• 한국환경보건학회지
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• 제39권2호
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• pp.166-177
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• 2013

Objectives: The genus Legionella is common in aquatic environments. Some species of Legionella are recognized as potential opportunistic pathogens for human, notably Legionella pneumophila that causes, Legionellosis. Thus, we investigated the contamination of Legionella pneumophila on water supply systems in Seoul, including cooling towers, public baths, hospitals and fountains. Methods: The existence of 16S rRNA and mip gene of L. pneumophila was confirmed in the genome of the isolated strains by PCR. Results: During the summer season of 2010 and 2011, Legionella pneumophila were detected from 163 samples (21.1%) out of 772 samples collected. Among the 163 strains of L. pneumophila, eighty one isolates belonged to serogroup 1 (57.4%), 23 isolates were serogroup 5 (16.3%), 21 isolates were serogroup 6 (14.9%), 8 isolates were serogroup 2 (5.79%), and 8 isolates were identified in serogroup 3 (5.7%). Through PFGE (pulsed-field gel electrophoresis) analysis using Sfi I, genetic types of L. pneumophila were classified into five (A to E) patterns by the band similarity with excess of 70% from public baths. Conclusions: The PFGE patterns of the serotypes showed a tendency for diversity of L. pneumophila. Our results suggest the existence of serological and genetic diversity among the L. pneumophila isolates.

• Annals of Clinical Neurophysiology
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• 제18권1호
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• pp.1-6
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• 2016

Background: Moyamoya disease is characterized by a progressive stenosis or occlusion of the intracranial internal carotid artery and/or the proximal portion of the anterior cerebral artery and middle cerebral artery. Whether the onset time was childhood or adulthood, the bony carotid canal diameter might be different, but reflects the size of internal carotid artery passing through the bony carotid canal. In this study, we aimed to identify the relationship between bony carotid canal diameter and clinical manifestation. Methods: 146 consecutive patients diagnosed with moyamoya disease by brain imaging studies were included. We measured the diameter of a transverse portion of bony carotid canal on bone window of a brain computed tomography(CT) image. Patients were divided into two groups, ischemic or hemorrhagic stroke according to clinical manifestation. As a result, 115 patients were included. The Suzuki stage was used as criteria for disease progression. Results: Bony carotid canal diameter was $3.6{\pm}0.5$ (right) and $3.6{\pm}0.4$ (left) in the hemorrhagic stroke group, and $3.7{\pm}0.4$ (right) and $3.6{\pm}0.4$ (left) in the ischemic stroke group. The bony carotid canal diameter of the moyamoya vessels (3.6 mm) was smaller than the diameter of non-moyamoya vessels (3.8 mm), significantly (p = 0.042). However, there was no difference in the collateral patterns and clinical manifestation in a comparison of both groups. Conclusions: In our study, there was no significant difference of clinical manifestations and collateral patterns depend on the bony carotid canal diameter in patients with moyamoya disease. These findings suggest that the clinical presentations of moyamoya disease are not related to the onset time of the disease.

• Korean Journal of Radiology
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• 제22권2호
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• pp.281-290
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• 2021

Objective: To assess the performance of content-based image retrieval (CBIR) of chest CT for diffuse interstitial lung disease (DILD). Materials and Methods: The database was comprised by 246 pairs of chest CTs (initial and follow-up CTs within two years) from 246 patients with usual interstitial pneumonia (UIP, n = 100), nonspecific interstitial pneumonia (NSIP, n = 101), and cryptogenic organic pneumonia (COP, n = 45). Sixty cases (30-UIP, 20-NSIP, and 10-COP) were selected as the queries. The CBIR retrieved five similar CTs as a query from the database by comparing six image patterns (honeycombing, reticular opacity, emphysema, ground-glass opacity, consolidation and normal lung) of DILD, which were automatically quantified and classified by a convolutional neural network. We assessed the rates of retrieving the same pairs of query CTs, and the number of CTs with the same disease class as query CTs in top 1-5 retrievals. Chest radiologists evaluated the similarity between retrieved CTs and queries using a 5-scale grading system (5-almost identical; 4-same disease; 3-likelihood of same disease is half; 2-likely different; and 1-different disease). Results: The rate of retrieving the same pairs of query CTs in top 1 retrieval was 61.7% (37/60) and in top 1-5 retrievals was 81.7% (49/60). The CBIR retrieved the same pairs of query CTs more in UIP compared to NSIP and COP (p = 0.008 and 0.002). On average, it retrieved 4.17 of five similar CTs from the same disease class. Radiologists rated 71.3% to 73.0% of the retrieved CTs with a similarity score of 4 or 5. Conclusion: The proposed CBIR system showed good performance for retrieving chest CTs showing similar patterns for DILD.

• 한국융합학회논문지
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• 제10권12호
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• pp.135-142
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• 2019

본 연구에서는 동거형태에 따른 노인의 심혈관질환과 치주질환의 분포정도 및 관계를 분석하여 각각 특성에 맞는 프로그램 개발을 위한 기초 자료를 제공하기 위해 국민건강영양조사 제6기의 자료를 분석하였다. 일반적 특성에 따른 심혈관질환자의 분포는 가족동거노인의 경우 성별, 교육수준, 독거노인의 경우에는 나이, 소득수준에 따라 차이가 있었다. 구강건강상태 및 구강보건형태와 심혈관질환자의 분포는 가족동거노인의 경우 최근 1년간 치통경험이 있는 군, 최근 1년간 구강검진을 하지 않은 군, 치주염군, 독거노인은 구강건강상태가 나쁘다고 인지한 군과 치주질환 정상 군에서 더 많았다. 심혈관질환과 치주질환의 관계에서는 가족동거노인은 고혈압이 관련이 있었고 독거노인의 경우에는 관련이 없었다. 심혈관질환과 치주질환은 노인에게 가장 많은 질환이며 두 질환의 발생 연관성이 전혀 없다고는 할 수 없기 때문에 두 질환을 같이 고려하여 추후 건강상태 확인 및 다양한 가족동거 형태에 따른 차이점에 대해서 반복연구를 통해 구체적인 건강관리 방법이 논의되어야 한다.

• Korean Journal of Health Education and Promotion
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• 제3권1호
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• pp.21-37
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• 2001

Over the past few decades, dramatic socioeconomic developments have resulted in the change of epidemiological transition from infectious to chronic diseases as leading causes of death in Korea$^{1)}$ . Behavioral factors, particularly smoking, diet and activity patterns, alcohol consumptions are among the most prominent contributors to mortality.(omitted)

• 대한한의정보학회지
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• 제16권2호
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• pp.163-187
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• 2010

The concept of latent-gi(伏氣) was first mentioned in Yellow Emperor's Canon of Internal Medicine. For example, Elementary Questions states, "Damage by cold in winter necessarily engenders warm disease in the spring." Zhang Zhong-Jing of Han Dynasty in On Cold Damage and Miscellaneous Diseases mentions warm disease, stating, for example, "Greater yang disease with heat effusion and cough and without aversion to cold is warm disease. If sweating is applied, and there is generalized heat, this is wind warmth." However, the concept of warm disease was not central to his systematic presentation of externally contracted disease which placed the emphasis on wind and cold as the major causes of these diseases. Zhang Zhong-Jing's theories centuries after in the Sung Dynasty were to become the focus of the cold damage school, whereas the concept of warm disease was to become the focus of a rival school, the warm disease school. In the Sui-Tang Period, The Origin and Indications of Disease mentions warm diseases, their causes, patterns, and major principles of treatment. Successive generations of doctors wrote about warm disease, and in the Ming Dynasty writings on the subject become more prolific. This development is attributable on the one hand to the opening up of the south of China where febrile diseases tended to be of a different nature than in the north, and on the other to pestilences arising as a result of wars. In this period, Wu You-Xing in On Warm Epidemics explained in detail the laws governing the origin, development and pattern identification of warm epidemics. Notably, he posed the etiological notion of a contagious perverse gi.

• 동의생리병리학회지
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• 제24권2호
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• pp.177-186
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• 2010

This study is about researching DongEuiBoGam by analysing with pattern identification of modern Traditional Korean medical patholgy as more logical, systematic and standardized theory. Disease pattern mechanisms of essence, spirit, qi and blood in NaeGyungPyeb of DongEuiBoGam are these. In Essence, this explain mechanism of disease patterns those are seminal emission, dream emission, spermatorrhea, white ooze. These disease pattern's mechanisms are kidney yang deficiency, kidney yin deficiency, heart yang deficiency, heart yin deficiency, heart qi deficiency, spleen qi deficiency and so on. On viewpoints of viscera and bowels they are related with heart, kidney, spleen. And most of them are deficiency from deficiency-excess Pattern Identification. Classifying disease pattern of qi is about upward, downward movement and more concentrated deficiency than excess pattern. Fright palpitations can be classified heart deficiency with timidity, heart blood and qi deficiency, heart qi deficiency, heart blood deficiency, heart qi movement stagnation, water qi intimidating the heart, phlegm-fire harassing the heart, phlegm clouding the pericardium, and so on. Palpitations can be classified heart blood deficiency, heart yin deficiency, heart deficiency with timidity, heart spleen blood deficiency, spleen qi deficiency, phlegm-fire harassing the heart, intense heart fire, and so on. Forgetfulness can be classified heart spleen blood deficiency, heart spleen qi deficiency, kidney essence deficiency, heart qi deficiency, non-interaction between the heart and kidney, etc. for deficiency pattern, phlegm clouding the pericardium for excess pattern. In Blood just say inside bleeding pattern's category, there are nose bleeding, flopping syncope, qi counterflow, blood vomiting, hemoptysis, spitting of blood, bloody stool, hematuria, and so on. Like these, this study identify pattern of disease in DongEuiBoGam by mechanism of disease theory.

• 한국콘텐츠학회논문지
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• 제21권12호
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• pp.322-330
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• 2021

수산 양식장에서 어류 질병을 초기에 발견하지 못하는 경우 밀폐된 공간 안에서 확산하기 때문에 집단 폐사로 이어질 확률이 매우 높다. 이런 이유로 질병의 조기 발견은 양식업에서 매우 중요하다. 양식장에서 질병의 확산을 막기 위해서는 초기에 병이 든 어류를 자동식별이 가능한 방법이 필요하다. 최근 딥러닝 기반의 어류 질병 자동식별 방법이 많이 사용되고 있는데, 어류의 질병 이미지가 충분하지 않아 객체 식별에 많은 어려움이 있다. 본 논문은 질병 자동식별 예측을 위한 질병 이미지의 부족 문제를 해결하기 위해서 SinGAN 딥러닝 모델을 이용하여 정상 이미지와 질병 이미지를 합성해 다양한 어류 질병 이미지를 자동 생성하는 방법을 제안한다. 넙치에서 가장 빈번히 발생하는 3가지 질병 스쿠티카병, 비브리오증, 림포시스티스에 대해서 SinGAN 기반으로 질병 이미지를 증강한다. 본 연구에서는 넙치 정상 이미지 11장에 각 질병 패턴 10가지를 합성하여서 스쿠티카병 110장, 비브리오증 110장, 림포시스티스 110장으로 총 330장을 만들었고 이를 통해 생성된 이미지는 4배수 하여 1,320장의 이미지를 생성할 수 있었다.

• 대한한의학원전학회지
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• 제22권2호
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• pp.231-261
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• 2009

"Byunjeung-okham(辨證玉函)" is composed of four volumes, Eumjeung-yangjeungbyun(陰症陽症辨, Vol.1), Heojeungsiljeungbyeon(虛症實症辨, Vol.2), Sangjeunghajeungbyun(上症下症辨, Vol.3) and Jinjeunggajeungbyun(眞症假症辨, Vol.4) (卷之一 "陰症陽症辨", 卷之二 "虛症實症辨", 卷之三 "上症下症辨", 卷之四 "眞症假症辨"). It is based on the 74 types of disease symptoms, and compared to "Byunjeungrok(辨證錄)", it is rather brief and concise. Thus, its name, "Byunjeung-okham". This study researched vol.2, "Heojeungsiljeungbyun(虛症實症辨)", which is organized according to the deficiency and excess pattern of 20 disease patterns, such as cough. The disease pattern system mentioned in this book is unique compared with other disease pattern systems. The role of the kidney is especially emphasized, and the application of the Five-phase[五行] theory is very original. Consequently, it contributed greatly in the process of broadening the disease pattern system of Traditional Korean Medicine.

• Parasites, Hosts and Diseases
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• 제47권4호
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• pp.413-415
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• 2009

Genotyping of Toxoplasma gondii has been performed in 23 PCR positive blood samples from stray cats in Korea. We used 2 separate PCR-restriction fragment length polymorphism (RFLP) patterns of SAG2 gene, amplifying the 5' and 3' ends of the locus. The results revealed that all samples belonged to the type I clonal lineage. Although T. gondii organisms were not isolated from the samples, the results of the present study represent that stray cats with T. gondii infection should be seriously concerned in our environment. Adequate and continuous control programs of stray cats are needed to reduce the risk of transmission of T. gondii as a zoonotic infection threatening the public health.