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Epidemiological changes in infectious diseases during the coronavirus disease 2019 pandemic in Korea: a systematic review

  • Ahn, Jong Gyun
    • Clinical and Experimental Pediatrics
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    • v.65 no.4
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    • pp.167-171
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    • 2022
  • In the era of the coronavirus disease 2019 (COVID-19) pandemic, countries worldwide have implemented several nonpharmaceutical interventions (NPIs) to contain its spread before vaccines and treatments were developed. NPIs included social distancing, mask wearing, intensive contact tracing and isolation, and sanitization. In addition to their effectiveness at preventing the rapid spread of COVID-19, NPIs have caused secondary changes in the epidemiology of other infectious diseases. In Korea, various NPI stages have been implemented since the first confirmed case of COVID-19 on January 20, 2020. This review, based on a PubMed database search, shows the impact of NPIs on several infectious diseases other than severe acute respiratory syndrome coronavirus 2 in the COVID-19 pandemic era in Korea.

Gap Junctional Intercellular Communication: A "Biological Rosetta Stone" Concept for Understanding Epigenetic Toxicology

  • Trosko, James E.
    • Toxicological Research
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    • v.17
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    • pp.1-9
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    • 2001
  • Some would argue that the search for the origin and treatment of this disease will continue over the next quarter century in much the same manner as it has in the recent past, by adding further layers of complexity to a scientific literature that is already complex almost beyond measure. But we anticipate otherwise: those researching the cancer problem will be practicing a dramatically different type of science than we have experienced over the past 25 years. Surely much of this change will be apparent at the technical level. But ultimately, the more fundamental change will be conceptual.

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In silico High-Throughput Screening by Hierarchical Chemical DB Search by 3D Pharmacophore Model

  • Shin, Jae-Min
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.181-182
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    • 2002
  • Recentadvancesin '-omics ' technologies enable us to discover more diverse disease- relevant target proteins, which encourages us to find out more target-specific novel lead compounds as new drug candidates. Therefore, high-throughput screening (HTS) becomes an essential tool in this area. Among many HTS tools, in silico HTS is a very fast and cost-effective tool to try to derive a new lead compound for any new targets, especially when the target protein structures are known or readily modeled. (omitted)

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A Review on Current Situation and Control of Avian Coccidiosis in Korea (국내 닭 콕시듐균의 발생 현황과 방제대책)

  • 김기석
    • Korean Journal of Poultry Science
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    • v.20 no.1
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    • pp.17-31
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    • 1993
  • Several aspects about the epidemiological status of chicken coccidiosis, its control measures and recent research activities in Korea are discussed in this paper. Medication with different available anticoccidial drugs has been reasonably effective in treating and preventing serious outbreaks of coccidiosis in chicken, but the disease remains one of the most expensive and common diseases of popultry production in this country, and more recently its incidence is increasing, possibly due to the more intensive methods of husbandry and the immergence of resistant strains of coccidia. Therefore, this necessitates a continuous search for new methods such as medication program (shuttl and rotation program) and immunization using attenuated strains or parasite antigens.

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Effects of Active Ceramic Water on the Cholesterol and Sodium Cholate Diet-fed Rats

  • Kim, Young-tae;Jeong, Kyu-shik
    • Proceedings of the Korean Society of Veterinary Pathology Conference
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    • 2003.10a
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    • pp.17-17
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    • 2003
  • Accumulation of cholesterol may occur due to liver injury like hepatic steatosis and fibrosis as well as athrosclerosis and coronary heart disease. The aim of this study was search for protective effect of active ceramic water on experimental hepatic injury induced by high cholesterol diet(containing 1.0 % cholesterol and 0.3 % sodium cholate) in rats. (omitted)

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Virus communicable disease cpidemic forecasting search using KDD and DataMining (KDD와 데이터마이닝을 이용한 바이러스성전염병 유행예측조사)

  • Yun, JongChan;Youn, SungDae
    • Proceedings of the Korea Information Processing Society Conference
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    • 2004.05a
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    • pp.47-50
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    • 2004
  • 본 논문은 대량의 데이터를 처리하는 전염병에 관한 역학조사에 대한 과정을 KDD(Knowledge Discovery in Database)와 데이터마이닝 기법을 이용해서 의료 전문인들의 지식을 데이터베이스화하여 데이터 선정, 정제, 보강, 예측과 빠른 데이터 검출을 하도록 하였다. 그리고 각 바이러스의 동향은 데이터마이닝을 활용하므로 일부분만의 데이터를 산출하지 않고 전체적인 동향을 산출, 예측하도록 한다.

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A study on the indications of Five Viscera Source Point Acupuncture extended from Taegeuk Acupuncture : Focused on Yeoungchu(靈樞) (태극침법(太極鍼法)의 확장형인 오장원혈침법(五臟原穴鍼法)의 적응증 연구 - "황제내경(黃帝內經).영추(靈樞)"를 중심으로 -)

  • Moh, Han Young;Lim, Gyo-Min;Baek, Jin-Ung
    • Journal of Korean Medical classics
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    • v.25 no.4
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    • pp.123-147
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    • 2012
  • Objective : By establishing the Five Viscera Source Point Acupuncture as the targeted acupuncture treatment for stadardization, as the first step, this study was conducted to sort the indications of each acupuncture remedies, which can be referred as one of the most important factors in acupuncture treatment, based on Yeoungchu. Method : This study selected only the contents related to indications of five viscera, by extracting the relevant sentences from Yeoungchu using the search words Liver(Liver Meridian, First Yin), Heart(Pericardium, Heart Meridian, Second Yin), Spleen(Spleen meridian, Third Yin), Lung(Lung Meridian, Third Yin), and Kidney(Kidney Meridian, Second Yin). Result & Conclusion : 1. We selected and extracted text related to liver disease from Chapter 16, heart (pericardium) disease from Chapter 16, spleen disease from Chapter 19, lung disease from Chapter 17, and finally kidney disease from Chapter 17 of Yeoungchu. 2. The basic theory of applying Five Viscera Source Point Acupuncture to five viscera diseases is first assorting the diseases according to its state (i.e. deficiency or excess), then draining the source point of the appropriate viscus in case of excess, or supplementing the source point of the appropriate viscus in case of deficiency. 3. For the correct application of Five Viscera Source Point Acupuncture, the classification of the disease, not only the judgement on its state, must be presented systematically and synthetically in combination with Four Examinations. Therefore the follow-up studies needs to be conducted.

A Review of the Neuroprotective Effects of Cinnamon in Experimental Studies on Parkinson's Disease (파킨슨병 관련 실험 연구에서 육계의 신경 보호효과에 대한 고찰)

  • Heo, Hyemin;Han, Juhee;Jeong, Minjeong;Kim, Hongjun;Jang, Insoo
    • The Journal of Internal Korean Medicine
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    • v.41 no.6
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    • pp.1089-1099
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    • 2020
  • Objective: The purpose of this study was to investigate the effect of cinnamon on the treatment of Parkinson's disease (PD) and to introduce its use in Korea. Method: We searched the experimental studies in electronic databases (PubMed, CNKI, Wanfang, CiNii, J-STAGE, Science ON, and OASIS) using the key search terms "cinnamic acid", "cinnamon", "cinnamomum", "Parkinson's disease", "Parkinson disease", "Parkinsonism", and "dopamine". This study only involved experimental studies (in vivo and in vitro) that adopted cinnamon as a single administration and measured indicators relating to Parkinson's disease, including parkin, tyrosine hydroxylase (TH), and dopamine. Results: A Total of 11 literature studies were selected, and they all showed that treatment with cinnamon has a neuroprotective effect. Cinnamon activated neuroprotective factors and restored neurotransmitters and it reduced the rate of oxidative stress and inflammation in neurons. As a result, cell viability was upregulated, while cell apoptosis and neurodegeneration were downregulated. Five in vivo studies, through behavioral tests, also confirmed that cinnamon recovers locomotor function in PD models. Conclusion: We identified that cinnamon is an effective neural protector and improves motor performance in behavioral testing in the experimental PD studies.

An Analysis of Clinical Research Trends on Interventions of Oriental Medicine for Postpartum Disease and Postpartum Care (산후병 및 산후관리에 대한 국내 한의학 임상 연구 동향 분석)

  • Kim, Nu-Ree;Lee, Eun-Hee
    • The Journal of Korean Obstetrics and Gynecology
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    • v.35 no.1
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    • pp.34-58
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    • 2022
  • Objectives: This study was performed to analyze the interventions of Oriental Medicine which had been commonly used for postpartum disease and postpartum care. Methods: We searched research on the interventions for postpartum disease and postpartum care in 4 domestic search engines. After that, we conducted eligibility screening based on inclusion and exclusion criteria. Results: 1. We selected total 50 studies. There were 2 randomized controlled trial (RCT), 5 non-RCT, 35 case reports, 8 case series within the 6~8 weeks after childbirth. 2. Of the 35 case reports, several interventions were used : acupuncture (22), moxibustion (11), cupping therapy (7), pharmacopuncture (5), chuna manipulation (4), herbal medicine (34). The most common symptoms were musculoskeletal symptoms (8), followed by postpartum depression (7). Various prescriptions and acupoints of oriental medicine were used depending on the diseases or symptoms. 3. Of the 8 case series, 382 subjects in 5 case series had taken Saenghwa-tang-gagam. And Acupuncture, moxibustion, cupping therapy (5), pharmacopuncture (1) were used as an intervention. 4. The most commonly used acupoint is 腎兪 (BL23) in the pain including postpartum back pain and 三陰交 (SP6), 關元 (CV4) in the postpartum care. 關元 (CV4) is the most commomly used moxibustion point not only the postpartum disease but also the postpartum care. Conclusions: In clinical studies of oriental medicine related to postpartum disease and postpartum care, pain-related clinical studies that belong to or progress to Sanhupung were the most common (30%), and among them, postpartum low back pain studies were the most common (20%). Based on this, we believe that large-scale clinical studies with high quality using oriental interventions including chuna and pharmacopuncture are needed to establish guidelines for the management of pain treatment including postpartum back pain.