• 2012

The purpose of this study is to investigate the variable factors influencing children's interpersonal relationship skills and analyze the effects of marital perspective-taking ability, managing responses of young children and emotional intelligence on the interpersonal relationship skills of children. The study subjects were young children aged from four to seven attending private kindergartens or public day care centers in Seoul or Kyeongki-do and their mothers. The results are as follows : 1) First, marital perspective-taking abilities were indicated higher on boys than girls, children in a full-day program than those in a half-day program, university graduates or higher degree holders than collage graduates, single-income families than double-income families. In case of managing responses of young children, boys showed high avoidance of offensive disposition and girls showed high emotions dissipation. Also, young children in a full-day program showed non-responses on managing responses but high responses on emotions dissipation, and children of mothers with bachelor's degree or higher education showed support and children from double-income family showed no responses in high. Moreover, emotional intelligence of young children in a full-day program was higher than that of children in a half-day program, interpersonal relationship skills were showed higher on girls than boys, half-day children than full-day ones, children from single-income family than those from double-income family. 2) Meaningful relationships were indicated between these variables; managing responses of young children, emotional intelligence and interpersonal relationship skills by partly showing correlations. 3) Children in a half-day program with low in emotions dissipation, non-responses, offensive dispositional managing responses but high on Avoid, emotional intelligence showed high interpersonal relationship skills.

• Journal of Pharmaceutical Investigation
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• 제22권1호
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• pp.11-21
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• 1992

The effects of colchicine on the plasma elimination and biliary excretion of various organic anions in rats were examined. Elimination of indocyanine green (ICG) or rose bengal (RB) from plasma was significantly delayed when rats were treated with colchicine (3 mg/kg body weight) 3 hr prior to the administration of the dye. On the other hand, disappearance of sulfobromophthalein (BSP) or bromophenol blue (BPB) from plasma was not influenced by colchicine. The plasma disappearance and biliary excretion of organic anions were kinetically analyzed based on a compartment model, in which the deep compartment and the unknown disposition are incorporated. The transfer rate constants of ICG or RB, $k_{23}$ (from the liver to the deep compartment) and $k_{3B}$ (from the deep compartment to the bile), were decreased by colchicine, but those of BSP or BPB were not changed. A mechanism for the decrease in the $k_{23}$ and $k_{3B}$ values for ICG and RB might be explained by a inhibition of colchicine to the intracellular cytoskeleton. The hepatocellular distribution of RB or BPB was then determined. BPB mainly distributed to the cytosolic fraction, but RB distributed to each hepatocyte organelle. Taken together. it was suggested that ICG or RB is transported through hepatocytes into bile with the aid of the cytoskeleton, whereas BSP or BPB is handled by hepatocytes in a different way.