• 성인간호학회지
• /
• 제16권4호
• /
• pp.556-565
• /
• 2004

Purpose: According to Lazarus & Folkman (1984), appraising a stressor as a threat is associated with negative psychological and physical adjustment, whereas appraising a stressor as a challenge is positive psychological and physical adjustment. This study examined how cognitive appraisal of PTCA(heart disease threat and treatment appraisal) related to the cardiac risk reduction behaviors(smoking cessation, low salt and low cholesterol diet, regular exercise and stress management) 6 weeks following discharge. Method: Data were collected from 50 subjects with successful primary PTCA. Result: Heart disease threat was negative related to treatment appraisal (r=-0.240, p=0.046). Psychological well-being was negative related to heart disease threat (r=-0.317, p=0.012) and positive related to treatment appraisal(r=0.402, p=0.002). The cardiac risk reduction behaviors score was negative related to heart disease threat(r= -0.296, p=0.018) and positive related to treatment appraisal(r=-0.291, p=0.020). Conclusion: More negative appraisal was related to lower the cardiac risk reduction behaviors score. But more positive appraisal was related to higher the cardiac risk reduction behaviors score. So, there is a need to develop the cognitive-behavioral intevention that increase the coping strategy to replace with positive appraisal.

• BMB Reports
• /
• 제42권9호
• /
• pp.580-585
• /
• 2009

Dimethyl sulfoxide (DMSO) is widely used in chemistry and biology as a solvent and as a cryoprotectant. It is also used as a pharmaceutical agent for the treatment of interstitial cystitis and rheumatoid arthritis. Previous reports described DMSO as being reduced by methionine-S-sulfoxide reductase (MsrA). However, little is known about the DMSO reduction capability of methionine-R-sulfoxide reductase (MsrB) or its effect on the catalysis of methionine sulfoxide reduction. We show that mammalian MsrB2 and MsrB3 were unable to reduce DMSO. This compound inhibited MsrB2 activity but did not inhibit MsrB3 activity. We further determined that DMSO functions as an inhibitor of MsrA and MsrB2 in the reduction of methionine sulfoxides via different inhibition mechanisms. DMSO competitively inhibited MsrA activity but acted as a non-competitive inhibitor of MsrB2 activity. Our study also demonstrated that DMSO inhibits in vivo methionine sulfoxide reduction in yeast and mammalian cells.

• Journal of mucopolysaccharidosis and rare diseases
• /
• 제5권1호
• /
• pp.22-28
• /
• 2021

Mucopolysaccharidosis type III (MPS III) or Sanfilippo disease is an orphan-inherited lysosomal storage disease. It is one of the most common MPS subtypes. The classical presentation is an infantile-onset neurodegenerative disease characterized by intellectual regression, behavioral and sleep disturbances, loss of ambulation, and early death. Unlike other MPS, no disease-modifying therapy has been approved. Here, we review the curative therapy developed for MPS III, from historically ineffective hematopoietic stem cell transplantation and substrate reduction therapy to the promising enzyme replacement therapy or adeno-associated/lentiviral vector-mediated gene therapy. Preclinical studies are presented with recent translational first-in-man trials. We also present experimental research with preclinical mRNA and gene-editing strategies. Lessons from animal studies and clinical trials have highlighted the importance of early therapy before extensive neuronal loss. Disease-modifying therapy for MPS III will likely mandate the development of new early diagnosis strategies.

• 한국잠사곤충학회지
• /
• 제14권1호
• /
• pp.37-42
• /
• 1972

잠병이 잠작에 미치는 영향을 조사하기 위하여 경기도 용인군 남사면 방아리, 경북 칠곡군 약목면 그리고 경북 칠곡군 북삼면의 양잠농가를 대상으로 잠병에 대한 피해율을 조사한 결과는 다음과 같다. 1) 잠병에 의한 감수율은 춘잠기에는 5.5%, 추잠기에는 8.9%이었고 년간 평균 7.2%였으며 하견을 병해견으로 환산한다면 8.3%였다. 2) Virus 다각체병과 연화병에 의한 병해율은 전발병의 치잠기에는 17.8%, 장잠기에는 82.2%로서 높은 비율을 나타내었다. 3) 평균산견량은 상자당 27.74kg이었는데 추정산견량에 대하여 잠병에 의한 감수량은 2.411kg이었다. 4) 원인불명의 감수량이 3.611kg으로서 잠병에 의한 감수량의 약 1.5배였다. 이 원인불명의 감수량은 주로 유실잠과 하견이 많았기 때문이다. 5) 잠작이 비교적 안정된 농가수는 춘기에는 54.7%, 추기에는 21.9%였다. 6) 잠병이외의 피해율은 10.70%였고 전감잠비율은 17.87%였다.

• 한국콘텐츠학회논문지
• /
• 제21권12호
• /
• pp.250-263
• /
• 2021

본 연구는 항공사를 이용하는 고객들이 코로나19라는 감염병 인식과 감염병에 대한 지각된 위험이 위험감소행동과 관광지 전환의도에 미치는 영향관계를 분석하고자 실시하였다. 2021년 6월 2일부터 24일까지 일년 이내에 항공기를 이용한 여행 경험이 있는 소비자를 대상으로, 온라인을 통해 설문을 실시하였다. SPSS 20.0과 AMOS 23.0 통계 프로그램을 활용하였고, 유효한 250부의 설문으로 분석을 실시하였다. 연구의 결과는 첫째, 코로나19의 감염병 인식은 지각된 위험에 유의한 영향을 미치는 것으로 나타났다. 둘째, 코로나19의 감염병 인식은 위험감소행동에 유의한 영향을 미치는 것으로 나타났다. 셋째, 코로나19의 지각된 위험은 위험감소행동에는 유의한 영향을 미치는 것으로 나타났다. 넷째, 코로나19의 지각된 위험은 관광지 전환의도에는 영향을 미치지 못하는 것으로 나타났다. 다섯째, 위험감소행동은 관광지 전환의도에 유의한 영향을 미치는 것으로 나타났다. 본 연구를 통해 코로나19 감염병에 대한 항공사 고객들의 인식을 통해 감염병에 대한 위험과 위험감소행동과 관광지 전환의도에 대한 관계를 실증적으로 규명하고 분석하고자 하였다. 코로나19의 장기적인 위기 속에서 외부 변수에 취약한 관광산업이 이에 대한 대응방안을 모색해야 할 것이다.

• 지역연구
• /
• 제38권3호
• /
• pp.41-49
• /
• 2022

본 논문의 목적은 감염병 조건이 도시열섬현상 저감을 위해 시행한 옥상녹화 사업에 대한 서울시민들의 지불의사금액에 미치는 영향을 파악하는 것이다. 이를 위해 감염병 조건과 비감염병 조건 하에서 옥상녹화 사업에 대한 지불의사액을 조건부가치추정법을 통해 산정 및 비교분석하였다. 그 결과 감염병 조건에 따른 지불의사액이 통계적으로 유의미한 차이가 있게 나타났고, 감염병 조건의 지불의사액이 비감염병조건보다 낮음을 확인하였다.

• The Plant Pathology Journal
• /
• 제16권5호
• /
• pp.257-263
• /
• 2000

Infection with rice blast fungus (Magnaporthe grisea) significantly reduced foliar net photosynthesis (A) of rice cultivars: Ilpoom, Hwasung, and Choochung in greenhouse experiments. By measuring the amount of diseased leaf area with a computer image analysis system, the relation between disease severity (DS) and net photosynthetic rate was curvilinearly correlated (r=0.679). Diseased leaves with 35% blast symptom can be predicted to have a 50% reduction of photosynthesis. The disease severity was linearly correlated (r=0.478) with total chlorophyll (chlorophyll a and chlorophyll b) per unit leaf area(TC). Light use efficiency was reduced by the fungal infection according to the light response curves. However, dark respiration (Rd) did not change after the fungal infection (p=0.526). Since the percent of reduction in photosynthesis greatly exceeded the percent of leaf area covered by blast lesions, loss of photosynthetic tissue on an area basis could not by itself account for the reduced photosynthesis. Quantitative photosynthetic reduction can be partially explained by decreasing TC, but cannot be explained by decreasing Rd. By photosynthesis (A)-internal CO$_2$ concentration (C$_i$ curve analysis, it was suggested that the fungal infection reduced ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) activity, ribulose-1,5-bisphosphate (RuBP) regeneration, and inorganic phosphate regeneration. Thus, the reduction of photosynthesis by blast infection was associated with decreased TC and biochemical capacity, which comprises all carbon metabolism after CO$_2$ enters through the stomata.

• The Korean Journal of Pain
• /
• 제24권4호
• /
• pp.231-234
• /
• 2011

Kummell's disease is a spinal disorder characterized by delayed post-traumatic collapse of a vertebral body with avascular necrosis. Although definitive treatment for Kummell's disease has not been established, it has been reported that percutaneous vertebroplasty or kyphoplasty has shown good results. However, these procedures are not recommended for severely collapsed vertebral bodies because of the risk of cement leakage or technical difficulties. Authors report a rare case of spontaneous reduction in vertebral height by the insertion of a working cannula into the vertebral body in Kummell's disease.

• Hip & pelvis
• /
• 제36권2호
• /
• pp.155-160
• /
• 2024

We report two cases of postoperative total hip arthroplasty periprostehtic fracture of the acetabulum which treated by open reduction with internal fixation without acetabular cup revision. From these cases, we should consider open reduction with internal fixation as the first treatment option in cases where spot welding of the cup to the host bone is observed.

• Journal of Oral Medicine and Pain
• /
• 제25권2호
• /
• pp.173-189
• /
• 2000

The purpose of this study was to evaluate the effect of specific head positions on the mandibular rotational torque movements in maximum mouth opening, protrusion and lateral excursion. Thirty dental students without any sign or symptom of temporomandibular disorders(TMDs) were included as a control group and 90 patients with TMDs were selected and examined by routine diagnostic procedure for TMDs including radiographs and were classified into 3 subgroups : disc displacement with reduction, disc displacement without reduction, and degenerative joint disease. Mandibular rotational torque movements were observed in four head postures: upright head posture(NHP), upward head posture(UHP), downward head posture(DHP), and forward head posture(FHP). For UHP, the head was inclined 30 degrees upward: for DHP, the head was inclined 30 degrees downward: for FHP, the head was positioned 4cm forward. These positions were adjusted with the use of cervical range-of-motion instrumentation(CROM, Performance Attainment Inc., St. Paul, U.S.A.). Mandibular rotational torque movements were monitored with the Rotate program of BioPAK system (Bioresearch Inc., WI, U.S.A.). The rotational torque movements in frontal and horizontal plane during mandibular border movement were recorded with two parameters: frontal rotational torque angle and horizontal rotational torque angle. The data obtained was analyzed by the SAS/Stat program. The obtained results were as follows : 1. The control group showed significantly larger mandibular rotational angles in UHP than those in DHP and FHP during maximum mouth opening in both frontal and horizontal planes. Disc displacement with reduction group showed significantly larger mandibular rotational angles in DHP and FHP than those in NHP during lateral excursion to the affected and non-affected sides in both frontal and horizontal planes(p<0.05). 2. Disc displacement without reduction group showed significantly larger mandibular rotational angles in FHP than those in any other head postures during maximum mouth opening as well as lateral excursion to the affected and non-affected sides in both frontal and horizontal planes. Degenerative joint disease group showed significantly larger mandibular rotational angles in FHP than those in any other head postures during maximum mouth opening, protrusion and lateral excursion in both frontal and horizontal planes(p<0.05). 3. In NHP, mandibular rotational angle of the control group was significantly larger than that of any other patient subgroups. Mandibular rotational angle of disc displacement with reduction group was significantly larger than that of disc displacement without reduction group during maximum mouth opening in the frontal plane. Mandibular rotational angle of disc displacement without reduction group was significantly larger than that of disc displacement with reduction group or degenerative joint disease group during maximum mouth opening in the horizontal plane(p<0.05). 4. In NHP, mandibular rotational angles of disc displacement without reduction group were significantly larger than those of the control group or disc displacement with reduction group during lateral excursion to the affected side in both frontal and horizontal planes. Mandibular rotational angle of disc displacement without reduction group was significantly smaller than that of the control group during lateral excursion to the non-affected side in frontal plane. Mandibular rotational angle of disc displacement without reduction group was significantly larger than that of disc displacement with reduction group during lateral excursion to the non-affected side in the horizontal plane(p<0.05). 5. In NHP, mandibular rotational angle of the control group was significantly smaller than that of disc displacement with reduction group or disc displacement without reduction group during protrusion in the frontal plane. Mandibular rotational angle of disc displacement without reduction group was significantly larger than that of the disc displacement with reduction group or degenerative joint disease group during protrusion in the horizontal plane. Mandibular rotational angle of the control group was significantly smaller than that of disc displacement without reduction group or degenerative joint disease group during protrusion in the horizontal plane(p<0.05). 6. In NHP, disc displacement without reduction group and degenerative joint disease group showed significantly larger mandibular rotational angles during lateral excursion to the affected side than during lateral excursion to the non-affected side in both frontal and horizontal planes(p<0.05). The findings indicate that changes in head posture can influence mandibular rotational torque movements. The more advanced state is a progressive stage of TMDs, the more influenced by FHP are mandibular rotational torque movements of the patients with TMDs.