• The Korean Journal of Physiology and Pharmacology
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• v.24 no.1
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• pp.27-37
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• 2020

Neuroinflammation is an important process underlying a wide variety of neurodegenerative diseases. Carvacrol (CAR) is a phenolic monoterpene commonly used as a food additive due to its antibacterial properties, but it has also been shown to exhibit strong antioxidative, anti-inflammatory, and neuroprotective effects. Here, we sought to investigate the effects of CAR on inflammation in the hippocampus and prefrontal cortex, as well as the molecular mechanisms underlying these effects. In our study, lipopolysaccharide was injected into the lateral ventricle of rats to induce memory impairment and neuroinflammation. Daily administration of CAR (25, 50, and 100 mg/kg) for 21 days improved recognition, discrimination, and memory impairments relative to untreated controls. CAR administration significantly attenuated expression of several inflammatory factors in the brain, including interleukin-1β, tumor necrosis factor-α, and cyclooxygenase-2. In addition, CAR significantly increased expression of brain-derived neurotrophic factor (BDNF) mRNA, and decreased expression of Toll-like receptor 4 (TLR4) mRNA. Taken together, these results show that CAR can improve memory impairment caused by neuroinflammation. This cognitive enhancement is due to the anti-inflammatory effects of CAR medicated by its regulation of BDNF and TLR4. Thus, CAR has significant potential as an inhibitor of memory degeneration in neurodegenerative diseases.

• Education of Primary School Mathematics
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• v.17 no.2
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• pp.159-171
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• 2014

Spatial ability has been valued as one component of intelligence and as an talented domain. And it is associated with the achievements in science, technology, engineering, and mathematics (STEM) disciplines. So, the instrument for measuring spatial ability is very important. The purpose of this study is to develop Spatial Visualization Tests for Elementary School Children and examine internal consistency reliability evidence and construct validity evidence on confirmatory factor analysis of that instrument. For this purpose, 'The Spatial Visualization Tests for Elementary School Children was administered to 1482 Korean elementary school students. As a result, this study show that internal consistency reliability evidence using Cronbach' alpha showed item consistency and construct validity evidence from confirmatory factor analysis in the Spatial Visualization Tests for Elementary School Children. And also, this study show ed that item difficulty and item discrimination of the Spatial Visualization Tests for Elementary School Children were within an acceptable range.

• Korean Journal of Soil Science and Fertilizer
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• v.34 no.3
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• pp.173-177
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• 2001

This study was conducted to investigate a potential utilitization of multivariate statistical analysis(Factor analysis, Discrimination analysis) on interpretation of rice plant lodging reason. Rice plants were sampled in paddy around Taegu city at from 25 to 29 of September in 2000. Mineral nutrient content(phosphate, potassium) of rice plant were significantly higher at 99% level, Silicate content were lower at 95% level in lodged samples than in normal. Plant characteristics associate with lodging(Culm length, second and third internode length, bight of center gravity) were significantly longer in lodged rice plant than in non lodged. Result of Factor analysis were that first principle component were culm length, second(N2) and third internode length(N3), second principle component were Ca content, first internode length(N1) and N3/culm length, third principle component were center gravity length(G) and G/culm length, fourth were nitrogen, phosphate, and potassium content, fifth were N2/culm length, N2+N3/culm length, Sixth was silicate content of rice plant. Linear discriminant equation distinguished lodged rice plants with non lodged rice plants very well. Prediction value was 100%, most explainable variable were phosphate content, culm length and third length.

• Journal of the Korean Society of Tobacco Science
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• v.22 no.2
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• pp.184-189
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• 2000

This study was conducted to develop the objective evaluation method for tobacco smoke. The evaluation was carried out by using the data of cut or blended tobacco components, smoke components, electric nose system (ENS), and sensory test. By using the statistical methods, such as cluster analysis, discriminant analysis, factor analysis, correlation analysis, and multiple regression analysis, the relationship among the data of tobacco, smoke, ENS, and sensory evaluation was studied. By the results of cluster analysis, the data from smoke analysis by GC and ENS were able to select the difference of tobacco leaf characteristics. As the results of discriminant analysis, grouping by the components of tobacco leaves and smoke was possible and the results of GC analysis of smoke could be used for discrimination of tobacco leaves. In the results of factor analysis, nicotine, tar, CO, puff No and pH in the smoke were the factors effecting on the tobacco leaf characteristics. From the correlation analysis, aroma, taste, irritation, and smoke volume of sensory test had high relation to tar, p-cresol threonolatone, levoglucosane, and quinic acid- ${\gamma}$ -lactone of smoke. The ENS data showed high efficiency for discriminant analysis and cluster analysis, but it was not good for factor analysis, and correlation analysis. It was possible to estimate tobacco leaves and their blending characteristics by the analytical data of tobacco leaves, smoke, ENS, and sensory test results. By the multiple regression analysis, some correlation among selected chemical components and sensory evaluation were found. This study strongly indicated that the some chemical analysis data was available for the objective evaluation of tobacco sensory attributes.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.11 no.2
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• pp.27-44
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• 2007

Background: Eight-Constitution Medicine (ECM) classifies the human body into eight constitutions. Diagnosis of discrimination of the eight constitutions depends on a unique pulse diagnosis. However, pulse diagnosis is subjective and requires vigorous training. Objectives: This study aims to analyze the validity and reliability of the Eight-Constitution Questionnaire as a diagnostic method. Methods: Participants of this study were outpatients in six ECM clinics located in Seoul. The resources were collected from 409 patients who were classified into one of the eightconstitutions according to their pulse types and their responses to constitution-acupuncture therapy. SPSS 13.0 for Windows was used for statistical analysis: factor analysis, reliability analysis, independent sample t-test, and multinomial logistic regression were used to verify the results. Results and Conclusions: 1. The proportion of participants' constitutions is in the order of Pancreotonia (23.7%), Colonotonia (19.8%), Pulmotonia (18.1%), Hepatonia (16.9%), Vesicotonia (8.1%), Cholecystotonia (7.3%), Renotonia (5.3%) and Gastrotonia (0.7%). 2. Sevencomponents and 74 items were selected through factor factor and relaibility analysis performed on about 251 items. 3. The firstcomponent's mean is significantly higher in Pancreotonia than that in other constitutions (p<0.05). The second is in Pulmotonia and Colonotonia, whereas the third is in Hepatonia and Cholecystotonia. Fifth is in Vesicotonia, the sixth is in Colonotonia, and the fourth and seventh are not significant in specific constitutions. 4. The percentage that Pancreotonia is correctly predicted is 96.9%, Pulmotonia is 91.9%, Colonotonia is 91.4%, Hepatonia is 88.4%, Vesicotonia is 81.8%, Gastrotonia is 66.7%, Renotonia is 66.7%, Choleeystotonia is 30.0%, and the total percentage is 85.3%.

• The Korean Journal of Applied Statistics
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• v.11 no.2
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• pp.435-449
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• 1998

In this article we have introduced a Bayes criterion for the variable selection in multiple discriminant analysis (MDA). The criterion is a default Bayes factor for the comparision of homo/heteroscadasticity of the multivariate normal means. The default Bayes factor is obtained from a development of the imaginary training sample method introduced by Spiegelhalter and Smith (1982). Based an the criterion, we also provided a test for additional discrimination in MDA. The advantage of the criterion is that it is not only applicable for the optimal subset selection method but for the stepwise method. More over, the criterion can be reduced to that for two-group discriminant analysis. Thus the criterion can be regarded as an unified alternative to variable selection criteria suggested by various sampling theory approaches. To illustrate the performance of the criterion, a numerical study has bean done via Monte Carlo experiment.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.42 no.3
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• pp.8-14
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• 2019

Most of the data envelopment analysis (DEA) models evaluate the relative efficiency of a decision making unit (DMU) based on the assumption that inputs in a specific period are consumed to produce the output in the same period of time. However, there may be some time lag between the consumption of input resources and the production of outputs. A few models to handle the concept of the time lag effect have been proposed. This paper suggests a new multi-period input DEA model considering the consistent time lag effects. Consistency of time lag effect means that the time delay for the same input factor or output factor are consistent throughout the periods. It is more realistic than the time lag effect for the same output or input factor can vary over the periods. The suggested model is an output-oriented model in order to adopt the consistent time lag effect. We analyze the results of the suggested model and the existing multi period input model with a sample data set from a long-term national research and development program in Korea. We show that the suggested model may have the better discrimination power than existing model while the ranking of DMUs is not different by two nonparametric tests.

• Journal of Oriental Neuropsychiatry
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• v.33 no.3
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• pp.277-285
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• 2022

Objectives: Gastrodia elata (GE) has been used to treat cognition impairment, including Alzheimer's disease (AD) in Korea. The purpose of this study was to investigate the effects of GE water extracts (GEE) on the lipopolysaccharide (LPS)-induced AD model in mice. (Aβ). Methods: We classified six groups as follow; group 1: control (CON), group 2: LPS (0.5 mg/kg/day, four times), group 3: 4 mg/kg donepezil (DP), group 4: 100 mg/kg GEE+LPS, group 5: 200 mg/kg GEE+LPS, group 6: 500 mg/kg GEE+LPS. Results: We found that GEE has an effect that inhibits decrease of discrimination index in object recognition test, as well as spontaneous alteration in the Y-maze test by LPS. Treatment with LPS increased amlyloid-β (Aβ) concentration, and decreased brain-derived neurotrophic factor (BDNF) in cerebral cortex of mice. However, GEE significantly protected against LPS-induced Aβ and BDNF changes. Our findings also showed that the inflammatory cytokines [tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β)] mRNA and protein were up-regulated by the LPS injection. But GEE significantly suppressed LPS-induced inflammatory cytokines increase in a dose-dependent manner. Conclusions: This study suggests that the GEE may be an effective AD therapeutic agent, in treating neurodegenerative diseases including AD.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.5
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• pp.1881-1895
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• 2015

Background: The vascular endothelial growth factor family has been implicated in tumorigenesis and metastasis. The prognostic value of each vascular endothelial growth factor family member, particular VEGF/VEGFR co-expression, in patients with non-small lung cancer remains controversial. Materials and Methods: Relevant literature was identified by searching PubMed, EMBASE and Web of Science. Studies evaluating expression of VEGFs and/or VEGFRs by immunohistochemistry or ELISA in lung cancer tissue were eligible for inclusion. Hazard ratios (HRs) and 95% confidence intervals (CIs) from individual study were pooled by using a fixed- or random-effect model, heterogeneity and publication bias analyses were also performed. Results: 74 studies covering 7,631 patients were included in the meta-analysis. Regarding pro-angiogenesis factors, the expression of VEGFA (HR=1.633, 95%CI: 1.490-1.791) and VEGFR1 (HR=1.924, 95%CI: 1.220-3.034) was associated separately with poor survival. Especially, VEGFA over-expression was an independent prognostic factor in adenocarcinoma (ADC) (HR=1.775, 95%CI: 1.384-2.275) and SCC (HR=2.919, 95%CI: 2.060-4.137). Co-expression of VEGFA/VEGFR2 (HR=2.011, 95%CI: 1.405-2.876) was also significantly associated with worse survival. For lymphangiogenesis factors, the expression of VEGFC (HR=1.611, 95%CI: 1.407-1.844) predicted a poor prognosis. Co-expression of VEGFC/VEGFR3 (HR=2.436, 95%CI: 1.468-4.043) emerged as a preferable prognostic marker. Conclusions: The expression of VEGFA (particularly in SCC and early stage NSCLC), VEGFC, VEGFR1 indicates separately an unfavorable prognosis in patients with NSCLC. Co-expression VEGFA/VEGFR2 is comparable with VEGFC/VEGFR3, both featuring sufficient discrimination value as preferable as prognostic biologic markers.

• Korean Journal of Social Welfare
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• v.63 no.2
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• pp.319-336
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• 2011

There is recent recognition that the approach toward family members is crucial for understanding problems in multi-cultural families by emerging from typical approach focused on migrant women. While researches have reported serious conflicts and adaptation problems from cultural difference between parent-in-law and foreign daughter-in-law, cultural stress of parent-in-law has not been systematically examined. The purpose of this study was to develop and validate a scale to measure acculturation stress of parent-in-law who have a foreign daughter-in-law. The sample consisted of 266 parents-in-law from three provinces of South Korea. Initially, 16 items were generated based on the existing scale of acculturation stress and they are tested by item-analysis through the descriptive and correlational analysis. An exploratory factor analysis was conducted to investigate the factor structure of the scale and a confirmatory factor analysis was used to validate the scale. By item-analysis, five items were deleted from initial scale items because of redundancy. Findings from an exploratory factor analysis provided the evidence that the scale consists of three factors which are the perception of prejudice and discrimination, conflicts from different cultural value, and daily discomfort. Cronbach's ${\alpha}$ for the scale is 0.86. Multiple fit indices from confirmatory factor analysis indicated that the hypothesized three-factor model for acculturation stress achieved a good fit with the data. Results showed the evidence for the reliability and validity of the scale for acculturation stress of the parent-in-law who have foreign daughter-in-law. The scale would have potential effects for assessing psychological stress for parent-in-law in research and clinical practice. Further implications and limitation of the study and suggestions for future studies were discussed.