• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제11권1호
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• pp.35-40
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• 2022

본 논문에서는 임상 의사 결정 지원을 위하여 의학 지식을 통해 임상 관계를 추출하고 딥러닝 모델을 이용하여 질병을 예측하는 방법을 제안한다. 의학 사전인 UMLS(Unified Medical Language System)와 암 관련 의학 지식에 포함된 임상 용어를 5가지로 분류한다. 분류된 임상 용어들을 사용하여 위키피디아 의학 문서를 추출한다. 추출한 위키피디아 의학 문서와 추출한 임상 용어를 매칭하여 임상 관계를 구축한다. 구축한 임상 관계를 이용하여 딥러닝 학습을 진행한 후 질의에서 표현된 의학 용어를 바탕으로 질의와 연관된 질병을 예측한다. 이후, 예측한 질병과 관계가 있는 의학 용어를 확장 질의로 선택한 뒤 질의를 확장한다. 제안 방법의 유효성을 검증하기 위해 TREC Clinical Decision Support(CDS), TREC Precision Medicine(PM) 테스트 컬렉션에 대해 비교 평가한다.

• 철학연구
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• 제121호
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• pp.1-24
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• 2018

본 논문의 목적은 영혼의 질병과 치유와 관련된 고대 논변들을 통해 플라톤이 말하는 정신의 질병과 건강은 무엇인지 알아보는 것이다. 고대 그리스에서 의학은 몸의 건강을 돌보는 것이었다면, 철학은 영혼의 건강을 돌보며 삶을 변화시키는 것이었다. 따라서 정신적 질병의 개념을 규정하는 것은 의학의 영역이기보다 철학의 영역이며, 철학의 실천적 기능은 우리의 영혼을 돌보는 삶이다. 그리고 영혼을 돌보기 위해서는 영혼의 질병은 무엇이며 어디서부터 오는지에 관한 진단이 우선시 된다. 플라톤은 정신적 질병을 (1) 국부적인 뇌의 문제가 아니라 인격의 총체적 문제이며, (2) 이는 불균형과 부조화에 기이하는 것으로, (3) 무지 또한 정신적 질병이라 할 수 있다고 말한다. (4) 더 나아가 그는 부정의와 악덕 역시 정신적 질병이라고 진단하며, 정신적 질병의 문제를 개인을 넘어서 국가의 문제로 확대시킨다. 결과적으로 플라톤은 철학의 목적을 영혼의 건강을 유지하기 위해 덕을 가지고 공동체 속에서 정치적 정의를 이루어 나가는 것이라고 주장한다.

• Environmental Analysis Health and Toxicology
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• 제30권
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• pp.12.1-12.7
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• 2015

Objectives In South Korea, health insurance data are used as material for the health insurance of national whole subject. In general, health insurance data could be useful for estimating prevalence or incidence rate that is representative of the actual value in a population. The purpose of this study was to apply the concept of episode of care (EoC) in the utilization of health insurance data in the field of environmental epidemiology and to propose an improved methodology through an uncertainty assessment of disease course and outcome. Methods In this study, we introduced the concept of EoC as a methodology to utilize health insurance data in the field of environmental epidemiology. The characterization analysis of the course and outcome of applying the EoC concept to health insurance data was performed through an uncertainty assessment. Results The EoC concept in this study was applied to heat stroke (International Classification of Disease, 10th revision, code T67). In the comparison of results between before and after applying the EoC concept, we observed a reduction in the deviation of daily claims after applying the EoC concept. After that, we categorized context, model, and input uncertainty and characterized these uncertainties in three dimensions by using uncertainty typology. Conclusions This study is the first to show the process of constructing episode data for environmental epidemiological studies by using health insurance data. Our results will help in obtaining representative results for the processing of health insurance data in environmental epidemiological research. Furthermore, these results could be used in the processing of health insurance data in the future.

• BMB Reports
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• 제50권11호
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• pp.535-536
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• 2017

A novel approach has been used to identify functional interactions relevant to human disease. Using high-throughput human-yeast genetic interaction screens, a first draft of disease interactome was obtained. This was achieved by first searching for candidate human disease genes that confer toxicity in yeast, and second, identifying modulators of toxicity. This study found potentially disease-relevant interactions by analyzing the network of functional interactions and focusing on genes implicated in amyotrophic lateral sclerosis (ALS), for example. In the subsequent proof-of-concept study focused on ALS, similar functional relationships between a specific kinase and ALS-associated genes were observed in mammalian cells and zebrafish, supporting findings in human-yeast genetic interaction screens. Results of combined analyses highlighted MAP2K5 kinase as a potential therapeutic target in ALS.

• 대한예방의학회:학술대회논문집
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• 대한예방의학회 1994년도 교수 연수회(역학)
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• pp.154-157
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• 1994

The evaluation of diagnostic tests attempts to obtain one or more statistical parameters which can indicate the intrinsic diagnostic utility of a test. Sensitivity. specificity and predictive value are not appropriate for this use. The likelihood ratio has been proposed as a useful measure when using a test to diagnose one of two disease states (e.g. disease present or absent). In this paper, we generalize the likelihood ratio concept to a situation in which the goal is to diagnose one of several non-overlapping disease states. A formula is derived to determine the post-test probability of a specific disease state. The post-test odds are shown to be related to the pre-test odds of a disease and to the usual likelihood ratios derived from considering the diagnosis between the target diagnosis and each alternate in turn. Hence, likelihood ratios derived from comparing pairs of diseases can be used to determine test utility in a multiple disease diagnostic situation.

• 대한한의학원전학회지
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• 제27권1호
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• pp.99-109
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• 2014

Objectives : The concepts of many Korean medicine terms have changed for a long time and cumulatively been recorded in later medicine literatures. And, the same terms have very often been used for different meanings depending on context. Methods : This study was performed so that conceptual magnitude of Korean medicine terms could intuitively be recognized for the purpose of quantization. Results : This study was performed under the premise that terms used in old literatures of Korean medicine are related mostly to treatments that could immediately be reverted to types of medical herbs used. Through this, conceptual magnitude of terms was quantified by the method that frequency of medical herbs used for treatment was changed to numerical values. For this, data of "Compilation of Formulas and Medicinals Addendum" were used. First, after 'specificity' of each medicine herb corresponding to representative disease symptoms was calculated, medians in the set were selected, and 'values of conceptual magnitude' for representative disease symptoms were calculated. Conclusions : As a result, if disease symptoms are diverse, concept range is diachronically changed greatly, and specific disease symptoms of great conceptual difference are included, value of conceptual magnitude was great. Meanwhile, if disease factor and treatment are singular or limited to several types, and many medical herbs with high specificity are used, value of conceptual magnitude was less.

• 사상체질의학회지
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• 제14권1호
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• pp.34-50
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• 2002

1. Background and Purpose At the year of 2000, the society of sasang constitutional medicine acqired ${\ulcorner}$HamsanSachon DongyiSuseBowon GoboGubon${\lrcorner}$ which is presumed as the copy of ${\ulcorner}$GoboGubon${\lrcorner}$. According to Lee Sung-Su who is the great-grandson of DongMu's older brother, $[\ulcorner}$HamsanSachon DongyiSuseBowon GoboGubon${\lrcorner}$ was worked by Lee Jin-Yoon who is the grandson of DongMu's older brother and it was copied by Han Min-Gab and now is owned by Lee Sung-Su who is the son of Lee Jin-Yoon. 2. Method This paper was written in order to understand the character of the discourse on the constitutional symp toms and diseases of ${\ulcorner}$HamsanSachon DongyiSuseBowon GoboGubon${\lrcorner}$. 3. Result and Conclusion 1) Each constitutional symptoms and diseases is classed as that of exterior and interior and then classsed again as that of exterior's exterior, exterior's interior, interior's exterior and interior's interior. 2) The degree of completion is high at the chapter of Soeumin and Soyangin comparing with that of Taeeumin and Taeyangin which don't exist as the contrasted explanation. 3) Soeumin's exterior-disease is divided Taiyang(太陽) and Yangmyung(陽明)'s disease by the sweating, that's interior-disease is same to Sinchukbon(辛丑本). BaboBon already have the concept of UlKwang(鬱狂) and mangYang(亡陽), so the discourse on the constitutional symptoms and diseases of Soyangin is early establish comparing with other constitution. 4) The Cold and Hot, the constitutional symptoms and diseases, the disease theory of Soyangin can be accessible to opposite side of Soeumin's that. The disease of exterior's exterior is only explained abdominal pain and diarrhea without the concept of Mangeum(亡陰) disease, but at the time of SinchukBon the concept of Mangeum-disease is invented. 5) There is many different with SinchukBon that the classification of symptoms and diseases of Taeeumin, and not mentioned the physiology and pathlogy of the airs and fluids metabolism. 6) Healthy Energy(保命之主) show us that JungKi(正氣) is key-point of the utility of the symptoms and diseases.

• 동의생리병리학회지
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• 제20권5호
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• pp.1111-1116
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• 2006

Medical science is an area of study that focuses on maintaining health and treating disease. However, modern medicine focuses on treating disease and neglects methodology of maintaining health. Although the definition of heal this defined by the World Health Organization (WHO) and as the concept of harmonizing Yin and Yang in Korean medicine, there is no specific details regarding the definition. Thus, the following conclusion was obtained after the concept of health is viewed through Yin-Yang(陰陽), Vital Essence(精), Qi(氣), and Healthy Person(平人). Although Yin and Yang have opposite properties, they work very closely, maintaining the overall balance and harmony. Secondly, Vin and Yang would each function by the effects of one another, and the body could maintain normal physiological activities through this function. Thirdly, it maintains normal physiological state through the ascending Kidney-Water and descending Heart-Yang(水升火降). Fourthly, Vital Essence is divided into the congenital Essence(先天之精) and the acquired Essence(後天之精) in which the former is related with reproduction and the latter, nourishing. Fifthly, Qi is resistant to pathogens and related with the physique so that Qi and physique should be balanced. Sixthly, Healthy Person is the state where the exchange of Qi-Blood is active.

• 대한한의학원전학회지
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• 제21권1호
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• pp.153-162
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• 2008

Three Eum and Three Yang[三陰三陽] is a way of studying the changing of nature from a Eum(陰) and Yang(陽) point of view, Juhakhae(周學海) divides this into two dimensions. The first is the concept of dividing the exterior part of the body excluding the organ into 6 divisions as Eumyang(陰陽) of front and rear characteristic. The second is the concept of dividing the systematic bio-activity of the central organ into another 6 dimensions. The former concept is illustrated in the body as a certain meridian controlling a certain field of the body, while the latter is presented as a certain organ performing an activity of Gi(氣). Three Eum and Three Yang[三陰三陽] is not based on fixed substances. but it is a thought process model of observing the structural-functional changes of the body in disease state. Therefore, by understanding Three Eum and Three Yang[三陰三陽] of field and activity of Gi(氣) respectively and comprehensively putting these into practice, we will be able to approach the essence of the disease state in a more precise manner.

• 한국의사학회지
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• 제32권1호
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• pp.77-86
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• 2019

The Diary of Muk-Jae is a historical record that describes many social aspects of the Joseon period in the 16th century. It records many scenes of its author, Lee Mun-Geon, treating patients. This paper uses The Diary of Muk-Jae to examine changes in the perception of the concept of cold damage and the text of the Shanghanlun (Treatise on Cold Damage) in the Joseon period in the 16th century. In The Diary of Muk-Jae, cold damage is understood in connection with two categories: 'dangerous disease' and 'disease caused by cold'. The Diary of Muk-Jae also presents the Shanghanlun not as a work limited to the concept of cold damage, but as a medical text that could be widely used for many different diseases. Thus, The Diary of Muk-Jae may represent a point of transition between in the perception of cold damage as seen in the Uibang Yuchui (The Collection of Medical Procedures) of the 15th century and the Donguibogam of the 17th century.